最新刊期
卷 37 ， 期 10 ， 2014
- 摘要：Yin-yang theory plays an important role both in Neijing and Book of changes. Discussion on inheritance and application of yin-yang theory from Book of changes contributes to master the source of yin-yang theory in Neijing. The aim is to set forth Neijing inheritance of yin-yang theory from Book of changes such as the following three respects. Firstly,yin-yang as the law of the heaven and earth was probed into through the theory of correspondence between human and nature. Secondly,the properties and connotations of yin-yang were studied in its integrity（ invariance property,variability property and simplification property） and relativity（ honorable Yang and humble yin,location and movement of yinyang,correspondence of homogeneity,growth and decline of heterogeneity） respectively. Thirdly,the classification methods of yin-yang were summarized into dichotomy and trichotomy.关键词：yin-yang theory;Neijing;Book of changes
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发布时间：2021-05-20 - 摘要：<正>麻杏石甘汤出自《伤寒论》,是一首治疗肺热咳喘的经典方剂,因其配伍精当,疗效卓著,故为历代医家所喜用,同时也成为现代学者研究经方配伍规律的首选代表方。由于数据库的强大检索和快捷查询功能,为现代中医药研究者提供了强有力工具。因此,在研究总结其用药规律时,所有文献来源几乎均侧重于期刊数据库。医案是历代医家宝贵经验的记述,里面蕴藏着丰富的信息,故对经方使用或配伍规律的研究,首先应重视原方医案尤其是对历代著关键词：麻杏石甘汤;医案;辨治规律
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发布时间：2021-05-20 - 摘要：<正>慢性肾脏病（Chronic kidney disease,CKD）是肾小球肾炎、肾盂肾炎、过敏性紫癜肾炎、红斑狼疮肾炎、痛风肾、肾病综合征、膜性肾病、糖尿病肾病、高血压肾病、多囊肾肾病等肾脏疾病的临床统称。其病程虽缓慢,但具有进行性发展趋势,如果不能及时有效诊治,最终将发展为终末期肾病。湿浊作为中医学的一种重要致病因素,是许多疑难杂症的病理因素,与慢性肾脏病的发生发展更是关系密切。对湿浊内涵及其在慢性肾脏病中作用的深入认识,有关键词：湿浊;慢性肾脏病;病因病机;治疗经验
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发布时间：2021-05-20 - 摘要：<正>明代李时珍《本草纲目》是我国目前进入《世界记忆名录》的两种重要中医古籍之一,是一部伟大的著作,但由于受时代风气与条件的影响,李时珍引书标注很不规范,存在同名异书、同书异称、人书混杂,等等混乱情况,造成对此书的理解及原文追溯方面的困难。因此,考察核准《本草纲目》引用书目是各项研究的基础,有助于该书的阅读及准确追溯原始文献。本文以核准《本草纲目》所引医药古籍为例,指出目前该项研究必须统一计点及标注书目的关键词：李时珍;本草纲目;文献考证;医药书目
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发布时间：2021-05-20 - 摘要：Objective To study therapeutic effect of Jingui Shenqi pill on reproductive dysfunction in male mice exposed to microwave radiation. Methods Overall 70 BALB / C mice were randomly divided into 7 groups,parallel group and three pairs of radiation groups. Parallel control group was treated without radiation nor treatment. Standard radiation groups consisted of control group and TCM group,both exposed to microwave of 2 450 MHz frequency,power density of 10 mW / cm2 for 1 h each day for 18 consecutive days. Prolonged rediation groups consisted of control group and TCM group,both exposed to radiation 4 hours each day. Power-increasing groups consisted of control group and TCM group,in which power density increased to 40 mW / cm2. All the control groups were intragastrically administrated saline water,and all the TCM groups were administrated Jingui Shenqi pill. Percentage of sperm motility（ PR +NP） and progressively motile sperm（ PR）,sperm deformity rate and ratio of testis weight and body weight were calculated, while morphological changes of testicular tissue were observed.Results Microwave radiation decreased significantly sperm PR + NP and PR in mice,while increased significantly sperm deformity rate. Although time prolonged and power increased further reduced sperm PR,PR + NP and sperm deformity rate showed no significant changes. Ratio of testis weight and body weight showed no differences in both standard microwave radiation group and prolonged radiation group,while significant reduction in power-increasing group. Jingui Shenqi pill increased sperm PR + NP and PR dramatically to normal level,and decreased sperm deformity rate. On the other hand,Jingui Shenqi pill increased ratio of testis weight and body weight to normal level. Conclusion Jingui Shenqi pill had obvious and remarkable therapeutic effects on reproductive dysfunction in male mice exposed to microwave radiation.关键词：Jingui Shenqi pill;microwave;electromagnetic radiation;reproductive dysfunction;male mice
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发布时间：2021-05-20 - 摘要：Objective To investigate the effects of Shengqing formula and Jianpi Liqi formula on the rat with diet-induced obesity（ DIO） and influence on adiponectin and given inflammatory factors.Methods 10 of 120 Wistar male rats were chosen as blank group（ i. g. saline 2 m L / d）,the other 110 rats were fed with high-fat and high-nutrition diet for 17 weeks. According to body weights,40 DIO rats and 10 DIO-resistence（ DIO-R） rats were obtained. Then,DIO rats were randomly divided into four groups: model group（ i. g. saline 2 m L / d）,sibutramine group（ i. g. 1. 6 mg / kg）,Jianpi Liqi group（ i.g. 3. 2 g / kg） and Shengqing group（ i. g. 3. 2g / kg）; while DIO-R group rats were i. g. saline 2 m L / d.During the 16-week-intragastic administration,blank control group was fed with basic diets,and the other five groups were still fed with high-fat diets. After 16 weeks,body weight,body length and all fat removed from abdomen were measured to evaluate the level of obesity and fat content. Serum concentration of glucose,triglycerides,cholesterol,tumor necrosis factor（ TNF-α） and adiponectin were tested,followed by insulin resistance index（ IRI） calculated. Levels of TNF-α and adiponectin in abdominal adipose tissue were tested. Results Compared with blank group,in model group,body weight,Lee’s index,fat coefficient index,concentration of cholesterol,levels of TNF-α both in plasma and adipose tissue,and IRI significantly increased（ P < 0. 05,P < 0. 01）. However,level of adiponectin in serum and adipose tissue decreased significantly（ P < 0. 05）. Meanwhile,compared with mode group,in DIO-R group,body weight,Lee’s index,fat coefficient index,and IRI all decreased（ P < 0. 05,P <0. 01）; both levels of adiponectin increased（ P < 0. 01）,TNF-α decreased（ P < 0. 05,P < 0. 01）.Jianpi Liqi formula decreased the level of TNF-α in adipose tissue,and Shengqing formula increased levels of adiponectin and decreased those of TNF-α both in serum and adipose tissue（ P < 0. 05,P < 0. 01）.Conclusion Shengqing formula can inhibit fat diet-induced obesity and insulin resistance, whose mechanism probably is allied to increaing the expression of adiponectin and decreasing level of TNF-α.Furthermore,in Chinese medicine theory, " Spleen failing to govern ascending clear" may be one of the key pathogenesis of obesity.关键词：diet-induced obesity rats;diet-induced obesity resistant rats;insulin resistance;adiponectin;tumor necrosis factor-α;Shengqing formula;Jianpi Liqi formula;rats
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发布时间：2021-05-20 - 摘要：Objective To explore the potential mechanism of twirling reinforcement-reduction method of acupuncture in rats with stress-induced hypertension by investigating the effects on plasma concentration of endothelin（ ET）,norepinephrine（ NE） and 5-hydroxytryptamine（ 5-HT）. Methods Overall 60 male Wistar rats were randomly divided into normal group,model group,acupuncture control group,twirling reinforcement acupuncture group and twirling reduction acupuncture group,12 rats in each group. The model of stress-induced hypertension was established by foot-shock and noise stimulation. All three acupuncture groups were treated with acupuncture in left Taichong（ LR3） with corresponding methods. The plasma concentrations of ET,NE and 5-HT and hypothalamic concentration of ET were detected after 7 d. Results Compared with normal group,concentrations of ET,NE and 5-HT in blood plasma and hypothalamus in model group increased significantly（ P < 0. 05）. There is no statistical differences between acupuncture control group and model group（ P > 0. 05）. Compared with model group,concentrations of ET,NE and 5-HT decreased significantly in twirling reduction acupuncture group（ P < 0. 05）,even,decreased to the levels of normal group（ P > 0. 05）; however,those tested showed no statistical differences in acupuncture control group and twirling reinforcement group.Conclusion Twirling reduction method of acupuncture decreased the concentration of ET,NE and 5-HT in rats with stress- induced hypertension. The regulation of blood pressure is associated with concentrations of of central and peripheral ET,NE and 5-HT,which is maybe the interaction between peripheral sympathetic nervous system and vascular endothelial system.
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发布时间：2021-05-20 - 摘要：Objective To investigate the underlying mechanism of Qingre Huoxue decoction（ QRHXD）in inhibiting synovial angiogenesis through observing its effects of promoting blood circulation and removing blood stasis. Methods Rat model of type II collagen-induced arthritis（ CIA） was taken as the study object. Overall 50 SD rats were divided into 5 groups: normal group,model group,positive drug（ LY294002） group,QRHXD low-dose group（ low-dose group） and QRHXD high-dose group（ high-dose group）. Volume of paw swelling,pathological sections of the ankle joints and synovial tissue and microvessel density（ MVD） were observed. In addition,the serum content of interferon（ INF）-γ,endothelial nitric oxide synthase（ e NOS） and tissue plasminogen activator（ tP A） were measured by ELISA. Results QRHXD significantly alleviated paw swelling in CIA rats. Pathological sections showed that QRHXD alleviated synovial hyperplasia,articular cartilage and bone destruction in joint,as well as decreased inflammatory cells infiltration and MVD in synovial tissue. Compared with model group,expression levels of INF-γ in both QRHXD groups were decreased significantly（ P < 0. 05）; release of tP A in high-dose group was decreased significantly（ P < 0. 05）; expression of e NOS was down-regulated both in low-dose group（ P < 0. 05） and high-dose group（ P < 0. 01）. Conclusion QRHXD has a satisfactory therapeutic effect on active rheumatoid arthritis through relieving the inflammation of arthritis,synovial proliferation and articular cartilage and bone destruction.关键词：rheumatoid arthritis;Qingre Huoxue decoction;angiogenesis;rats
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发布时间：2021-05-20 - 摘要：Objective To study anti-inflammatory effect of Qingdai powder on rat model of ulcerative colitis（ UC） and on murine macrophage RAW264. 7 cells. Methods Overall SD rats were randomly divided into 4 groups: normal group,model group,Qingdai high-dose group（ high-dose group） and Qingdai low-dose group（ low-dose group）. Rat model of UC was induced by intracolonical administration of 2,4,6-trinitrobenzene sulfonic acid（ TNBS）-ethanol solution. Qingdai suspension liquid was administered intragastrically once a day for 10 d. Serum concentration of IL-1,IL-6 and IL-8 was tested by ELISA assay. On the other hand,murine macrophage RAW264. 7 cells were induced by 10μg / m L LPS for 24 h to establish an UC inflammatory cell model. Cell viability was detected by MTT assay to determine the safe range of concentrations. After direct and prophylactic intervention of high-,mid- and low-dose Qingdai suspension on RAW264. 7 cell respectively,concentration of IL-6 and TNF-α in supernatant were tested by ELISA assay. Results Compared with normal group,serum concentration of IL-1,IL-6 and IL-8 in model group increased significantly（ P < 0. 05）; compared with model group,those of IL-1,IL-6 and IL-8 in high-dose group,and IL-6 and IL-8 in low-dose group decreased significantly（ P < 0. 05）. Compared with normal group,concentration of IL-6 and TNF-α in supernatant increased significantly in model group（ P < 0. 05）. After direct intervention,those of IL-6 and TNF-α in supernatant in 10 μmol / L Qingdai group reduced significantly（ P < 0. 05） compared with model group;while after prophylactic intervention,only IL-6 in 10 μmol / L Qindai group reduced（ P < 0. 05）.Conclusion Effects of anti-inflammation of Qingdai showed both in vivo and in vitro,and the potential mechanism probably was through down-regulating the expression of inflammatory factors.关键词：Qingdai;ulcerative colitis;rats;RAW264.7 cells;anti-inflammation
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发布时间：2021-05-20 - 摘要：objective To obtain the optimum medicinal system and its composition form,by the way of comparation of pharmacokinetic characteristics of different medicinal forms of salidroside and tyrosol in the rat model of migraine. Methods The plasma concentrations of salidroside and tyrosol after oral administration in rat model were measured by UPLC-PDA, by which the data of pharmacokinetic characteristics were obtained. Then the characteristics of different forms of salidrosides and tyrosol were compared by correlation analysis（ PK-DI）. Results Both salidroside and tyrosol were detected in preparations group and mixed group（ pure salidroside mixed with pure tyrosol）. Only salidroside or tyrosol was detected in pure salidroside group and high-dose pure tyrosol group respectively. While nothing was found in low-dose pure tyrosol group whose concentration was equivalent to preparations of salidroside. There was no difference in bioavailability of salidroside showed in preparation group,mixed group and pure salidroside group,on the contrary,those of tyrosol showed significant difference in preparation group,mixed group,low-dose tyrosol in ascending order. Conclusion Salidroside was retained unchanged in migraine model rat after oral administration,however,for tyrosol,a substantial increase of maximum plasma concentration and changed pharmacokinetics parameters showed under the condition of salidroside coexisted. The best medicinal system in treating migraine was found and supported by synergistic effects of salidroside and tyrosol,by which provide techniques for medicinal research and development.关键词：migraine;salidroside;tyrosol;pharmacokinetic;rats
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发布时间：2021-05-20 - 摘要：<正>2014年9月26日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2013年"百种中国杰出学术期刊"称号（封二）,并入选"第3届中国精品科技期刊"即"中国精品科技期刊顶尖学术论文（F5000）"项目来源期刊（封三）。2013年《中国科技期刊引证报告》（核心版）共收录中国科技核心期刊1 989种,《北京中医药大学学报》2013年核心影响因子0.589,核心总被引频次2 110,综合评价总分73.8,综合评价总分排名第111位。多年
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发布时间：2021-05-20 - 摘要：Objective To approach an optimal extraction procedure of saccharides from Rubus amabilis by using response surface methodoloy. Methods With the saccharides content of water extract as an evaluation index,single-factor experiment was conducted on 5 factors respectively,including extraction temperature（ X1）,extraction time（ X2）,solvent ratio（ X3）,crush size（ X4） and extraction times（ X5）. 3 factors（ X1,X2,X3） were determined to be crucial. According to the central composite experimental design principles（ Box-Benhnken）,three different levels of each of 3 factors selected was adopted by response surface methodology（ saccharides content was chosen as response value,while response surface and contour curves were plotted）,in search for multiple quadratic linear regressions between the crucial 3 factors and saccharides content. Results The optimum extraction conditions of the saccharides from Rubus amabilis were calculated from the formula above as the following: powdered herbs filtrated through 40 meshes,extraction temperature was set at 65 °C,extraction time was 2. 5 hours with21 times of water（ w / v） and extracted once. Under these conditions,the content of saccharides from Rubus amabilis was up to 13. 39%,which was in accordance with the theoretical prediction 13. 77%.Conclusion The extraction condition optimized was reliable,stable and effective,which can meet with the requirement of industrial production.关键词：Rubus amabilis;saccharides;extraction;response surface methodology;optimization
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发布时间：2021-05-20 - 摘要：Objective To optimize the extracting technique of rhizoma gastrodiae（ Tianma） and radix puerariae（ Gegen） in Yunding granule in according to pharmacodynamic index and content of gastrodin and puerarin. Methods The contents of gastrodin and puerarin of the four extracts were determined by HPLC. After establishment of the mice model of dizziness,overall 8 treatment groups were orally administrated high-dose and low-dose of four extracts respectively. Positive control group was orally administrated Rhizoma gastrodiae capsule,and blank group,sham-operation group and model group were all orally given normal saline for 7 d. Body weight,locomotor activity and latency time of escaping from electric shock were recorded before and after oral administration. Results The highest extraction rate of gastrodin was 89. 66% from water extraction procedure of Yunding formula,and the highest extraction rate of puerarin was 87. 86% from alcohol extraction procedure of Yunding formula. However,a practical procedure was selected after comprehensive evaluation,of which alcohol extraction followed by water extraction of Yunding formula with the extraction rate of gastrodin and puerarin 86. 21% and 86. 79%respectively,and extractum rate 15. 12%. The extract obtained from the above selected procedure significantly increased body weight and locomotor activity of model mice（ P < 0. 05）,and dramatically decreased latency time to avoid electric shock（ P < 0. 05）. Conclusion Extraction procedure of gastrodin and puerarin in Yunding formula was scientific and rational,and the results showed positive correlation between the content and effects in vivo.关键词：pharmacodynamic index;Yunding formula;Rhizome gastrodiae;Radix puerariae;extraction technique;HPLC
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发布时间：2021-05-20 - 摘要：Objective Analyze the overall level of TCM public knowledge obtained from Beijing residents,and provide reasonable advices to Chinese Medicine science popularization. Methods The research was conducted through questionnaire survey. The questionnaire was designed based on related government guidelines and research. We selected 490 respondents using random sampling in Beijing,and recovered 336 effective questionnaires. The contents of the questionnaire included basic demographic information（ 7 items such as gender and age） and TCM public knowledge（ 17 questions related to the attribution of TCM public knowledge,TCM discipline advantage,and basic rules of life and health）. We established a database and applied SPSS 20. 0 for analyses. The overall level of TCM public knowledge obtained from Beijing residents was represented by mean ± standard error. Then we used the normal distribution test,the homogeneity of variance test,and the one-way ANOVA analysis to examine how demographic factors influenced the overall TCM public knowledge level. We used LSD test if the variance was homogeneous,and used Tamhance ’T2 test if not. Results The overall level of TCM public knowledge obtained from Beijing residents was 2. 13 ± 0. 55. Medication precaution had the highest level of cognition among all the respondents（ 2. 56）. Wuxing Theory had the lowest level of cognition（ 1. 80）.Among different age groups,40 49 age group had the lowest TCM public knowledge level. The difference between 40 49 age group and 20 29 age group was 6. 147. Education status was a significant variable,especially between groups lower than junior secondary school level and groups above high school. Monthly income was another significant variable. Families with 5,000 9,999 monthly income were statistically different from families with less than 1,000 monthly income（ P < 0. 05）,and also significantly different from families with 1,000 4,999 monthly income（ P < 0. 01）. Some demographic variables were significantly influencing the overall TCM public knowledge level. Respondent’s education and profession were main influencing factors（ P < 0. 001）. Conclusion The overall level of TCM public knowledge obtained form Beijing residents can still be improved. Government departments should take effective methods to improve Chinese Medicine science popularization,enrich TCM public knowledge through targeted methods,and improve health consciousness and ability,especially among peasantry,low-income families,low-educated people,and 40 49 age people. At the same time,government departments should also focus on developing Chinese Medicine science popularization theory,in order to build a scientific,applicable,and popular TCM public knowledge system.关键词：beijing residents;chinese medicine science popularization;cognitive situation
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》系中央级的高级中医药学术刊物,1959年创刊,由教育部主管、北京中医药大学主办。现分别属于中国自然科学核心期刊、中国中文核心期刊、全国中医药优秀期刊、全国优秀科技期刊、中国科学引文数据库首批入选的315种期刊之一、北京高校自然科学学报系统及全国高等医药院校学报系统优秀学报等。我刊1999年被美国《化学文摘》（CA）正式列为文摘刊源,2007年又被美国《国际药学文摘》（IPA）、美国《剑桥科学文摘》（CSA）、美国《乌利希期刊指南》（Ulrich PD）正式列为来源期刊。进入国际著
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发布时间：2021-05-20 - 摘要：The academic analysis report of Education of Chinese Medicine supplied by WANFANG DATA was used to conduct statistic research on published paper number,citation frequency,citation frequency per paper and downloaded paper number from the year 2003 to 2013. The relationship among the above data was studied,the existing problems and suggestions for improvement were raised,so as to provide theoretical foundation for reform the journal.关键词：Education of Chinese medicine;citation analysis;published paper number;downloaded paper number
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发布时间：2021-05-20
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