最新刊期
卷 37 ， 期 3 ， 2014
- 摘要：<正>气候环境史命题在世界范围内肇始于20世纪70年代。王冰在《重广补注黄帝内经素问》《玄珠密语》《太始天元玉册》几书已补充了运气七篇大论,并肯定人体、环境之间存在着相互作用。运气学说虽具有一定的可验证、可复制性,但是并不意味理论本身无懈可击,其仍存在很多缺陷。运气学对宏观周期、象术结构论两方面讨论的不足,即为运气学说必须补正的问题。1气候环境史角度下,对运气学说的补充认识关键词：运气;医学学派
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发布时间：2021-05-20 - 摘要：<正>《医林改错》[1]为清代医家王清任所著。他是我国著名医学大家,在临床医学上有着卓越的贡献,对中医学的影响巨大。他认为"诸病之因,皆由血瘀",提出了50余种的瘀血病证,丰富和发展了中医学瘀血学说的理论和治疗方法[2],创立了系列治疗瘀血证的诸多著名方剂,灵活运用活血化瘀法治疗很多疾病,体现了中医"异病同治"的辨证论治思关键词：瘀血证;医林改错;异病同治
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发布时间：2021-05-20 - 摘要：Objective To study the syndromes and syndrome factors of Helicobacter pylori（ Hp）-related chronic gastritis,and discuss the expressions of TCM syndromes of Hp infection. Methods The patients with non-atrophic gastritis and atrophic gastritis（ each n = 200） were chosen,and their data from TCM four examinations were analyzed by using factor analysis and entropy-reactor of complex system. Results There were 4 syndrome factors related to disease locations of Hp-positive chronic gastritis, including liver,stomach,spleen and gallbladder（ gallbladder being given up after clinical and expert questionnaire）,and there were 3 of Hp-negative chronic gastritis,including liver,stomach and spleen. There were 9 syndrome factors related to disease nature of Hp-positive or Hp-negative chronic gastritis, including qi deficiency,yin deficiency,yang deficiency,qi stagnation,phlegm,heat,blood stasis,food accumulation and cold. There were 8 basic syndrome types,including para-syndrome of depression-heat in liver and stomach, para-syndrome of spleen-stomach weakness, para-syndrome of damp-heat accumulation,para-syndrome of food stagnation,para-syndrome of spleen cold and stomach heat,parasyndrome of stomach yin deficiency,para-syndrome of liver qi invading stomach and para-syndrome of stasis in stomach collateral. After Chi-square test,the distribution of the syndrome factors related to disease nature had no difference between Hp-positive chronic gastritis and Hp-negative chronic gastritis, but that of basic syndrome types had difference. The results of pairwise comparison showed that Hp infection was significantly correlated to syndrome distribution（ P < 0. 01）,and it was most closely related to para-syndrome of stomach yin deficiency and followed by para-syndrome of spleen-stomach weakness, para-syndrome of damp-heat accumulation and para-syndrome of depression-heat in liver and stomach. Conclusion Hp infection is correlated to dampness and heat,especially to yin deficiency. As a kind of external pathogenic factor,the evil nature of Hp is closely related to heat and dampness and more closely to heat,which is easy to cause impairment of yin.关键词：chronic gastritis;Helicobacter pylori;syndromes;syndrome factors
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of Qishen Yiqi Gutta Pills on heart function and ventricular remodeling in minipigs with heart failure induced by Ameroid constrictor. Methods The model of chronic myocardial ischemic heart failure was established in Bama minipigs（ n = 22） through putting Ameroid constrictor in left anterior descending coronary artery,and then divided into model group,digoxin group and Qishen Yiqi Gutta Pills group（ Qishen group,each n = 6） and other 4 included into sham- operation group. On the 4th week after the operation,digoxin group was given digoxin once a day（ 0. 0125 mg / kg once） and Qishen group was given Qishen Yiqi Gutta Pills 3 times a day（ 0. 025 g / kg once） for 8 weeks. The heart function was detected by using echocardiogram in all groups before medication and on the 2nd week,4thweek and 8thweek after medication. The pathological changes of myocardial tissue were observed on the 8thweek after medication. Results The results of echocardiogram showed that LVEF decreased significantly（ P < 0. 01） in model group before medication. LVDV,LVSV and EF% were significantly improved（ P < 0. 05） in digoxin group 2 weeks after medication,and those were significantly improved（ P < 0. 05 or P < 0. 01） in Qishen group 4 weeks after medication. HE staining showed that abnormal structure of myocardial cells and a lot of inflammatory cell infiltration in model group,which were relieved in Qishen group. Masson staining showed that diffuse distribution of myocardial collagen in model group, and dendritic distribution in Qishen group. The content of myocardial collagen was less in Qishen group than that in model group. Conclusion Qishen Yiqi Gutta Pills can significantly improve heart function and inhibit ventricular remodeling in minipigs with myocardial ischemic heart failure induced by Ameroid constrictor.关键词：Qishen Yiqi Gutta Pills;heart function;ventricular remodeling;minipigs
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发布时间：2021-05-20 - 摘要：Objective To study the regulating effects of Peiben Fang and its disassembled formulas on unbalanced Th1 / Th2 in rats with asthma. Methods SD rats were randomly divided into normal group, model group,whole formula group of Peiben Fang（ whole formula group）,disassembled formula group 1,disassembled formula group 2 and Asmeton group. The rat model of chronic asthma was established through OVA sensitization. The content of interferon-γ（ IFN-γ） and interleukin-4（ IL-4） in serum and BALF was detected by using radioimmunoassay or enzyme-linked immunosorbent assay（ ELISA）. The expressions of lung IFN-γ and IL-4 were detected by using immunohistochemistry technique, and expressions of lung T-bet mRNA and GATA-3 mRNA were detected by using reverse transcriptionpolymerase chain reaction（ RT-PCR）. Results Compared with normal group,the content of BALF IFN-γ decreased significantly（ P < 0. 01）,content of serum and BALF IL-4 and ratio of IL-4 to IFN-γ（ IL-4/IFN-γ） increased significantly（ P < 0. 01）,positive cell count and OD of lung IL-4 and IL-4/ IFN-γ increased significantly（ P < 0. 01）, all positive expression indexes of IFN-γ decreased significantly（ P < 0. 05 or P < 0. 01）,expression of lung T-bet mRNA and ratio of T-bet to GATA-3（ T-bet/GATA-3） decreased significantly（ P < 0. 01）,and expression of GATA-3 mRNA increased significantly（ P < 0. 01） in model group. Compared with model group,the content of serum and BALF IL-4 and serum IL-4 / IFN-γ decreased significantly（ P < 0. 05 or P < 0. 01）,expression of T-bet mRNA was up-regulated and that of GATA-3 mRNA was down-regulated（ P < 0. 05 or P < 0. 01） in whole formula group and disassembled formula groups. The content of serum and BALF IFN-γ and lung T-bet / GATA-3 increased（ P < 0. 05 or P < 0. 01）,and BALF IL-4 / IFN-γ decreased（ P < 0. 05,P < 0. 01） in whole formula group and disassembled formula group 1. The expression of lung IL-4 and OD,and IL-4 / IFN-γ were significantly inhibited（ P < 0. 01）,and all positive expression indexes of IFN-γ were significantly up-regulated（ P < 0. 05 or P < 0. 01） in whole formula group. Conclusion One of antiasthma mechanisms of Peiben Fang is the regulation of unbalanced Th1 / Th2 through influencing IL-4 / IFN-γ. The regulation to T-bet / GATA-3 at transcription level is the upper mechanism of Peiben Fang and its disassembled formulas in adjusting Th1 / Th2 balance.关键词：Peiben Fang;disassembled formulas;Th1 /Th2;asthma;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the mechanism of Chinese medicinal with actions of regulating blood lipid and unblocking vessels in regulating inflammatory cytokines in rabbits with atherosclerosis. Methods The rabbit model of atherosclerosis was established by using high fat diet and balloon injury method. The rabbits were randomly divided into normal group,model group,sham-operation group, atorvastatin group and Chinese medicinal group. The observations were carried out after treatment for 45 d and 90 d. The levels of serum C-reactive protein（ CRP）,transforming growth factor-β（ TGF-β）, interleukin-6（ IL-6）,IL-10 and IL-17 were detected by applying enzyme-linked immunosorbent assay（ ELISA）. Results At different time points,the levels of serum CRP,IL-6 and IL-17 increased significantly（ P < 0. 01） and TGF-β and IL-10 decreased significantly（ P < 0. 01） in model group compared with sham-operation group. In Chinese medicinal group,the levels of serum IL-6,CRP and IL-17 decreased significantly（ P < 0. 01） and TGF-β and IL-10 increased significantly（ P < 0. 01） compared with model group,but had no difference compared with atorvastatin group. Conclusion The intervention of Chinese medicinal with actions of regulating blood lipid and unblocking vessels can significantly relieve atherosclerosis. The mechanism may be related to that the Chinese medicinal can reduce the levels of IL-6,CRP and IL-17,recover the structure and function of damaged endothelial cells,and abate the intimal lipid deposition in arterial wall.关键词：Chinese medicinal with actions of regulating blood lipid and unblocking vessels;atherosclerosis;inflammatory cytokines;ELISA;rabbits
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发布时间：2021-05-20 - 摘要：Objective To investigate the protective effect of Yiqi Jiedu Fang and its different components on cerebral mitochondria in rats with focal cerebra ischemia. Methods Male SD rats were randomly divided into sham-operation group,model group,control group（ with positive drug EGb761,4 mg / kg）,high-dose,mid-dose and low-dose Yiqi Jiedu Fang groups（ 25 mg / kg,5 mg / kg and 1 mg / kg）,high-dose,mid-dose and low-dose ginsenosides groups（ 25 mg / kg,5 mg / kg and 1 mg / kg）,high-dose,mid-dose and low-dose berberine groups（ 25 mg / kg,5 mg / kg and 1 mg / kg） and high-dose,mid-dose and low-dose geniposide groups（ 25 mg / kg,5 mg / kg and 1 mg / kg）. The model was established withmiddle cerebral artery occlusion（ MCAO）. The neuroethology was scored 24 h after MCAO,and suspension of mitochondria from ischemic brain tissue was prepared for reviewing the morphological and functional indexes. Results Compared with sham-operation group,the scores of neuroethology increased significantly in model group（ P < 0. 01）. Compared with model group,the scores of neuroethology decreased significantly in all Yiqi Jiedu Fang groups and high-dose other component groups（ P < 0. 05 or P < 0. 01）. The function of mitochondria was improved at different levels in all medicated groups.Compared with other component groups,the improvements of neuroethological scores and mitochondrial function were more significant in all Yiqi Jiedu Fang groups showing some dose-dependent manner.Conclusion Yiqi Jiedu Fang can play a role in mitochondrial protection,which may be its an important mechanism in antagonizing cerebral ischemia and treating ischemic stroke. Moreover,compared with its three individual components（ ginsenosides,berberine and geniposide）,the combination formula（ Yiqi Jiedu Fang） exerted better pharmacological effects to all indexes. It is suggested that combined medicinal administration will play better integrated therapeutic effects than its single component administration.
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发布时间：2021-05-20 - 摘要：Objective To study the effective mechanism of puerarin to diabetic nephropathy（ DN）. Methods Male KKAymice（ n = 12,14 weeks old） were randomly divided into model group and puerarin treatment group（ treatment group,1. 3 mL / kg / d）,and other 8 male C57BL /6J mice with the same age were included into normal group. On the 20thw and 24thw,the levels of plasma glucose,serum creatinine（ Cr） and blood urea（ BU） were detected in mice of all groups. On the 24thw,the mice were executed to collect kidney sample for observing renal pathological changes with light microscope and electron microscope. Results The levels of plasma glucose,serum Cr and BU decreased significantly in treatment group than those in model group（ P < 0. 05 or P < 0. 01）,the level of plasma glucose was significantly higher in treatment group than that in normal group（ P < 0. 01）,but levels of Cr and BU had no statistical difference. The morphological observation showed increased renal tubular mesangial cells and mesangial matrix,obvious vacuoles in cytoplasm of tubular epithelial cells and protein casts in renal tubules in model group. After the treatment with Puerarin Injection,all renal pathological changes were alleviated in treatment group. Conclusion Puerarin Injection can improve kidney function,abate renal pathological lesion and protect kidney in KKAymice with type 2 diabetes.关键词：KKAymice;puerarin injection;diabetic nephropathy;pathological changes
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发布时间：2021-05-20 - 摘要：Objective To study the influences of medicated serum of Pingmu Fang and its disassembled formulas on proliferation and apoptosis of orbital preadipocytes of Graves’ ophthalmopathy. Methods The orbital preadipocytes from the patients were cultured in vitro,identified,transferred and induced to differentiation,and then identified as mature adipocyte by using oil red O staining. The medicated serum samples were prepared and divided into whole Pingmu Fang group（ whole formula group）,replenishingqi group（ disassembled formula group 1）,warming-yang group（ disassembled formula group 2）, resolving-phlegm dispelling-stasis group（ disassembled formula group 3）,replenishing-qi warming-yang group（ disassembled formula group 4）, replenishing-qi resolving-phlegm dispelling-stasis group（ disassembled formula group 5） and warming-yang resolving-phlegm dispelling-stasis group（ disassembled formula group 6）. The influences of medicated serum of Pingmu Fang and its disassembled formulas on the proliferation and apoptosis rate of orbital preadipocytes were observed respectively by using MTT and flow cytometry. Results The results of MTT showed that the proliferation of orbital preadipocytes was inhibited in whole formula group and all disassembled formula groups,which was the most significant in whole formula group and followed by disassembled formula group 4,and there was statistical difference between dexamethasone group and blank group. After 12 d,OD had significant difference（ P < 0. 05） in whole formula group,disassembled formula group 3,disassembled formula group 4,disassembled formula group 5 and disassembled formula group 6,which was more significant after 16 d and had no statistical significance in dexamethasone group. The results of flow cytometry showed that compared with blank group,the apoptosis rate of orbital preadipocytes increased in whole formula group,disassembled formula group 4,disassembled formula group 5 and disassembled formula group 6（ P < 0. 05）,which was the highest in whole formula group（ 10. 5 ± 1. 45） and followed by disassembled formula group 4（ 9. 9 ± 0. 60）,and had no statistical significance in dexamethasone group. Conclusion Pingmu Fang and its disassembled formulas have different effects on the accumulation of orbital adipocytes of non-active Graves ’ ophthalmopathy. The whole formula group has an overall advantage,and disassembled formula group 4 has a significant effect. The treatment effect on Graves’ ophthalmopathy may be related to that Pingmu Fang and its disassembled formulas can inhibit the proliferation of orbital preadipocytes,improve the apoptosis of adipocytes and reduce the accumulation of orbital adipocytes.关键词：Pingmu Fang;Graves’ ophthalmopathy;non-active stage;orbital adipocytes;proliferation;apoptosis;rats
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发布时间：2021-05-20 -
Influences of moxibustion on inflammatory factors and synoviocytes in rats with rheumatoid arthritis
摘要：Objective To discuss the mechanism of moxibustion in treating rheumatoid arthritis（ RA）. Methods Wistar rats（ n = 40） were randomly divided into normal group,model group,moxibustion group,acupuncture group and infrared group（ each n = 8）. The degree of plantar swelling was observed and content of serum IL-1 and IL-2,and protein expressions of Bcl-2 and Caspase-3 in knee synomium were detected in rats of all groups. Results In model group,plantar and ankle inflammatory swelling was observed,plantar circumference was significantly longer compared with normal group,IL-1 content increased,IL-2 decreased,and expressions of Bcl-2 and Caspase-3 increased（ P < 0. 05）. After treatment,plantar circumference was shorter,IL-1 content decreased,IL-2 increased,expression of Bcl-2 decreased（ P < 0. 05）,and expression of Caspase-3 increased（ P < 0. 05） in moxibustion group, acupuncture group and infrared group. Conclusion Moxibustion on Shenshu（ BL23） can inhibit secondary plantar swelling and release of IL-1, increase IL-2 content, improve the expression of Caspase-3 and decrease expression of Bcl-2 in knee synomium in RA rats.关键词：moxibustion;rheumatoid arthritis;Bcl-2;Caspase-3;rats- 14
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发布时间：2021-05-20 - 摘要：Objective To study the central mechanism of acupuncture in the Pericardium Meridian（ meridian acupoints） in regulating the network of emotion,memory and cognition by applying restingstate functional magnetic image（ fMRI）. Methods Healthy participants（ n = 14） were given fMRI, including the first time resting-state scanning（ R1）,scanning after acupuncture in all acupoints of the Pericardium Meridian（ AP） and the second time resting-state scanning（ R2）. The posterior cingulate cortex（ PCC） was chosen as seed point for studying functional connectivity by using REST software. Results The functional connectivity of PCC was enhanced in bilateral middle temporal gyrus and inferior temporal gyrus,and was significantly weakened in left middle frontal gyrus,left inferior gyrus and right cerebellum posterior lobe only under AP state but not under R1 and R2 states. The functional connectivity of PCC was significantly weakened in right cerebellum posterior lobe,right declive,right uvula and right inferior frontal gyrus only under R2 state but not under R1 and AP states. Conclusion After acupuncture in the acupoints of the Pericardium Meridian,the functional connectivity between PCC and prefrontal cortex and cerebellum was inhibited,and that between PCC and temporal cortex was enhanced synchronously. Through the inter regulation of above-mentioned cerebral zones with higher cognitive function, acupuncture can control memory and emotion,which may be the effective mechanism of acupuncture in the acupoints of the Pericardium Meridian in treating the disorders of memory,emotion and cognition.关键词：acupuncture;Pericardium Meridian;posterior cingulate cortex;functional connectivity
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发布时间：2021-05-20 - 摘要：Objective To analyze the correlation between tongue manifestations and endoscopic representations of portal hypertension in the patients with liver cirrhosis,and provide evidence for investigating the characteristics of tongue manifestations and pathogenesis of liver cirrhosis. Methods A national cross-section epidemiological survey was conducted by using a collection form of liver cirrhosis clinical information made by the research group uniformly for collecting the tongue data from the patients with liver cirrhosis. The information about endoscopic representations of portal hypertension was recorded by using electron endoscope, and the correlation between tongue manifestations and endoscopic representations of portal hypertension was analyzed by using SPSS frequency and rate and correlation analysis. Results In 182 patients,there were 59 at the compensated stage and 123 at the decompensated stage,and the endoscopic representations of portal hypertension were mild at the compensated stage. When the patients with esophageal and gastric varices or portal hypertensive gastropathy at the compensated stage,sublingual veins thickened and occurrence frequency of tortuous sublingual veins were higher（ P < 0. 05）. The occurrence frequency of yellow tongue fur was higher（ P < 0. 05） and that of ecchymosis / petechia was lower（ P < 0. 05） at the decompensated stage. The tongue manifestations correlated to endoscopic representations of portal hypertension（ positive correlation） were thickened and tortuous sublingual veins,and dark purple or deep red tongue at the compensated stage（ P < 0. 05）,and enlarged tongue at the decompensated stage（ P < 0. 05）. Conclusion The tongue manifestations are correlated to endoscopic representations of portal hypertension at both compensated stage and decompensated stage, which indicates initially that the main pathogenesis is blood stasis at the compensated stage and water retention at the decompensated stage.关键词：liver cirrhosis;tongue manifestations;portal hypertension;endoscopie
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发布时间：2021-05-20 - 摘要：Objective To discuss the correlation between liver pathological changes and TCM syndromes and constitutional types in carriers of chronic hepatitis B virus. Methods The constitutional types of 80 carriers of chronic hepatitis B virus were judged according to Professor WANG Qi’s new classification standard of TCM constitutional types. The data of symptoms,signs,tongue manifestations and pulse conditions were collected,and the characteristics of TCM syndromes and distribution of syndrome types were summed up. The carriers were divided into groups according to hepatic tissue inflammation grading（ G） and hepatic fibrosis degrees,and the difference in distribution of constitutional types was compared among all groups. Results The type of normal constitution was common in non-fibrosis group,and with the increase of fibrosis degree the occurrence frequency of pathological or abnormal constitutional types increased significantly. The comparison in total distribution of constitutional types showed statistical significance between the carriers with S1 fibrosis grade or S2 fibrosis grade. The type of normal constitution was common in non-inflammation group,and with the increase of inflammation degree the occurrence frequency of pathological or abnormal constitutional types increased significantly. The comparison in total distribution of constitutional types showed statistical significance between the carriers with G1 inflammation grade or G2 inflammation grade. The constitutional types in the carriers were mainly liver qi depression syndrome,liver qi invading stomach syndrome,syndrome of damp-heat encumbering the middle energizer and liver-gallbladder damp-heat syndrome,while liver-kidney yin deficiency syndrome,spleen qi deficiency syndrome,kidney qi deficiency syndrome,kidney yang deficiency syndrome and qi-blood deficiency syndrome were less. With the increase of fibrosis degree, the occurrence frequency of deficient syndromes decreased gradually. In non-inflammation group,excess syndromes were common and occurrence frequency of deficient syndromes decreased gradually with the increase of inflammation degree. Conclusion The results of liver pathological changes indicated that pathological constitutional types increased and occurrence frequency of deficient syndromes decreased significantly with the increase of inflammation grading and exacerbation of fibrosis. The reviewing on TCM constitutional types and syndromes in the carriers of chronic hepatitis B virus will provide some evidences for reviewing indirectly the inflammation grading and fibrosis staging of liver pathological tissue.关键词：carriers of chronic hepatitis B virus;liver pathological changes;TCM syndromes;TCM constitutional types
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发布时间：2021-05-20 -
Curative effect of Zishen Yisui Fang on motor symptoms and non-motor symptoms of Parkinson’s disease
摘要：Objective To investigate the curative effect of Zishen Yisui Fang on motor symptoms and non-motor symptoms of Parkinson’s disease（ PD）. Methods The patients（ n = 60） were randomly divided into treatment group and control group and treated with anti-PD Western drugs for 3 months,and treatment group was additionally given Zishen Yisui Fang. The administration of Western drugs was recorded for 3 months. The Unified Parkinson’s Disease Rating Scale（ UPDRS）,Motor Function of Parkinson’s Disease Rating Scale（ MDRSPD） and 30-item non-motor symptoms screening questionnaire（ NMS 30-item） were reviewed at three time points-before treatment,treatment for 1 month and treatment for 3 months. The curative effect of Zishen Yisui Fang on motor symptoms and non-motor symptoms of PD was studied through comparing score changes of these scales. Results In treatment group,the scores of MDRSPD and NMS 30-item had statistical difference（ P < 0. 05） before and after treatment,and scores of UPDRS and NMS 30-item had statistical difference（ P < 0. 05） in 2 groups after 3 months. The dose changes of anti-PD Western drugs had statistical difference（ P < 0. 05） between two groups during treatment. Conclusion Zishen Yisui Fang can relieve the motor symptoms and non-motor symptoms of PD.关键词：Parkinson’s disease;Zishen Yisui Fang;observation on curative effect- 13
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发布时间：2021-05-20 - 摘要：Objective To observe the curative effect of Chinese medicinal with action of dispelling toxin on post-operative mixed hemorrhoid,and compare these medicinal with Jinxuanzhike Xunxi San and normal saline solution. Methods The patients（ n = 120） were randomly divided into 3 group: Chinese medicinal group,Jinxuan group and saline group（ each n = 40）. After hemorrhoidectomy for one day, all groups were given fuming-washing therapy and hipbath therapy and then Shengji Yuhong Gao twice a day. A therapeutic course was 2 w. The curative effect on swelling,pain and healing time（ day）,and syndrome integrals were compared and analyzed before and after treatment. Results After treatment with Chinese medicinal with action of dispelling toxin,the relief of swelling and pain and healing of wound were significantly superior in Chinese medicinal group to those in Jinxuan group and saline group（ P < 0. 01）. Conclusion Chinese medicinal with action of dispelling toxin have significant effects of antiinflammation,analgesia,antibacteria and improving wound healing.关键词：Chinese medicinal with action of dispelling toxin;fuming-washing therapy with Chinese medicinal;post-operative mixed hemorrhoid
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发布时间：2021-05-20 - 摘要：<正>2013年9月27日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2012年"百种中国杰出学术期刊"称号。这是《北京中医药大学学报》继2008年、2011年进入"中国精品科技期刊"后首次获得"百种中国杰出学术期刊"称号。中国科学技术信息研究所每年出版的《中国科技期刊引证报告》（核心版）,发布当年中国科技论文与引文数据库收录的中国科技论文核心期刊科学计量指标。中国科技期刊综合评价指标体系,采用层次分析法,
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发布时间：2021-05-20
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