最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：Objectives To explore the application patterns of Yunqi theory by ancient TCM physicians in the differentiation and treatment of disease,in the hope of providing reference for current clinical practice.Methods Medical records related to the Yunqi theory were searched and identified in ten representative books of ancient TCM medical records. The characteristics of Yunqi medical records were extracted,including disease patterns,Yunqi characteristics,pathogenesis,syndrome differentiation,treatment,and prognosis. The data were summarized and analyzed,so as to explore the role of Yunqi in ancient TCM clinical practice. Results Twenty-eight medical records involving seventeen disease patterns were included. The time when diseases were prevalent tended to be Fire-yun year,while the Guest qi mainly manifested as Yang-ming in the first half of the year and Shao-yin in the second half of the year. In terms of differentiation of the eight principles,most diseases were yang,interior,heat and excess patterns. The combination of conventional TCM syndrome differentiation and Yunqi theory was helpful to understand the etiology and pathogenesis of diseases. Therefore,it could improve therapeutic efficacy and help make accurate prognosis. Conclusion The ancient medical records involving the Yunqi theory have shown that Yunqi theory exerted great effect on the etiology,pathogenesis,syndrome differentiation,treatment,and prognosis of some diseases. Such experience as what ancient TCM doctors had in using Yunqi theory in diagnosis and treatment of disease is still of value to the current clinical practice of TCM.关键词：Yunqi Theory;ancient physicians;clinical application;medical records
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发布时间：2021-05-20 - 摘要：<正>2014年9月26日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2013年"百种中国杰出学术期刊"称号（封二）,并入选"第3届中国精品科技期刊",即"中国精品科技期刊顶尖学术论文（F5000）"项目来源期刊（封三）。2013年《中国科技期刊引证报告》（核心版）共收录中国科技论文核心期刊1 989种,《北京中医药大学
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发布时间：2021-05-20 - 摘要：Balancing the ascending and descending movement of qi is a basic principle and important method in the treatment of disease,whose theoretical framework was formed in Huang Di Nei Jing. Later doctors established more comprehensive therapeutic principles according to the theory of ascending and descending qi movement. Ascending and descending qi movement disorder is a common pathologic process,leading to imbalance of the tumor and the body, and also the commonality of tumor pathogenesis. But variances do exist in the pathogenesis of different tumors,which could be found in the ascending and descending qi movement of the viscera. Therapeutic strategies formulated for the treatment of tumor based on this theory could provide more specific targets for treatment, more significant therapeutic effects,and enlightment for the development of major new drugs.关键词：tumor;the theory of ascending and descending qi movement;treatment principle;development of major new drugs
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发布时间：2021-05-20 - 摘要：Based on the comparison and contrast of the theory of generating-restricting five elements and the theory of middle-earth five elements,this article analyzed the relationship and difference between these two theories,and then further illustrated their different applications in TCM,which was of great significance to the optimization of TCM theory and guidance for clinical practice.关键词：five elements;generating-restricting five elements;middle-earth five elements;ascending and descending qi movement
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发布时间：2021-05-20 - 摘要：The language of classical traditional Chinese medicine literature was affected by Chinese people’s language habits in the ancient time. As part of the traditional culture in China,traditional Chinese medicine was influenced inevitably by Taoist culture and thought. It could also reflect the Chinese Taoist thought in different historical periods. We should pay special attention to the influence of cultural,philosophical and social background on the medical language,and also the ways Taoism language helped build,optimize,and innovate the traditional Chinese medicine language. Through discussing the combination of traditional Chinese medicine and Taoism languages linguistically and culturally, we can get new cultural and philosophical insights into the traditional Chinese medicine language.关键词：traditional medical literature;the Taoist;language;culture
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发布时间：2021-05-20 - 摘要：Objective To investigate the effects of serum with yin-enriching,qi-replenishing,and bloodactivating Chinese medicine on the expressions of SREBP-1c and FAS in steatotic Hep G2 cells. Methods Hep G2 cells were randomly divided into the control group,model group,and 15% medicated serum group. The control group and model group were cultured with normal rat serum DMEM while the 15%medicated serum group was given 15% medicated serum DMEM. Moreover,mixed fatty acids（ oleic acid,hexadecanoic acid = 2∶ 1）（ 0. 5 mmol / L） were added to the model group and the 15% medicated serum group. The lipid content in Hep G2 cells was analyzed by using oil red O staining method. The mRNA expressions of SREBP-1c and FAS were detected by using reverse transcription-polymerase chain reaction（ RT-PCR）. The protein expressions of SREBP-1c and FAS were detected by using the immunohistochemistry technique. Results Serum with yin-enriching,qi-replenishing,blood-activating Chinese medicine induced a decrease in lipid accumulation in 15% medicated serum group and it also down-regulated the mRNA and protein expressions of SREBP-1c and FAS in the model group.Statistically significant difference was observed（ P < 0. 01）. Conclusion The serum medicated with yin-enriching,qi-replenishing, and blood-activating Chinese medicine improves the excessive lipid accumulation in steatotic Hep G2 cells by down-regulating the expressions of SREBP-1c and FAS.关键词：Chinese medicine;Hep G2 cells;steatosis;SREBP-1c;FAS;rats
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发布时间：2021-05-20 - 摘要：Objective To establish a rat model of atherosclerosis,observe the expression of group IIa secretory phospholipase A2（ s PLA2 IIa） in the aorta,and explore possible mechanism of Shuxuetong injection. Methods Thirty Wistar rats were randomly divided into three groups: healthy control group（ n =10）,model group（ n = 10）,and Shuxuetong group（ n = 10）. The rats in healthy control group were fed with normal diet; Those in model group were fed with high-fat diet; rats in Shuxuetong group received high-fat diet and accepted intravenous Shuxuetong Injection（ 4 m L / kg / d）. At the end of 12 weeks,the lipid and glucose level in the blood among rats in each group were measured together with the expression of s PLA2 IIa in their aorta with immunocytochemistry and western blot method. Results s PLA2 IIa expression was mainly located in the aortic wall smooth muscle cells and amorphous material of atherosclerotic plaques. Compared with the normal group,the expression of s PLA2 IIa in the aortic wall in model group was significantly increased（ P < 0. 01）; Compared with model group,the level of s PLA2 IIa in the Shuxuetong injection group was significantly reduced（ P < 0. 01）. Conclusion The expression of s PLA2-IIa may play an important role in the pathogenesis of atherosclerosis. Through reducing the expression level of s PLA2-IIa in aorta,Shuxuetong injection may work by delaying the process of atherosclerosis.关键词：group IIa secretory phospholipase A2;Shuxuetong injection;atherosclerosis;aorta;rats
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发布时间：2021-05-20 - 摘要：Objective To compare the effects of acupuncture and electroacupuncture（ EA） on the expression of p-JNK,c-jun,Caspase-3 in rats with chronic stress-induced depression,and investigate the mechanism in the treatment of depression. Methods 50 SD rats were randomly divided into healthycontrol group,model group,acupuncture group,EA group,and paroxetine group. The expression of p-JNK,c-jun,Caspase-3 were measured by using Western blot method. Results The level of expressed p-JNK protein was increased in model group compared with that in healthy control group（ P < 0. 01）,but decreased in acupuncture group compared with model group（ P < 0. 05）. The decrease of p-JNK expression in EA group was not statistically different（ P > 0. 05）; compared with healthy control group,c-jun in model group was increased（ P < 0. 01）. The differences of above parameters also decreased but no significant difference was found between acupuncture group and EA group（ P > 0. 05）; compared with normal group,Caspase-3 in model group was increased（ P < 0. 01）; compared with model group,Caspase-3 in acupuncture group and EA group was decreased（ P < 0. 01）; compared with paroxetine group,the expression of Caspase-3 was decreased significantly in acupuncture group and EA group（ P <0. 01）. Conclusion The activation of JNK pathway and increased expression of related apoptosis protein were present in the rat model of chronic stress-induced depression. EA and acupuncture could down-regulate expression of c-jun and Caspase-3. Acupuncture seems to be more effective than EA treatment in the down-regulation of p-JNK expression,suggesting that EA and acupuncture may have different molecular mechanism in the treatment of depression.关键词：chronic stress;depression;acupuncture;electroacupuncture;p-JNK;c-Jun;Caspase-3;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the effects of Rhizoma Atractylodis extract on gastrointestinal motility in rats with experimental spleen deficiency pattern,and to elucidate its underlying mechanism.Methods Male SD rats were randomly divided into the following groups: healthy control group,model group,high-,middle- and low- dose Rhizoma atractylodis extract groups,and domperidone group.Except the healthy control group,the other groups were fed with Minor Purgative Decoction（ Xiǎo Chéng Qì Tāng） plus irregular diet for 15 days to establish the rat models of spleen deficiency pattern. After modeling,low-,middle- and high- dose Rhizoma atractylodis extract groups were gavaged respectively with Rhizoma Atractylodis extract decoction（ 2 m L） at the concentration of 5,10,20 g / kg respectively.The domperidone group was gavaged with domperidone suspension solution（ 2 m L） at the concentration of 5 mg / kg while the healthy control group and the model group gavaged with physiological saline（ 2m L）. Both the decoction and saline were given once a day for 10 days. Ten days later,blood samples were drawn from abdominal aorta to measure rat plasma MTL,SP and SS. Colorimetric assay was performed to determinate the ATP content of jejunum epithelial cells,and the immunohistochemical method was used to measure the MLCK expression of rat gastric antrum smooth muscle cells and c-kit expression of colon tissue volume. Results Compared with the model group,the gastric remnant rates in the healthy control group, high-, middle- and low-dose Rhizoma atractylodis extract groups, and domperidone group decreased markedly,small intestinal propulsion ratios were increased significantly,while the plasma MTL,SP and SS contents were increased at varying degrees. The differences were statistically significant among all groups（ P < 0. 05 or P < 0. 01）. At the same time,compared with the model group,the ATP content of jejunum epithelial cells,MLCK expression of smooth muscle cells in rat gastric antrum and c-kit expression of colon tissue volume in the healthy control group,high-,middleand low- dose Rhizoma Atractylodis extract groups,and domperidone group were increased at different degrees,and the differences were statistically significant（ P < 0. 05 or P < 0. 01）. Conclusion Rhizoma Atractylodis extract can improve gastrointestinal dysfunction caused by spleen deficiency,and have better regulatory and therapeutic effects on the functional gastrointestinal disorders due to spleen deficiency.关键词：Rhizoma Atractylodis extract;spleen deficiency pattern;gastrointestinal function;signal transduction;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the mechanism of phlegm-resolving and stasis-dissipating method in improving the effect of radiotherapy for intermediate and advanced esophageal cancer. Methods A multi-center and randomized trial was performed. Sixty cases of esophageal cancer were randomly divided into two groups which were administrated either with radiotherapy or radiotherapy combined with phlegmresolving and stasis-dissipating therapy. Efficacy was evaluated after radiotherapy. Results Phlegmresolving and stasis-dissipating therapy combined with radiotherapy could relieve the patients’ symptoms,improve their life quality,elevate tumor stability rate,and protect bone marrow,which was superior to radiotherapy alone. Conclusion Phlegm-resolving and stasis-dissipating therapy could improve efficacy and reduce toxicity of radiotherapy,including elevation of recovery and tumor stability rate,improvement of the patients’ life quality,symptom relief,and toxicity reduction on bone marrow of radiotherapy in patients with intermediate and advanced esophageal cancer.关键词：esophageal cancer;phlegm-resolving and stasis-dissipating method;radiotherapy;synergistic effects with toxicity reduction.
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发布时间：2021-05-20 - 摘要：Objectives To establish quality-representation and perform correlation analysis method of Yuanzhi（ Polygala tenuifolia Willd.） based on quality evaluation model of medicinal system to assess its quality. Methods Four phenolic compounds as effective index components,including sibricose A5,sibricose A6,polygala shantung Ⅲ,and 3,6 ’- disinapoy sucrose,were measured by using HPLC,while tenuifolin（ terpenoids） was assessed according to China pharmacopoeia. Correlation analysis of these data was then performed. Results The content of effective index components and their content ratio as the quality index was presented based on medicinal system. Correlation analysis was performed using non-correlation coefficient, non-correlation index, and correlation index to demonstrate the correlation between samples and reference decocting pieces. The result showed the total content of effective index components in sample No. 2,No. 3,and No. 6 was higher than that in sample No. 4,whereas it was similar between sample No. 9 and No. 4. The correlation ranking could be produced as follows when sample No. 4 was used as the reference standard to calculate non-correlation coefficient of other samples: Sample No. 4（ 0 /100%） > No. 3（ 0. 41 /94. 18%） > No. 9（ 0. 94 /86. 60%） > No. 6（ 0. 96 /86. 31%） > No. 2（ 1. 05 /85. 01%） > No. 11（ 1. 15 /83. 62%） > No. 1（ 1. 21 /82. 65%） > No. 12（ 1. 23 /82. 43%） > No. 8（ 1. 35 /80. 72%） > No. 14（ 1. 39 /80. 10%） > No. 10（ 1. 52 /78. 27%） > No. 7（ 1. 55 /77. 91%） > No. 5（ 1. 64 /76. 63%） > No. 15（ 2. 27 /67. 56%） > No. 13（ 3. 12 /55. 44%）. Samples No. 3,No. 9,No. 6,and No. 2 had a higher correlation with the reference standard of sample No. 4.Therefore,based on quality representation and correlation analysis,the quality of samples No. 3,No. 6,No. 2,and No. 9 was superior to that of samples No. 11,No. 1,and No. 12. Conclusion Quality representation and correlation analysis of Yuanzhi based on a new quality evaluation model of medicinal system could be used to assess its quality. Quality representation,the content and relative content ratio of effective index components,was calibrated with decocting pieces of definite efficacy as the reference standard. When combined with correlation analysis,it could be a comprehensive and accurate quality evaluation model to assess the quality of Yuanzhi. This approach evidences screening technologies for the Chinese medicinal as well as its quality control and application. This study may serve as a reference for methodology and application in the quality evaluation of other Chinese medicinals.关键词：Yuanzhi（Polygala tenuifolia Willd.）;quality evaluation;correlation analysis;sibricose A5;sibricose A6;Polygala shantong Ⅲ;3,6’-disinapoy sucrose;tenuifolin
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发布时间：2021-05-20 - 摘要：Objective To establish a quick method for simultaneous quantitative determination of four flavonoid glycosides in Mentha haplocalyx Briq,including hesperidin,diosmin,didymin and linarin by using HPLC-MS / MS. Methods The procedure of HPLC-MS / MS was performed on the chromatographic column of Inertsil ODS-3 column（ 4. 6 mm × 150 mm,5 μm）,by gradient elution using methanol-0. 1% formic acid water as the mobile phase at a flow rate of 0. 5 m L / min. The column temperature was30 ℃. Electrospray ionization source,monitoring in positive ion mode and multiple reaction monitoring（ MRM） were applied for the quantitative determination. Results Complete separation of the four compounds（ hesperidin,diosmin,didymin,linarin） was achieved. The four regression equations showed linear relationships between peak areas and contents of each compound. The average recoveries（ n = 6）of the compounds listed above were 99. 40%,98. 63%,99. 08%,98. 62% and RSD were 2. 5%,2. 7%,2. 6%,2. 4%,respectively. Conclusion This method is simple,rapid and accurate with high specificity,which can be used for the content determination of mentha haplocalyx Briq.关键词：Mentha haplocalyx Briq.;HPLC-MS / MS;hesperidin;diosmin;didymin;linarin;content determination
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发布时间：2021-05-20 - 摘要：Objective To explore the clinical symptom associated changes of default Mode Network of patients suffering from chronic cervical radicular pain（ CCRP） after traditional Chinese massage therapy.Methods 10 patients of CCRP received 12 weeks ’ Chinese massage therapy. Scale of cervical spondylosis was evaluated and resting state functional magnetic resonance scan was given in a 3. 0T SIEMENS scanner before and after the treatment. Default Mode Network（ DMN） was extracted using independent component analysis. Support Vector Machine（ SVM） algorithm was applied to find the most significant brain regions to distinguish the pre therapy and post therapy data of DMN. Correlation analysis was then adopted between DMN in these regions and clinical scale. Results The brain regions positively related to disease included left triangular part of inferior frontal gyrus,left orbital part of middle frontal gyrus,left lingual gyrus,and right precuneus. While negatively related brain regions covered right middle and superior frontal gyrus,right inferior parietal gyrus,and right post central gyrus.Conclusion Traditional Chinese massage could reduce the CCRP patients ’ clinical symptoms by enhancing DMN connection to somatosensory and executive cortex,meanwhile inhibiting DMN connection to cognitive,visual,and memory cortex.关键词：traditional Chinese massage;cervical spondylotic radiculopathy;chronic pain;resting state functional MRI;Default Mode Network;support vector machine
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发布时间：2021-05-20 - 摘要：Objective To investigate the demographic distribution,the distribution of TCM syndromes and comorbidities of type 2 diabetes based on the massive data in real world hospital information system（ HIS） database. Methods In the HIS of 20 top-three general hospitals,the information of 72,772 patients diagnosed firstly as type 2 diabetes were collected and analyzed with descriptive statistics,on the demographic characteristics, TCM diagnosis upon admission and discharge, complications and comorbidities. Results Among 72,772 patients diagnosed firstly as type 2 diabetes,a total of 41,805cases（ 57. 45%） aged from 45 to 89 years old; the male to female ratio being 1. 41 ∶ 1; 45,982（ 64. 31%） patients had health insurance; a total of 25,691（ 35. 30%） patients had hospitalization duration of 8-28 days; most common TCM diagnoses upon discharge were qi-yin deficiency（ 36. 05%）;the top five comorbidities were 32,601（ 19. 02%） cases of hypertension,16,912（ 9. 87%） cases of coronary artery disease,9,344（ 5. 45%） cases of cerebral infarction,8,940（ 5. 22%） cases of lipoprotein metabolic syndrome and 5,096（ 2. 97%） cases of non-alcoholic fatty liver. Conclusion Most patients with type 2 diabetes are senile,more males than females,and the most common syndrome type upon discharge was qi-yin deficiency.关键词：type 2 diabetes;HIS;clinical features
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发布时间：2021-05-20 - 摘要：Objective To design two sets of feasible questionnaires: one is on the life styles and symptoms of early-stage lung cancer patients,and the other one is on the feedbacks from their doctors.Methods Literature review,focus group discussions,and consultations with multidisciplinary experts were used. Results The former questionnaire was on the life styles and early symptoms of early-stage lung cancer patients with 5 dimensions and 33 items,including patients’ diet,sleep,physical exercises,personal habits,occupation,and living environment and,as well as symptoms and medical history. The latter questionnaire was on the feedbacks from the doctors of lung cancer patients with 5 dimensions and23 items,including the pathological classifications,syndrome differentiation,symptoms and signs of lung cancer as well as the treatment of their lung cancer patients. Conclusion The two sets of questionnaires were both reliable and valid. The specific information of the life styles and symptoms of early-stage lung cancer patients as well as the diagnosis of their lung cancer could be obtained with these instruments for the related study on lung cancer.关键词：lung cancer;clinical syndromes;pathology;life style;symptoms of early stage
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发布时间：2021-05-20 - 摘要：Objective To explore the effects of Helicobacter pylori（ Hp） infection on blood lipid and serum inflammatory cytokines level in atherosclerotic（ AS） patients with different TCM syndrome types.Methods Using clinical epidemiological method,120 AS patients and 20 cases of healthy check-up were recruited in Dongzhimen Hospital. AS patients were divided into the following groups: liver and kidney yin deficiency,phlegm and blood stasis trans-resistance,and qi deficiency and blood stasis groups. Their fasting venous blood was extracted. Their blood lipid,serum IL- 6 and TNF α level were also measured. Results The expression level of serum Hp Ig G in descending order was: liver and kidneyyin deficiency group > qi deficiency and blood stasis group > phlegm and blood stasis transresistance group > control group（ P < 0. 01）. Level of serum Hp Ig G in all groups of AS patients was significantly higher than that of healthy controll group（ P < 0. 01）. Moreover,level of serum Hp Ig G in patients of liver and kidney yin deficiency group had a significant difference compared with Phlegm and blood stasis trans-resistance group（ P < 0. 01）. Level of TC,IL-6 and TNF-α in AS patients was significantly higher than that of healthy controlled group（ P < 0. 01）. The serum Hp Ig G level of AS patients was positive correlation to the level of serum TC,IL-6 and TNF-α. Conclusion Level of serum Hp Ig G in the AS patients was significantly higher than that of healthy control group. Level of serum Hp Ig G in patients of liver and kidney yin deficiency group was higher than that in the patients of phlegm and blood stasis trans-resistance group. Helicobacter pylori infection might trigger AS by participating in activation of serum inflammatory cytokines and interfering with lipid metabolism.关键词：atherosclerosis;Helicobacter pylori;TCM syndromes;blood lipid;inflammatory cytokines
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发布时间：2021-05-20
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