最新刊期
卷 37 ， 期 6 ， 2014
- 摘要：In the theory of qi-monism,original qi is introduced to explain the generation and nature of the universe,which belongs to the category of ontology in ancient philosophy.The basic content of Chinese ancient natural philosophy includes theory of qi-monism,yin-yang theory,and five phase theory.However,the theory of qi-monism plays a significant role in the formation of ideology of traditional Chinese medicine in Neijing,such as holistic conception of unity of heaven and man,thinking mode of analogy,theory of qi transformation,life conception of taking five viscera as the core,and theory of kidney qi governing the innate foundation.关键词：theory of qi-monism;qi transformation;thinking mode of analogy
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发布时间：2021-05-20 - 摘要：<正>"透热转气"乃清代温热病大师叶天士提出的温病营分证的重要治法,后世温病学家对其含义多有阐释,但均认为其关键在于祛除与热邪相合而形成的阻隔气营的病理产物,使热邪有透出气分而解的出路。综观史料,这一治疗思路与《金匮要略》中"随其所得"之治有异曲同工之妙。"当随其所得而攻之"是《金匮要略》中治疗杂病的一条重要原则,历代医家认为其有"脏病取腑""攻除邪气所结""随其所宜而治""随其所喜而治"等含义。笔者认为上关键词：随其所得;透热转气;金匮要略;温病
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发布时间：2021-05-20 - 摘要：<正>《太素》卷第二十五《五藏热病》:"肾热病者,先腰痛胻酸,苦渴数饮食身热,热争则项痛而强,胻寒且酸,足下热,不欲言,其项痛貞貞澹澹。"[1]532肾热病是由邪人肾脏而引发的热性肾病,常见饮酒时或久行久坐时腰部作痛,如扩散于上身,常见颈椎左右大筋疼痛,颈项僵痛不能转背。可见,"项痛"是肾热病表现于头颈部的明显症状之一,也就是萧延平本《太素》《素问》中所记叙的"项痛员员澹澹"。关键词：澹澹;憺憺;员员;贞贞;涢涢;■
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发布时间：2021-05-20 - 摘要：<正>《鲁峰医案》是国家中医药管理局"中医药古籍保护与利用能力建设项目"整理的400种古籍之一。历代文献关于鲁峰及《鲁峰医案》笔触甚少,笔者在校注整理该书的过程中,对鲁氏生平及《鲁峰医案》的版本、学术思想进行了简单梳理,仅作抛砖,以期得到学界更多的关注。1作者考《鲁峰医案》作者鲁峰,字观岱,生平事迹不详。关键词：鲁峰;鲁峰医案;版本;学术思想
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发布时间：2021-05-20 - 摘要：Objectives To explore the preparing method and reviewing system for establishing diseasesyndrome combination rat model of ischemia stroke-heat toxin syndrome.Methods The rat model of ischemia stroke-heat toxin syndrome was established with intraperitoneal injection of carrageenan combining thread approach of middle cerebral artery occlusion（MCAO）.The representations of rat tongue,auricle,nail and,tail,and changes of body temperature,relative coagulation indexes and cerebral morphology were observed and detected at different time points for establishing a review system.Results The model rats showed some stasis-heat representations including black tongue,thickened sublingual collateral vessels,red auricle,swelling and purple nail and dark tail after the intraperitoneal injection of carrageenan.After MCAO,the representations were more significant in model group than those in sham-operation group and exacerbated persistently.The body temperature increased sharply after24 h,and was still higher in model group than that in sham-operation group after 72 h,which was similar to TCM heat toxin syndrome.The coagulation indexes showed that whole blood viscosity increased but blood was low coagulation state in model group at different time points.The changes of cerebral morphology were accorded with ischemia changes.Conclusion The intraperitoneal injection of carrageenan combining thread approach of MCAO can be used for establishing rat model of ischemia stroke-heat toxin syndrome.The review system of the model can be consisted of representations,body temperature,coagulation indexed and changes of cerebral morphology.关键词：ischemia stroke;disease-syndrome combination animal model;heat toxin syndrome;carrageenan
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发布时间：2021-05-20 - 摘要：<正>为尽可能缩短论文出版时滞,及时有效地传播中医药类优秀学术论文,促进最新成果的快速交流,使作者能及早行使其作品"首发权",《北京中医药大学学报》在2013年1月采用永久数字标识符（DOI）,并于2014年6月,与万方数据知识服务平台合作实现了以单篇论文为单位的在线优先出版。在线优先出版是数字化出版的一种创新形式,等同于正式出版。凡通过同行评审录用并经修改编校后
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of Danggui Buxue Tang on function of circulating endothelial progenitor cells（EPCs） and Bcl-2 expression.Methods Human mononuclear cells in peripheral blood were isolated and cultured for 7 d.After adherent cells identified,EPCs were randomly divided into 6 groups:blank group,control group,simvastatin group,and high-dose,mid-dose and lowdose Danggui Buxue Tang groups（high-dose group,mid-dose group and low-dose group）.Blank group was cultured with nutrient solution without medicated serum,control group,0.2%bovine serum albumin,simvastatin group,0.1 μmol/L simvastatin,and high-dose group,mid-dose group and lowdose group,respectively,4 g,2 g and 1 g Danggui Buxue Tang.The supermatant was eliminated 24 h after culturing,and then all groups were given nutrient solution without medicated serum for continuous culturing for 24 h.The proliferation ability,adhesive force,migration ability and tubule formation of EPCs were detected,respectively,by using MTT,adhesion test,Transwell assay and in vitro angiogenesis kit.The expressions of Bcl-2 mRNA and Bcl-2 protein were detected respectively by using RT-PCR and Western blot.Results All functions of EPCs were significantly improved and expression of Bcl-2 mRNA was up-regulated in high-dose group and simvastatin group（P<0.05）.The proliferation,migration of and tubule formation of EPCs were improved but adhesive force and expression of Bcl-2mRNA were not affected in mid-dose group and low-dose group.The expression of Bcl-2 protein was up-regulated in high-dose group,mid-dose group,low-dose group and simvastatin group（P <0.05）.Conclusion Danggui Buxue Tang can improve the function of EPCs through up-regulating the expressions of Bcl-2.关键词：Danggui Buxue Tang;endothelial progenitor cells;Bcl-2;proliferation ability;adhesive force;migration ability;tubule formation
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发布时间：2021-05-20 - 摘要：<正>2013年9月27日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2012年"百种中国杰出学术期刊"称号。这是《北京中医药大学学报》继2008年、2011年进入"中国精品科技期刊"后首次获得"百种中国杰出学术期刊"称号。2012年《中国科技期刊引证报告》（核心版）共收录中国科技核心期刊1994种,《北京中医药大学学报》2012年核心影响因子0.769,核心总被引频次2 188,综合评价总分91.6,综合评价总分排名第24
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发布时间：2021-05-20 - 摘要：Objective To investigate the mobilizing effect of panax notoginseng saponins（PNS） on marrow mesenchymal stem cells after cerebral infarction.Methods The rat model of MCAO was established by referencing Zea-Longa method.The modeled rats were randomly divided into model group and high-dose,mid-dose and low-dose Xuesaitong Capsules groups（high-dose group,mid-dose group and low-dose group）,and then according to time points divided into 1-d,7-d,14-d and 28-d subgroups.High-dose group,mid-dose group and low-dose group were treated with Xuesaitong Capsules（60 g/L,40 g/L and 20 g/L,10 g/kg once a day）,and normal group and model group were orally given normal saline water once a day for 28 d.The positive percentage of CD54,CD106,CD105 and CD117 in peripheral blood and bone marrow were detected by using flow cytometer at different time points,and expression of stem cell factor（SCF） in peripheral blood and bone marrow was detected by using ELISA at different time points.Results SCF level and positive percentage CD117 and CD105 increased in high-dose group,mid-dose group and model group on the first day,reached the peak on the 14 th day,and then decreased gradually,but the increased trend is superior in high-dose group and mid-dose group to model group（P<0.05）.The expressions of CD54 and CD106 reached the peak in model group,high-dose group,mid-dose group and model group on the first day and then decreased gradually,and decreased in mid-dose group and high-dose group at all time points compared with model group especially in high-dose group（P < 0.05）.Conclusion PNS can mobilize marrow mesonchymal stem cells from bone marrow to peripheral blood and promote number of homing stem cells through improve SCF level and decreasing expressions of CD54 and CD106.关键词：panax notoginseng saponins;marrow mesenchymal stem cells;cerebral infarction;mobilization of stem cells;rats
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发布时间：2021-05-20 - 摘要：Objective To observe the expression of brain-derived neurotrophic factor（BDNF） in rats with post-encephalorrhagia depression,and study the mechanism of therapy of reinforcing kidney and regulating qi（Yinao Jieyu Fang） in treatment of post-encephalorrhagia depression.Methods The rats（n=32） with the similar scores of open-field test were chosen and randomly divided into normal group,model group,Chinese medicial group（treated with Yinao Jieyu Fang） and Western medicial group（treated with Baiyoujie,each n=8）.The changes of BDNF expression were observed by using immunohistochemistry technique in normal group,model group,Chinese medicial group and Western medicial group.Results In model group,the areal density（AD）,optical density（OD） in hippocampus CA1 and CA3 zones and OD in CA2 zone of BDNF positive cells decreased significantly compared with normal group（P<0.05）,and AD of BDNF positive cells in CA1 zone,and AD and OD in CA3 zone increased significantly in Western medicinal group compared with model group（P<0.05）.Compared with normal group,AD and OD in cingulum cortex and AD in hypothalamus decreased significantly in model group（P<0.05）.In Chinese medicial group,AD and OD of BDNF positive cells increased in CA3 zone compared with model group（P<0.05）,OD increased significantly in cingulum cortex compared with model group,and AD increased in hypothalamus compared with model group（P<0.05）.Conclusion Yinao Jieyu Fang can promote the repair and regeneration of neurons and relive depression symptoms through increasing BDNF expression in rats with post-encephalorrhagia depression.关键词：therapy of reinforcing kidney and regulating qi;post-encephalorrhagia depression;brain-derived neurotrophic factor;hippocampus;cingulum cortex;hypothalamus;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the influence of Bushen Shengxue Jiedu Fang on erythropoiesis in myelosuppression mice induced by physical and chemical compound factors.Methods BALB/C mice（n=50） were randomly divided into blank group,model group,and low-dose,mid-dose and high-dose Chinese medicinal groups（low-dose group,mid-dose group and high-dose group）.The model of aplastic anemia（AA） was established with 60Co-γ ray and cyclophosphamide injection.Bushen Shengxue Jiedu Fang was used for intervention in low-dose,mid-dose and high-dose groups（6.14 g/kg,12.29 g/kg and24.57 g/kg）.The changes of erythrocyte parameters were detected by using blood cell counter.The level changes of erythrogenin（EPO） and interferon γ（IFNγ） were detected by using ELISA,and expressions of EPO receptor and IFNγ receptor were detected by using RT-PCR.Results Bushen Shengxue Jiedu Fang increased erythrocyte parameters,relieved anemia symptoms,increased the level of serum EPO and improved significantly the expressions of EPO receptor gene in bone marrow cells,decreased the content of IFNγ in peripheral blood,and inhibited the expression of IFNγ receptor gene.Conclusion Bushen Shengxue Jiedu Fang may have curative effect on AA through increasing EPO activity,inhibiting immune reaction induced by IFNγ,recovering normal function of hematopoietic stem cell,and promoting normal differentiation and mature of red blood cells.关键词：Bushen Shengxue Jiedu Fang;aplastic anemia;erythrocyte parameters;erythrogenin;interferonγ;interferonγ receptor;mice
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发布时间：2021-05-20 - 摘要：Objective To observe the influences of Majie Chuanke Fang on endothelin（ET）,nitric oxide（NO） and pulmonary artery in rat model of pulmonary heart disease,and discuss the therapeutic mechanism of Majie Chuanke Fang in treatment of pulmonary heart disease.MethodsSD rats（n = 56）were randomly divided into high-dose,mid-dose and low-dose Majie Chuanke Fang groups（high-dose group,mid-dose group and low-dose group）,Feilike group,captopril group,model group and normal group.The rat model of pulmonary heart disease was established with monocrotaline.High-dose group,mid-dose group and low-dose group were given Majie Chuanke Fang in doses of 12 g/kg,6 g/kg and 3 g/kg respectively,Feilike group,Feilike Capsules（1.08 g/kg） and captopril group,captopril（0.01 mg/kg）.After 14 d,the content of NO and ET-1 was detected,and right ventricle hypertrophy index（RVHI）,pulmonary artery area and pulmonary artery wall area were calculated,and morphological changes of pulmonary artery were observed in all groups.Results The content of ET-1 decreased significantly in high-dose group,mid-dose group and low-dose group,and NO content increased significantly in mid-dose group and low-dose group.The unbalance of ET-l/NO was ameliorated in highdose group,mid-dose group and low-dose group（P < 0.05 or P<0.01）.The pulmonary artery wall area and lumen area were significantly reduced in low-dose group compared with model group（P <0.01）.Majie Chuanke Fang had no significant effect on the indexes of right ventricular hypertrophy.The results of histopathologic examination showed that Majie Chuanke Fang reduced pulmonary artery wall thickness and increased lumen area（P <0.01） in varying degrees.Conclusion Majie Chuanke Fang can relieve the sympotoms of acute pulmonary heart disease through alleviating the unbalance of ET-l/NO,right ventricle hvpertrophy and Dulmonary vessel remodeling.关键词：therapy of diffuse lung to calm panting;model of pulmonary heart disease;endothelin;nitric oxide;right ventricle hypertrophy index;pulmonary artery;rats
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发布时间：2021-05-20 - 摘要：Objective To discuss the characteristics and laws of neuron electric signals induced by lifting-thrusting manipulations of acupuncture with different frequency.Methods Healthy and adult SD rats were chosen and anesthetized,and then nerve filaments innervating the region of Zusanli（ST36）were isolated from spinal dorsal root nerve tract L4,and put on bipolar platinum electrode.The liftingthrusting manipulations of acupuncture with different frequency（50 time/min,100 time/min,150 time/min and 200 time/min） were used for stimulating ST36.The discharge of nerve filaments innervating the region of ST36 were recorded,and needling electric signals were analyzed by applying signal sorting after noise reduction for finding out the laws of types and quantity of needling frequency and variation tendency of neuronal discharge.Results Needling electric signals was composed of discharges of 3 types of neurons.As needling frequency increased,the discharge number of the first type of neurons and second type of neurons increased too,but the third type of neurons had no discharge.Conclusion The liftingthrusting manipulations of acupuncture with different frequency mainly excite two types of neurons.In the frequency ranges of this study,it can be inferred that increased lifting-thrusting frequency will not cause the reaction of neurons that have no responds originally.关键词：lifting-thrusting;frequency;electric signals;signal sorting;rats
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发布时间：2021-05-20 - 摘要：Objective To survey the effects of 3 kinds of penetration enhancers,evodia rutaecarpa alkaloids,sinapine thiocyanate and berberine hydrochloride,on transdermal permeation of paeoniflorin in vitro,screen effective penetration enhancers and improve the transcutaneous permeability of paeoniflorin.Methods The abdomen skin of mice in vitro was taken as permeation barrier.The content of paeoniflorin was determined by using HPLC for studying the influences of 3 kinds of penetration enhancers on kinetic parameters of in vitro transdermal absorption of paeoniflorin including cumulative permeation quantity,transdermal absorption rate and transdermal time-lag within 12 h.Results The transcutaneous permeability of evodia rutaecarpa alkaloids,sinapine thiocyanate and berberine hydrochloride was,respectively,0.543 9 g/cm2·h,0.993 0 g/cm2·h and 3.709 9 g/cm2·h,enhancing rate was,respectively,1.50,2.74 and 10.22,and transdermal time-lag was,respectively,2.10 h,1.12 h and0.34 h.Conclusion Evodia rutaecarpa alkaloids,sinapine thiocyanate and berberine hydrochloride can significantly improve the transdermal absorption of paeoniflorin.关键词：paeoniflorin;penetration enhancers;evodia rutaecarpa alkaloids;sinapine thiocyanate;berberine hydrochloride;mice
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发布时间：2021-05-20 - 摘要：Objective To determine the best preparation forms of medicinal in Zisu Fang,and answer the question of how to develop high-quality medicinal.Methods The content of baicalin,salvianolic acid B,rosmarinic acid,tanshinone II A,matrine,oxymatrin（effective index components in different medicinal preparation forms from Zisu Fang） were detected by using HPLC-PDA under acidic and alkaline systems.The quality of medicinal preparation from Zisu Fang were characterized based on the content,relative quantity,relative ratio of content,yield rate and antibacterial effect in vitro and in vivo,and the characterized results were given correlation analysis.Results The content of 6 kinds of effective index component（totally 53.43%） in enrichment from Zisu Fang increased significandy,which was 3.2times higher than in ethanol extract and 3.6 times higher than in water extract,and the yield rate decreased by one-third of that of ethanol extract and water extract.The relative ratio of components was more reasonable,and medicinal system had higher antibacterial effect in vitro and in vivo.The enrichment was the best preparation form of medicinal in Zisu Fang.Conclusion It is an important way for develop high-quality medicinal to explore the fittest content and relative ratio of medicinal components based on the basic composition of medicinal system and yield rate.关键词：Zisu Fang;medicinal system;quality characteristics;correlation analysis
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发布时间：2021-05-20 - 摘要：Objective To study the curative effect of needling in 3 acupoints around eye[Jingming（BL1）,Chengqi（ST1） and Shangming]and Fengchi（GB20） on optic atrophy.Methods The patients（n = 40） were randomly divided into treatment group and control group（each n = 20） by applying prospective randomized controlled method.Control group was given Chinese medicinal decoction and support therapy of nerve nutrition,and treatment group was given acupuncture in Jingming（BL1）,Chengqi（ST1）,Shangming and Fengchi（GB20） once a day besides of the same treatment as control group.After 4 w,the changes of vision,visual field and visual evoked potential（VEP） were observed in two groups.Results The total effective rate was 81%in treatment group and 52%in control group.After treatment and in treatment group,vision was significantly improved,mean light sensitivity（MS）increased significantly,mean defect（MD） decreased significantly and evoked potential amplitude increased significantly（P < 0.05）.Conclusion Needling in 3 acupoints around eye and Fengchi（GB20） has good curative effect on optic atrophy.关键词：optic atrophy;acupuncture;three acupoints around eye;Fengchi（GB20）;vision;visual field;visual evoked potential
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发布时间：2021-05-20 - 摘要：Objective To investigate the distribution of gene polymorphism of PvuII and Xbal in gene 1of estrogen receptor-a（ERa） in patients with hypomenorrhea.Methods The gene polymorphism of ERa in peripheral blood was detected by using polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） in experimental group and normal group.The distribution difference in genotypes of Pvu II and Xba I and allele count were compared between two groups.Results The frequency distribution of genotypes of PP,Pp and pp of ERa PvuII and genotypes of XX,Xx and xx Xbal had significant difference between two groups（P < 0.05）.The constituent ratio of genotypes in experimental group was orderly as follows:PP:5.45%,Pp:40.00%,pp:54.55%,XX:1.82%,Xx:36.36%,and xx;61.82%.The constituent ratio of genotypes in normal group was orderly as follows;PP:18.18%.Pp:40.91%,pp:40.91%,XX:9.09%,Xx:50.00%,and xx:40.91%.The frequency distribution of allele P,p and X,x had significant difference between two groups（P < 0.05）.The risk of hypomenorrhea of allele P was 0.55 times higher than allele p,and allele X was 0.483 times higher than allele x.Conclusion There is correlation between gene polymorphism of PvuII and Xbal of Era and hypomenorrhea.Allele p and allele x may be the risk factors,and genotype pp and genotyme xx may be susceptible to hypomenorrhea.关键词：hypomenorrhea;estrogen receptor-a;gene polymorphism
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发布时间：2021-05-20 - 摘要：Through collecting the cited data of issued papers on Journal of Beijing University of Traditional Chinese Medicine（JBUTCM） by Chinese Science Citation Database（CSCD） from 2006 to 2012,the annual cited paper quantity,cited rate and total cited frequency of JBUTCM were summed up and analyzed.The issued papers with top annual cited rate,amount of other journals cited papers on JBUTCM and involved discipline fields were abstracted for summing up experience and providing reference to develop highlevel journal.关键词：Journal of Beijing University of Traditional Chinese Medicine;Chinese Science Citation Database;issued papers;cited frequency
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发布时间：2021-05-20 - 摘要：<正>兹定于2014年9月27-9月29日在北京中医药大学举办"红外成像检测技术在中医诊断中的应用"培训班,授予1类继续教育学分8分。本培训班为2014年中华中医药学会继续教育项目（编号:2014330501053）,由北京中医药大学继续教育学院承办,聘请国内外著名中医红外专家授课。培训内容:红外成像技术的基本原理、红外成像检测技术主要功能、中医临床应用、中医经络应用、国际红外检测技术概况
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发布时间：2021-05-20
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