最新刊期
      卷 39 ， 期 1 ， 2016
      • Vol. 39, Issue 1, Pages: 1-2(2016)
        摘要：<正>《北京中医药大学学报》是由教育部主管、北京中医药大学主办的中央级的高级中医药学术期刊,主编为中国中医界学术权威王永炎院士。本刊分别属于中国自然科学核心期刊,中国中文核心期刊,全国中医药优秀期刊,全国优秀科技期刊,国内6大检索系统10余种检索刊物的主要刊源,美国《化学文摘》（CA）、美国《剑桥科学文摘》（CSA）、美国《国际药学文摘》（IPA）、美国《乌利希期刊指南》（Ulrich PD）、美国《史蒂芬斯全文数  
          
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      • Vol. 39, Issue 1, Pages: 2(2016)
        摘要：<正>亲爱的读者、作者朋友们:凝聚着读者的期望、作者的重托、编者的心愿,2016年度的《北京中医药大学学报》又以崭新的面貌同大家见面了。作为中央级的高级中医药学术刊物,我刊在新的一年里,将继续不遗余力地奉行这样的运作方针:以弘扬中医药学术、促进中医药科技进步为根本任务,以高校学术层次、学术成就、学术优势为基本依托,采取严肃认真的办刊态度,始终坚持把办刊的社会效益放在首位,追求刊物的综合质量,通过不断加强刊物自身的学术内涵建设、编排规范建设以及提  
          
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      • LIU Hongfang,ZHANG Xiangwei
        Vol. 39, Issue 1, Pages: 5-9(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.001
        摘要：Diabetic nephropathy（ DN） is the most critical microvascular complication in patients with diabetes mellitus. In China,therapeutic options also include application of Chinese herbal compounds guided by syndrome differentiation treatment. Chinese medical treatment can attenuate greatly symptoms and improve the life quality,by contrast,the effects of reducing the objective indicators such as urine protein and serum creatinine are far from satisfactory. This article summarizes the theory of genuine yin and vital essence proposed by ZHANG Jingyue,a renowned TCM doctors in Ming Dynasty,as the following explanations. Firstly,genuine yin staying at the gates of vitality in kidneys,saves essence of five zang-organs. Secondly,genuine yin has both the functions of water and fire,as the carrier of yin essence and the foundation of yang essence. Thirdly,treatment of disease should be based on the root cause which locates in vital essence. Fourthly,the primary treatment of deficiency of yin essence is nourishing genuine yin by application of Radix Rehmanniae Praeparata（ Shu Dihuang） to reinforce qi and produce yin essence. After the analysis of clinical trials,we think that the core pathogenesis of DN is deficiency of genuine yin leading to deficiency syndrome transforming to excess syndrome. And the five rules of Chinese medical treatment on DN are listed as: the primary therapeutic principle is nourishing genuine yin;the primary therapy is powerfully tonifying genuine yin through the way of reinforcing qi and producing genuine yin,through the way of controlling and astringing essence to strengthen effects,and through the way of eliminating pathogenic factors and recovering essence to aid to nourishing genuine yin.  
        关键词：Zhang Jingyue;genuine yin;vital essence;diabetic nephropathy;clinical application   
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      • LIU Chang,WANG Chun,ZHENG Yuan,WANG Linyuan,LI Wei,ZHANG Jianjun
        Vol. 39, Issue 1, Pages: 10-15(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.002
        摘要：Objective To explore the effects and mechanism of Lishi Huoxue（ damp-dispersing and blood-activating） formula and two decomposed recipes Chinese herbal compound,on the vascular endothelial cells by detecting the serum levels of functional indicators of vascular endothelial cells and the aortic morphology of the rat model of hyperuricemia. Methods Male SD rats were randomly divided into seven groups: normal group,model group,benzbromarone group,Simiao Pill group,Lishi Huoxue formula（ LSHX） group,decomposed recipe I for clearing heat and damp（ recipe I） group,decomposed recipe Ⅱ for activating blood and resolving stasis（ recipe Ⅱ） group. The rat model of hyperuricemia was established by intragastrical（ i. g.） administration of yeaut and adenine. After successful modeling,rats of each medication group were administered i. g. with corresponding drugs,while normal group and model group were i. g. distilled water for consecutive 14 days. Then the serum contents of uric acid（ UA）and nitric oxide（ NO） were detected by ultraviolet-visible spectroscopy,and endothelin（ ET-1）,thromboxane B2（ TXB2） and 6-keto-PGF1αwere measured by radioimmunoassay. Besides,thoracoabdominal aorta of all rats were dissected and stained using HE and Masson. Results Compared with normal group,the serum level of UA,ET-1 and TXB2 increased significantly in model group（ P < 0. 05） and level of NO and 6-keto-PGF1αdecreased（ P < 0. 05）. Compared with the model group,the serum contents of UA,ET-1 and TXB2 showed significantly decreasing in LSHX group（ P < 0. 05）,while in recipe I group UA and ET-1 decreased（ P < 0. 05） and serum contents of NO,6-keto-PGF1αin LSHX group,recipe ⅠandⅡ groups increased（ P < 0. 05）. Furthermore,compared with LSHX group,the levels of TXB2 in both recipe groups and ET-1 in recipe Ⅱ group showed on statistical difference. Although LSHX and the two partial prescriptions（ recipe I,II） protected against the injury of aorta,the whole prescription（ LSHX）was more effective than the two decomposed recipes. Conclusion LSHX formula could reduce the serum UA,and protect vascular endothelium and the aorta of rats with hyperuricemia.  
        关键词：hyperuricemia;uric acid;nitric oxide;endothelin;thromboxane B2;6-keto-PGF1α;aortic morphology;Lishi Huoxue formula;rats   
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        发布时间：2021-05-20
      • ZHANG Jisheng,SHANG Xuezheng,BAI Yu,WANG Yanan,MA Weiguo,LIU Hui,WANG Kang,CHEN Yi,LU Yan,SHEN Zhiming,MENG Fengxian
        Vol. 39, Issue 1, Pages: 16-20(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.003
        摘要：Objective To observe the protective effect of Tangshenqing Formula II（ TSQF） on the renal function of mice with type 2 diabetes mellitus（ DM）. Methods KK-Ay mice,a spontaneous DM model,were fed with fat-enriched diet for three weeks. Based on their serum glucose（ Glu） and body weight（ BW）,the mice were divided into model group,valsartan group,high,middle,and low dose of TSQF（ high-,mid-,low- dose） group（ n = 6 each） and were treated for consecutive 12 weeks. And six C57 BL /6J mice were included into control group. At the timepoint of Week 0,4,8,12,Glu,urine albumin（ Alb）,urine creatine（ Cr）,Alb/Cr（ ACR） and 24-h urine protein（ pr /24 h） were detected. At the end of Week 12,all the mice were sacrificed and their serum samples were collected. And the serum levels of TG,TC,Scr,BUN and β2-MG were measured. Results Compared with the control group,the levels of pr /24 h,ACR,Scr,TG and TC in the model group significantly increased（ P < 0. 05 or P< 0. 01）,While BUN,β2-MG and ratio of kidney weight to body weight showed no statistcal differences（ P > 0. 05）. Compared to the model group,the levels of Scr,TG and ACR in valsartan group and three TSQF groups significantly decreased（ P < 0. 05 or P < 0. 01）,and those of TC,Glu,and pr /24 h decreased at different degree. Conclusion TSQF could reduce the serum levels of Glu,Scr and TG of kk-Ay mice,and alleviate the kidney injuries to reduce the progression of diabetic nephropathy.  
        关键词：diabetic nephropathy;renal function;Tangshenqing Formula Ⅱ;mice   
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        发布时间：2021-05-20
      • XIAO Congrui,TAO Siyu,YAN Xingli,GAO Zengping,SHI Ruirui,WANG Juan,WANG Jing
        Vol. 39, Issue 1, Pages: 21-25(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.004
        摘要：Objective To investigate the effects of 11-ethoxyviburtinal of Valeriana jatamansi Jones on the expression of enterochromaffin cells（ EC） and mast cells（ MC） in rats with irritable bowel syndrome（ IBS）. Methods The IBS rat model was induced by chronic unpredictable stress with isolation. Male SD rats were randomly divided into six groups: control group,model group,pinaverium group at the dose of 25 mg/kg,and high-,mid- and low- dose of 11-ethoxyviburtinal group at dose of 1. 2,0. 6,and 0. 3mg/kg respectively. The number of 5-HT positive immunoreactive colonic EC was detected by the method of immunohistochemistry and that of colonic MC was measured with toluidine blue staining. Results Compared with control group,the number of 5-HT positive immunoreactive colonic EC and MC increased significantly in model group（ P < 0. 05）. The high dose of 11-ethoxyviburtinal could significantly decrease the number of colonic EC and MC（ P < 0. 05）. Conclusion The 11-ethoxyviburtinal of Valeriana jatamansi Jones could significantly reduce the number of 5-HT positive immunoreactive 5-HT positive immunoreactive EC and MC in colon tissue of rats with IBS.  
        关键词：Valeriana jatamansi Jones;11-ethoxyviburtinal;irritable bowel syndrome;enterochromaffin cell;mast cell;rats   
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      • GU Xinyi,LIU Aiwei,SU Yan,YAN Xiaoling,WU Luhua,XIA Yanting,ZHAO Pengbo,ZHOU Jian
        Vol. 39, Issue 1, Pages: 26-29(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.005
        摘要：Objective To observe the effects of Astragalus Injection（ AI） on the expressions of nerve growth factor（ NGF） and tyrosine kinase receptor A（ Trk A） in retinal tissue of rat model of optic nerve injury by stretch. Methods Altogether 48 healthy male Wistar rats were randomly divided into three groups: sham group,model group and AI group（ n = 16 each）. The rat model of optic nerve injury was induced by horizontal stretching the optic nerve of left eye by tensiometer with 0. 10 N for 20 seconds,and the rats of sham group were only exposed optic nerves,without undergoing stretching. After successful modeling,the rats of AI group were injected intraperitoneally（ i. p.） AI and the those of model group were i. p. normal saline for consecutive 14 days. The retinal tissues of all rats were dissected out of the eye balls and the expressions of NGF and Trk A were detected by Western Blot. Results Compared with the sham group,the expression levels of NGF and Trk A in the model group decreased significantly（ P <0. 05）. After 14-day-treatment,the expressions of NGF and Trk A of retinal tissues increased in AI group compared with the model group（ P < 0. 05）. Conclusion The protection of AI against optic nerve injury was proved by upregulating of the expressions of NGF and Trk A in the rat retinal tissue.  
        关键词：optic nerve injury;astragalus injection;nerve growth factor;tyrosine kinase receptor A;rats   
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      • WANG Junyan,ZHANG Lin,JIA Lianqun,CHEN Wenna,SUN Hongwei,SHAO Chuqian,YANG Guanlin
        Vol. 39, Issue 1, Pages: 30-34(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.006
        摘要：Objective To observe the effects of Ziyin Xifeng Fang（ ZYXFF）,a Chinese medicine compound formulated by the method of nourishing yin and extinguishing wind,on the blood pressure and renal JAK/STAT signal pathway in the rat model of spontaneously hypertension（ SH）. Methods 40 SH rats were randomly divided into four groups（ n = 10 each） : model group,low dose of ZYXFF（ low-dose）group,high dose of ZYXFF（ high-dose） group and compound apocynum group. Another 10 SKY rats with the same background were included in the control group. The rats of three treatment groups were administered intragastrically（ i. g.） proper drugs,and those of control group and model group were i. g. saline for consecutive 42 days. The systolic blood pressure（ BP） was measured by using small animal noninvasive blood pressure meter at Day 0,7,14,21,28,35 and Day 42. Two hours after i. g. at the last day of medication,all the rats were sacrificed. The serum contents of creatinin（ Cr）,blood urea nitrogen（ BUN）,and uric acid（ UA） were determined. The serum contents of IL-6 and TNF-α were detected by ELISA assay,and the protein expression of renal p-JAK1 and p-STAT1 were measured by Western blot.Results Compared with control group,BP,Cr,BUN,UA,IL-6 and TNF-α increased significantly in model group,and the all indexes of the rats of the three medication groups decreased remarkably（ P <0. 05 or P < 0. 01）,especially the effects of high dose of ZYXFF and compound apocynum were stronger than those of low dose ZYXFF. Compared with control group,in model group rats renal p-JAK1,pSTAT1 protein expression significantly increased（ P < 0. 01）. The protein expressions of p-JAK1 and pSTAT1 decreased in the three medication groups compared with the model group（ P < 0. 05 or P < 0.01）. Conclusion The mechanism of ZYXFF lowering blood pressure and attenuating the renal function impairment should be by the way of inhibiting the activation of JAK / STAT signal pathway.  
        关键词：Ziyin Xifeng Fang;hypertension;kidney damage;JAK/STAT signal pathway;rats   
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      • XUE Zhanxia,GAO Yongshan,WU Haixia,HAO Junrong,SHEN Lixia
        Vol. 39, Issue 1, Pages: 35-39(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.007
        摘要：Objective To study the effects of different concentration of chrysophanol on the activity and glutamate metabolism of primarily cultured astrocytes in vitro. Methods Primarily cultured mice astrocytes were treated with chrysophanol at concentration of 10,20,40,60,80,100,200,and 250 mg/L（ chry 1 8 group） for 1 d,2 d,and 3 d. The cell activities were measured by MTT method,mRNA expressions of glutamate/aspartate transporter（ GLAST） and glutamate acid transporter 1（ GLT-1） were detected by using RT-PCR,and the activities of glutamine synthetase（ GS） and glutathione peroxidase（ GSH-Px） were also determined. Results Time-dependence and concentration-dependence of the effects of chrysophanol showed on the following: activity of astrocytes inhibited,mRNA expressions of GLAST and GLT-1 upregulated,and the activities of GSH-Px and GS increased. However,the effect of chrysophanol on extra-cellular concentration of glutamate didn’t depend on the number or activity of the cells. Conclusion Chrysophanol inhibited the activity of astrocytes in mice,and its effect on glutamate metabolism was concentration- and time-dependent.  
        关键词：chrysophanol;astrocyte;glutamate/aspartate transporter;glutamate acid transporter 1;glutathione peroxidase;glutamine synthetase;mice   
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      • WANG Qing,WANG Yingzi,LI Youlin,NI Jian,ZHANG Xiuting,LI Fengying,ZHANG Chunni
        Vol. 39, Issue 1, Pages: 40-45(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.008
        摘要：Objective To establish the HPLC fingerprint of new preparation of Honghe Fang,a Chinese medicine compound,and to study the correlation of the preparation,effective components,and the fingerprint of raw herbal materials,so as to underlie its quality control. Methods The effective components were separated by HPLC with Inertsil ODS-3 column（ 5 μm,4. 6 mm × 250 mm） in a gradient elution of acetonitrile and water with 0. 01 H3PO4 as the mobile phase at the flow rate of 1 mL / min and temperature of 25℃ and detection wavelength of 338 nm for 125 min. Then the common peaks were analyzed and identified by the alignment of HPLC fingerprint of Honghe Fang,effective components of raw herbal medicines,raw herbal medicines and negative control preparation. Results Altogether 28 common peaks separated completely from the 10 batches of Honghe Fang were confirmed by using the software"Similarity Evaluation System for Chromatographic Fingerprint of TCMs（ Version 2004A） ",and of which six peaks were identified. The similarity based on the information of common peaks were all above0. 96,a high similarity index. And each common peak could be identified in HPLC chromatograms of effective components and raw herbal medicines. Conclusion This method proved to be simple,accurate and repeatable,could be applied in quality control of Honghe Fang.  
        关键词：Honghe Fang preparation;effective components;fingerprint;quality control   
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      • Vol. 39, Issue 1, Pages: 45(2016)
        摘要：<正>《北京中医药大学学报》由教育部主管,北京中医药大学主办,中国工程院院士王永炎教授担任主编,创刊于1959年,国内刊号CN11-3574/R,国际刊号ISSN1006-2157。由北京报刊发行局向全国发行,国内代号82-414;国外发行由中国国际图书贸易总公司（北京399信箱）办理,国外代号M734。近日,我刊发现有数个网站以本刊名义对外征稿,为维护我刊声誉及广大作者及读者的利益,我刊特此郑重声明:《北京中医药大学学报》是面向国内外发行的中医药类同行评审的中医药科技期刊,开设唯一网  
          
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      • YANG Guanghui,WU Lingfang,ZHANG Xiaoxue,ZHU Dan,SHAO Yanyan,MAO Xin,LIANG Wenyi,CHEN Wenjing,SHI Renbing,ZHANG Lanzhen
        Vol. 39, Issue 1, Pages: 46-50(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.009
        摘要：Objective To study in vitro the effect of human intestinal bacteria on the transformation of total tannins extracted from emblic leafflower（ Yuganzi,Phyllanthus emblica L.）,a usually used Tibetan herbal medicine. Methods Based on the earlier stage work of the extraction of total tannins from Phyllanthus emblica L.,activated human gut microbiota was anaerobically incubated in the culture medium GAM containing the total tannins at 37℃ for 72 hours. After centrifugation and protein precipitation,the characteristics of the metabolites were determined by using HPLC/MSnand the contents of each component determined were measured by using HPLC-UV,on which the time-content curve was drawn.Results Total 13 components were determined,including four metabolites（ pyrogallic acid,methyl-derivative of gallic,urolithin B,and urolithin A）,four prototype components（ gallic acid,corilagin,galloyl glucose,and digalloyl glucose） and five components to be determined. The accumulated contents of gallic acid and ellagic acid were the highest at Hour 12,10-fold higher than that of the beginning; the accumulated content of corilagin was the highest at Hour 6 with twice higher of the beginning.Conclusion After the total tannins from Phyllanthus emblica L. were transformed by human gut microbiota in vitro,certain bioactive prototype components remained and antitumor components were found.  
        关键词：Phyllanthus emblica L.;total tannins;human gut microbiota;metabolism   
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      • LIU Shuchen,QU Baoping,KONG Hui,SHAN Wenchao,CHENG Jinjun,ZENG Wenhao,QU Huihua,WANG Qingguo,ZHAO Yan
        Vol. 39, Issue 1, Pages: 51-54(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.010
        摘要：Objective To determine the contents of baicalin in Gegen Qinlian Tablet produced by seven manufacturers,a Chinese patent drug used widely in acute gastroenteritis,virus diarrhea,and bacillary dysentery, by using indirect competitive enzyme-linked immunosorbent assay（ ic-ELISA）.Methods The ic-ELISA method was established by using anti-baicalin monoclonal antibody（ anti-BA MAb）,in which the linear relation,accuracy and the recovery rate were measured. Based on the icELISA method,the contents of baicalin in Gegen Qinlian Tablet from different manufacturers were determined. Results The linear range of the ic-ELISA method established was from 16. 157 to 1 280 mg/L,the relative standard deviation（ RSD） was≤5. 1% in the intra- assay,and≤9. 0% in the inter-assay,with the average recovery rate of 107. 1%（ RSD = 4. 9%）. The baicalin contents in Gegen Qinlian Tablet from seven manufacturers ranged from 4. 45 to 13. 41 mg per tablet. Conclusion The ic-ELISA method for the baicalin determination was convenient,accurate,and repeatable,which could be applied to the quality control of traditional Chinese herbal compound containing baicalin.  
        关键词：indirect competitive enzyme-linked immunosorbent assay method;Gegen Qinlian tablet;baicalin;content determination   
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      • Vol. 39, Issue 1, Pages: 54(2016)
        摘要：<正>2015年10月21日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2014年"百种中国杰出学术期刊"称号,这是《北京中医药大学学报》连续第三次获得"百种中国杰出学术期刊"称号。2014年《中国科技期刊引证报告》（核心版）共收录中国科技核心期刊2 312种,《北京中医药大学学报》2014年核心影响因子0.722,核心总被引频次2 235,综合评价总分78.30,总排名第102位,位居全国中医药  
          
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      • ZHU Xiaoling,XU Haijie,DONG Yu,TIAN Zi
        Vol. 39, Issue 1, Pages: 55-60(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.011
        摘要：Objective To establish a simultaneous quantitative determination method for six lactones（ santamarine,costunolide,dehydrocostuslactone,alantolatone,isoalantolactone and 11,13-dihydroisoalantolantone） from nutmeg-5,a Mongolian medicine compound. Methods HPLC analysis was performed by an Elite C18column（ 4. 6 mm × 250 mm,5 μm） at temperature 30℃ with gradient elution（ acetonitrile and aqueous solution） at a flow rate of 0. 8 m L/min 204 nm. Results The six lactones were separated completedly by using the established HPLC method,and the regression equation of each lactone showed good linear correlation between concentration and peak area with the correlation coefficient more than 0. 999. Each average recovery rate with relative standard deviation（ RSD） of six lactones was listed as the following: santamarine 102. 54%（ RSD 1. 02%）,costunolide 103. 35%（ RSD 0. 82%）,dehydrocostuslactone 100. 38%（ RSD 1. 75%）,alantolatone 97. 81%（ RSD 1. 59%）,isoalantolactone96. 65%（ RSD 1. 98%）,and 11,13-dihydroisoalantolantone 99. 64%（ RSD 1. 68%）. Conclusion The HPLC method was validated and found to be specific,linear,precise,and accurate. This chromatographic system can be readily used on a routine way for determination of lactones from nutmeg-5.  
        关键词：Mongolian medicine nutmeg-5;santamarine;costunolide;dehydrocostuslactone;alantolatone;isoalantolactone;11,13-dihydroisoalantolantone;HPLC   
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        发布时间：2021-05-20
      • SONG Panhong,FEI Ye,ZENG Zuping,PENG Bing,YAN Xingli,CHEN Jing,DOR Jerenchen,GAO Zengping
        Vol. 39, Issue 1, Pages: 61-66(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.012
        摘要：Objective To explore the method to control the quality of Rheum nobile.,a widely used Tibetan herbal medicine. Methods The herb powder of ten batches of Rheum nobile was identified by thin layer chromatography（ TLC） with piceatannol-4’-O-β-D-glucopyranoside as the reference substance,and the moisture content,total ash and acid-insoluble ash were detected in accordance with Appendix IX of Chinese Pharmacopoeia 2010 Edition. The contents of piceatannol-4’-O-β-D-glucopyranoside and resveratrol-4’-O-β-D-glucopyranoside were determined by using HPLC. Results The spots of piceatannol-4’-O-β-D-glucopyranoside of ten batches of Rheum nobile were clear and well separated. The range of moisture content was from 7. 46% to 9. 14%,and that of total ash was 2. 72% to 8. 75%,and that of acid-insoluble ash 0. 50% to 2. 51%. The content of piceatannol-4’-O-β-D-glucopyranoside was showed a good linear relationship at the range of 1. 768 to 70. 720 mg/L（ r = 0. 999 8） and the recovery rate was101. 11%（ RSD = 0. 89%）,by parallel,that of resveratrol-4’-O-β-D-glucopyranoside was showed a good linear relationship at the range from 0. 416 to 16. 640 mg/L（ r = 0. 999 6） and the recovery rate was99. 68%（ RSD = 2. 54%）. Conclusion The methods of TLC and HPLC are simple,accurate and repeatable,which could be the option of the quality control of Rheum nobile.  
        关键词：Rheum nobile;TLC identifation;HPLC;content determination   
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      • Vol. 39, Issue 1, Pages: 66(2016)
        摘要：<正>《北京中医药大学学报》已入编《中国学术期刊（光盘版）》。为此郑重声明如下:一、凡在《北京中药大学学报》发表的文章,如作者事先未表示异议,则相应地被编入《中国学术期刊（光盘版）》。《中国学术期刊（光盘版）》免收作者版面费。二、《中国学术期刊（光盘版）》免费向作者提供引文率统计资料。作者可通过所在单位设立的中国学术期刊文献检索咨询站查询,检索本人在《中国学术期刊（光盘版）》中发表论文的被引用情况;如本单位未设  
          
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      • LI Hui,MA Shuwei,LIU Yan,RU Qingguo,LIU Jia,CHEN Yanyan,WU Qing
        Vol. 39, Issue 1, Pages: 67-72(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.013
        摘要：Objective To optimize the procedure of extracting components from Sophora alopecurcurodies（ Kudouzi）. Methods After external use of the extracts of Kudouzi by four different extraction procedures on the footpad inflammation rat model induced by carrageenan,the swelling rate was observed as the therapeutic index. The contents of oxysop hocarpine and oxymatrine of extracts from Kudouzi,as the two chemical indexes,were measured by using HPLC. The extraction procedure was screened by therapeutic index combined with chemical indexes. Then the parameters of the procedure screened were optimized by orthogonal test. Results All the extracts inhibited footpad swelling in rats,and the effect of the ethanol extract was the strongest,and in which the contents of oxysop hocarpine and oxymatrine were the highest. The footpad swelling rate was negatively correlated with the contents of the two chemical indexes. The optimized extraction procedure was obtained with 10 times of 80%（ V/V） alcohol,4 hours at50℃. Conclusion The extraction procedure of Kudouzi was stable and feasible,and the contents of active components were positively correlated with their effects.  
        关键词：Sophora alopecurcurodies;extraction procedure;therapeutic indexes;chemical components;orthogonal test   
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      • SHEN Rongmin,ZHANG Yan,WANG Ji,SUN Shuxian,YANG Fei,BAO Lei,MIN Jiayu,YAO Haiqiang,WANG Qi
        Vol. 39, Issue 1, Pages: 73-76(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.014
        摘要：Allergic diseases are some of the most common and refractory diseases. Professor WANG Qi,a National Chinese Medical Science Master,treats the allergic diseases guided by the model of "differentiation of constitution-differentiation of disease-differentiation of syndrome"and achieves remarkable effects.The authors summarize the experiences of Master WANG on treating the allergic disease. Firstly,treatment should be reinforcing the healthy qi priority to eliminating pathogenic factors. Secondly,patients can be exposed to allergens properly when they are undergoing TCM treatment. Thirdly,according to the pathogenesis rules of certain allergic disease,the exact time of treatment is determined. Finally,medication to adjust Constitution is simpler and more flexible than medication applied to the patients suffering the allergic diseases.  
        关键词：allergic Constitution;allergic diseases;adjust constitution;experience   
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      • YANG Xiaojing,HUANG Chuanbing,LIU Yifei,YANG Xiuli,JIA Jingyun,WU Min
        Vol. 39, Issue 1, Pages: 77-81(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.015
        摘要：Objective To explore the effects of spleen-fortifying and kidney-replenishing therapy on manifestation and quality of life in patients with systemic lupus erythematosus disease（ SLE）. Methods 50 SLE patients were randomly divided into treatment group and control group. Both groups were given prednisone tablets combined with hydroxychloroquine sulfate while the treatment group also took the Spleenfortifying and Kidney-replenishing Decoction（ Jianpi Yishen Tang）. Changes of clinical manifestations and laboratory parameters before and after treatment were used to evaluate the efficacy and effects on the quality of life. Results Total effective rate of 88. 0% with 4 cases of clinical response,10 cases of remarkable effect,8 cases of effect and 3 cases of non-respond in the treatment group,was significantly higher than 72. 0% of the control group（ clinical response 2 cases,remarkable effect 6 cases,effect 10 cases and non-response 7 cases）（ P < 0. 05）. There was no significant difference between the two groups in SLEDAI scores. The treatment group was significantly superior to the control group（ P < 0. 01） in improving patients’ quality of life and scores of SDS and SAS. TCM symptom scores in the treatment group were significantly lower than those in the control group（ P < 0. 05）. Ig G,CRP and other laboratory parameters in the treatment group were also significantly lower than that of the control group（ P < 0. 05）.Levels of Ig M,C4,WBC,and RBC in the treatment group were significantly higher than those in the control group（ P < 0. 05）. Conclusion Spleen-fortifying and kidney-replenishing therapy could significantly attenuate clinical manifestations,disease activity,TCM symptom scores and relieve anxiety and depression in SLE patients. The efficiency and safety had been proved to improve the quality of patents’ life.  
        关键词：spleen-fortifying and kidney-replenishing therapy;systemic lupus erythematosus;efficacy evaluation;quality of life   
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      • LIU Zhao,YANG Jinsheng,CHEN Min,HUANG Lingling,HE Xiuqing,WU Guanyi,QI Shu-lan,WU Yuan,WANG Yingying
        Vol. 39, Issue 1, Pages: 82-88(2016) DOI: 10.3969/j.issn.1006-2157.2016.01.016
        摘要：Objective To explore the predictors for the compliance of cigarette smokers who were acupunctured for stopping smoking in Hong Kong. Methods Motivated daily smoking quitters were recruited from the project of Plot Study of Acupuncture for Smoking Cessation conducted by Institute of Acupuncture and Moxibustion of China Academy of Chinese Medical Sciences and Hong Kong Pok Oi Hospital from August,2010 to June,2015. After comparing the subjects dropped out of the study with the ones completed it,the data of demography,smoking background,desire of smoking cessation were obtained.Then the compliance data at the 8th week and the 52 nd week were taken as independent variable,and the predictors were screened by using Logistic regression analysis. Results Altogether 4 480 volunteers were eligible,with the compliance rate at the 8th week,26 th week and 52 nd week of 68. 86%,58. 24%and 49. 51% respectively. The participants were primary males（ 62. 25%）,the age was 43. 50 ± 12. 04 years,and 62. 46% had a secondary education. The smoking background was listed as the following:smoking history was（ 25. 09 ± 11. 61） years,number of smoked cigarettes per day（ CPD） was 17. 68 ±7. 90,Fagerstrom Test For Nicotine Dependence（ FTND） score was 5. 35 ± 2. 29,the percentage of previous quit attempts was 81. 12% and 80. 96% quit attempts concerned about health. The participants received 5. 40 ± 3. 25 sessions of acupuncture. The results of Logistic regression analysis indicated that the predictors for smoke cessation with acupuncture treatment were some different for eight weeks and for 52 weeks. At the eight-week-treatment,the predictors were "FTND score"（ OR = 1. 048,95% CI[1. 007,1. 092]）,"due to persuasion"（ OR = 0. 795,95% CI[0. 708,0. 892]）,"reasons to select acupuncture"（ OR = 1. 101,95% CI[1. 031,1. 176]）,"total cessations of acupuncture received"（ OR = "1. 346,95% CI[1. 290,1. 404 ]）,and "whether finished six cessations of acupuncture in the first month"（ OR = 2. 975,95% CI[2. 424,3. 652 ]）. At the 52-week-treatment,the predictors were "gender"（ OR = 1. 406,95% CI[1. 207,1. 637]）,"total cessations of acupuncture received"（ OR = 1. 134,95% CI[1. 097,1. 173]）,and "whether received six cessations of acupuncture in the first month"（ OR= 5. 128,95% CI[4. 242,6. 220 ]）. Conclusion The compliance of the smoking quitters treated with acupuncture was high,and the predominant predictor in increasing the compliance was high-quality acupuncture received.  
        关键词：acupuncture;smoking cessation;compliance;nicotine dependence;Hong Kong   
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      • Vol. 39, Issue 1, Pages: 88(2016)
        摘要：<正>为了更好地服务作者、读者,提高工作效率,《北京中医药大学学报》编辑部自2011年1月1日起开通网上采编系统（http://xb.bucm.edu.cn）,请广大作者和读者登陆本刊网站,随时通过此系统投稿、查稿、修改稿件或浏览最新目录等,首次登陆需先行注册。20102015年杂志及现刊内容已在网上全文刊出,可在线全文阅读。本刊不再接受电子邮件与纸版投稿,请作者、读者相互转告。如有特殊情况请与本刊编辑部联系。  
          
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