最新刊期
卷 36 ， 期 4 ， 2013
- 摘要：The significance of the study on primitive dosage of classical formulas is clarified from five aspects by applying literature research methods,including revealing the original appearance of original dosage of classical formulas,exploring the historical track of dosage of formulas,making clear the regular dose range of formulas,telling the cause of historical changes of dosage of formulas,and improving the effect of classical formulas.It is concluded that the study on the original dosage of classical formulas is not only a problem about medical history,more importantly finding the optimal dosage range in order to guarantee and improve the curative effect of formulas in clinic.关键词：classical formulas;dosage;primitive dosage of classical formulas;literature research
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发布时间：2021-05-20 - 摘要：How many symptoms in Chinese medicine has been inconclusive,because there is no common view on the define method of symptoms in TCM circle.The paper,followed logic rules,obtained 2 751 symptoms from medical records in all ages,and found out six conceptual relationships including identical relationship,containment relationship,crossing relationship,contrary relationship,contradictory relationship and disparate relationship,two judgment relationships including essential judgment and relation judgment,and one causal relationship.Therefore,there were 399 independent symptoms determined with minimum connotation except of surgical symptoms.It is hoped to useful to the standardization of TCM symptoms.关键词：symptoms;independent symptoms;concept;judgment;causal relationship
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发布时间：2021-05-20 - 摘要：Traditional Chinese life nurturing is guided by holism in practice,and values the harmony between human and environment ecology,between physique and morality and between emotions,and between man and society.The basic principle is conforming to nature,integration of body and spirit,dynamic and static combination,and suiting measures to three factors（time,place and person）.Individuation life nurturing is the most important according to different characteristics of different persons.Traditional Chinese life nurturing emphasizes just and gentle,and unity of heaven and man in macroscopic objective.关键词：life nurturing;conforming to nature;suiting measures to three factors;just and gentle;unity of heaven and man
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发布时间：2021-05-20 - 摘要：<正>为了更好地服务作者、读者,提高工作效率,《北京中医药大学学报》编辑部自2011年1月1日起开通网上采编系统（http://xb.bucm.edu.cn）,请广大作者和读者登陆本刊网址,随时通过此系统投稿、查稿、修改稿件或浏览最新目录等,首次登陆需先行注册。2010—2012年杂志及现刊内容已在网上全文刊出,可在线
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发布时间：2021-05-20 - 摘要：<正>中医药学学科的发展离不开学派建设,学派促进学科的发展,这是学科发展所经历的一条必由之路。中医药理论的创立、发展及完善,自始至终学派都在发挥关键的作用。但是,学派意识的欠缺却是目前存在的一个严重问题。学派意识的欠缺对学科关键词：中医药学;学派;学派意识;学科
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》已入编《中国学术期刊（光盘版）》。为此郑重声明如下:一、凡在《北京中医药大学学报》发表的文章,如作者事先未表示异议,则相应地被编入《中国学术期刊（光盘版）》。《中国学术期刊（光盘版）》免收作者版面费。
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发布时间：2021-05-20 - 摘要："Not eating miscellaneous foods" is a traditional viewpoint in TCM dietetic life nurturing,which was taken as the theoretic basis by ancient literature for researching incompatible foods.Because of the literature related to the saying,"not eating miscellaneous foods",is so age-old,its source is not clear and there are a lot of errors in the course of copying.The paper proved that a paragraph of text in Bowuahi wrote "za shi" as "sui shi" by mistake.And the saying,"Eating sui shi is not encouraged,because it may offend some taboo" in Beijiqianjinyaofang,Yixinfang and Taipingyulan was originated from WANG Shu-he,a famous physician in the Western Jin Dynasty.The author of Yangshenglun contained in Taipingyulan is not GAO Zhan,but ZHANG Zhan in the Eastern Jin Dynasty,and what is called Yangshenglun is actually Yangshengyaoji.关键词：not eating miscellaneous foods;incompatible foods;WANG Shu-he;Zhang Zhan
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发布时间：2021-05-20 - 摘要：Objective To observe the influence of Qizhi Yifei Granules on expression of transforming growth factor β1（TGF-β1） of lung tissue in rats with chronic obstructive pulmonary disease（COPD）,and discuss the mechanism of Qizhi Yifei Granules in inhibiting small airway remodeling of COPD.Methods Wistar rats（n=72） were randomly divided into blank group,model group and treatment group.The rat model of COPD was established by using the method combining smoking fuming and intratracheal LPS instillation.From the 21st day,model group was given intragastrically saline once a day,treatment group,Qizhi Yifei Granules once a day and blank group,normal feeding.All rats were killed on the 30th day,40th day and 60th day in batches.The expression of TGF-β1 protein was detected by using immunohistochemistry technique,and expression of TGF-β1 mRNA was detected by using real-time fluorescence quantitative polymerase chain reaction（RT-PCR）.Results The expression of TGF-β1 protein increased in model group compared with blank group on the 30th day,40th day and 60th day,and the difference was significant（P<0.05） on the 30th day and 40th day.The expression of TGF-β1 protein was lower in treatment group than that in model group on the 30th day,40th day and 60th day,and the difference was significant（P<0.05） on the 30th day.The expression of TGF-β1 mRNA was higher in model group than that in blank group on the 40th day and 60th day（P<0.05）.The expression of TGF-β1 mRNA was lower in treatment group than that in model group on the 30th day,40th day and 60th day（P<0.05）.Conclusion Qizhi Yifei Granules can intervene the small airway remodeling of COPD through down-regulating the expression of TGF-β1 of lung tissue and small airway epithelium in rats with COPD.关键词：Qizhi Yifei Granules;chronic obstructive pulmonary disease;small airway remodeling;transforming growth factor β1（TGF-β1）;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the pathogenesis of post-cerebroischemia depression through phosphatidylinositol（PI） signal pathway and intervention mechanism of Yinao Jieyu Fang.Methods After establishing the rat model of post-cerebroischemia depression,the content of inositol triphosphate（IP3） was detected by using enzyme-linked immunosorbent assay（ELISA）,and changes of protein kinase C（PKC） and intervention effect of Yinao Jieyu Fang were detected by using Western-blot analysis.Results The content of IP3 in cortex and hippocampus increased significantly in model group compared with normal group（P<0.01）,and decreased significantly in Chinese medicinal group and Western medicinal group compared with model group（P<0.01）.There was no significant difference in content of IP3 in cortex between Chinese medicinal group and Western medicinal group（P>0.05）,but there was significant difference in hippocampus（P<0.05）.The content of PKCα in cortex and hippocampus increased significantly in model group and sham-operation group compared with normal group（P<0.05,P<0.01）.After treatment,the content of PKCα in cortex and hippocampus decreased significantly in Chinese medicinal group and Western medicinal group compared with model group（P<0.01）.Conclusion The onset of post-cerebroischemia depression is related to PI signal pathway.Yinao Jieyu Fang and fluoxertine hydrochloride have intervene effect on PI signal pathway,which may be the effect target of Yinao Jieyu Fang in the treatment of post-cerebroischemia depression.关键词：Yinao Jieyu Fang;post-cerebroischemia depression;phosphatidylinositol signal pathway;inositol triphosphate;protein kinase C;rats
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发布时间：2021-05-20 - 摘要：Objectives To observe the influences of wind-dispelling and tonifying Chinese medicinals in Houshihei San on the expressions of Caspase-3 and poly-ADP-ribose polymerase（PARP） in rat with cerebral ischemia.Methods The model of middle cerebral artery occlusion（MCAO） was established by using thread approach,and then the rats were randomly divided into model group,wind-dispelling group,tonifying group and combining group.The expressions of Caspase-3 and PARP in hippocampus CA1 zone,parietal cortex and corpus striatum of ischemia side were detected by using immunohistochemistry technique and imagine analysis at three time points（6 hours,24 hours and 48 hours after the operation）.Results After ischemia for 6 hours,the wind-dispelling Chinese medicinals reduced the expression of Caspase-3 in CA1 zone and parietal cortex and regulated downwards PARP expression in corpus striatum.The tonifying Chinese medicinals regulated upwards PARP expression in CA1 zone,parietal cortex and corpus striatum.After ischemia for 24 hours,the wind-dispelling Chinese medicinals reduced significantly the expression of Caspase-3 in CA1 zone and parietal cortex.After ischemia for 48 hours,the wind-dispelling Chinese medicinals reduced significantly the expression of Caspase-3 in parietal cortex and corpus striatum and regulated downwards PARP expression in corpus striatum,and the tonifying Chinese medicinals regulated upwards significantly PARP expression in corpus striatum.Conclusion The wind-dispelling Chinese medicinals in Houshihei San can regulate downwards the expression of Caspase-3 selectively at different time points and positions,and tonifying Chinese medicinals can regulate upwards PARP expression to improve the self-rehabilitation of brain cells to prevent apoptosis.关键词：cerebral ischemia;wind-dispelling Chinese medicinals;tonifying Chinese medicinals;Caspase-3;poly-ADP-ribose polymerase;rats
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发布时间：2021-05-20 - 摘要：Objective To review the influence of Yiqi Yangyin Shengjing Fang on the relative parameters of reproductive system in male rats after microwave radiation.Methods Male Wistar rats（n=54） were randomly divided into control group（n=14）,radiation group（n=20） and Chinese medicinal group（n=20）.The radiation group and Chinese medicinal group were radiated with high-power pulsed microwave for one week,and then Chinese medicinal group was intragastrically given Yiqi Yangyin Shengjing Fang.The control group was not radiated and given conventional feeding.After 14 days the blood samples were collected from rat femoral artery for separating serum.The levels of serum sex hormones were detected by using chemiluminescence.The total sperm count and active sperm density in epididymis and epididymal duct were detected by applying WL-90000 sperm analyzer,and the histological changes of testicular tissue were observed with the light microscope.Results The concentration of testosterone（T） was lower and that of progesterone（P） was higher in radiation group than those in control group（P<0.05）.The concentration of T was higher and that of P was lower in Chinese medicinal group than those in radiation group（P<0.05）.The total sperm count and active sperm density decreased in radiation group compared with control group（P<0.05）.The total sperm count increased significantly in Chinese medicinal group compared with radiation group and control group（P<0.05）.The observation results of light microscope showed the loose of spermatogenic epithelium,degeneration,necrosis and exfoliation of spermatogenic cells,and decrease of sperms in epididymal ducts,and accumulation of interstitial protein edematous fluid in seminiferous tubules.After treatment with Chinese medicinals,significant concentrated sperms and higher sperm count were observed in seminiferous tubules.Conclusion The radiation of high-power pulsed microwave can induce early damage of testis,and the changes of T indicate that testis interstitial cells are sensitive to high-power radiation.Yiqi Yangyin Shengjing Fang can improve the levels of serum sex hormones,correct the changes of T and P,promote the quality of sperms,relieve the pathological changes of testis and boost fecundity in rats after microwave radiation.关键词：Yiqi Yangyin Shengjing Fang;microwave radiation;testis;sex hormones;semen;rats
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发布时间：2021-05-20 - 摘要：Objective To explore the influences of the medicated serum of three cultivars of Ezhu（Rhizoma Zedoariae）,including Peng’ezhu,Guang’ezhu and Wen’ezhu,on proliferation,apoptosis and nucleo-cytoplasmic ratio in human gastric carcinoma cells BGC823,and provide the experimental base for selecting cultivars of Ezhu in treatment of gastric carcinoma and anti-tumor compound formulas.Methods BGC823 were cultured in vitro and then the medicated serum of three cultivars of Ezhu was added in high dose,medium dose and low dose.The morphologic changes of BGC823 were observed with inverted phase contrast microscope.The effect of medicated serum on BGC823 was studied by using methyl thiazolyl tetrazolium test（MTT）,flow cytometry and nucleo-cytoplasmic ratio analysis.Results Compared with negative control group,the proliferation of BGC823 was inhibited in high-dose and low-dose Wen’ezhu groups,high-dose and mid-dose Guang’ezhu groups and mid-dose Peng’ezhu group（P<0.05） after 48 hours,and the inhibitory rate was the highest in high-dose Wen’ezhu group（P<0.01）.The apoptosis of BGC823 was significantly inhibited in all Wen’ezhu groups compared with negative control group（P<0.05）.The high-dose Wen’ezhu group had higher effect on nucleo-cytoplasmic ratio of BGC823,and karyopyknosis and nucleo-cytoplasmic ratio were reduced significantly compared with negative control group.Conclusion The medicated serum of Peng’ezhu,Guang’ezhu and Wen’ezhu all can inhibit the proliferation and apoptosis of BGC823,and Wen’ezhu in higher dose has higher effect on nucleo-cytoplasmic ratio of BGC823.It is suggested that Wen’ezhu can be selected for treating gastric carcinoma.关键词：Ezhu（Rhizoma Zedoariae）;different cultivars;medicated serum;gastric carcinoma;proliferation;nucleo-cytoplasmic ratio
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发布时间：2021-05-20 - 摘要：Objective To study the correlation between the incidence of dysentery in Beijing area and meteorological factors three years ago and in current year based on theory of "pestilence occurring after three years".Methods The data of dysentery incidence in Beijing area from 1970 to 2004（35 years） and meteorological data at the same period were given correlation,regression and statistics analysis.The correlation between the incidence of dysentery and meteorological factors three years ago and in current year was discussed.Results The incidence of dysentery was significantly related to temperature,wind speed and relative humidity three years ago（P<0.05）.The wind speed of the second qi（from six qi in theory of five circuits and six qi） was chosen into stepwise regression equation,and regression equation was Y=-260768.31+113844.99X2（2）.The incidence of dysentery was significantly related to temperature and wind speed in current year（P<0.05）.The wind speed of the first qi was chosen into stepwise regression equation,and regression equation was Y=-175 561.65+89 055.08X2（1）.Conclusion The incidence of dysentery is correlated to climatic changes three years ago,and theory of "pestilence occurring after three years" can used for forecasting the incidence of dysentery.关键词：dysentery;meteorological factors;pestilence occurring after three years;statistical analysis;theory of five circuits and six qi
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of music electroacupuncture on hippocampus monoamine neurotransmitters,5-hydroxytryptamine（5-HT）,dopamine（DA） and norepinephrine（NE）,in rats with chronic stress depression.Methods SD rats were randomly divided into blank group,model group,flouxetine group and music electroacupuncture group.The rat model of chronic stress depression was established by applying chronic stress combining separation in all groups except blank group.The behavior changes of rats were reviewed through open-field test,sucrose consumption detection and body weight measure.The expressions of 5-HT,DA and NE were detected by using radioimmunoassay.Results Compared with blank group,number of horizontally crossed grids,standing times,sucrose consumption and body weight decreased significantly in model group（P<0.01）.Compared with model group,number of horizontally crossed grids,standing times,sucrose consumption and body weight increased significantly in flouxetine group and music electroacupuncture group（P<0.05）.Compared with blank group,the content of 5-HT,DA and NE decreased significantly in model group（P<0.01）.Compared with model group,the content of 5-HT,DA and NE increased in flouxetine group（P<0.05）,and increased in music electroacupuncture group（P<0.01,P<0.05）.Compared with flouxetine group,the content of 5-HT increased in music electroacupuncture group（P<0.05）.Conclusion Music electroacupuncture can relieve the ethologic symptoms in rats with chronic stress depression,so it has anti-depression effect.Music electroacupuncture can improve the levels of 5-HT,DA and NE,which may be one of its anti-depression mechanisms.关键词：music electroacupuncture;chronic stress;depression;5-hydroxytryptamine;dopamine;norepinephrine;rats
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发布时间：2021-05-20 - 摘要：Objective To optimize the best extraction technique of obacunone,a chemical reference substance in Baixianpi（Cortex Dictamni）.Methods The content of obacunone was determined by applying HPLC.The influences of ethanol concentration（65% to 95%）,solid-liquid ratio（1:6 to 1:12）,exaction time（1 h to 4 h） and extraction times（1 time to 4 times） on the extraction ratio of obacunone were observed by using single factor test.A four-factor,three-level orthogonal experiment method was designed respectively according to factors of ethanol concentration,solid-liquid ratio,exaction time and extraction times for determining the best extraction technique of obacunone.Results In the single factor test,the best ethanol concentration was from 75% to 95%,the best range of solid-liquid ratio was from 1:8 to 1:12,the best range of exaction time was from 1 hour to 3 hours,and the best range of extraction times was from 1 time to 3 times.The range analysis of orthogonal experiment showed that all influence factors were,in a descending order,solid-liquid ratio,extraction times,ethanol concentration and exaction time according to their influence degree.The best extraction technique of obacunone was as follows: 8 times amount of 95% ethanol was used to extract 2 times and each time for one hour in the extraction.The extraction ratio of obacunone was 4.192 mg/g by this optimized extraction technique.Conclusion This extraction technique is feasible and simple with higher extraction ratio.关键词：reference substance;Baixianpi（Cortex Dictamni）;obacunone;extraction technique
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of acupuncture on TCM symptom scores of lung and intestine after acupuncture in acupoints of lung and large intestine meridians in the patients with bronchial asthma,and explore the clinical value of acupoint selection according to the theory of lung and large intestine being interior-exteriorly related in the treatment of lung system diseases.Methods The eligible patient（n=96） were divided into acupuncture group 1（needling in acupoints of lung meridian）,acupuncture group 2（needling in acupoints of large intestine meridian）,acupuncture group 3（needling in acupoints of lung and large intestine meridians） and control group（each n=24）.All groups were given ventolin aerosol as routine treatment and the first three groups were,additionally,given acupuncture treatment.Acupuncture group 1 was needled in Zhongfu（LU1）,Chize（LU5） and Lieque（LU7）,acupuncture group 2,in Quchi（LI11）,Hegu（LI4） and Tianshu（ST25）,and acupuncture group 3,in Chize（LU5）,Lieque（LU7）,Hegu（LI4） and Tianshu（ST25）.The acupuncture was given every other day,3 times a week（12 times as one therapeutic course）,and totally for 3 courses（12 weeks）.The score changes of TCM symptoms（symptoms of lung and intestine systems） were observed by using TCM symptom scale in all groups.Results The total symptom scores of lung and intestine systems decreased in group 1,group 2 and group 3 after the treatment（P<0.01 or P<0.05）.The comparison among groups showed there was significant different between all acupuncture groups and control groups（P<0.01 or P<0.05）,while the comparison among all acupuncture groups had no significant different（P>0.05）.The changes of total symptom scores in lung system were strongly correlated to those in intestine system（P<0.01）.Conclusion The symptoms of lung system and symptoms of large intestine system can be relieved in the patients with bronchial asthma treated from lung,from intestine or from lung and intestine,and the relief of lung symptoms and relief of intestine symptoms is significantly correlated.关键词：treating diseases from lung and intestine;acupuncture;bronchial asthma;TCM symptoms
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发布时间：2021-05-20 - 摘要：<正>根据国家标准GB3358-82《统计学名词及符号》的有关规定,请作者书写统计学符号时注意:①样本的算术平均数用英文斜体小写x珋表示,不用正体珚X,也不用M或Mean（中位数仍用M）;②标准差用英文斜体小
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发布时间：2021-05-20 - 摘要：The pathological basis of postpartum depression is woman’s unique physiology and puerperal pathology,and the disease positions involve mainly heart,liver and spleen with qi deficiency and blood deficiency.The authors indicated that kidney deficiency plays an important role in the onset of postpartum depression,and common pathogenesis is kidney deficiency and liver depression through analyzing etiology and pathogenesis.The therapy for the disease is to tonify kidney and regulate qi.The paper analyzed further the characteristics of medicinal administration and formula modification in the treatment of postpartum depression.关键词：tonifying kidney;regulating qi;postpartum depression
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发布时间：2021-05-20 - 摘要：Objective To review the curative effect of modified Banxia Xiexin Tang on cold-heat complex syndrome of non-erosive reflux disease（NERD） and its influence on the quality of life.Methods The patients（n=127） were randomly divided into treatment group（n=64） and control group（n=63）.The treatment group was treated with modified Banxia Xiexin Tang twice a day for 8 weeks,and control group,with pantoprazole（40 mg） once a day for 8 weeks.The curative effect and quality of life were reviewed by applying Reflux Disease Diagnostic Questionnaire（RDQ）,Pittsburgh sleep quality index（PSQI） and Hospital Anxiety and Depression Scale（HAD） before and after treatment.Results The total effective rate was 87.50% in treatment group but it was not statistically significant compared with control group（P>0.05）.In treatment group,the total integral of RDQ,RDQ frequency integrals of heartburn,acid reflux and retrosternal pain,and RDQ degree integrals of heartburn,acid reflux,retrosternal pain and regurgitation were statistically significant after treatment compared with those before treatment（P<0.05,P<0.01）,but were not statistically significant compared with control group（P>0.05）.The integrals of PSQI and HAD were statistically significant in treatment group compared with control group（P<0.05） after treatment.Conclusion Modified Banxia Xiexin Tang can effectively relieve the reflux symptoms and its curative effect is similar to that of pantoprazole in the patients with cold-heat complex syndrome of NERD.At the same time,it can improve the quality of sleep and quality of life and is better than pantoprazole.关键词：Banxia Xiexin Tang;non-erosive reflux disease;sleep quality;anxiety;depression;quality of life
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发布时间：2021-05-20 - 摘要：The stagnation of Qi movement and disorder of diffusing and down-sending of lung qi is the basic pathological features of pulmonary diseases.The therapeutic principle should be applying unblocking therapy,including unblocking lung qi,purging lung,regulating pivot,dispersing lung orifice,clearing interstices,freeing lung collaterals,promoting blood circulation and draining waterways.The unblocking therapy is an important one for pulmonary diseases,which not only fits the physical and pathological features of lung,but also hits the key of pulmonary diseases.关键词：pulmonary diseases;unblocking therapy;clinical application
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发布时间：2021-05-20 - 摘要：<正>为规范本刊作者投稿中参考文献的著录格式,按照2005年3月发布2005年10月1日开始实施的GB/T 7714-2005《文后参考文献著录规则》和有关编辑出版的规定和要求,结合本刊长期以来采用的《顺
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发布时间：2021-05-20
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