最新刊期
      卷 38 ， 期 6 ， 2015
      • HE Juan
        Vol. 38, Issue 6, Pages: 365-368(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.001
        摘要：The theory of five circuits（ yun） and six climatic factors（ qi）,an indispensable part of Traditional Chinese Medicine,studies the cycle of climatic changes and its influence on life activities.According to the theory of Huangdi ’s Internal classic,The influence of ganzhi（ heavenly stems and earthly branches） yunqi on life activity is not limited to the development of diseases or syndromes related to changes of yunqi within corresponding year; this impact also extends to inherent physical constitution determined by the yunqi of pregnancy year. This physical characteristic is also associated with its susceptibility to diseases. Yunqi theory originates from the theory of qi transformation in Huangdi ’s Internal classic,which is the extension of qi-monism theory in ancient philosophy.  
          
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        发布时间：2021-05-20
      • Vol. 38, Issue 6, Pages: 369-372(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.002
        摘要：<正>"十二原"首载于《灵枢·九针十二原》,是《内经》中一个重要名词术语。然考其历史沿革,变义甚多,其名称、数目、含义均经历了不同时代的演变,故时至今日,仍有诸多学者对"十二原"本义的理解有较多含混不清、未尽经旨之处。如《内经》中"十二原"为7个穴,而目前公认的"十二原穴"却是12个穴;再如五脏之原如太冲,毫无疑义即可称为肝之原;又可称为肝经之原,而对于六阳经之原穴如合谷,究竟称大肠原穴还是大肠经原穴则产生分歧。  
        关键词：内经;十二原;原气;规范术语   
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        发布时间：2021-05-20
      • ZHANG Xin-yang,GUO Zi-ning
        Vol. 38, Issue 6, Pages: 373-376(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.003
        摘要：Tongue coating is an essential component in the diagnostic system of Traditional Chinese Medicine. Modern research has demonstrated that tongue coating can be indicative of diseases,especially digestive diseases. In our clinical practice,we also observed such phenomona and reviewed the pathological basis for some of the tongue coating manifestations. Corresponding treatment methods were offered to test the relations between tongue coating,diseases,and patterns,so as to propose a hypothesis that tongue coating can be used as an early sign of diseases. This paper explores the relation between tongue coating,diseases,and patterns on the basis of current research on tongue coating mechanism. The results of the paper could offer reference for the clinical application of tongue coating diagnosis and facilitate the standardization of objective tongue diagnosis.  
        关键词：tongue coating;diagnosis;digestive diseases;spleen and stomach function   
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        发布时间：2021-05-20
      • LIANG Xiao,ZHANG Yun-ling,WANG Xin-xiang,LIU Xue-mei,ZHENG Hong,YAO Ting,WANG Jian-wei
        Vol. 38, Issue 6, Pages: 377-382(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.004
        摘要：Objectives To study the synergetic effects of heat-clearing and blood-activating combination in the treatment of acute cerebral ischemia of heat toxin pattern. Methods Animal model of acute cerebral ischemia of heat toxin pattern was established by using middle cerebral artery occlusion（ MCAO） and carrageenan injection in rats. Rats were randomly divided into eight groups: normal group,sham group,ischemia 1. 5 h / reperfusion 72 h group,Kudiezi（ KDZ） injection group（ heat-clearing,group A）,Xueshuantong（ XST） injection group（ blood activating,group B）,KDZ1. 8 mL / kg + XST20 mg / kg（ group C）,KDZ1. 8 mL / kg + XST80 mg / kg（ group D）,and KDZ7. 2 mL / kg + XST20 mg / kg（ group E）. Infarction area ratios was measured by TTC staining; activity or content of NF-κB p65 and IKKβ of cerebral tissues,by Western bolt; gene expression of NF-κB p65 and IKKβ,by real-time PCR.Results Cerebral tissue ischemia in all treatment groups was reduced（ P < 0. 05）. Heat-clearing and blood-activating combined treatment improved significantly（ P < 0. 01） compared with the model group,yet there were no significant differences between these groups. NF-κB p65 and IKKβ in model group were highly expressed（ P < 0. 01） compared with the normal group. They both decreased in all treatment groups. NF-κB p65 protein expression in group C and E significantly decreased compared with the model group（ P < 0. 01）; and they also decreased（ P < 0. 05） in group A and B. Expression of IKKβ protein decreased in combination treatment groups（ group C,D,E and A） markedly（ P < 0. 01）. In addition,IKKβ protein expression in groups C,D and E were lower than that in group B significantly（ P < 0. 01）;It was markedly lower in groups C and E than in KDZ group（ P < 0. 01）. Expression of NF-κBp65、IKKβ mRNA in the model group was higher（ 0. 48%） than that in the normal group（ 0. 37%）. NF-κB p65 and IKKβ mRNA expression in each treatment group decreased compared with the model group.Expression of NF-κB p65 and IKKβ mRNA in group D and the expression of IKKβ mRNA in group E was lower than the model group; the expression of NF-κB p65 mRNA in group E was significantly different compared with the model group. Conclusion Heat-clearing and blood-activating combination has synergetic effects on acute cerebral ischemia via regulating the protein and gene expression of NF-κB p65 and IKKβ in NF-κB signaling pathway.  
        关键词：acute cerebral ischemia;heat toxin pattern;inflammatory reaction;NF-κB signaling pathway;rats   
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      • Vol. 38, Issue 6, Pages: 382(2015)
        摘要：<正>为了更好地服务作者、读者,提高工作效率,《北京中医药大学学报》编辑部自2011年1月1日起开通网上采编系统（http://xb.bucm.edu.cn）,请广大作者和读者登陆本刊网址,随时通过此系统投稿、查稿、修改稿件或浏览最新目录等,首次登陆需先行注册。本刊创刊以来所有内容均可在线全文阅读。  
          
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        发布时间：2021-05-20
      • DONG Ning,TANG Qi-sheng,ZHAO Rui-zhen,LUO Bin,WANG Wen-long
        Vol. 38, Issue 6, Pages: 383-387(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.005
        摘要：Objective To explore the effects of liver-soothing heat-clearing and spleen-fortifying method on the expressions of bax and bcl-2 in cerebral Papez’s circuit in rat with generalized Anxiety Disease（ GAD）. Methods A total of 40 male Wistar rats were divided into normal group,model group,treatment group,and control group,with 10 rats in each group. GAD model was established by using the stimulation of uncertain empty drinking bottle. Then the treatment group and control group were intragastrically given Danzhi Xiaoyao San（ Cortex Moutan and Fructus Gardeniae Free Wanderer Powder） and Buspirone Hydrochloride once a day for 7 consecutive days respectively. The model group was given distilled water once a day for a week. The expressions of bax and bcl-2 in rat hippocampus and mamillary body were measured by applying western blot assay after resecting rat brains. Results The expression of bax in hippocampus and mamillary body of model group increased significantly compared with normal group（ P < 0. 05 or P < 0. 01） and the expression of bcl-2 decreased markedly（ P < 0. 01）. Compared with model group,the level of bax in hippocampus and mamillary body of treatment group and control group was reduced（ P < 0. 05 or P < 0. 01） and the level of bcl-2 increased significantly（ P < 0. 05 or P< 0. 01）. Conclusion The therapeutic method of liver-soothing heat-clearing and spleen-fortifying method represented by Danzhi Xiaoyao San could reduce the level of bax in hippocampus and mamillary body of GAD rat brain,elevate the level of bcl-2 and reduce bax / bcl-2,prevent and inhibit cell apoptosis in Papez’s circuit and then ameliorate anxiety symptoms.  
        关键词：liver-soothing heat-clearing and spleen-fortifying method;generalized anxiety disease;Papez’s circuit;bcl-2;bax;rats   
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        发布时间：2021-05-20
      • DONG Ying-ying,WU Jun,CHEN Dan-jun,LI Gen-mao,GE Dong-yu,QIU Ze-ji,HAO Yu
        Vol. 38, Issue 6, Pages: 388-392(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.006
        摘要：Objective To compare the effects of truncated and routine methods in the treatment of mice pneumonia induced by influenza virus. Methods ICR mice（ n = 80） were randomly divided into normal group,model group,routine treatment group and truncated treatment group. The last three groups were infected with mouse lung-adapted influenza virus strain by inoculating intranasally. One hour after the inoculation,the truncated treatment group was intragastrically given Xijiao dihuang Tang（ Rhinoceros Horn and Rehmannia Decoction） combined with Yinqiao San（ Lonicera and Forsythia Powder） decoction while the routine treatment group was intragastrically given Yinqiao San decoction only on the first three days and Xijiao dihuang Tang only on the following four days. All groups were treated for 7 consecutive days. The survival rate,average survival days and body weights were calculated during 14 days ’observation. Balb / c mice（ n = 128） were divided into the same four groups described above with the same corresponding intervention. These mice were sacrificed on the 2nd,4th,6thand 8thdays respectively. Specimen were obtained and evaluated. The viral titers in lung homogenate and the lung index weremeasured dynamically; the lung gross lesions and tissue pathological changes were observed on the 8th day. Results The survival rate of truncated treatment group was twice as high as routine treatment group and average survival days also increased significantly; the lung index of truncated therapy group significantly decreased compared with the routine group on the 8thday. The viral titers of truncated treatment group in lung homogenate decreased on the 2nd,4th,6thand 8thday compared with the routine treatment group,yet the difference was not statistically significant. The pulmonary gross lesions and tissue pathological changes under light microscope were less severe than the routine treatment group.Conclusion Truncated method seemed to be superior to routine method in the treatment of severe influenza viral pneumonia mice. Its mechanisms may not lie in its stronger anti-viral effect,but in its stronger inhibitory effect on inflammatory cascade after viral infection compared with routine treatment.  
        关键词：truncated method;viral pneumonia;Xijiao dihuang Tang combined with Yinqiao San;influenza virus;mice   
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        发布时间：2021-05-20
      • LI Gang,XU Shu-ya,ZHAO Li-min,LU Guang-ying,SUN Dao-han,WANG Ya-li,Tang Xue-yang,PENG Ping,JIANG Yan-yan,SHI Ren-bing
        Vol. 38, Issue 6, Pages: 393-399(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.007
        摘要：Objective To establish quality representation and correlation analysis method of Puhuang（ Pollen Typhae Angustifoliae） pieces based on drug system and evaluate Puhuang quality comprehensively. Methods HPLC was used for simultaneous determination of five major active ingredients and their total amount in 16 batches of Puhuang（ Pollen Typhae Angustifoliae.） decocting pieces,including typhaneoside,isorhamnetin-3-O-neohesperidoside,isorhamnetin,stigmasterol,and β-sitosterol. Ferric chloride-potassium ferricyanide colorimetric method was used for measuring the content of phenols in flavonoids while vanillin-perchloric acid colorimetric method was used for the determination of pollen by measuring the total sterol content of pollen Typhae. Non-correlation coefficient, noncorrelation degree,and correlation degree were used to represent quality correlation between samples and reference products. Results Levels of active ingredients were higher in No. 7,3,5,4,10 and 13 Puhuang pieces than No. 8（ reference product）. No. 5,7,6,10,1,and 13 batches had high relevance with the reference product No. 8. Consolidated quality characterization and correlation analysis showed that the quality of No. 7,5,10,and 13 were superior. Conclusion Based on drug quality evaluation system,measurement of active ingredient levels,total amount and relative ratio combined with correlation analysis of reference product with definite efficacy could offer a comprehensive assessment of quality of Puhuang decocting pieces. This method could provide evidence for screening, quality control and application of Puhuang decocting pieces. It also serves as references for quality evaluation of Chinese materia medica both in methodology and application.  
        关键词：Puhuang（Pollen Typhae Angustifoliae）;quality evaluation;correlation analysis;typhaneoside;isorhamnetin-3-O-neohesperidoside;Isorhamnetin;Stigmasterol;β-sitosterol   
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        发布时间：2021-05-20
      • SA Chu-la,BAI Pu,DONG Yu,XING Kai-xia
        Vol. 38, Issue 6, Pages: 400-404(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.008
        摘要：Objective To establish the characteristic chromatograms of Mongolian compound Sengdeng-4in vivo and in vitro,analyze and identify its chemical components in vitro and serum. Methods After the model of rheumatoid arthritis was established,SD rats were orally administered Mongolian compound Sengdeng-4 and each single ingredient respectively. The medicinal serum were separated and measured with HPLC. The HPLC characteristic chromatograms of Mongolian compound Sengdeng-4 in vitro and medicinal serum were identified. The characteristic chromatograms of Mongolian compound Sengdeng-4,single ingredient in vitro and medicinal serum were analyzed,and the chemical composition of Mongolian compound Sengdeng-4 in vitro, original crude medicinal in blood were identified and compared.Results The results of HPLC characteristic chromatograms of Mongolian compound Sengdeng-4 showed that 47 peaks were identified. There were 14 chemical compositions absorbed into blood,among them 9were original ingredients and 5 were metabolites. The second peak was from Wenguanmu; the fifth,sixth,and seventh peaks were from Zhizi; the first,eighth,and tenth peaks were from Hezi. The third peak was from Wenguanmu,Chuanlianzi and Hezi. The fourth and thirteenth peaks were from Mongolian compound Sengdeng-4. The ninth peak was from Wenguanmu and Chuanlianzi. The eleventh,twelfth and fourteenth peaks were from Wenguanmu and Hezi. 7 components of Mongolian compound Sengdeng-4were identified. Conclusion The chemical compositions and metabolites in blood may be the active ingredients with direct actions in vivo, which come from the ingredients of Mongolian compound Sengdeng-4.  
        关键词：Mongolian compound Sengdeng-4;characteristic chromatograms;chemical components;serum   
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        发布时间：2021-05-20
      • XU Jing-jing,Liu Bin
        Vol. 38, Issue 6, Pages: 405-410(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.009
        摘要：Objective To explore the active ingredients of Menthae Haplocalycis Herba by investigating the correlation between HPLC spectrum and antioxidant activity. Methods We established DPPH[1,1-Diphenyl-2-picrylhydrazyl radical 2,2-Diphenyl-1-（ 2,4,6-trinitrophenyl） hydrazyl,DPPH] and FRAP（ ferric ion reducing antioxidant power,FRAP） assay to determine the antioxidant activity of Menthae Haplocalycis Herba. The spectrum-effect correlation was studied by using PLS（ Partial least squares）.HPLC-MS / MSnwas applied to identify their structures. Results Six compounds including hesperidin,diosmin,buddleoside, thymusin and xanthomicrol, which made great contributions to the DPPH scavenging activity,were screened; eight compounds,including hesperidin,buddleoside,rosmarinic acid and trans Salvianolic acid J,were obtained which made great contributions to the total antioxidant activity. Conclusion It is an effective way to characterize spectrum-efficacy correlation and clarify the active components of Chinese medicinal.  
        关键词：Menthae Haplocalycis Herba;antioxidant activity;spectrum-effect relationship;DPPH;FRAP;PLS   
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        发布时间：2021-05-20
      • LI Li,LIU Ying,XIAO Yong-qing
        Vol. 38, Issue 6, Pages: 411-412(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.010
        摘要：The standard system of quality evaluation on Traditional Chinese Medicine is composed of standard Chinese medicine decoction pieces,chemical reference substance,control Chinese herbs and control extracts. This paper is aimed to discuss the significance,fields and methods on standard Chinese medicine decoction pieces（ standard pieces） applied as standard materials from the aspects of preparation,recognition of property and identification of characteristic,by which the unique advantages of standard pieces as the standard materials is explained,leading to beneficial exploration on further improvment of the standard system of quality evaluation on Traditional Chinese Medicine.  
        关键词：Chinese medicine decoction pieces;standard substance;quality evaluation system;recognition of property;identification of characteristics   
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        发布时间：2021-05-20
      • XU Si-qun,JIN Qi,WANG Hui,LI Zi,JIANG Xiang,LYU Mei,TAN Wei
        Vol. 38, Issue 6, Pages: 413-419(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.011
        摘要：Objective To understand Chinese public knowledge of Traditional Chinese Medicine（ TCM）and offer references for general education approaches. Methods Based on government guideline and previous research,a questionnaire was designed and distributed randomly among Chinese residents in the country. Among the 1,800 questionnaires distributed,1,486 was returned with 1,050 valid ones identified.The questionnaire consisted of seven demographic items including gender and ages; it also included seventeen items of general TCM knowledge such as the nature of TCM discipline,advantages of TCM,and common sense of health care in TCM. SPSS 20. 0 software was used to analyze the data obtained. Mean and standard deviation（ SD） was calculated for normal distribution and the homogeneity of variance test. Oneway ANOVA analysis was used to compare differences between groups. LSD test was conducted for homogeneous variance and Tamhance’T2 test for heterogeneous results. Results Chinese public knowledge about TCM was overall limited. Average score（ ） of all 17 questions was 2. 07（ SD = 0. 53）. The best known item was precautions for decoction administration（ = 2. 47） while the worst known one was about theory of five phases（ = 1. 78）. Comparison among groups indicated that students knew the most about TCM when compared with peasants（ P < 0. 001,Δaverage = 6. 125）; Difference was the most significant between groups of different incomes（ 5 000- 999 RMB / month vs. 1 000- 4 999 RMB / month,P < 0. 001,Δaverage = 2. 870）. Health status over the past year influenced the public’s knowledge as there was a significant difference between "I have been feeling better"and "I have been feeling worse"groups（ P <0. 001,Δaverage = 7. 058） Conclusions Chinese public knowledge about TCM was generally limited.General education is in urgent need to provide systematic training to help the public know more about TCM philosophy and basic theories. Educators need to work from the grass to promote public’s health care and benefit social awareness. The quantitative assessment of TCM general education also merits improvement. This study proves to be a positive innovation.  
        关键词：Chinese residents;TCM general education;knowledge   
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        发布时间：2021-05-20
      • DENG Yan-fang,QU Le,SONG Ya-nan,JIANG Yan
        Vol. 38, Issue 6, Pages: 420-425(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.012
        摘要：Objective To evaluate the effectiveness of Dahuang Zhechong Wan（ Rhubarb and Eupolyphaga Pill） for Chronic Hepatitis B. Methods Randomized controlled trials（ RCTs） of Dahuang Zhechong Wan for Chronic Hepatitis B published in domestic or foreign magazines were searched. Revman5. 2 was used to perform the Meta-analysis on the curative effect of Dahuang Zhechong Wan for chronic hepatitis B. Results A total of 21 RCTs were included,among which none used Dahuang Zhechong Wan only. 21 studies all used combined treatment on 1731 cases with 875 in treatment groups and 856 in control groups. The results of meta-analyses showed that at the end of the treatment,groups adding Dahuang Zhechong Wan was superior to those without. There were significant difference in both the clinical efficiency,HBV-DNA negative conversion,HBe Ag negative conversion,ALT and TBil recovery.Conclusion Combined therapy using Dahuang Zhechong Wan is superior to conventional medicine alone for chronic hepatitis B. However,because of low quality of the included studies,high-quality and largescale RCTs are needed to provide further evidence.  
        关键词：Dahuang Zhechong Wan;chronic hepatitis B;randomized controlled trial;systematic review   
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        发布时间：2021-05-20
      • HSU Wing-sze,ZHAO Guo-zhen,JI Bo,QI Dan-dan,GUO Meng-wei,REN Xiao-xuan,ZHAO Ya-fang,ZHANG Lu-fen,LI Xiao-hong,ZHU Jiang,ZHANG He,SONG Yan,LIU Ya-li,ZHANG Ping
        Vol. 38, Issue 6, Pages: 426-429(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.013
        摘要：Objective To evaluate the effects of acupuncture with different stimulation intensity at Sanyinjiao（ SP6） on uterine contraction and expression of endocrine-related molecular receptor gene in rats with dysmenorrhea of cold coagulation pattern and to explore whether there is association between"deqi（ qi arrival） "and stimulus intensity. Methods Diestrus female rats were randomly divided into 4 groups,including saline control group,model control group,deqi group（ with strong stimulus） and No deqi group（ with weak stimulus）. The levels of uterine contraction was recorded during 20 mins acupuncture treatment. The expression of PGF2α mRNA was measured. Results Compared with the model control group,the uterine contraction wave number and uterine activity were significantly reduced in deqi group. The expressions of PGF2αmRNA in both deqi and No deqi group were also reduced compared with model group.Conclusion Our finding indicates that using thick needles,deep insertion with hand-manipulation seems more effective and could achieve desired level of "deqi"in dysmenorrhea rats.  
        关键词：dysmenorrhea;uterine contraction;different acupuncture stimuli;deqi;PGEP22;PGE2α;rats   
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      • Vol. 38, Issue 6, Pages: 430-432(2015) DOI: 10.3969/j.issn.1006-2157.2015.06.014
        摘要：<正>王居易教授是北京市中医管理局薪火传承"3+3"工程名医传承工作站专家,他于1956年进入北京中医学院学习,已从事针灸工作50余年。他勤于思考,尊崇经典、发扬经典,在国内外针灸界都有一定的学术影响力。在临床工作中,他以经典针灸理论指导临床治疗,在治疗过程中又进一步加深了对经典针灸理论的认识与理解。通过临床实践中的不断探索,王教授解析、发展了经典针灸理论,在经络  
        关键词：名老中医;针灸;学术思想   
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