最新刊期
卷 38 ， 期 9 ， 2015
- 摘要：It is well known that the collateral vessels,in TCM,is the unity of structures and functions of qi collaterals,blood collaterals and collateral loops. The term of "collateral vasculopathy"refers to the process of the normal collateral vessels turning into the diseased collateral vessels and leading to the collateral vessel diseases at last. And the syndrome of stirring wind arising from "collateral vasculopathy"is defined as "endogenous collateral-wind",the presentation form of diseased collateral vessels,reflecting the mutability of shapes and characters of collateral vessels. The syndrome of "endogenous collateralwind"is due to collateral deficiency,heat-toxin stagnation or exogenous wind. Furthermore,the concepts of "endogenous collateral-wind"and "endogenous liver-wind"have something in common,but not really the same. The theory of endogenous collateral-wind have been successfully applied to percutaneous coronary intervention（ PCI） post-operation,acute exacerbation of heart failure or cardiorenal syndrome,and tachyarrhythmias. It will become one of directions of TCM scientific research,we believe,that the study for the theory of endogenous collateral- wind to treat collateral vessel diseases guiding the treatment and diagnosis of multiple difficult and complicated diseases.关键词：collateral vessels;diseased collateral;collateral diseases;endogenous collateral wind;theoretical discussion
- 16
- |
- 1297
- |
- 26
发布时间：2021-05-20 - 摘要：<正>2014年10月27日,教育部科学技术司发布《关于公布"第五届中国高校精品·优秀·特色科技期刊"评比结果的通知》(教技司[2014]288号。《北京中医药大学学报》荣获"中国高校精品科技期刊"称号。这是我刊连续第5次获此殊荣。中国高校科技期刊评比活动始创于2006年,每2年评比1次,其中"精品期刊"要求学术质量、编辑出版质量均属上乘,在国内科技期刊界居于领先地位,得到高校内外学术界认可,经得起高校内外期刊编辑同行
- 8
- |
- 13
- |
- 0
发布时间：2021-05-20 - 摘要：Objective To explore the methods of automatic identification of TCM terminology and to expand the forms of natural language processing in TCM documents. Methods Based on the methods of conditional random field（ CRF）,annotation and automatic identification on terms of symptoms,diseases,pulse-types and prescriptions recorded in Shanghan Lun as the research subjects,the effects of different combinations of the features,such as Chinese character itself,part of speech,word boundary and term category label,on identification of terminology were analyzed and the most effective combination was selected. Results The TCM terminology automatic identification model,combining with the features of Chinese character itself,part of speech,word boundary and term category label,had the precision of85. 00%,recall of 68. 00% and F score of 75. 56%. Conclusion The multi-features model of combination of Chinese character itself,part of speech,word boundary and the term category label achieved the best identifying result in all combinations.关键词：TCM terminology;conditional random fields;Shang Han Lun;automatic identification
- 8
- |
- 273
- |
- 3
发布时间：2021-05-20 - 摘要：<正>牛膝是中医临床常用的一味中药,药用历史悠久。牛膝的传统功能主治收载在历代本草中,并借助古代方剂配伍应用到具体病证而充分体现出来,《中华人民共和国药典》一部（简称《药典》）收录的牛膝功能主治,主要由这些内容的归纳整理、提炼升华而来。通过检索《普济方》数据管理系统[1]中含牛膝复方的病证分布情况,再与历代本草和2010年版《药典》收录的功用相比较,结果发现,三者之间并非完全吻合,主要在于传统功用宽泛,《药典》功关键词：牛膝;普济方;文献研究
- 7
- |
- 370
- |
- 16
发布时间：2021-05-20 - 摘要：Objective To study the effects of Chaiqi decoction（ CQD） at different doses on glucose and lipid metabolism and insulin resistance（ IR） in metabolic syndrome（ MS） rat model. Methods The MS rat model was induced by feeding diet of high fat,high sugar and high salt. Altogether 56 male rats were randomly divided into normal group（ n = 16）,model group（ n = 16）,CQD low dose group（ low-dose group,n = 8）,CQD middle dose group（ mid-dose group,n = 8） and CQD high dose group（ high-dose group,n = 8）. The low-,mid-,and high- groups were taken CQD by intragastric administration at dose of 1. 90,5. 71 and 17. 13 g/kg daily for four weeks. At the end of the 8th week,eight rats of normal group and model group were sacrificed,and at the end of the 12 th week,all the rats in each group were sacrificed. Serum TG,TC,HDL-C,LDL-C,fasting blood glucose（ FBG） and fasting insulin（ FINS）were detected,while insulin resistance index（ IRI） was calculated. Results After taking CQD for four weeks,compared with model group,FINS and TG in low-dose group decreased significantly（ P < 0. 05）while HDL-C increased significantly（ P < 0. 05）; FINS,TG,TC,IRI decreased significantly while HDL-C increased significantly in both mid-and high-dose groups（ P < 0. 05）. Conclusion CQD would attenuate the lipid metabolism of rats with metabolic syndrome and reduce IR. Furthermore,the mid-dose group and high-dose group got better effects than those of low-dose group.关键词：Chaiqi decoction;metabolic syndrome;glucose and lipid metabolism;insulin resistance;rats
- 11
- |
- 200
- |
- 1
发布时间：2021-05-20 - 摘要：Objective To study the effect of Louqin Zhisou decoction（ LQZSD）,a Chinese herbal medicine compound formulated by the TCM method of clearing heat and resolving phlegm,on the airway mucus hypersecretion of the AECOPD rat model,so as to improve the transportation of antibiotics in lung tissue. Methods Altogether 50 Wistar male rats were randomly divided into normal group,model group,ambroxol group,Erchen decoction（ ECD） group,Louqin Zhishou decoction（ LQZSD） group（ each n =10）. The rat model of AECOPD with phlegm-heat syndrome was established by passive cigarette smoking,intratracheal instillation of lipopolysacchricle（ LPY） and intranose instillation of staphylococcus aureus combined with wind-heat stimulation. After modeling,ambroxol group was intraperitoneally injected ambroxol at dose of 6 mg/kg per day,ECD group and LQZSD group were intragastrically administered ECD and LQZSD at dose of 3. 33 g/kg per day respectively. The treatment duration was seven days. The secretion of acidic mucin in goblet cells was observed by using AB-PAS staining. The goblet cells in each visual field were counted and the proportion of goblet cells to epithelial cells was calculated. The contents of serum neutrophil elastase（ NE） and MUC5 AC in bronchoalveolar lavage fluid（ BALF） were detected by using ELISA assay. Results Compared with model group,the secretion of acidic mucin and the number of goblet cells significantly decreased in each treatment group（ P < 0. 05）. Furthermore,serum NE and MUC5 AC both decreased in LQZSD group significantly（ P < 0. 05）,while there were no statistical differences in the other treatment groups. Conclusion The potential mechanism of LQZSD improving the transportation of antibiotics would be related to reduction the secretion of acidic mucin and the number of goblet cells,as well as decrease the contents of serum NE and MUC5 AC in BALF; as the result,the reduction of the secretion of mucus in airway led to clearance the airway obstruction and promotion the forward diffusion of antibiotics in rat’s lung tissue.关键词：method of clearing heat and resolving phlegm;AECOPD;phlegm-heat syndrome;airway mucus hypersecretion;rats
- 8
- |
- 359
- |
- 5
发布时间：2021-05-20 - 摘要：Objective To study the effects and mechanism of serum containing modified Shengmai liquid（ MSL） on migration and adhesion of non small cell lung cancer（ NSCLC） cells. Methods Rabbit serum containing MSL was prepared by intragastric administration（ i. g.） with MSL at the dose of 18 g/kg and control serum was prepared by i. g. normal saline. NSCLC cells were cultured,and those in logarithmic growth phase collected were divided into four groups: 10% control serum（ CS） group,2. 5%,5%,10% MSL serum group. Migration cells were detected by using Transwell invasion assay,and adhension rate was measured by using matrigel adhensive assay. The expressions of N- cad and vimentin were determined by RT-PCR. Results The number of migration cells decreased as the concentration of serum containg MSL increased: migration rate of 5% MSL group was 25. 64% and that of 10% MSL group was13. 31%（ P < 0. 01）. As the concentration of serum containing MSL increased and the duration of treatment prolonged,heterogeneous adhesion rate decreased and was negatively correlated with serum concentration and duration; while the gene expressions of N-cad and vimentin decreased in dose- and time- dependent manner. Conclusion The mechanism of inhabitation migration and reduction heterogeneity adhension of MSL on NSCLC cells would be related to the epithelial-mesenchymal transition.关键词：serum containing modified Shengmai liquid;non small cell lung cancer;migration;adhesion;cell cultured
- 8
- |
- 183
- |
- 1
发布时间：2021-05-20 - 摘要：Objective To observe the effect of TCM compound of resolving stagnation for tranquilization（ RST） on neurotransmitters and brain derived neurotrophic factors（ BNDF） in depression rat model induced by chronic unpredictable stress（ CUS）,and to reveal the mechanism of RST on the treatment of depression. Methods Altogether 60 male SD rats were randomly divided into normal group,model group,high-,mid- and low- dose RST groups at dosage of 8. 2,16. 3,32. 7 g/kg,and fluoxetine group with dose of 10 mg/kg. The rats of four therapy groups were administered intragastrically drugs with undergoing CUS for consecutive thirty-five days. The behavioral changes of rats were observed by open field test and novelty-suppressed feeding-test. The content of dopamine（ DA）,5-hydroxeytryptamine（ 5-HT）,5-hydroxyindole acetic acid（ 5-HIAA） and norepi-nephrine（ NE） in hippocampus and cortex were determined by HPLC. And the expression of BDNF in hippocampus was measured by Western blot.Results Compared with the normal group,the rats ’ weight increased slowlier and the spontaneous activity decreased in model group; the contents of 5-HT and NE in cortex and the content of 5-HT,5-HIAA and NE in hippocampus significantly reduced（ P < 0. 05）. Compared with the model group,the spontaneous activity significantly increased in all therapy groups; the contents of 5-HT and NE in cortex dramatically increased in fluoxetine group and mid-,high- dose group（ P < 0. 05）; the contents of 5-HT and 5-HIAA in hippocampus significantly increased in all three RST groups（ P < 0. 05）; the content of NE in hippocampus significantly increased in low- and high- dose group（ P < 0. 05）. The expression of BDNF in hippocampus significantly increased in fluoxetine group and high-dose RST group（ P < 0. 05）.Conclusion The anti-depression mechanism of TCM compound formulated by principle of resolving stagnation for tranquilization may be related to the effects of increasing neurotransmitters and upregulation of BDNF.关键词：relieving stagnation and tranquilizing;chronic unpredictable stress（CUS）;neurotransmitters;brain derived neurotrophic factor（BDNF）;rats
- 12
- |
- 403
- |
- 3
发布时间：2021-05-20 - 摘要：<正>2014年9月26日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2013年"百种中国杰出学术期刊"称号（见封二）,并入选"第3届中国精品科技期刊",暨"中国精品科技期刊顶尖学术论文（F5000）"项目来源期刊。2013年《中国科技期刊引证报告》（核心版）共收录中国科技论文核心期刊1 989种,《北京中医药大学学报》2013年核心影响因子0.589,核心总被引频次2 110,综合评价总分73.8,综合评价总分排名第111位。
- 8
- |
- 15
- |
- 0
发布时间：2021-05-20 - 摘要：Objective To establish the method to distinguish the constitution of MRL/lpr lupus mice and to study the gene and protein expression of renal B cell-activating factor（ BAFF）,B cell stimulating factor receptor（ BAFF-R）,so as to reveal the factors at molecular biological level leading to the differences of constitution. Methods Firstly,MRL/lpr female mice of 12-week age were classified into cold constitution,heat constitution and normal constitution. Secondly,20 mice were randomly selected respectively from cold constitution group,heat constitution group and normal constitution group. Thirdly,every 10 mice in each group were sacrificed at 12-week age and at 20-week age respectively. Then,expressions of renal BAFF mRNA,BAFF-R mRNA,BAFF protein and BAFF-R protein were examined by real-time PCR and Western Blot. Results Expressions of BAFF mRNA,BAFF protein and BAFF-R protein were the lowest in the cold constitution group of all the groups. The expression of BAFF-R mRNA showed no significant difference among all groups. Conclusion The constitutional differences could be related to the expressions of renal BAFF mRNA,BAFF protein and BAFF-R protein.关键词：systemic lupus erythematosus;constitution;B cell-activating factor;B cell-activating factor receptor;mice
- 8
- |
- 138
- |
- 2
发布时间：2021-05-20 - 摘要：Objective To study the characteristic of absorption of euphorbia factor L1 in intestine of rats,and to observe the effects of P-glycoprotein（ P-gp） and multidrug resistance-associated protein（ MRP2） on intestinal absorption of euphorbia factor L1. Methods The contents of euphorbia factor L1 of intestinal perfusion fluid of duodenum,jejunum,ileum and colon in the rats in situ single-pass intestinal perfusion model were determined by using HPLC. The drug absorption rate constant（ Ka） and the apparent absorption coefficient（ Papp） in four intestinal regions were calculated. Results Kaand Pappof euphorbia factor L1 at colon were the highest of the whole rat intestine. Significant increase of Kaand Pappshowed at rat colon when co-perfused with verapamil hydrochloride,by contrast,decrease of Kaand Pappfound when co-perfused with indomethacin. Conclusion We inferred that verapamil hydrochloride be the substrate of P-gp and that indomethacin be not the substrate of MRP2.关键词：single-pass intestinal perfusion;euphorbia factor L1;P-glycoprotein;multidrug resistance-associated protein;rats
- 8
- |
- 323
- |
- 1
发布时间：2021-05-20 - 摘要：Objective To assess the quality of reports and abstracts of randomized controlled trials（ RCT） of treating Alzheimer’s disease（ AD） with Chinese herbal medicines. Methods The RCT reports were included from online search of database of Pub Med and CNKI. Based on the Consolidating Standards for Reporting Trials（ CONSORT） checklists,supplementary checklists of herbal medicine intervention and requirements of medical design,the quality of studies were performed. Results Eleven reports in English and eighteen ones in Chinese published in general medical journals were included. The number of items in six reports（ 20. 7%） was over 50%,while the mean items in Chinese was 10. 94（ 30%） and in English 20. 27（ 55%）. Altogether nine reports（ 31%） got the Jadad score of three or above,while the mean Jadad score of reports in Chinese was 1. 67 ± 0. 77 and in English was 2. 61 ±0. 93. Seven reports（ 24. 1%） got the score of 2. 5 or above in checklists of herbal medicine intervention,in which in Chinese got the mean score of 1. 58 ± 0. 39 and English got 2. 61 ± 0. 93. Zheng（ TCM syndrome） was reported only in one paper（ 3. 4%） in Chinese,and comparison of the types between and after treatment was conducted. Conclusion The quality of reports in English was better than that in Chinese. The main problems in Chinese study reports existed in lacking of details of random design and blind design,insufficient treatment duration,improper positive drugs controlled and poorly targeted indices selected.关键词：Alzheimer’s disease;Chinese herbal medicine;randomized controlled trial report;quality assessment
- 10
- |
- 335
- |
- 1
发布时间：2021-05-20 - 摘要：Objective To compare the long-term prognosis of chronic heart failure（ CHF） patients with different TCM syndrome elements of phlegm stagnation,qi deficiency,yin deficiency,blood statis and yang deficiency. Methods Subjects were 191 CHF inpatients in Guang’anmen Hospital from January2006 to August 2011. The clinic information of the patients were collected, including general information,incidence and TCM syndrome elements. After discharging from the hospital,all the patients were visited in outpatient or followed up by telephone for years to get the occurrence and duration of allcause mortality. Results The long-term prognosis of CHF patients with TCM syndromes ranked from the best to the worst: phlegm stagnation,qi deficiency,yin deficiency,blood stasis and yang deficiency（ P < 0. 01）. The prognosis of patients with syndrome of phlegm stagnation was better than those without phlegm stagnation（ P = 0. 017）; patients with syndrome of qi deficiency had a better prognosis than those without qi deficiency（ P = 0. 011）; there was no significant difference in patients with or without yin deficiency（ P = 0. 633）; the overall prognosis of blood stasis patients showed no significant difference with non blood-stasis patients（ P = 0. 182）,but went worse from the 500thday; the prognosis of patients with syndrome of yang deficiency was worse than patients without yang deficiency（ P = 0. 002）.Conclusion The long-term prognosis of CHF patients is definitely poor. The prognosis of CHF patients with different TCM syndromes showed striking difference. Syndrome of qi deficiency and syndrome of phlegm stagnation would be ordinary in early stage of CHF,and syndrome of yin deficiency played a role through the whole progression of CHF. The effect of syndrome of blood stasis could be associated with CHF disease progression,and the prognosis of patients with blood statis was worse. The syndrome of yang deficiency would be the main syndrome in late stage.关键词：chronic heart failure;long-term prognosis;TCM syndrome elements
- 10
- |
- 293
- |
- 7
发布时间：2021-05-20 - 摘要：Objective To explore the effects of Yupao decoction（ YPD）,a Chinese herbal compound formulated by the method of reinforcing kidney,on the follicle blood flow and pregnancy rate in patients undergoing artificial insemination by husband（ AIH）. Methods Altogether 60 infertile women with small follicular ovulation undergoing AIH were divided into control group（ n = 34） and YPD group（ n =26） according to random number table. Patients in control group were induced ovulation by clomiphene,and those of YPD group were taken ovulation induction with orally administration YPD. The pulsatility index（ PI） and resistant index（ RI） of follicle blood flow at the day of HCG injection and pregnancy rate（ PR） were observed. Results PI,RI,PR were dramatically higher in YPD group than those of control group（ P < 0. 05）. In YPD group,the clinical PR was 34. 61 %（ 9 /26） and cycle PR was 19. 56 %（ 9 /46）,by the contrast,the clinical PR was 11. 76%（ 4 /34） and the cycle PR 6. 06%（ 4 /66） in control group. Conclusion TCM kidney-reinforcing method combined with clomiphene could significantly improve the clinical pregnancy rate of patients undergoing AIH. The potential mechanism of combined therapy would exist in the improve ment the follicle quality by increasing follicle blood flow.关键词：kidney-reinforcing method;artificial insemination by husband（AIH）;follicle blood flow;clinical pregnancy rate
- 9
- |
- 130
- |
- 3
发布时间：2021-05-20 - 摘要：Objective To reveal the rule of TCM syndromes of postoperative patients with cancerous goiter and to provide clinical evidence for TCM treatment on the patients. Methods Based on the literature search and TCM standard of syndromes,Questionnaire of TCM Syndromes of Patients with Cancerous Goiter was established. A cross-sectional study of TCM syndromes was performed on 183 postoperative patients with cancerous goiter. Results Altogether four TCM syndromes existed in 183 patients. The ratio of syndrome of deficiency of both vital qi and yin was 34. 43%（ n = 63）,that of syndrome of stagnation of liver qi was 26. 23%（ n = 48）,that of syndrome of intermingled phlegm and blood stasis was 24. 59%（ n = 45） and that of syndrome of yang deficiency of spleen and kidney was 14. 75%（ n = 27）. Furthermore,distribution of TCM syndrome types showed no statistically differences（ P < 0. 05） among ages and disease courses. Conclusion The rule of distribution of TCM syndromes in postoperative patients with cancerous goiter would guide the syndrome differentiation and treatment.关键词：cancerous goiter;postoperative;TCM syndromes;clinical survey
- 10
- |
- 613
- |
- 2
发布时间：2021-05-20
- Postal code：100029
- Tel：(010)53911857 Email：jbutcm@bucm.edu.cn
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
0