最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：Mental image,one of key concepts in Chinese traditional philosophies,is the mode of TCM original thinking. Through interpretation under the embryology viewpoint and academic connotation,mental image is revealed to be rooted in philosophy of mind of Chinese traditional philosophies. Mental image is foremost defined as the form of representation,presented in the form of mind,spirit,emotion,dream,void-quietness,noumenon,and so on.关键词：image;mental image;TCM;Chinese traditional philosophies
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发布时间：2021-05-20 - 摘要：<正>2014年10月27日,教育部科学技术司发布《关于公布"第五届中国高校精品·优秀·特色科技期刊"评比结果的通知》（教技司[2014]288号）。《北京中医药大学学报》荣获"中国高校精品科技期刊"称号。这是我刊连续第5次获此殊荣。中国高校科技期刊评比活动始创于2006年,每2年评比1次,其中"精品期刊"要求学术质量、编辑出版质量均属上乘,在国内科技期刊界居于领先地位,得到高校内外学术界认可,经得起高校内外期刊编辑同行的检验,是国内高校科技期刊界的最高荣誉之一。本届评比中,总计1 600多种高校科技期刊中只有37种
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发布时间：2021-05-20 - 摘要：<正>木防己汤方出自《金匮要略·痰饮咳嗽病篇》第24条,用于治疗痰饮病,本条条文通过对临床证候的勾划,提示了木防己汤证的病机核心,而具体的病机本质则需要学者对证候现象的归纳总结,这体现了中医的辨证思维是从现象到本质的过程。本文兹从以方证（方剂、证候）测机（病机）和类似方剂相互比较的角度,研究木防己汤方所主治病机的范畴,并采撷叶天士之临证和吴鞠通之议论发挥,加以印证。1木防己汤证病因病机特点关键词：木防己汤;张仲景;叶天士;吴鞠通;湿病
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发布时间：2021-05-20 - 摘要：Objective To investigate the rule of TCM syndromes,combination and distribution of syndrome elements on hypertension,so as to provide a basis for standardization of TCM research on hypertension. Methods After search the literature of TCM treatment of hypertension from 1986 to 2013,database was established by Note Express software,followed by frequency and rate of the syndrome elements were collected and calculated by SPSS 12. 0 statistical software. Results Altogether 91 895 cases and 57 Chinese medicine syndromes were involved in 3 986 articles. The main syndromes were ranked as following: hyperactivity of liver-yang（ 25. 32%）,hyperactive liver fire（ 18. 07%）,phlegm turbidity obstruction（ 8. 23%）,liver-kidney yin deficiency（ 6. 99%）,deficiency of yin and yang（ 6. 94%）,kidney qi deficiency（ 5. 89%）. And syndrome elements were distributed into excess syndrome（ yang hyperactivity,internal heat,phlegm turbidity,liver wind,blood stasis and liver qi stagnation） and deficiency syndrome（ yin deficiency and qi deficiency）. Affecting targets of syndrome elements located in liver,kidney and heart. Conclusion In view of complicated TCM diagnosis principles of hypertension and clinical syndromes,the study of syndrome and syndrome elements is crucial to standardization of TCM differentiation and treatment of hypertension.关键词：hypertension;TCM medicine syndrome;syndrome elements
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发布时间：2021-05-20 - 摘要：Objective To investigate the distribution of syndrome differentiation of yin-yang in severe sepsis and septic shock patients,and to study correlation between yin syndrome or yang syndrome with inflammatory markers. Methods Based on the principles of TCM syndrome differentiation,98 of 208 patients with severe sepsis and septic shock were diagnosed as yin syndrome,and 110 patients as yang syndrome. Acute physiology and chronic health evaluation Ⅱ（ APACHE Ⅱ） score and systemic inflammatory response syndrome（ SIRS） score were recorded,as well as 28 d mortality. Lactic acid（ LAC）,WBC,percentage of neutrophils（ NE%）,C-reactive protein（ CRP） and procalcitonin（ PCT）were determined. Results Yin syndrome patients with mean SIRS score 2. 51 ± 0. 62 were significantly lower than yang syndrome patients with 3. 06 ± 0. 80（ P < 0. 05）. However,PCT in yin syndrome patients were significantly higher than those in yang syndrome patients（ P < 0. 05）. No statistically differences were showed in APACHE Ⅱ score,WBC,NE% and CRT. In yin syndrome patients,72 of 98 were survival（ survival group） and 26 were dead（ death group）. APACHEⅡ score and NE% in survival groupwith yin syndrome were significantly lower than death group（ P < 0. 05）. APACHEⅡ score and PCT in survival group（ n = 81） with yang syndrome were significantly lower than death group（ n = 29）（ P <0. 05）. Conclusion Syndrome differentiation of yin-yang can be used in predicting the inflammatory state and prognosis in patients with severe sepsis and septic shock.关键词：severe sepsis;septic shock;syndrome differentiation of yin-yang;inflammatory
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发布时间：2021-05-20 - 摘要：Objective To observe the nonlinear parameters in excess syndrome and deficiency syndrome in patients with coronary heart disease（ CHD）,so as to explore the characteristics of nonlinear chaos existed in TCM syndromes. Methods Based on principles of TCM syndrome differentiation,44 of 243 patients with CHD were diagnosed as excess syndrome（ excess group）,148 as mingled syndrome（ mingled group） and 51 as deficiency syndrome（ deficiency group）. Each patient underwent 24 h dynamic electrocardiogram（ Holter）. Correlation dimention（ CD）,complexity（ Comp） and approximate entropy（ Ap En） were calculated relied on the data obtained from Holter to find out the difference of these parameters in all three groups. Results Except for CD in excess group was less than mingled group,the values of CD,Comp and Ap En had a feature in common with the highest in excess group,medium in mingled group and lowest in deficiency group. Conclusion Nonlinear analysis,as a new methodology,can be introduced into TCM syndrome differentiation关键词：CHD;syndrome of excess and deficiency;heart rate variability;nonlinear character;chaos
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发布时间：2021-05-20 - 摘要：Objective To reveal the rules of selection and matching meridians and acupoints for simple obesity on the basis of data mining. Methods All data were collected from literatures in CNKI regarding to acupuncture treatment of simple obesity during the latest 10 years,so as to establish a prescription database for simple obesity. The descriptive analysis,association rules analysis and clustering analysis were conducted by SPSS 17. 0 and Clementine 12. 0 software. Results The leading three selection of meridians were Stomach meridian,Ren meridian and Spleen meridian,and the leading acupoints were Zhongwan（ CV12）,Zusanli（ ST36）,Fenglong（ ST40）,Sanyinjiao（ SP6） and Tianshu（ ST25）. The association rules analysis showed that Quchi（ LI11）,Fenglong（ ST40）,Qihai（ CV6） and Zhongwan（ CV12） had the highest correlation among all the selected acupoints. The clustering analysis figured out altogether 9 core clustering groups and two kinds of acupoints,comprised of special acupoints which were the most common choice and specific acupoints which were selected by syndrome differentiation.Conclusion The rules of meridians and acupoints selection can guide acupuncture treatment of simple obesity.关键词：acupuncture treatment;simple obesity;characteristics of acupoints;data mining
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发布时间：2021-05-20 - 摘要：Objective To study the relationship among subjective memory complaints（ SMC）,objective cognitive impairment,depression,and liver depression syndrome. Methods Subjects were comprised of two groups: SMC group（ n = 95） and control group without SMC（ n = 19）. Subjective memory complaints were assessed by subjective memory complaints visual analog Scale（ SMC-VAS）. Objective cognitive were examined by mini-mental state examination（ MMSE） and Montreal cognitive assessment（ Mo CA）. Depression was evaluated by Hamilton depression rating scale（ HAMD）. And the scores of liver depression syndrome were calculated. Then, the regression analysis of factors on SMC were conducted. Results MMSE and Mo CA scores in SMC group were lower than control group（ P < 0. 05）,while HAMD score was higher（ P < 0. 05）. The scores of liver depression syndrome in SMC group werehigher than control group（ P < 0. 05）. Logistic regression analysis showed that lower MMSE and higher HAMD scores predicted more incidence of SMC. Linear regression analysis indicated that lower MMSE scores,higher HAMD scores,first-degree relatives with dementia and living alone all predicted worse memory self-assessment. Conclusion SMC is closely allied to objective cognitive and depression. Liver depression syndrome is connected with subjective or objective cognitive impairment. Liver qi stagnation may be the main pathogenesis of SMC in TCM.关键词：subjective memory complaint;objective cognitive;depression;liver depression syndrome
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发布时间：2021-05-20 - 摘要：Objective To investigate the inhabitation effects of Feixian Formula on angiogenesis in rat with interstitial pulmonary fibrosis. Methods Male Wistar rats were randomly divided into 7 groups:sham-operation group,model group,3 groups treated with high-,mid-,and low-dose of Feixian Formula（ high-dose group,mid-dose group and low-dose group）,and 2 groups treated with western medicine losartan and prednisone respectively（ losartan group and prednisone group）. All the rats,except for those in sham-operation group,were established as the model of interstitial pulmonary fibrosis by perfusion of bleomycin（ 3 mg / kg） through tracheal intubation. From the second day after modeling,all rats were intragastrically administrated with drugs or saline,according to different groups designed. The rats were sacrificed at the 14 th day and at the 28 th day. The pathological changes of interstitial pulmonary by HE staining and MASSON staining were observed,to evaluate the degree of the alveolitis and pulmonary fibrosis. Expressions of VEGF,VEGF 1 and 2 mRNA were detected by RT-PCR. Results Both highdose and mid-dose Feixian Formula had obvious effects of inhabiting alveolitis and pulmonary fibrosis,as well as downregualting the expressions of VEGF,VEGFR1 and 2 mRNA,which were remarkable in mide-dose group compared with model group（ P < 0. 05）. Conclusion The effects of Feixian Formula on inhabition of angiogenesis and resistance to interstitial pulmonary fibrosis may be involved in the downregulation of VEGF,VEGFR1 and VEGFR2 gene expression.关键词：Feixian Formula;interstitial pulmonary fibrosis;vascular endothelial growth factor（VEGF）;vascular endothelial growth factor receptor 1（VEGFR1）;vascular endothelial growth factor receptor 2（VEGFR2）;rats
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发布时间：2021-05-20 - 摘要：<正>2014年9月26日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2013年"百种中国杰出学术期刊"称号（封二）,并入选"第3届中国精品科技期刊"即"中国精品科技期刊顶尖学术论文（F5000）"项目来源期刊。2013年《中国科技期刊引证报告》（核心版）共收录中国科技核心期刊1 989种,《北京中医药大学学报》2013年核心影响因子0.589,核心总被引频次2 110,综合评价总分73.8,综合评价总分排名第111位。多年来,《北京中医药大学学报》始终坚持突出中医药特色,立足基础,追踪前沿,发表中医药最新研究成果,其学
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发布时间：2021-05-20 - 摘要：Objective To observe the effects of ginsenoside Rg1 on cardiac fibroblasts（ CFs）proliferation,protein secretion and Wnt signal pathway,followed the establishment of CFs proliferation model in vitro induced by high concentration of glucose. Methods Cell proliferation was detected by MTT method,cell cycle was measured by flow cytometry,concentration of type I,III collagens and TGF-β1protein were tested by ELISA assay. Protein expression of β-catenin,GSK-3β and P-GSK-3β were determined by Western blot,aimed to investigate the effects of ginsenoside Rg1 on Wnt signal pathway.Results Ginsenoside Rg1 inhibited CFs proliferation（ P < 0. 01）,reduced type I and III collagens secretion（ P < 0. 05） and synthesis of TGF- β1（ P < 0. 01）. Expression of β-catenin was inhibited and expression of P-GSK-3β was upregulated at the molecular level. Conclusion Ginsenoside Rg1 can relieve myocardial fibrosis,due to inhibition of proliferation,secretion of collagens and TGF-β1in CFswhich were cultured in high concentration of glucose,leading to inhibition of abnormal expression of Wnt signal pathway.关键词：ginsenoside Rg1;high concentration of glucose;cardiac fibroblasts;Wnt signal pathway
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发布时间：2021-05-20 - 摘要：Objective To investigate the effects of ethyl acetate extract of Cynomorim songaricum Rupr.（ Suoyang） on behaviors and synapse in ovariectomized rats. Methods SD rats（ n = 40） were randomly divided into normal group,model group,estradiol group and ethyl acetate extract of Suoyang（ Suoyang group）. Alzheimer ’s disease model was established by ovariectomization. One week after surgery,estradiol group and Suoyang group were intragastrically administered with estradiol and ethyl acetate extract of Suoyang（ 33 mg / kg） respectively for 8 consecutive weeks. After 6 days’ behavioral observation by Morris water maze, specimen were collected from the hippocampal area. HE staining,immunohistochemistry reaction of growth associated protein（ GAP-43） and ultra-micro perspective electron microscopy were used to observe hippocampal neurons. Results Compared with model group,stage of latency was significantly shorter and the times of passing platform was significantly more in Suoyang group（ P < 0. 01）. The neurological changes of pyramidal cells in CA3 zone of hippocampus were ameliorated,and the expression of GAP-43 increased significantly（ P < 0. 01） 。Conclusion Ethyl acetate extract of Suoyang can improve the learning and memory ability in ovariectomized rat model with Alzheimer’s disease,attributed to increasing the content of GAP-43 in hippocampus and the formation of synapse in brain.关键词：ethyl acetate extract of Suoyang;ovariectomized rat model with Alzheimer ’ s disease;hippocampal neurons;behavior
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发布时间：2021-05-20 -
Effects and mechanism of peppermint oil on membrane fluidity and potentials of Ha Ca T keratinocytes
摘要：Objective To observe the effects of peppermint oil on membrane fluidity and membrane potentials of Ha Ca T keratinocytes,so as to reveal the potential mechanism of enhancing transdermal penetration. Methods The cytotoxicity of peppermint oil was evaluated by using cell counting kit（ CCK-8） assay. The fluorescence recovery after photobleaching（ FRAP） technique was adopted to measure the change of membrane fluidity of Ha Ca T cells. The flow cytometer was used to study the alteration of membrane potentials of Ha Ca T cells,and to determine the intracellular concentration of Ca2 +.Ca2 +-ATPase activity in Ha Ca T cells was detected by using Ca2 +-ATPase Kit. Results Compared with azone,a common chemical penetration enhancer,peppermint oil extracted from Mentha haplocalyx Briq.had lower cytotoxicity. Peppermint oil increased Ha Ca T cells membrane fluidity and decreased membrane potentials. Meanwhile,the intracellular concentration of Ca2 +was increased significantly,and the Ca2 +-ATPase activity was decreased（ P < 0. 05）. Conclusion Peppermint oil influenced the membrane fluidity and potentials of cells by breaking the Ca2 +balance of the inner and outer membrane,leading to the higher skin permeability to enhance the transdermal absorption of drugs.关键词：peppermint oil;Ha Ca T;membrane fluidity;membrane potential;Ca2 +;penetration enhancer- 10
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发布时间：2021-05-20 - 摘要：Objective To observe the effects of Xiaopi granule on gene P21WAF1 and gene Cyclin D1,which was formulated by replenishing qi,resolving stasis and detoxification,in chronic atrophic gastritis with dysplasia in rats. Methods 50 of 60 Wistar rats were randomly selected to be modeled,and the rest of rats in blank group（ n = 10）. After establishment of model,the alive rats（ n = 33） were randomly divided into model group,vitacoenzyme tablet group（ western medicinal group） and Xiaopi granule group（ Chinese medicinal group）（ each n = 11）. Model group,western medicinal group and Chinese medicinal group were intragastrically administered once a day saline water,vitacoenzyme and Xiaopi granule respectively for 12 consecutive weeks. Real- time fluorescence quantitative polymerase chain reaction（ RT-PCR） and Western blot were used to determine the expressions of P21WAF1 and Cyclin D1 genes in rats of all groups. Results The expression of P21WAF1 mRNA and protein significantly increased in Chinese medicinal group compared with model group and western medicinal group（ P < 0. 05）. The expression of Cyclin D1 mRNA and protein dramatically decreased in Chinese medicinal group compared with model group and western medicinal group（ P < 0. 05）. Conclusion Chinese medicine Xiaopi granule can reverse the gastric mucosal dysplasia,due to increasing the expression of P21WAF1 and inhibition the expression of Cyclin D1,leading to redressing the balance of P21-CDK-Cyclin D1 pathway.关键词：chronic atrophic gastritis with gastric dysplasia;replenishing qi,resolving stasis and detoxification;P21WAF1;Cyclin D1;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the promotion effect of panax notoginseng saponins（ PNS） on CD105+-bone mesenchymal stem cells（ BMSC） homing to the cerebral infarction marginal zone.Methods The rat model of MCAO was established by referencing Zea-Longa method. The modeled rats were randomly divided into model group and high-dose,mid-dose and low-dose PNS group（ high-dose group,mid-dose group and low-dose group）,and then according to time points divided into 1 d,3 d,7d,14 d and 28 d subgroups. High-dose group,mid-dose group and low-dose group were treated with Xuesaitong Capsules（ 60,40 and 20 g / L once a day）,and normal group and model group were orally administered saline water once a day for 28 d. The positive cells of CD105+-BMSC,MAP-2,GFAP and IIIβ-Tubulin were detected by immunohistochemical method at different time points. Results The positive cells of CD105+-BMSC,MAP-2,GFAP and IIIβ-Tubulin increased in model group and PNS groups on the first day,reached the peak on the 7th day,and then went down gradually. The positive cells of CD105+-BMSC,Map-2,GFAP and IIIβ-Tubulin in model group and all PNS groups compared with model group increased significantly（ P < 0. 05）. Conclusion PNS can repair the damaged cerebral tissue induced by infarction by promoting the proliferation and differentiation of BMSCs homing to infarction marginal zone.关键词：panax notoginseng saponins;bone marrow mesenchymal stem cells;cerebral infarction;rats
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发布时间：2021-05-20 - 摘要：Objective To explore the effects of Sishen pill on colitis model induced by trinitrobenzene sulfonic acid（ TNBS） or dextran sulfate sodium（ DSS） in mice. Methods TNBS colitis model（ TNBS colitis） was induced by intrarectally administration of 1. 5 mg TNBS in 50% ethanol. DSS colitis model（ DSS colitis） was induced by feeding with 4%（ w /v） DSS dissolved in drinking water. One day after modeling,mice were intragastically administrated with Sishen pill（ 2. 3 g / kg） for 8 days. Changes in disease activity index（ DAI） together with histological scores were evaluated,and myeloperoxidase（ MPO） in colonic tissue was detected. Results Sishen pill significantly reduced DAI and histological scores of mice in both TNBS colitis and DSS colitis,it also alleviated inflammatory cell infiltration of colonic tissue in both models. Conclusion Amelioration efficacy of Sishen pill on mice with TNBS colitis and DSS colitis were obtained.关键词：Sishen pill;colitis;trinitrobenzene sulfonic acid;dextran sulfate sodium;mice
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发布时间：2021-05-20 - 摘要：Objective To determine rapidly the concentration of alcohol extract of Jingutongxiao pill by using near-infrared（ NIR） spectroscopy and chemometrics methods. Methods The contents of alcohol extract of 100 batches of Jingutongxiao pill were determined and NIR spectrograms were collected. Partial least squares（ PLS） combined with second derivative（ SD） was used as spectral processing options. The NIR calibration model of alcohol extracts was established by TQ 8. 0 software combined with PLS.Results There were 7 main factors in the quantitative model,whose range was between 8 116. 04 and 11983. 82 cm- 1. The correlation coefficient of calibration（ R2） was 0. 99 778,root mean square error of cross validation（ RMSEC） was 0. 0376, and external prediction deviation（ RMSEP） was 0. 547.Predicted average relative error was 2. 39%. Conclusion The quantitative model established by using near-infrared spectroscopy for determination of alcohol extract of Jingutongxiao pills is rapid,simple and accurate.关键词：Jingutongxiao pills;alcohol extract;near-infrared spectroscopy;quantitative model
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发布时间：2021-05-20 - 摘要：Objective In comparation with spray drying technology,to study belt vacuum drying technology on production of Lianhua Qingwen capsule. Methods According to the operating principle of pharmaceutical belt vacuum dryer,altogher six specifications were measured,including flour yield,angle of repose, bulk density, percentage of moisture absorption and the active ingredient contents of forsythiaside A and chlorogenic acid; all those were investigated in spray drying technology parallel.Results The belt drying vacuum technology solved effectively moisture absorption and agglomeration of Lianhua Qingwen capsule,without loss of the active ingredient contents of forsythiaside A and chlorogenic acid. Conclusion Belt vacuum drying technology was suitable for the drying process of industrialization of Lianhua Qingwen capsule.关键词：Lianhua Qingwen capsule;belt vacuum drying technology;spray drying technology;industrialization
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发布时间：2021-05-20
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