最新刊期
卷 37 ， 期 2 ， 2014
- 摘要：Terminology standardization of acupuncture and moxibustion is important to modernization, internationalization and informatization of acupuncture and moxibustion. The scientific methodology provides guarantees to the terminology standardization of acupuncture and moxibustion. Through summing up the course of study and methodology in the work of terminology standardization,it was found that the methodologies such as philology,system theory,logics,linguistics,etymology,information science, computer science and standardization were used in selection,naming,concept system building,information processing and standardized application of terminology of acupuncture and moxibustion.关键词：acupuncture and moxibustion;terminology;standardization;methodology
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发布时间：2021-05-20 - 摘要：Professor REN Ying-qiu,a contemporary famous TCM expert,had devoted his life to inherit and improve Chinese medical sciences,paying his particular attention to the literature of Chinese medical history. Through collecting and systemizing Professor REN Ying-qiu ’s writings,papers and other literature materials, his academic achievements in philology of Chinese medical history can be summarized as follows: creating doctrines of different TCM schools,establishing the discipline basis of TCM classical literature,prompting the research methods of Chinese medical philology and exploring the research direction of Chinese medical history.关键词：REN Ying-qiu;philology of Chinese medical history;achievements
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发布时间：2021-05-20 - 摘要：<正>唐代孙思邈所著《千金要方》为中医学史上第一部医学百科全书。1066年,北宋校正医书局对该书进行了大规模的整理修订并刊行天下,使其广为流传,影响深远,目前国内通行的《千金要方》即为此宋校本。北宋时期是理学兴盛的年代,大量儒生入医,将理学的思想和方法引入医学领域,对中医学术的发展产生了重要的影响。宋人校改医书的原则和方法,亦受到宋代理学的全面影响。他们对《千金要方》的整理,采用正讹谬、补遗佚、删重复、缉事关键词：宋校本;千金要方;特点
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发布时间：2021-05-20 - 摘要：Objective To discuss the therapeutic mechanism of Yinlai Tang to mucosa immunologic barrier of mice with dyspepsia combined with influenza virus infection,to demonstrate the effectiveness of treating lung and stomach simultaneously,and to provide experimental evidence for dyspepsia combined with respiratory tract infection prevention and treatment. Methods Mice were randomly divided into normal group,infection group,dyspepsia group,dyspepsia and infection group,dyspepsia treated group and dyspepsia and infection treated group. The experimental period was 8 days. The mice in normal group and infection group were fed with standard diet,and the mice in the other groups were fed with high fat and high calorie diet and given intragastric administration of milk from the 1stday of experiment to the 4thday. The mice in infection group and dyspepsia and infection group were given intranasal instillation of influenza virus at the 4thday. The mice in dyspepsia treated group and dyspepsia and infection treated group were given Yinlai Tang from the 4thday to the 8thday. The levels of secreted immunoglobulin A（ sIgA）,tumor necrosis factor-a（ TNF-a） and interleukin-10（ IL-10） in intestinal mucosa of mice of all groups were detected. Results The levels of sIgA,TNF-α and IL-10 in intestinal mucosal tissues of mice decreased significantly in dyspepsia group as well as dyspepsia and infection group compared with those in normal group（ P < 0. 01）. The levels of sIgA,TNF-α and IL-10 in dyspepsia treated group were significantly higher than those in dyspepsia group（ P < 0. 01）,and the level of TNF-α in dyspepsia treated group was significantly lower than that in normal group（ P < 0. 01）,but there was no significant difference in sIgA and IL-10 between dyspepsia treated group and normal group（ P > 0. 05）. The levels of sIgA,TNF-α and IL-10 in dyspepsia and infection treated group were significantly higher than those in dyspepsia and infection group and normal group（ P < 0. 01）. Conclusion Yinlai Tang can promote intestinal mucosa to secrete sIgA,regulate the levels of TNF-α and IL-10 moderately, and have protective effect on mechanical and immunologic barrier of intestinal mucosa.关键词：Yinlai Tang;dyspepsia combined with influenza virus infection;secreted immunoglobulin A;tumor necrosis factor-a;interleukin-10;mice
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of Huanglian Jiedu tang ’s active fractions,which consists of total alkaloids,total flavonoids and total iridoids,on the expressions of penumbra neuronal nuclei（ NeuN）,cysteine aspartic acid proteinase 3（ Caspase-3） and poly-ADP-ribose polymerase（ PARP） in rats after cerebral ischemia,and to discuss the mechanism of protective effects of these fractions on neurons. Methods The rat model of permanent middle cerebral artery occlusion（ pMCAO） was chosen. Male SD rats were randomly divided into sham-operation group,model group,aqueous extract group（ 800 mg / kg）,total alkaloids group（ 44 mg / kg）,total flavonoids group（ 50 mg / kg） and total iridoids group（ 80 mg / kg）. All groups were orally given corresponding medicinals once a day for 7 d. The expressions of NeuN,Caspase-3 and PARP were detected by using immunofluorescence staining combined image analysis technique. Results In model group,the number of NeuN positive cells decreased in ischemic penumbra cortex decreased,expression of NeuN decreased,and expressions of Caspase-3 and PARP increased significantly compared with sham-operation group（ P < 0. 01）. In aqueous extract group,total alkaloids group,total flavonoids group and total iridoids group,the number of NeuN positive cells increased in ischemic penumbra cortex,expression of NeuN increased,and expressions of Caspase-3 and PARP decreased compared with model group（ P < 0. 05）. Conclusion The aqueous extract,total alkaloids,total flavonoids and total iridoids in Huanglian Jiedu Tang have protective effect on neurons in ischemic penumbra cortex through depressing the activity of Caspase-3 and decreasing the over-expression of PARP.关键词：Huanglian Jiedu Tang;cerebral ischemia;neuronal nuclei;cysteine aspartic acid proteinase 3;poly-ADP-ribose polymerase;rats
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发布时间：2021-05-20 - 摘要：Objective To compare the hemorheology indexes and coagulation parameters of 6 rat models of blood stasis syndrome which were established by using six different methods,and to discuss the characteristics and applicability of each rat model. Methods Six different rat models of blood stasis syndrome were established including congealing cold with blood stasis group, adrenaline group, dextranum group,hyperlipidemia with congealing cold group,hyperlipidemia group and blood deficiency with blood stasis group. The differences in whole blood viscosity（ WBV）,plasma viscosity,erythrocyte deformability,hematocrit（ HCT）, platelet aggregation,prothrombin time（ PT）, activated partial thromboplastin time（ APTT） and fibrinogen（ FIB） content were compared among all groups. Results The hemorheology indexes and coagulation parameters were improved in adrenaline group,hyperlipidemia group,hyperlipidemia group and blood deficiency with blood stasis group,which was more significant in adrenaline group with higher applicability. The hemorheology indexes were significantly influenced in dextranum group,especially RBC-related parameters. The coagulation parameters were significantly influenced in congealing cold with blood stasis group. Conclusion The rat models of blood stasis syndrome established by using different methods show different characteristics in hemorheology indexes and coagulation parameters,and have different applicability. This study provides some reference for choosing rat models of blood stasis syndrome in the research on the activities of medicinals with the actions of activating blood and resolving stasis.关键词：model of blood stasis syndrome;hemorheology;anticoagulant;rats
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发布时间：2021-05-20 - 摘要：Objective To study the influences of Tiaozhi Tongmai Granules on expressions of aortic arch nuclear factor-κB（ NF-κB）,intercellular adhesion molecule-1（ ICAM-1） and lymphocyte functionassociated antigen-1（ LFA-1） in apolipoprotein E gene knockout（ ApoE- /-） mice. Methods Male ApoE- /-mice（ 6 weeks old） were randomly divided into model group,Xuezhikang group,and lowdose,mid-dose and high-dose Tiaozhi Tongmai Granules groups（ low-dose group,mid-dose group and high-dose group,each n = 8）. C57BL /6J mice（ n = 8） were chosen as normal control group. The mice were fed with high fat diet combined with drugs for 12 weeks. The changes of serum lipid were detected by using serological test,histomorphological changes of aortic arch root were observed by using HE staining,and expressions of NF-κB,ICAM-1 and LFA-1 were detected by immunohistochemical method. Results The levels of serum total cholesterol（ TC）,low density lipoprotein（ LDL）,high density lipoprotein（ HDL） in model group,Xuezhikang group and Tiaozhi Tongmai Granules groups increased significantly compared with those in control group（ P < 0. 05）. The level of serum triglyceride（ TG） increased significantly in model group and low-dose group compared with that in normal control group（ P < 0. 05）. The level of TG decreased significantly in mid-dose group,high-dose group and Xuezhikang group compared with that in model group（ P < 0. 05）. HE staining showed that there were no atherosclerosis plaques formed in aortic intima in control group,yet there were vulnerable atherosclerosis plaques formed in thickened aortic intima in model group,and stable atherosclerosis plaques formed in Xuezhikang group and high-dose group. The expressions of NF-κB,ICAM-1 and LFA-1 increased significantly in model group,Xuezhikang group,low-dose group,mid-dose group and high-dose group compared with those in normal control group（ P < 0. 05）. The expressions of NF-κB,ICAM-1 and LFA-1 decreased significantly in high-dose group compared with those in model group（ P < 0. 05）. Conclusion Tiaozhi Tongmai Granules can reduce the level of serum TG and expressions of aortic arch NF-κB,ICAM-1 and LFA-1,so as to alleviate artery atherosclerosis lesion.关键词：ApoE knockout mice;nuclear factor-κB;intercellular adhesion molecule-1;lymphocyte function-associated antigen-1;serum lipid;immunohistochemistry
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发布时间：2021-05-20 - 摘要：Objective To investigate the influence of external dryness on proinflammatory cytokines and anti-inflammatory cytokines in airway and the significance. Methods Kunming mice（ n = 72） were randomly divided into normal-temperature and normal-dampness group,warm-dryness group and cooldryness group（ each n = 24）. The mouse model was established by the synthetic stimulation of temperature-relevant humidity-wind. On the 6thday and the 12thday the histopathological changes of respiratory tract and lung ultrastructure were observed,and the content of neutrophil elastase（ NE）,α1-antitryptase（ α1-AT）,interlukin-10（ IL-10）,tumor necrosis factor-α（ TNF-α）,IgG and secretory IgA（ sIgA） in bronchoalveolar lavage fluid were detected. Results There were squamous metaplasia of airway epithelium and cilium function defect,blood stasis and edema in pulmonary alveoli accompanied by pulmonary emphysema in warm-dryness group and cool-dryness group compared with normaltemperature and normal-dampness group on the 6thand 12thday. The observation on lung ultrastructure indicated that the number of mitochondria and osmiophilic multilamellar body of alveolar type II（ ATⅡ） decreased in warm-dryness group and cool-dryness group,meanwhile the level of NE increased,while the levels of α1-AT and IL-10 decreased（ P < 0. 05）. In warm-dryness group the levels of IgG and sIgA were decreased（ P < 0. 01）. In cool-dryness group the level of IgG decreased but the changes of sIgA level had no significance. Conclusion External dryness can increase NE and cause dysfunction of down-modulatory role of IL-10 in airway and impair immune defending function of airway,which is related to pathogenesis of pulmonary injury.关键词：external dryness;neutrophil elastase;interlukin-10;mice
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of Wuzi Jiangtang Fang on hepatic glycogen and AKT / glycogen synthase kinase-3β（ GSK-3β） signal pathway in rat model of type 2 diabetes,and to explore its molecular mechanism in improving glucose metabolism. Methods The rat model of type 2 diabetes was established by feeding high fat diet combining intrapreitoneal injection of low-dose streptozotocin（ STZ）, and then all rats were divided into model group,metformin group,and low-dose,mid-dose and high-dose Wuzi Jiangtang Fang groups（ low-dose group,mid-dose group and high-dose group）. The doses giving the rats in low-dose group,mid-dose group and high-dose group were 3. 5 g / kg,7. 0 g / kg and 14. 0 g / kg respectively. And a normal group was set up. The normal group and model group were intragastrically given purified water,and other groups were given corresponding drugs for 6 w. The rats were killed after 6 w. The content of glycogen in liver tissues and the expressions of AKT and GSK-3β were detected. Results The levels of fasting blood glucose（ FBG） and 2-h postprandial blood glucose（ 2-h PBG） increased,content of hepatic glycogen decreased,content of AKT decreased,AKT phosphorylation level decreased,content of GSK-3β increased,and GSK-3β phosphorylation level decreased in model group compared with normal group（ P < 0. 05）. The levels of FBG and 2-h PBG decreased,content of hepatic glycogen increased,content of AKT increased,AKT phosphorylation level increased,content of GSK-3β decreased,and GSK-3β phosphorylation level increased in Wuzi Jiangtang Fang group compared with model group（ P < 0. 05）. Conclusion Wuzi Jiangtang Fang can ameliorate glucose metabolism and increase the content of hepatic glycogen in rat model of type 2 diabetes,which may be related to increasing phosphorylation levels of AKT and GSK-3β.关键词：Wuzi Jiangtang Fang;type 2 diabetes;blood glucose;hepatic glycogen;AKT;glycogen synthase kinase-3β;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the influences of Yiqi Huoxue Fang and Bushen Shengsui Fang on the genetic and protein expressions of Ctnnb1 and Krt1 in rats with focal cerebral ischemia / reperfusion. Methods The rat model of focal cerebral ischemia /reperfusion was established. The rats were randomly divided into sham group,model group,Yiqi Huoxue Fang group（ Y group） and Bushen Shengsui Fang group（ B group）. After cerebral ischemia for 2 h and reperfusion,the genetic expressions of Ctnnb1 and Krt1 in ischemic frontoparietal cortex were detected by using PCR assay,and protein expressions of Ctnnb1 and Krt1 in ischemic frontoparietal cortex and hippocampus CA1 zone were detected by using immunohistochemistry Envision two- step method. Results The genetic expressions of Ctnnb1 and Krt1 increased significantly in model group compared with sham group（ P < 0. 05）, and decreased significantly in Y group compared with model group（ P < 0. 05）. The genetic expression of Ctnnb1 decreased significantly in B group（ P < 0. 05）,which had significant difference compared with Y group（ P <0. 05）. The protein expressions of Ctnnb1 and Krt1 in frontoparietal cortex and hippocampus CA1 zone increased significantly in model group compared with sham group（ P < 0. 05）,and decreased significantly in Y group compared with model group（ P < 0. 05）. The protein expression of Ctnnb1 was significantly lower in Y group than that in B group（ P < 0. 05）. Conclusion Yiqi Huoxue Fang and Bushen Shengsui Fang can improve the repairing of injured cerebral tissue through reducing the the genetic and protein expressions of Ctnnb1 and Krt1 in cortex and hippocampus and regulating notch signal pathway.
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发布时间：2021-05-20 - 摘要：Objective To discuss the protective mechanism of hedysarum polybotrys polysacchcaide（ HPS） on kidney in mice with diabetic nephropathy（ DN） through studying the influences of HPS on renal protein kinase Cα（ PKCα） and vascular endothelial growth factor（ VEGF） in db / db mice with DN. Methods Male db / db mice（ n = 50,12 weeks old） were randomly divided into five groups: lowdose,mid-dose and high-dose HPS groups（ low-dose group,mid-dose group and high-dose group）, enalapril group,model group. The mice in normal group（ n = 10） were db / m mice of the same age. The mice in all groups were given intervention respectively for 8 w. The concentration of blood glucose was detected before intervention and at the end of the 2ndw,4thw,6thw and 8thw after intervention. The mice were killed at the end of 8thw after 24-h urine was collected and 24-h urine protein excretion quantity was detected. The levels of serum creatinine（ Scr） and blood urea nitrogen（ BUN） were detected. The mRNA and protein expressions of renal PKCα and VEGF were detected by using reverse transcription polymerase chain reaction（ RT-PCR） and Western blotting. Results The level of blood glucose decreased in HPS groups after 8 w compared with model group（ P > 0. 05）,and Scr,BUN and 24-h urine protein excretion quantity decreased significantly compared with model group（ P < 0. 05）. There was no significant difference in protein expression between low-dose group and model group（ P > 0. 05）. The protein expression in all intervention groups decreased compared with model group（ P < 0. 05）,which was more significant in high-dose group（ P < 0. 01）. Conclusion HPS has a therapeutic effect on DN in db / db mice with type 2 diabetes,while the effect dose not dependent on hyperglycemic. HPS may slow down DN progression by inhibiting the excessive expression of PKCα and VEGF.
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发布时间：2021-05-20 - 摘要：<正>为了更好地服务作者、读者,提高工作效率,《北京中医药大学学报》编辑部自2011年1月1日起开通网上采编系统（http://xb.bucm.edu.cn）,请广大作者和读者登陆本刊网址,随时通过此系统投稿、查稿、修改稿件或浏览最新目录等,首次登陆需先行注册。2010—2013年杂志及现刊内容已在网上全文刊出,可在线全文阅读。本刊不再接收电子邮件与纸版投稿,请作者、读者相互转告。如有特殊情况请与本刊编辑部联系。电话:010-64287405。
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发布时间：2021-05-20 - 摘要：Objective To study the extraction kinetic mechanism and fit out extraction kinetics equation during water decocting taken total flavonoids extracted from Gusuibu（ Rhizoma Drynariae） as determination index. Methods At first,the existing model in laboratory was simplified and deduced, and then the concentration of extracting solution with different extraction time（ t） and solvent loading（ M） was detected by using ultraviolet spectrophotometry according to the parameters and characteristics of the model. The parameters of equation were deduced based on Fick’s scattering laws,and the results were substituted into mathematic model for equation fitting. Results The natural logarithm of concentration of total flavonoids had good linear relationship as t and M were redoubled. According to the slopes and intercepts of linear regression equation under different conditions,the calculated results as follows: n =- 0. 323 54,a = 27. 730 05 and f1= 0. 023 019. A equation was established with accurate detecting results and standard deviation was controlled within industrial tolerance interval. Conclusion The established model can be applied to and descript well the kinetic extraction course of Gusuibu（ Rhizoma Drynariae）.关键词：Gusuibu（Rhizoma Drynariae）;extraction kinetic model;model simplification;total flavonoids
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发布时间：2021-05-20 - 摘要：Objective To prepare Olive Effervescent Tablets with a good flavor and antioxidant effect. Methods The prescription of Olive Effervescent Tablets was optimized by using Box-Behnken response surface methodology. The content of phenolics was detected by using Folin-Ciocalteu assay, and antioxidant effect of which were verified by detecting scavenging activity of diphenyl picrylhydrazyl（ DPPH）. Results The main components in optimum prescription were as follows: active pharmaceutical ingredients accounted for 35. 1%,mannitol,27. 9%,tartaric acid,19. 5%,sodium bicarbonate,15. 6%,ethyl alcohol,1. 6%,and PEG 6000 0. 4%. Phenolics accounted for 54. 09 mg per tablet（ 0. 38 g）. The scavenging activity of DPPH of Olive Effervescent Tablets was superior to Vitamin C. Conclusion Prepared Olive Effervescent Tablets has a good flavor and antioxidant effects, and its antioxidant effect has clear market positioning.关键词：olive（Canavium album Raeuseh）;effervescent tablets;response surface methodology;1,1-diphenyl picrylhydrazyl
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发布时间：2021-05-20 - 摘要：Objective To provide clinical reference for syndrome differentiation and treatment through investigating distribution characteristics of TCM syndrome factors in patients with chronic heart failure（ CHF） of coronary heart disease（ CHD）. Methods The case observation form was designed and the patients with CHF（ n = 924） were chosen from 17 Chinese medicine hospitals. The distribution of syndrome factors was given descriptive statistical analysis and distribution rules of syndrome factors were discussed in 915 patients from 924 ones. Results The main names of TCM diseases were chest impediment,heart failure,heart palpitations,dyspnea syndrome and edema. The syndrome factors involving disease nature were mainly qi deficiency,blood stasis,water fluid,yin deficiency,phlegm turbidity and yang deficiency. The syndrome factors involving disease location were mainly heart,kidney, spleen,lung and liver. The syndrome factors involving disease nature were blood stasis（ 72. 73%）,qi deficiency（ 63. 64%）,yin deficiency（ 45. 45%） and phlegm turbidity（ 27. 27%） in 11 patients with grade Ⅰ cardiac function. The syndrome factors involving disease nature were qi deficiency（ 77. 73%）, blood stasis（ 76. 52%）,phlegm turbidity（ 28. 34%） and yin deficiency（ 27. 53%） in 247 patients with grade Ⅱ cardiac function. The syndrome factors involving disease nature were blood stasis（ 80. 71%）,qi deficiency（ 79. 59%）,water fluid（ 35. 06%）,yin deficiency（ 21. 34%） and yang deficiency（ 20. 59） in 539 patients with grade Ⅲ cardiac function. The syndrome factors involving disease nature were qi deficiency（ 78. 81%）,blood stasis（ 74. 58%）,water fluid（ 57. 63%）,yang deficiency（ 29. 66%）,phlegm turbidity（ 29. 66%） and yin deficiency（ 27. 12%） in 118 patients with grade Ⅳ cardiac function. Conclusion With the deterioration of cardiac function,the main syndrome factors will turn from qi deficiency,blood stasis,yin deficiency and phlegm turbidity into qi deficiency, blood stasis,yang deficiency and water fluid in patients with CHF,which suggests that the distribution of syndrome factors will change with the deterioration of cardiac function.关键词：chronic heart failure;coronary heart disease;syndrome factors;cardiac function
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发布时间：2021-05-20 - 摘要：Objective To investigate the classification methods of TCM syndromes of primary IgA nephropathy and syndrome affiliation of micro-manifestations by using clinical and epidemiological survey,and provide some evidences for differentiation of syndromes of IgA nephropathy combining macroscopic and microscopic information. Methods The data related to information of four examinations in TCM,physical examinations,laboratory examinations and renal pathology were collected from the multicenter patients with IgA nephropathy（ n = 354）,and a database was built. A study on nonlinear dimension reduction of TCM syndromes was conducted to analyze the macroscopic and microscopic information of 69 factors by using methods of factor analysis and clustering analysis. Results A total of 19 common factors were extracted and 5 TCM syndrome types of IgA nephropathy were summed up, including spleen-kidney yang deficiency combined with blood stagnation syndrome,spleen qi deficiency combined with phlegm dampness syndrome,liver-kidney yin deficiency,lung qi deficiency combined with wind-heat syndrome,and qi-yin deficiency combined with dampness-heat syndrome. The micromanifestations,such as glomerular filtration rate（ GFR,15- 29 mL / min）,renal tubular atrophy or renal interstitial fibrosis（ T2）,interstitial inflammatory infiltration（ > 50%）,were more common in spleenkidney yang deficiency combined with blood stagnation syndrome,urine protein（ ≥3. 5 g / d）,decrease of blood albumin and increase of blood cholesterol were found mostly in spleen qi deficiency combined with phlegm dampness syndrome,higher blood pressure,urine protein( 0. 2- 3. 5 g / d,GFR（ 30%-89%）,renal tubular atrophy or renal interstitial fibrosis（ T1）,crescents fiber,inflammatory infiltration（ 25%-50%）,ball hardening and small arterial wall thickness were common in liver-kidney yin deficiency syndrome,and urine occult blood level（ ≥ + + +）,mesangial cell hyperplasia（ M1）, segmental glomerular sclerosis or adhesions（ S1）,capillary fiber hyperplasia（ E1）,crescent cells and crescent fiber cells were mostly seen in qi-yin deficiency combined with dampness heat syndrome. Conclusion It is helpful for classification study on TCM syndromes of IgA nephropathy by using factor analysis and clustering analysis. Meanwhile,it will provide reference of objective and microcosmic basis for diagnosis of IgA nephropathy combined with macroscopic and microscopic information.关键词：IgA nephropathy;TCM syndrome;factor analysis;clustering analysis
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发布时间：2021-05-20 - 摘要：The postgraduate dissertations published on Journal of Beijing University of Traditional Chinese Medicine · Clinical Medicine from 2007 to 2012 years were summed up. Postgraduate dissertations accounted for 34. 2% in total papers, which were mainly about clinical observation, theoretical discussion,literature review and experience summarization. In recent 2 years,the papers with project foundation increased quickly among all postgraduate dissertations,and the authors were mainly the postgraduates in Beijing University of Chinese Medicine. There were also some problems found,such as non-standard application of TCM terms,inaccurate citation of TCM classical literature and incomplete writing of TCM case records,and defects in application of statistical methods and document description.关键词：postgraduates;dissertations;compiling
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发布时间：2021-05-20
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