最新刊期
卷 36 ， 期 3 ， 2013
- 摘要：The authors discussed the misunderstandings in study of febrile disease,replenished the common pathology of febrile disease such as stagnation,phlegm forming,blood stasis and healthy qi deficiency,analyzed and presented personal reviews on nine questions including extent,etiology,pathogenesis,differences in diseases and syndromes,and understandings to defense,qi,nutrient and blood syndrome differentiation.The purpose is to definite and solve the problems existing in study of febrile disease,and improve the development of the study.关键词：febrile disease;study of febrile disease;misunderstandings
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发布时间：2021-05-20 - 摘要：Formula-related syndrome differentiation is a special form of clinical thinking of syndrome differentiation,which was proposed by ZHANG Zhong-jing in Shanghanzabinglun.The researchers of cold damage in Tang and Song Dynasties broke the system of six-meridian syndrome differentiation and generated a system of classifying syndromes according not to classics but formulas.Formula-related syndrome differentiation has been replenished and perfected gradually by formula-related syndromes of current formulas in later generations.Formula-related syndrome differentiation has characteristics of administrating directly,recognizing syndrome based on formulas,differentiating main syndromes,corresponding between pulses and syndromes and flexible adaptation.Modern people has recognized the importance of effect relationship between formulas and syndrome in formula-related syndrome differentiation,deeply studied origin,concept and features,and explored the connotation and application by using modern research methods for improving the system of formula-related syndrome differentiation.关键词：formula-related syndrome differentiation;formula-related syndromes;classical formulas;current formulas
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发布时间：2021-05-20 - 摘要：The connotation of the theory of liver corresponding to spring was studied,and the necessity and feasibility of discussing the pathogenosis of seasonal affective disorder（SAD） based on the theory were analyzed.The current poor understanding to SAD both in Chinese medicine and Western medicine was pointed out,and a close correlation in the neuroendocrine mechanism of liver-central monoamine neurotransmitter-melatonin-SAD was stated.In addiction,correct understanding to the connotation of liver corresponding to spring is greatly significant to recognizing pathogenesis of SAD seasonal attacks and remission,and its treatment and prevention.关键词：liver corresponding to spring;TCM pathogenesis;seasonal affective disorder;theoretical research
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发布时间：2021-05-20 - 摘要：Objective To observe the kidney protection effect and influence of Jianpi Yishen Huayu Tongluo Fang on oxidative stress in rats with diabetic nephropathy（DN） induced by streptozocin（STZ）.Methods Male Wistar rats（n=74） were intraperitoneally injected STZ（45 mg/kg） for establishing model,and then divided,after successful modeling and according to body weight,into normal grouop,model group,irbesartan（17.5 mg/kg） group and low-dose（30.8 mg/kg） and high-dose（123.2 mg/kg） Jianpi Yishen Huayu Tongluo Fang groups（low-dose group and high-dose group）.The body weight and 24-hour urine protein quantitate were measured every 4 weeks.On the 14th week the rats were executed for recording the ration of kidney weight to body weight（KW/BW） and detecting the levels of serum triglyceride（TG）,blood urea nitrogen（BUN）,serum creatinine（Scr）,nitric oxide（NO）,malondialdehyde（MDA） and superoxide dismutase（SOD）.The pathological changes and scores of kidney tissue were observed and analyzed after staining of HE,Mallory and PASM-HE.Results In low-dose group and high-dose group,the body weight increased significantly（P<0.05）,KW/BW decreased significantly,pathological changes of kidney tissue were relieved,levels of serum TG,BUN and Scr decreased significantly（P<0.05）,activity of serum SOD increased（P<0.05） and MDA decreased（P<0.05） compared with model group.Conclusion Jianpi Yishen Huayu Tongluo Fang can play a role of protecting kidney through antagonizing oxidative stress in DN rats.关键词：Jianpi Yishen Huayu Tongluo Fang;diabetic nephropathy;oxidative stress;rats
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发布时间：2021-05-20 - 摘要：Objective To observe the changes of sperm mitochondrial ultrastructure and membrane potential in rat model of oligoasthenotspermia prepared with tripterygium glycosides（GTW）,and discuss the intervention mechanism of therapy of tonifying kidney and replenishing essence to oligoasthenotspermia.Methods Male rats（weighing from 200 g to 220 g） were randomly divided into normal group,model group,Huangjing Zanyu Capsules group（positive group,3.24 g/kg）,and groups of low-dose,mid-dose and high-dose Bushen Yijing Fang（low-dose group,mid-dose group and high-dose group,0.68 g/kg,1.35 g/kg and 2.70 g /kg）.Except of normal group,other groups were orally given GTW（30 mg/kg/d） every day continuously for 8 weeks for preparing the model of oligoasthenotspermia.After modeling,all medicated groups were given corresponding medicinal for 30 days,and normal group and model group were given the same amount of distilled water.The level of sperm mitochondrial membrane potential（MMP） was detected by applying JC-1 fluorescence staining flow cytometry,and changes of sperm mitochondrial ultrastructure were observed with transmission electron microscope（TEM）.Results After modeling by GTW for 8 weeks,the level of MMP and fluorescent intensity of salmon pink decreased significantly in model rats.The tail of sperm showed edema and cavity,and mitochondria appeared swelling and unevenness with fracture of axoneme.After administration of Bushen Yijing Fang for 30 days,the level of MMP increased significantly.The sperm membrane showed integrity,mitochondrial swelling was alleviated and degeneration of axoneme was mild.Conclusion The protection of sperm mitochondrial structure may be one of effective ways for antagonizing the reproductive toxicity of GTW.Bushen Yijing Fang can treat oligoasthenotspermia through inhibiting the decrease of sperm MMP and protecting the integrity of mitochondrial structure.关键词：tripterygium glycosides;oligoasthenotspermia;mitochondrial membrane potential;ultrastructure;therapy of tonifying kidney and replenishing essence;rats
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of Huiyang Shengji Gao and its modified formulas on wound healing,interleukin-8（IL-8） and tumor necrosis factor-α（TNF-α） in rats with chronic skin ulcer.Methods SD rats（n=44） were randomly divided into model group,group of whole formula of Huiyang Shengji Gao（whole formula group）,group of modified Wenyang Yiqi formula（Wenyang Yiqi group） and group of modified Huoxue Shengji formula（Huoxue Shengji group）.The rat model of chronic skin ulcer was established by using compound factor superposition method of hormone intervention-dermal deficiency-bacterial infection.The general condition and wound healing rate were observed.The content of serum IL-8 and TNF-α were detected respectively 3 days and 7 days after medication.Results The modeled rats showed the basic features of syndrome of spleen-kidney yang deficiency.The wound healing rate was higher in Wenyang Yiqi group and Huoxue Shengji group than that in model group（P<0.05） 2 days after medication,and that was higher in whole formula group than that in model group（P<0.05） 4 days after medication.The content of IL-8 was higher in whole formula group and Wenyang Yiqi group than that in model group（P<0.05）3 days after medication,and the comparison between Huoxue Shengji group and model group had no statistical signficance（P>0.05）.The content of TNF-α was higher in whole formula group and model group than that in Wenyang Yiqi group（P<0.05）and Huoxue Shengji group（P<0.01）3 days after medication.Conclusion Huiyang Shengji Gao and its modified formulas all can improve wound healing in rats with chronic skin ulcer,and the effects of modified Wenyang Yiqi formula are related to improving local inflammatory reaction and stimulating the secretion of inflammatory factors.关键词：Huiyang Shengji Gao;chronic skin ulcer;interleukin-8;tumor necrosis factor-α;rats
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of the medicated serum of Wuzi Yanzong Wan on vitality of sertoli cells of testis in rats.Methods The original strain of sertoli cells of rat testis was cultured and medicated serum samples of Wuzi Yanzong Wan were prepared in high dose and low dose.The high-dose and low-dose serum samples were then divided into 20% group,10% group,5% group and blank group,and cultured together with original strain of sertoli cells of rat testis.The influence of Wuzi Yanzong Wan on the vitality of sertoli cells was observed by using methyl thiazolyl tetrazolium test（MTT） at 5 time points including 6 h,12 h,24 h,48 h and 72 h.Results At the time points of 6 h,12 h,24 h,48 h and 72 h,the vitality of sertoli cells increased in 20% group and 10% group along with the prolong of time,reached the highest at 24 h and decreased gradually after that time point.Conclusions The medicated serum of Wuzi Yanzong Wan has some improving effect on the vitality of sertoli cells,and the vitality will be the highest when 20% medicated serum and sertoli cells are cultured together for 24 hours.关键词：medicated serum of Wuzi Yanzong Wan;Sertoli cells;vitality;rats;testis
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》已入编《中国学术期刊（光盘版）》。为此郑重声明如下:一、凡在《北京中医药大学学报》发表的文章,如作者事先未表示异议,则相应地被编入《中国学术期刊（光盘版）》。《中国学术期刊（光盘版）》免收作者版面费。
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发布时间：2021-05-20 - 摘要：Objective To investigate the influence of Jiawei Buyang Huanwu Tang on apoptosis of retinal microvessel pericytes in rats with diabetes mellitus（DM）.Methods The rat model of DM was induced with streptozotoci,and DM rats were divided into treatment group treated with Jiawei Buyang Huanwu Tang（10.71 g/kg）,control group given calcium dobesilate（120 mg/kg） and blank group given normal saline（3 mL / d）,and additionally a normal group was set up.After successful modeling,the rats were given medicinal for 12 weeks.Retinal digest preparations were prepared and given PAS taining for observing the morphology of retinal microvessels.The area rate of microvessel net per sight was detected and the total pericyte count per sight was calculated.The apoptosis of retinal microvessel pericytes was detected by using terminal-deoxynucleoitidyl transferase mediated nick end labeling（TUNEL）.Results The arrange of retinal microvessels was regular,diameters of capillaries were uniform,and differences in area rate of microvessel net and total pericyte count per sight had no statistical significance among 4 groups（P >0.05）.There was no apoptosis of retinal microvessel pericytes observed in normal group,but there was in DM rats on the 12th week.The comparison between treatment group and normal group had no statistical significance（P > 0.05）,and the apoptosis was milder in treatment group compared with control group and blank group（P < 0.05）.Conclusion The apoptosis of retinal microvessel pericytes has appeared in DM rats on the 12th week,and Jiawei Buyang Huanwu Tang can inhibit the apoptosis.关键词：Jiawei Buyang Huanwu Tang;diabetes mellitus;diabetic retinopathy;pericytes;apoptosis;rats
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发布时间：2021-05-20 - 摘要：Objective To study the curative effect of Fuzheng Jiedu Huayu Granules on senile pneumonia with different risk stratifications reviewed with pneumonia severity index（PSI） and SMART-COP.Methods The patients（n=303） with senile pneumonia were randomly divided into control group（treated with routine treatment of Western medicine） and treatment group（treated with routine treatment of Western medicine and Fuzheng Jiedu Huayu Granules）.The risk degrees of patients were ranked according to PSI and SMART-COP,and then the stratification data of infection absorption degree showed by chest X-ray and TCM syndrome changes were given Chi-square test in the patients with different levels of PSI and different scores of SMART-COP.Results Compared with control group with the same stratifications,the distribution of infection absorption degree showed by chest X-ray（5 degrees） was better in treatment group than that in control group（P<0.05） when PSI was level Ⅱ or score of SMART-COP was 1.The distribution of symptom relieving was better in treatment group than that in control group（P<0.05） when the score of SMART-COP was 2.Conclusion The routine therapy of Western medicine combining Fuzheng Jiedu Huayu Granules has effects of improving infection absorption and relieving clinical symptoms in the patients with mild senile pneumonia（score of SMART-COP equal to or less than 2 or PSI equal to or less than level Ⅱ）.关键词：senile pneumonia;Fuzheng Jiedu Huayu Granules;pneumonia severity index;SMART-COP;evaluation on curative effect
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发布时间：2021-05-20 - 摘要：Objective To study and review the curative effect and mechanism of Yiqi Yangyin Xiaoji Yin combining chemotherapy on advanced non-small cell lung cancer（NSCLC）.Methods NSCLC patients（n=92） were randomly divided into Chinese medicinal combining chemotherapy group（combining group,n=31）,chemotherapy group（n=31） and Chinese medicinal group（n=30）,and treated respectively.The Chinese medicinal was self-made Yiqi Yangyin Xiaoji Yin and chemotherapy was related chemotherapy mode.The changes of cancer focus and quality of life were observed and reviewed in 3 groups before and after treatment.The changes of natural killer cells（NKC）,lymphocyte conversion rate（LBT） and lymphocyte subsets were detected before and after treatment.The marrow toxicity was compared between combining group and chemotherapy group before and after treatment.Results ① In the aspect of reducing tumor body: the remission rate was higher in combining group and chemotherapy group than that in Chinese medicinal group（all P<0.05）,and the stability rate was higher in combining group and Chinese medicinal group than that in chemotherapy group（all P<0.05）.②In the aspect of reviewing immune indexes in all groups: NKC,LBT and T lymphocyte subsets CD3+,CD4+ and CD8+ all increased significantly in 3 groups after treatment（P<0.01）,and the ratio of CD4+/CD8+ increased to some extent but without significant difference（P>0.05）.The comparison among 3 groups showed that all immune indexes presented significant advantages in combining group and Chinese medicinal group compared with chemotherapy group（all P<0.05）.③ In the aspect of reviewing quality of life: there was no significant difference in Karnofsky scores in combining group and Chinese medicinal group before and after treatment（P>0.05）,which decreased significantly in chemotherapy group after treatment（P<0.01）.④ In the aspect of reviewing marrow toxicity: in combining group,phase III+IV bone marrow suppression was significantly lower than that in chemotherapy group（P<0.05）.Conclusion The treatment of NSCLC with integrated Western and Chinese medicine is superior to simple chemotherapy or simple Chinese medicinal based on the analysis of comprehensive factors.关键词：cancer;non-small cell lung cancer;Yiqi Yangyin Xiaoji Yin
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发布时间：2021-05-20 - 摘要：Objective To observe the curative effect of the therapy of replenishing qi,nourishing yin and activating blood for improving quality of life in patients with diabetic nephropathy（DN）.Methods DN patients（n=120） were randomly divided into Chinese medicinal group and control group（each n=60）.The control group was treated with comprehensive therapy for 2 months,and Chinese medicinal group was additionally given Chinese medicinal with actions of replenishing qi,nourishing yin and activating blood for 2 months.The patients were followed up after 6 months.The quality of life in 3 fields including physiology,society and psychology was investigated before and 2 months after treatment and during follow-up.Results After treatment for 2 months,the physical function,psychological status and total quality of life were improved in varying degrees in DN patients,and more significant in Chinese medicinal group compared with control group（P<0.01）.The field of social relations was improved in Chinese medicinal group after treatment for 2 months and the integral was significantly decreased than before treatment（P<0.01）.Conclusion The therapy of replenishing qi,nourishing yin and activating blood can significantly improve the total quality of life especially in the field of physical function and psychology.关键词：therapy of replenishing qi,nourishing yin and activating blood;diabetic nephropathy;quality of life
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发布时间：2021-05-20 - 摘要：Objective To discuss the laws of morphological changes of exfoliative cells of tongue fur in the patients with different TCM syndrome types of middle-advanced primary bronchogenic lung cancer,and provide objective evidence for TCM syndrome differentiation.Methods The patients（n=140） at from stage Ⅱ to stage Ⅳ of TNM staging were divided into 4 syndrome types including qi deficiency and phlegm-dampness syndrome（group 1）,syndrome of qi stagnation and blood stasis（group 2）,yin deficiency and heat-toxin syndrome（group 3）,and syndrome of dual deficiency of qi and yin（group 4）.The distribution characteristics of TCM syndrome types were investigated in the patients at different TNM stages of middle-advanced primary lung cancer.The maturity index（MI） and maturity value（MV） of exfoliative cells of tongue fur were detected and compared in the patients of different syndrome types,and other 30 normal people were taken as the control（normal group）.Results The distribution of TCM syndrome types was significantly different（P<0.01） at different TNM stages.Qi deficiency and phlegm-dampness syndrome was mainly occurred in ⅡB stage（72.42%）,syndrome of qi stagnation and blood stasis,in ⅢA stage（52.17%）,yin deficiency and heat-toxin syndrome,in ⅢB stage（66.67%）,and syndrome of dual deficiency of qi and yin,in Ⅳ stage（90.00%）.The proportion of middle layer cells was higher and that of superficial cells was lower in all syndrome groups than those in normal group.MV was lower in all syndrome groups than that in normal group（P<0.01）.The changes of MI and MV were the most significant in group 2（P<0.01） and the most mild in group 3（P<0.01）.The trend of MV showed a descending order in group 2,group 4,group 1,group 3 and normal group.There was no significant difference between group 4 and group 1,and there was difference among other groups（P<0.05 or P<0.01）.Conclusion The contribution of TCM syndrome types is different in patients with lung cancer in different TNM stages,and the changes of MI and MV of exfoliative cells of tongue fur are related to the TCM syndrome types of lung cancer.关键词：lung cancer;exfoliative cells of tongue fur;syndrome differentiation of Chinese medicine
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发布时间：2021-05-20 - 摘要：Objective To sum up the distribution and dynamic changes of common syndromes of psoriasis vulgaris in different decades through analyzing the modern literature for nearly 60 years after new China founded.Methods The relative literature was retrieved from 1949 to 2009,and a database of syndromes of psoriasis vulgaris was established by using Epidata 3.1 software,and all data was imputed to the database and analyzed by using SPSS17.0 statistical software.Results There was no eligible literature included into the study from 1949 to 1959.The types of syndromes and their accumulated frequency in other decades were as follows: in 1960s（2,2）,in 1970s（8,16）,in 1980s（29,116）,in 1990s（75,490）,and in the first ten years of the 21st century（140,1080）.The syndrome types which frequency was equal to or more than 30% and their times and frequency on each decade were as follows: in 1960s wind-cold syndrome（1,100%） and wind-heat syndrome（1,100%）,in 1970s blood-heat syndrome（5,62.50%） and blood-dryness syndrome（5,62.50%）,in 1980s blood-heat syndrome（23,60.53%）,blood-dryness syndrome（20,52.63%） and blood stasis syndrome（15,39.47%）,in 1990s blood-heat syndrome（99,63.87%）,blood stasis syndrome（81,52.26%） and blood-dryness syndrome（79,50.97%）,and in the first ten years of the 21st century blood-heat syndrome（247,73.08%）,blood stasis syndrome（184,54.44%） and blood-dryness syndrome（159,47.04%）.Conclusion The common syndrome types of psoriasis vulgaris,including blood-heat syndrome,blood stasis syndrome and blood-dryness syndrome,have no significant changes in different decades.The major therapeutic thought of this disease is to treat it from blood,while the amount of literature about its syndromes,methods of syndrome differentiation and syndrome types tend to more rich and more diversified.关键词：psoriasis vulgaris;Chinese medicine;syndromes;literature
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发布时间：2021-05-20 - 摘要：Objectives To observe the curative effect of acupotomy with different inserting depth on fasciitis of back muscles.Methods All patients were randomly divided into shallow insertion group and deep insertion group,and given treatment of acupotomy with shallow insertion and deep insertion respectively.The average values of Visual Analogue Scale（VAS） of pressing pain in treatment points were observed in each patients before and after treatment,and the short-term curative effect was reviewed.Results The average values of VAS were all lower in shallow insertion group than those in deep insertion group（P<0.05） 3 days and 7 days after treatment.The excellent rate was 70% in shallow insertion group and 30% in deep insertion group（P<0.05） after treatment.Conclusion The curative effect of shallow insertion of acupotomy is better than that of deep insertion,and shallow insertion can reduce medical risks effectively when using acupotomy on the back.关键词：acupotomy;fasciitis of muscles;backache;inserting depth of needling
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发布时间：2021-05-20 - 摘要：Chinese massage-related articles published on the original journals of Science Citation Index（SCI） from 2001 to 2011 were summed up and analyzed,and the domestic and overseas research achievements of Chinese message were investigated.There were totally 83 relative literature looked up through retrieving online database of Web of Science.From 4 aspects including statistics,content,discussion and prospective and by using Excel software and manual work,the domestic and overseas development tends of research on Chinese massage were elaborated systematically in the last 11 years.The clinical application and mechanism exploration were analyzed,and limitations and deficiencies in the literature were pointed out.It is expected that this study will play an active role in the research on Chinese message.关键词：Chinese massage;Science Citation Index;literature analysis
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》（以下简称《学报》）自1959年创刊至今已经53周年,始终贯彻为中医药教学、科研、医疗服务的方针,及时报道中医药研究的最新成果和动态,为促进中医药发展而努力。《学报》辟有学科展望、专家述评、理论研究、临床研究、文献研究、科技之窗、实验研究、中药化学、中药制剂、博士之光等专栏,以全面反映国内中医药研究关键词：北京中医药大学学报;影响因子;总被引频次;综合评价总分
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发布时间：2021-05-20 - 摘要：<正>为规范本刊作者投稿中参考文献的著录格式,按照2005年3月发布2005年10月1日开始实施的GB/T 7714—2005《文后参考文献著录规则》和有关编辑出版的规定和要求,结合本刊长期以来采用的《顺序编码制》的特点,特制订出《北京中医药大学学报》参考文献著录格式,希望作者遵照执行。
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