最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：The primitive dosage of classical formulas is the original dosage of ZHANG Zong-jing’s formulas,which is an important issue in the research on classical formulas and there are difference in various research results.The paper described the origin of primitive dosage of classical formulas by applying document research,and thought that the disorientation in the primitive dosage started from Tang Dynasty,continued in Song Dynasty,aggravated in Ming and Qing Dynasties and puzzled in the present age.The authors proposed that the reason of people not accepting the primitive dosage was the application of official weight balance in Eastern Han Dynasty.关键词：classical formulas;dosage;literature research;primitive dosage of classical formulas
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发布时间：2021-05-20 - 摘要：<正>为了更好地服务作者、读者,提高工作效率,《北京中医药大学学报》编辑部自2011年1月1日起开通网上采编系统（http://xb.bucm.edu.cn）,请广大作者和读者登陆本刊网址,随时通过此系统投稿、查稿、修改稿件或浏览最新目录等,首次登陆需先行注册。2010—2012年杂志及现刊内容已在网上全文刊出,可在线
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发布时间：2021-05-20 - 摘要：In view of history,the intact understanding of cold-attack disease and warm-heat disease has an obvious difference in times,and the independent academic development of warm-heat disease,after separating from the system of cold-attack disease,is the inevitable result of academic development in Chinese medicine.However,nowadays it is still in a confusion state of treatment of exogenous febrile diseases,in which,the methods of treating cold-attack disease are used for warm-heat disease or in reverse.Even worse,someone wants to combine the two different systems into one.It is the key point of this paper that,in order to keep and make full use of the clinical advantages of treatment of exogenous febrile diseases with Chinese medicine,the two systems of exogenous febrile diseases have to be clearly identified in the aspects of the disease characteristics,the process of disease development and changes,and the different therapeutic systems.Therefore,only in the condition of maintaining the different independent systems of cold-attack disease and warm-heat disease,it is then possible to promote the further academic development of these two systems neck and neck along with the continuous understanding of exogenous febrile diseases in Chinese medicine.关键词：cold-attack disease;warm-heat disease;theory research
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发布时间：2021-05-20 - 摘要：Objective The standard of Classification and Determination of Constitution in TCM has been published in April,2009 and applied in national test units for 4 years.The paper investigated the revise necessity of the standard and provided suggestions and thinking train for revise direction through surveying the application of the standard.The purpose is to further improve the sensitivity and contribution of the standard.Methods Taken the constitution scale in the standard as specific object,the questionnaire of application suggestion to the scale was issued to 130 national centers of preventive treatment of diseases and the feedback was collected,the reviews on the structure and content of the scale were collected from experts of related disciplines,and questionnaire was issued to common people for collecting the opinions in the application of the scale.All data was analyzed by using statistical method.Results After analyzing 30 pieces of questionnaire collected from national centers of preventive treatment of diseases,the results showed that the total structure of the scale was accepted by common people,but impalpable words were major questions in the scale.The on-site consultation in related experts showed that the content validity and construct validity reached the level required by the scale,and the numbers of items could be reduced,some describing modes could be changed and calculation method of constitutional types could be simplified.The survey in common people showed that the difference in age and educational degree had influences on filling questionnaire,and calculating and understanding of judging results.The outcomes had significance after statistical analysis（P<0.05）.Conclusion After spreading and application in national range for several years,the standard of Classification and Determination of Constitution in TCM has been well received by community hospitals,centers of preventive treatment of diseases and the State Administration of Traditional Chinese Medicine.However,hospitals,common people and experts in related disciplines have given revise suggestions and feedbacks.It is feasible and necessary to revise and adjust the standard partly.关键词：Classification and Determination of Constitution in TCM;standard;revise
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发布时间：2021-05-20 - 摘要：Through horizontal comparison among anatomy,cytobiology and the latest progress in the research on the substance of TCM visceral manifestation theory,the paper proposed that anatomical liver is"spleen" in TCM in macroscopic view rather than a part of manifestation of "liver" in TCM.The author thought that the substance of "liver" in TCM is closely related to nervous system and endocrine system in macroscopic view,and related to ligand-receptor-cellular signal transduction system at cell level in microscopic view.关键词：TCM visceral manifestation theory;liver;ligand-receptor-cellular signal transduction system;nervous system;endocrine system
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发布时间：2021-05-20 - 摘要：<正>北宋校正医书局于公元1066年前后刊刻的《备急千金要方》（以下称"宋校本"）和《重广补注〈黄帝内经素问〉》（以下称"《素问》"）分别为现今《千金要方》和《素问》这两部重要医籍的通行本。宋人分别在两书的序文中自述"公私众本搜访几遍,得以正其讹谬,补其遗佚。"[1]3下"采汉唐书录古医经之存于世者……正谬误者六千余字,增注义者二千关键词：宋人;素问;校补;千金要方
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发布时间：2021-05-20 - 摘要：Objective To quantify objectively the indexes of uric acid（UA）,excrement,urine and tongue manifestation in quail model of hyperuricemia,investigate the types of TCM syndromes,and provide reference for reviewing quail model of TCM syndromes.Methods The quail model of hyperuricemia was induced by high purine diet.The changes of UA level,characters of excrement and urine and tongue manifestation were observed dynamically,which was then given disproof with Juju（Herbacichorii） with the actions of fortifying spleen and draining dampness.The types of TCM syndromes were discussed in the quail model from two angles including four examinations and inferring syndromes by medicinal.Results The results of inquiry,listening-smelling and inspection showed that the net weight of excrement and urine trended to increase and dilute with strong smell in model group on the 17th day and 30th day.The color of tongue body is mainly red in normal group and pale in model group.The proportion of tongue redness r and red area decreased significantly on the 22nd day and 32nd day,and UA level increased significantly on the 14th day and 21st day in model group（P<0.05）.The net weight and dry weight of excrement and urine（P<0.05）,and proportion of tongue redness r and red area increased significantly in Juju group（P<0.05） compared with model group.The level of UA decreased significantly in Juju group on the 21st day（P<0.05）.Conclusion The quail model of hyperuricemia can be successfully induced by high purine diet.The quantified study on indexes of four examinations and inferring syndromes by medicinal indicates that part pathological changes of quail model is similar to spleen deficiency and phlegm-dampness syndrome induced by disorder diet.关键词：quails;syndromes;hyperuricemia;spleen deficiency and phlegm-dampness syndrome;four examinations
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发布时间：2021-05-20 - 摘要：Objective To investigate the effect of Qizhi Yifei Granules on remodeling of small airway and expressions of matrix metalloproteinase-9（MMP-9） and tissue inhibitor of metalloproteinase-1（TIMP-1） in rats with chronic obstructive pulmonary disease（COPD）.Methods All rats（n=72） were randomly divided into normal group,model group and treatment group.The rat model of COPD was established by using the method combining smoking fuming and intratracheal LPS instillation.From the 21st day,model group was intragastrically given saline once a day,treatment group,Qizhi Yifei Granules once a day and blank group,normal feeding.All rats were killed on the 30th day,40th day and 60th day in batches.The expressions of MMP-9 and TIMP-1 were detected by using immunohistochemistry technique.Results In model group,the expression of MMP-9 was lower on the 30th day and higher on the 60th day compared with normal group（P<0.05）.The expression of MMP-9 had no statistical difference in treatment group compared with model group at all time points.In model group,the expression of TIMP-1 had no difference compared with normal group at all time points,and decreased in treatment group on the 30th day（P<0.05）.The ratio of MMP-9 to TIMP-1 decreased in model group compared with normal group on the 30th day and 40th day,and increased in treatment group compared with model group（P<0.05）.Conclusion Qizhi Yifei Granules can intervene the remodeling of small airway in rats with COPD through up-regulating the ratio of MMP-9 to TIMP-1 before 40 days.关键词：chronic obstructive pulmonary disease;small airway remodeling;signal pathway;animal model;Qizhi Yifei Granules;rats
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发布时间：2021-05-20 - 摘要：<正>根据国家标准GB3358-82《统计学名词及符号》的有关规定,请作者书写统计学符号时注意:①样本的算术平均数用英文斜体小写x珋表示,不用正体珚X,也不用M或Mean（中位数仍用M）;②标准差用英文斜体小写s,不用SD;③标准误用英文斜体小写sx珋,不用SE,也不用SEM;④t检验用英文斜体小写t;⑤F检验用英
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of therapy of tonifying kidney and regulating qi on behaviors and levels of hippocampus 5-hydroxytryptamine（5-HT） and receptor of 5-HT 1A（5-HT1AR） in rats with postpartum depression.Methods Female SD rats were randomly divided into normal group,sham-operation group,model group,Yinao Jieyu Fang group and fluoxetine group.Except of normal group and sham-operation group,other three groups were given hormone to stimulate pregnancy and then stopping the hormone for establishing rat model of postpartum depression.The changes of rat behaviors were observed before and after medicinal intervention.The changes in hippocampus 5-HT content and 5-HT1AR expression were detected by using high performance liquid chromatography（HPLC） and immunohistochemistry technique.Results In model group,the behavior test showed that sucrose consumption decreased,scores of open-field test（OFT） were reduced and immobility time of forced swimming test（FST） was prolonged,so a depressive behavior state was effectively simulated.All of the above-mentioned changes of behaviors were relieved in Yinao Jieyu Fang group and fluoxetine group compared with model group.The 5-HT content in bilateral hippocampus decreased and positive cells of 5-HT1AR in hippocampus CA3 zone increased at first and then decreased in model group.The 5-HT content and positive cells of 5-HT1AR increased significantly in Yinao Jieyu Fang group and fluoxetine group compared with model group.Conclusion The TCM therapy of tonifying kidney and regulating qi had significant anti-depression effect in rat model of postpartum depression,and the mechanism may be related to the regulation of hippocampus 5-HT content and 5-HT1AR expression.关键词：tonifying kidney and regulating qi;postpartum depression;hormone-simulated pregnancy;serotonin system;rats
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发布时间：2021-05-20 - 摘要：Objective To discuss the correlation between attack of scarlet fever and six qi or meteorological factors in Beijing.Methods The numbers of patients with scarlet fever and corresponding daily mean meteorological data,including temperature,precipitation,relative humidity,vapor pressure and wind speed,were collected in Beijing area from 1970 to 2004（totally 35 years）.The data was staged according to six qi and give descriptive analysis and correlation analysis for screening the meteorological factors with higher correlation,establishing multiple stepwise regression equation and testing the equation.Results The attack of scarlet fever centered in winter and spring（the first qi,second qi and last qi）,and the correlation between it and 13 meteorological factors had statistical significance,including temperature（the first qi,second qi,third qi,fourth qi,fifth qi and last qi）,wind speed（the first qi,second qi,fifth qi and last qi） and relative humidity（the first qi,third qi and fourth qi）.The temperature of the first qi and wind speed of the fifth qi were fitted in the regression equation.The attack of scarlet fever was negatively correlated to the temperature of the first qi of the previous year and positively correlated to the wind speed of the fifth qi of the previous year.The regression equation was Y=-914.932-351.455X1+1351.195X2（X1 was the mean temperature of the first qi of the previous year and X2 was the mean wind speed of the fifth qi of the previous year）,which was meaningful in predicting the prevalence of scarlet fever.Conclusion The attack of scarlet fever is closely related to six qi and weather,and climate changes at different periods of the previous year can predict the attack of scarlet fever next year.关键词：scarlet fever;six qi;weather;correlation research
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发布时间：2021-05-20 - 摘要：Objective To discuss the mechanism of astragaloside intervening the ageing of human skin fibroblasts induced by the radiation of ultraviolet A（UVA）.Methods Skin fibroblasts were cultured in vitro,irradiated with UVA（10 J/cm2） and then intervened with astragaloside（20 mg/L）.After 24 h,48 h and 72 h,the changes of cell cycle distribution were detected by using flow cytometer,and after 24 h,the expressions of ageing-related genes p53,p16 and c-myc were detected by using real-time fluorescence quantitative polymerase chain reaction（RT-PCR）.Results Compared with control group,there were obvious blocks in G1 phase of fibroblasts in UVA group（P<0.01）.After 24 h,the proportion of fibroblasts in G1 phase increased from 59.31% in control group to 81.36% in UVA group,and after 72 h,the proportion increased further to 89.09%.In astragaloside group,the blocks in G1 phase of fibroblasts were significantly alleviated（P<0.01）,and proportion of fibroblasts in G1 phase decreased to 69.14%.The results of RT-PCR showed that the expressions of p53 mRNA and p16 mRNA increased and expression of c-myc mRNA decreased in UVA group（P<0.01）.The expressions of p53 mRNA and p16 mRNA were inhibited（P<0.01） and expression of c-myc mRNA was down-regulated in astragaloside group.The expression of c-myc mRNA was down-regulated further in UVA combining astragaloside group（combining group,P<0.01）.Conclusion The radiation of UVA can start the ageing process of skin fibroblasts through inducing the blocks in G1 phase.Astragaloside can inhibit this ageing process,and the mechanism may be related to regulating the expressions of ageing-related genes.
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发布时间：2021-05-20 - 摘要：Objective To study Professor KONG Guang-yi’s experience on menstrual diseases studied by using complex system entropy method.Methods Professor KONG Guang-yi’s medical records（n=612） of treating menstrual diseases were collected and neatened,and then studied on the medicinal in his formulas by using data mining technology.A single medicinal was studied by applying frequency statistical method,paired-medicinal correlation,by improved mutual information,and multi-medicinal correlation,by complex system entropy clustering technology.Results There are 30 medicinal that Professor KONG Guang-yi uses most frequently（over 100 times）,and of them the top five are Huangqin（Radix Scutellariae）,Chishao（Radix Paeoniae Rubra）,Chaihu（Radix Bupleuri）,Chenpi（Pericarpium Citri Reticulatae） and Xuduan（Radix Dipsaci）.There are 20 paired-medicinal used commonly with correlation coefficients above 0.05,and of them the top five are Zisugeng（Caulis Perillae）-Zisuzi（Fructus Perillae）,Baishao（Radix Paeoniae Alba）-Baizhu（Rhizoma Atractylodis Macrocephalae）,Qingpi（Pericarpium Citri Reticuiatae Viride）-Chenpi（Pericarpium Citri Reticulatae）,Baishao-Gancao（Radix Glycyrrhizae）,and Chuanxiong（Rhizoma Ligutici）-Rougui（Cortex Cinnamomi）.There are 27 kernel medicinal combinations used commonly,and of them the top five with the most close correlation are Banxia（Rhizoma Pinelliae）-Houpo（Cortex Magnoliae Officinalis）-Zisugeng-Zisuzi,Fuling（Poria）-Longdancao（Radix Gentianae）-Zhizi（Fructus Gardeniae）-Zhiqiao（Fructus Aurantii）,Fuling-Pugongying（Herba Taraxaci）-Zhizi-Zhiqiao,Jiangchan（Bombyx Batryticatus）-Jiegeng（Radix Platycodi）-Lianqiao（Fructus Forsythiae）-Qianhu（Radix Peucedani）,and Aiye（Artemisiae Argyi）-Chuanxiong-Yujin（Radix Curcumae）.Conclusion Professor KONG Guang-yi pays attention to regulating liver and spleen and tonifying kidney in the treatment of menstrual diseases.The study is meaningful and valued for inheriting the essence of Professor KONG Guang-yi’s experience on medicinal administration,and establishing an accurate and reliable mode of mining medication experience from famous and senior TCM physicians.关键词：complex system entropy method;prominent senior TCM doctors;menstrual diseases;medication experience
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发布时间：2021-05-20 - 摘要：Objective To determine common positional syndrome factors of viral hepatitis.Methods TCM collection system of clinical diagnosis and treatment information was applied to select 19 341 cases of viral hepatitis.The syndrome diagnosis and symptoms,formulas and Chinese medicinal corresponding to dampness-heat syndrome and liver-gallbladder dampness-heat syndrome were counted by using Visual FoxPro9.0 software.Referring to the positional syndrome factors,positional syndrome factors were extracted from syndrome diagnosis,analyzed statistically and compared with industrial standard.Results There were 13 positional syndrome factors involving viral hepatitis,including liver,spleen,gallbladder,kidney,stomach,heart,lung,meridian,large intestine,brain,the exterior,skin and lower energizer.The positional syndrome factors with higher frequency were,in turn,liver,spleen,gallbladder,kidney and stomach.Conclusion Liver-gallbladder dampness-heat syndrome is not a traditional TCM syndrome,which is proposed by modern physicians after Western medicine was introduced into China.Liver-gallbladder dampness-heat syndrome should be called spleen-stomach dampness-heat syndrome,and the main positional syndrome factor of viral hepatitis is spleen rather than liver.关键词：viral hepatitis;positional syndrome factors;liver-gallbladder dampness-heat syndrome;spleen-stomach dampness-heat syndrome
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发布时间：2021-05-20 - 摘要：Objective To study the TCM constitutional types of Leber hereditary optic neuropathy（LHON） from the angle of epidemiology,and explore the relationship between LHON and constitutional types.Methods The patients with LHON（n=83） from different families were followed up,and clinical data was collected from matrilineal relatives in 873 case for drawing family tree.The survey on constitutional types in matrilineal numbers of 690 cases and 100 control cases were carried out by applying Constitution in Chinese Medicine Questionnaire（CCMQ）.Results The total penetrance was 22.9%（158/690） in matrilineal numbers of 690 cases from 83 families,and 33.63% in the male and 12.89% in the female.After following up for average 214.51 months,the vision recovered to 0.3-1.5 in 39.9%（63/158） patients,and the recovery rate was 28.57%（32/112） in the male and 69.57%（31/46） in the female.The Chi-square analysis on the proportion of different constitutional types in LHON group and control group or in disease group and non-disease group showed that the distribution of normal constitution,yin deficiency constitution and qi depression constitution had statistical significance.The proportion of normal constitution decreased and proportion of yin deficiency constitution and qi depression constitution increased in LHON group and disease group.Conclusion The clinical features of LHON are typical,and vision prognosis is closely related to mutation types.The constitutional types are correlated to the attack of LHON.When normal constitution transforms to other constitutional types,especially yin deficiency constitution and qi depression constitution,LHON is easily to come on.
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发布时间：2021-05-20 - 摘要：Objective To investigate the curative effect of therapy of tonifying kidney and activating blood on clinical-stage diabetic nephropathy（DN）.Methods DN patients（n=104） were chosen according to MogenSen criterion from Apr.2010 to Mar.2012,and then divided randomly into treatment group and control group（each n=52）.The control group was treated with enalapril besides of basic treatment and treatment group was treated with Chinese medicinal decoction with the actions of tonifying kidney and activating blood besides of the same treatment as control group.After 8 weeks,the curative effect,syndrome integrals,fasting blood glucose（FBG）,postprandial blood glucose（PBG）,glycated hemoglobin（HbAlc）,quantitation of urine protein（UP）,endogenous creatinine clearance rate（CCr） and serum creatinine（SCr） were detected and analyzed statistically.Results All indexes in curative effect,syndrome integrals,UP quantitation,CCr and SCr were better in treatment group than those in control group（P<0.05）,and there was no significant difference in FBG,PBG and HbAlc,and no adverse reactions observed in two groups.Conclusion The therapy of tonifying kidney and activating blood combining enalapril can effectively abate and treat clinical-stage DN.关键词：diabetic nephropathy;kidney deficiency and blood stasis;tonifying kidney and activating blood;therapies of Chinese medicinal;clinical research
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发布时间：2021-05-20 -
Role of musculoskeletal sonography in syndrome differentiation and treatment of rheumatoid arthritis
摘要：Musculoskeletal sonography（MSUS） was widely used in the diagnosis of rheumatoid arthritis（RA）.It can detect RA early with good sensitivity,and can be used to assess RA condition and guide to set down treatment plan,as well as joint puncture.MSUS is helpful in the early detection,early diagnosis and treatment evaluation of RA,and it is of positive significance in the standardization and objectification of TCM syndrome differentiation and treatment for RA,and expands TCM four examinations.The microscopic pathological changes of RA will be observed,and the objectivity and veracity of syndrome differentiation and organic unity of overall and local syndrome differentiation will be improved.关键词：muscloskeletal sonography;rheumatoid arthritis;Chinese medicine;syndrome differentiation and treatment- 8
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发布时间：2021-05-20
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