最新刊期
卷 38 ， 期 10 ， 2015
- 摘要：Formula-pattern correspondence is a principle for prescribing formula for a specific mechanism.Correspondence between formula and pattern elements( formula-pattern element correspondence is a new principle developed on the basis of formula-pattern correspondence for formulating prescriptions. They are both under the guidance of " treatment according to pattern identification ". Exploring the meanings of formula-pattern and formula-pattern element correspondence can help improve flexibility of practitioners and promote standardization of clinical prescription,expand the modern clinical application of classical formulae and improve the therapeutic effects in the treatment of complicated diseases.
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发布时间：2021-05-20 - 摘要：<正>《现代中医临床》是教育部主管、北京中医药大学主办的中医药学术期刊,主编王永炎院士,办刊宗旨是贯彻"双百方针",报道中医药临床研究的新成果和新动态,服务中医药教学、科研和医疗,促进中医药学术发展和国际交流。设置专题研究、策论选读、名医传承、查房实录、临床研究、临床观察、循证医学、导师经验、理论探讨、中医临床基础研究、方药研究、文献研究、经典研读、思路与方法、经验交流、综述等栏目。现为中国科技核
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发布时间：2021-05-20 - 摘要：<正>《易筋经》一书托称达摩所创,不同传本的序跋涉及唐、宋、元、明、清代。乍看似乎流传有序,深究则相互矛盾,扑朔迷离,很大程度上干扰了该书成书年代的正确判断,进而妨碍其书的准确解读。调研国内外14家图书馆的48种现存《易筋经》传本之后,曾通过分析各传本中的避讳情况,结合所载内容,对各本抄刻年代做出大致判断[1],提出沈氏校本可能为此书之祖本[2]。在此基础上,如果不解决此书序跋的源流演变问题,仍然难以解答由此造成关键词：易筋经;中医养生;文献;导引;体育
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发布时间：2021-05-20 - 摘要：Inspecting and conjecturing the interior and exterior of diseases is a key concept implied in the chapter titled External Conjecture in The Spiritual Pivot（ Líng Shū,灵枢）. It can be interpreted with a new connotation. In the process of understanding diseases,we can conjecture the nature of diseases by inspecting the external manifestations or the other way around,in this dual direction of inspecting and conjecturing of the interior and exterior,we could have a more comprehensive and accurate knowledge of the disorder. This is a scientific idea of the The Inner Classic（ Nèi Jīng,内经） which matches both the scientific principle and development of TCM theory. This is supplementary to the traditional one direction of conjecturing the interior nature of disease by observing the external manifestations. Therefore a novel idea of inspecting and conjecturing both the interior and exterior could serve as a fundamental principle for TCM diagnosis.关键词：inspecting and conjecturing the interior and exterior;inspecting the exterior to conjecture the interior;inspecting the interior to conjecture the exterior;Neijing;diagnostic principle
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发布时间：2021-05-20 - 摘要：This paper selects three important versions of Basic Questions（ Sù Wèn,素问）. They are Gu Congde version in Ming Dynasty,Dushutang version in Yuan Dynasty,and Gulinshutang version in Yuan Dynasty. A comparative study was conducted to analyze the variance of texts in the different versions.Textual variance was categorized into three types and explained with examples from the texts,This study could promote better understanding of text meaning,and provide more reference for the further study on textual variance in Suwen.关键词：Suwen;edition;variance
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发布时间：2021-05-20 - 摘要：<正>《中医教育》创办于1982年,是教育部主管、北京中医药大学主办的中医药教育科学研究刊物。本刊物面向海内外公开发行,集导向性、学术性、研究性、应用性于一体,全方位服务于中医药教育事业。其读者对象为高等中医药院校、中等中医药学校等的师生和自学中医者,以及中医药继续教育的各级中医、中药、科研人员。本刊设有教育研究、校长论坛、教育论坛、人才培养模式创新与实践、教学园地、研究生教育、医学生素质
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发布时间：2021-05-20 - 摘要：<正>日本·丹波康赖所撰《医心方》（公元984年）,参考辑录200余种中国隋唐以前中医文献,不改原文直接引用,均标明出处,素以"取材宏富""各题名号"而被称道于世。该书一直以写本的形式流传,从未经后人整理,版本传承的脉络非常清晰,其内容基本保持了原著的本来面目。《千金要方》是《医心方》引用频率较高的文献,除卷19外,其余29卷均引有《千金要方》的内容,初步统计全书共直引500余处。这些辑录的医学文关键词：医心方;千金要方;方剂;考证
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发布时间：2021-05-20 - 摘要：Objective To investigate the time-course expressions of the basic fibroblast growth factor（ b FGF） in limbic system of cerebral ischemic rats and explore the effects of Yishen Tiaoqi（ kidneytonifying qi-regulating） Formula. Methods Male Wistar rats were randomly divided into normal group,sham-operation group,MCI group,treatment group and control group according to the scores of OpenField test. The normal group received no intervention. The sham-operation group received sham operation,and intragastric administration of distilled water. Homogenous microthrombus were injected into internal carotid artery through the external carotid artery of those rats in other groups to duplicate MCI model first. The treatment group and control group received intragastric administration of Yishen Tiaoqi Formula（ 6. 2g / kg） and Nimodipine（ 9. 45 mg / kg） respectively. The changes of limbic b FGF and intervention efficacy of Chinese medicinal were observed by using immunohistochemistry technique in the1 st Week,2nd Week and 4th Week. Results Immunohistochemistry test showed that positive cells ofb FGF increased significantly in MCI group. The expression of b FGF was significantly higher in the first week than in other time points in MCI group,reached peak at day 7 and then decreased gradually. The positive cells of b FGF increased significantly in Chinese medicinal group compared with MCI group and normal group in the 2nd Week and 4th Week. Conclusion There are changes of limbic b FGF in rats after cerebrovascular disease,and Yishen Tiaoqi Formula can block mental disorder after stroke with improved vascular repair and regeneration.关键词：cerebral ischemia;mental disorder;limbic system;b FGF;Yishen Tiaoqi Formula;rats
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发布时间：2021-05-20 - 摘要：<正>2015年10月21日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2014年"百种中国杰出学术期刊"称号,这是《北京中医药大学学报》连续第三次获得"百种中国杰出学术期刊"称号。2014年《中国科技期刊引证报告》（核心版）共收录中国科技核心期刊2 312种,《北京中医药大学学报》
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发布时间：2021-05-20 - 摘要：Objective To investigate the expression levels of miRNA-30 d and glucose-regulated protein78 k D（ GRP78） in podocyte injured model induced by D-glucose（ 50 mmo / L） plus Palmitic acid（ 2mmol/L）,and to observe the changes in miRNA-30 d and GRP78 expression levels with Zuogui Jiangtang Yishen（ left-restoring sugar-lowering kidney-tonifying） formula in medicated serum 48 h after treatment. Methods Cultured podocyte cells were divided into four groups: control group（ 25 mmo L / L glucose,10% blank serum）,model group（ D-glucose 50 mmo / L combining Palmitic acid 2mmol / L,10% blank serum）,Zuogui Jiangtang Yishen formula medicated serum group（ ZJYD,10% medicated serum,D-glucose 50 mmo / L combining Palmitic acid 2mmol / L）,and 4-Phenylbutyric acid group（ 4-PBA,10% medicated serum,D-glucose 50 mmo / L combining Palmitic acid 2mmol / L）. After incubation for 48 h,the miRNA-30 d expression level was analyzed with real-time PCR,and the protein and mRNA expression levels of GRP78 were measured with RT-PCR or western blot respectively. Results The expression level of miRNA-30 d was significantly down-regulated in model group,while expression levels of GRP78 protein and mRNA were up-regulated, the differences were statistically significant, as compared with control group（ P < 0. 01）,and the expression level of miRNA-30 d was inversely correlated with that of GRP78（ P < 0. 05）. As compared with model group,the expression level of miRNA-30 d was significantly up-regulated in ZJYD group,while down-regulated of GRP78 protein and mRNA（ P < 0. 01）,and the effects were partly as good as 4-PBA group. Conclusion 10% ZJYD serum can improve podocyte injury induced by D-glucose 50 mmo / L combining Palmitic acid 2mmol / L through up-regulating miRNA-30 d expression level,while down-regulating GRP78 mRNA and protein expression levels.关键词：podocyte;Zuogui Jiangtang Yishen formula;medicated serum;miRNA-30d;glucose-regulated protein 78k D;mouse
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发布时间：2021-05-20 - 摘要：Objective By observing the effects fangfeng-wumei pair on degranulation of mast cells and PAR-2 expression before and after the pairing to provide experimental basis for the research on its antiallergy mechanism. Methods A mast cell degranulation mouse model was established by stimulating mouse mast cell line P815 with trysin in vitro,and the levels of histamine as well as PAR-2mRNA and protein expression of P815 cells affected by fangfeng-wumei pair were measured using RT-PCR,Western blotting and ELISA. Results Fangfeng-wumei pair in vitro significantly inhibited the secretion of histamine and the expression of PAR-2 by mast cells in comparison to cell model group（ P < 0. 05 or P< 0. 01）. Conclusion The results demonstrated that inhibition of degranulation of mast cells was significantly enhanced by fangfeng-wumei pair,and that the expression of PAR-2 by mast cells might be involved in the anti-allergy mechanism of fangfeng-wumei pair.关键词：Fangfeng;Wumei;medicinal pair;PAR-2
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发布时间：2021-05-20 - 摘要：Objective To study the gene expressions of key cytokines involving NF-κB signaling pathway in collagen II-induced arthritic（ CIA） rats treated with Yiqi Huoxue Jiedu Fang（ qi-tonifying bloodactivating and toxin-removing formula）. Methods We used collagen II-induced arthritic（ CIA） rats by bovine II collagen as an animal model and Leflunomide as controls. CIA rats received treatment with Yiqi Huoxue Jiedu Fang. The levels of inflammatory cytokines in serum were measured with protein chip assay,and hematoxylin dyeing was used to observe the histopathological changes. The gene expressions of the key cytokines in NF-κB signal pathway were detected by real-time PCR. Results This formula inhibited the proliferation of synovial tissues,reduced inflammatory exudation and narrowed the range of fibroid necrosis. It also down-regulated inflammatory cytokines（ TNF,IL-1,IL-5,IL-6 and IL-10） in serum of CIA rats. The gene expressions of NF-κB and IKK decreased in CIA rats treated with thisformula. Conclusion Yiqi Huoxue Jiedu Fang could regulate the expressions of inflammatory cytokines and the key factor of NF-κB signal pathway for inhibiting inflammatory reaction in injured tissues,restoring the joint injury. Those could be the key active mechanism of RA treated with this formula.关键词：Yiqi Huoxue Jiedu Fang;collagen Ⅱ-induced arthritis;inflammatory cytokines;NF-κB signal pathway;rats
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发布时间：2021-05-20 - 摘要：Objective To observe the antioxidant effects of Gehua Jie Cheng Fang（ Kudzuvine Flower Formula for hang-over symptoms） on the orthotopic allograft mice. Methods Orthotopic allograft models were established using H22 ascites tumor cells. Cancerous mice were then treated. Pathological changes of the hepatic lobe were microscopically observed after HE staining. Levels of superoxide dismutase（ SOD）, Glutathione peroxidase（ GSH-Px）, and Malondialdehyde（ MDA） in the serum were determined by using ELISA methods. Expression levels of SOD,GSH-Px,and MDA in hepatic tissues were compared. Results Liver of the orthotopic allograft mice induced by H22 ascites tumor cells presented with pathological changes of unlimited proliferation and necrosis. Gehua Jie Cheng Fang affected the expression of SOD,MDA,and GSH-Px,which demonstrated the antioxidant effects. It could slow down carcinogenesis in these mice. Conclusion Gehua Jie Cheng Fang seems to have therapeutic effects on mice with hepatocarcinoma induced by H22 ascites cells. Its mechanism is related to the activation of antioxidation.关键词：Gehua Jie Cheng Fang;hepatocarcinoma;orthotopic allograft;antioxidation;mouse
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发布时间：2021-05-20 - 摘要：Objective To observe the effect of Astragalus mongholicus injection on the expression of epithelial-mesenchymal transition-related proteins in KKAymice with renal interstitial fibrosis.Methods Sixteen KKAymice were randomly divided into model group（ n = 8） and Astragalus mongholicus injection treatment group（ n = 8）,and 8 C57 BL /6J mice were used as normal control. The mice in treatment group were intraperitoneally given Astragalus mongholicus injection from the 14 th week.The fasting glucose levels were observed at the 16 th,20th,24 th week. The mice were sacrificed at the24 th week. The renal pathological changes were observed under light microscope. The expression of alpha-smooth muscle actin,E-cad and transforming growth factor β1 in the renal tissues were examined by immunohistochemical staining. Results Fibrosis was found in the KKAymice of model group,while the mice in treatment group showed a slight increase in renal interstitium. Treatment with Astragalus mongholicus injection decreased the protein expression levels of alpha-smooth muscle actin,transforming growth factor β1 in the kidney tissues as compared with those in model group. Conclusion Astragalus mongholicu injection reduces the expression of alpha-smooth muscle actin and restrains the protein expression of transforming growth factor β1 in the kidney tissue of KKAymice. These changes may inhibit and reverse the process of epithelial-mesenchymal transition,thus delaying the occurrence and development of renal interstitial fibrosis.关键词：renal interstitial fibrosis;epithelial-mesenchymal transition;astragalus mongholicus injection;alpha-smooth muscle actin;E-cad;transforming growth factor β1;mouse
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发布时间：2021-05-20 - 摘要：Objective To explore the mechanism of Houshi Hei San（ Hou’s Black Powder） against cerebral ischemia damage by observing effects of wind-dispelling drugs（ WDD）,deficiency-tonifying drugs（ DTD） and combined WDD-DTD in Houshi Hei San on the expressions of Brain-derived neurotrophic factor（ BDNF）,Phosphatidylinositol 3-kinase（ PI3K）,Protein Kinase B（ PKB,also called Akt）,and cyclic adenosine monophosphate response element binding protein（ CREB）. Methods Rats were subjected to permanent middle cerebral artery occlusion（ p MCAO） surgery and randomly divided into the sham-operation group,model group,WDD group,DTD group and combined WDD-DTD group. At 72 hours after cerebral ischemia,protein of ischemic hippocampus was extracted from the fresh brain. The expression of BDNF was detected by using ABC-ELISA; PI3 K,Akt and CREB were analyzed by using western blot. Results WDD had little effect on neurological deficits score and no remarkable effect on the expression levels of BDNF,PI3 K,Akt and CREB; DTD up-regulated the expression of BDNF and Akt markedly（ P < 0. 05）; combined WDD-DTDsignificantly up-regulated the expression level of BDNF,PI3 K,and Akt as well as CREB in the ischemic hippocampus,as compared to the model group（ P < 0. 05）. Conclusion WDD could assist DTD in Houshi Hei San against cerebral ischemic damage by regulating the key molecular signal of PI3 K/Akt.关键词：erebral ischemia;wind-dispelling drugs;deficiency-tonifying drugs;brain-derived neurotrophic factor;phosphatidylinositol 3-kinase / Akt pathway;rats
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发布时间：2021-05-20 - 摘要：Objective To study anti-dementia effects of Kaixin San（ Joyful Powder） and Radix Polygalae’s based on pharmacokinetic characteristics of sibiricose A5,sibiricose A6,3,6 ’- disinapoyl sucrose,and polygala xanthone III in rats with acquired dysmnesia model from three levels: monomer,medicinal and formula. Method Serum concentrations of sibiricose A5 and sibiricose A6 after oral administration in rat model were measured by using HPLC-PDA Pharmacokinetic data were obtained.Then different forms of sibiricose A5 and A6 were compared with correlation analysis（ PK-DI）.Result Concentration-time curves showed that the pharmacokinetic profiles were similar in the absorption phase when Radix Polygalae extract and Kaixin San were orally administered. A bimodal patternof sibiricose A5 and A6 in the serum profile was revealed. However,this phenomenon was not observed in the group of monomer. Radix Polygalae extracts and Kaixin San were similar in the measurements of AUC,and levels of monomer were decreased significantly（ P < 0. 01）. Compared to the oral administration of Radix Polygalae extract,Cmax-1 and Cmax-2 of Kaixin San were increased significantly（ P < 0. 05）. Conclution The results showed that the absorption of sibiricose A5 and A6 in rats was superior when Kaixin San was administered. This finding supports the rationale for using the Kaixin San combination in clinical use.关键词：Kaixin San;Polygala tenuifolia wild.;sibiricose A5;sibiricose A6;pharmacokinetic;drug properties
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发布时间：2021-05-20 - 摘要：Objective To investigate protein expression characteristics of qi-deficiency constitution and qi deficiency-related nasopharyngeal cancer（ NPC） by using protein chip technology. Methods Four cases with nasopharyngeal carcinoma and 4 cases with nasopharyngitis,all of the typical qi-deficiency constitution were examined. Springbio protein chip technology with the capacity of detecting 722 proteins was used to detect protein expressions in qi deficiency constitution,sopharyngeal carcinoma and sopharyngeal carcinoma of qi-deficiency type,so as to explore the characteristics of the protein. Results As compared with the healthy subjects,most protein expressions were down-regulated in qi deficiency patients. There had been 19 down-regulated proteins（ p < 0. 05）,mainly including the keratin protein and cyclin dependent kinase. As compared with nasopharyngitis,13 proteins were up-regulated while 9 were downregulated in nasopharyngeal carcinoma protein expressions. CD115 / c-fms / CSF-1R / M-CSFR and keratin showed lower expression in nasopharyngeal carcinoma and qi deficiency type. However,Cdk1 / p34cdc2 and p170 / MDR 1 protein were down-regulated in qi deficiency type,but up-regulated in nasopharyngeal carcinoma. Conclusion There is a specific protein expression characteristic in the deficiency constitution,manifesting as lowered expression of keratin and cyclin dependent kinase. Colony stimulating factor1 receptor and keratin protein low expression are characteristics of qi deficiency related to nasopharyngeal cancer.关键词：nasopharyngeal carcinoma;qi deficiency;keratin;colony stimulating factor 1 receptor;cyclin dependent kinase
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发布时间：2021-05-20 - 摘要：Objective To analyze the pattern characteristics of the type A Influenza in Beijing area.Methods Patients who were diagnosed with Type A Influenza and received treatment in Dongfang hospital,Beijing University of Chinese medicine were included into our research. First,all the included patients answered a TCM questionnaire to gather their basic data and symptoms. Then,patterns of all participants were differentiated according to ying,wei,qi and blood diagnostic principles. Results Of 151 cases with confirmed type A Influenza,149 cases（ 98. 7%） were identified as exogenous wind-heat patterns while only 2cases（ 1. 3%） were of exogenous wind-cold patterns. Of the wind-heat patterns,37 cases（ 24. 5%） were further differentiated as wind-heat with dampness pattern. Wei level pattern was found in 136 cases（ 90. 1%）.Qi level pattern was present in 91 cases（ 60. 3%）. Wei-Qi level pattern occurred in 78 cases（ 51. 7%）.Single Wei level pattern occurred in 59 cases（ 39. 1%）. Single Qi level pattern occurred in 14 cases（ 9.3%）. Among the Qi level pattern,52 cases were yangming heat pattern（ 34. 4%）,40 cases（ 26. 5%）were the shaoyang pattern,30 cases（ 19. 9%） were the excessive lung-heat pattern,28 cases（ 18. 5%） were the dampness-heat obstructing middle energizer pattern,and 10 cases（ 6. 6%） were the pattern of heat in the chest and diaphragm. There were significant differences between the constituent ratios of the Qi level patterns（ X2 =9.73,P =0.02）,and single Wei level pattern,of different durations（ X2 =8.78,P =0.03）. The longer the duration was,the higher the proportion of the Qi pattern was accounted for,and the lower the proportion of single Wei level pattern,the lower its occurrence was. However,no significant differences were observed among the distribution of patterns between season, age or its past disease history（ P > 0. 05）.Conclusion Duration of disease is an important factor which could affect the pattern distribution of type A influenza. In Beijing,the patterns of type A influenza are mostly externally contracted wind-heat pathogens,second by wind-heat with dampness. The most common pattern is the Wei-Qi pattern,followed by the single Wei level pattern,while the single Qi level pattern is very rare.关键词：type A influenza;pattern;factors
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发布时间：2021-05-20
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