最新刊期
卷 39 ， 期 5 ， 2016
- 摘要：This article put forward a novel idea that the TCM term of qi transformation,based on its original meaning and interpretation in Neijing,whose subject referred to qi transformation of heaven and earth,was a vital academic scope extended from the understanding of human body by natural philosophy of qi-monism theory. The connotation of qi transformation in Neijing was reflected in two aspects: qi transformation of heaven and earth generating everything in the world,qi transformation of heaven and earth involving qi transformation of life. Qi transformation is characterized by sequence,direction and internal homeostasis,which plays an important role in guiding TCM clinical practices.关键词：qi transformation;Neijing;qi transformation of heaven and earth;connotation;characteristics
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发布时间：2021-05-20 - 摘要：Traditional Chinese Medicine（ TCM） is characterized by holism concept. Through Inner Canon of Huangdi,the theory of "yin-yang of four seasons and five zang-organs"is one of the academic thoughts which presents wholism concept of "correspondence between nature and human". Siwu Tang has been appraised as the "saint prescription of gynecology",directed at various blood troubles. This article tries to study the mechanism of Siwu Tang against blood troubles from the view of the wholism concept of"yinyang of four seasons and five zang-organs".关键词：yin-yang of four seasons and five zang-organs;holism concept;Siwu Tang;blood troubles
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发布时间：2021-05-20 - 摘要：<正>中医理论的思想基础,一方面来自于古人对天地自然的认识以及由此形成的自然观,即"以大观小",从天地自然生成演化的基本规律隐喻类比生命过程与现象;另一方面,秉承了古代哲学思想中的"通""和"以及"平"的思想,认为,人与整个自然都是一气贯通的,"通"是自然及人身都固有的、内在的、本质的规律,"和"与"平"是生命最佳状态,如阴关键词：通;和;平;字源学;中医学
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发布时间：2021-05-20 - 摘要：Objective To compare the effects of truncated therapy and conventional therapy on the lung tissue inflammation of mice with pneumonia induced by influenza virus,so as to explore the mechanism of truncated therapy superior to conventional therapy and its relationship with inflammatory cascade after viral infections. Methods 192 Balb / c mice were randomly divided into healthy group,model group,conventional therapy group and truncated therapy group. Except for the healthy group,the mice of the other three groups were infected with 50 μL 30 LD50 mouse lung-adapted influenza virus strain（ FM1） by inoculating intranasally. After 1 h of inoculation,healthy group and model group were administered intragastrically（ i. g.） distilled water; conventional therapy group was administered i. g. twice daily Yinqiao Powder for the first three days,then Xijiao Dihuang Decoction for the next four days（ totae seven days）;truncated therapy group was administered i. g. Xijiaodihuang Decoction twice daily for consecutive seven days. Then the mice were sacrificed by taking the eyeballs on the 2nd,4th,6th,and 8thday for sampling and detecting. The WBC count in bronchoalveolar lavage fluid（ BALF） was detected,the levels of IL-1βand IL-18 in the supernatants of lung homogenate were measured by ELISA and NOD- like receptor family mem NOD-,LRR-and pyrin domain containing 3（ NLRP3） mRNA in the lung tissue were detected by quantitative realtime- PCR. Results Compared with the model group,the WBC counts of BALF,IL-1β,IL-18 and NLRP3 mRNA in truncated therapy group and conventional therapy group decreased（ P <0. 01）. WBC counts,IL-1β and IL-18 began to show the remarkable differences from that of model group since the 2nd day,while conventional therapy group didn’t. On 8thday,WBC count in truncated group was lower significantly than that in the conventional group（ P < 0. 01）. On the 4th day of being infected,NLRP3 mRNA of mice lung tissue expressed highly in the model group,while decreased significantly in the truncated group only. Conclusion The truncated therapy which may inhibit the inflammatory reaction induced by innate immunity at the early phase of infection,can prevent the inflammatory cascade,and can truncate the progress of the disease. The potential mechanism is linked to inhibiting the formation of NLRP3 inflammasome,interfering the mature and secretion of IL-1β and IL-18.关键词：truncated therapy;viral pneumonia;influenza virus;inflammation;mice
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发布时间：2021-05-20 - 摘要：Objective To investigate the safety of Majie Pingchuan cataplasm on skin. Methods 1Acute toxicity test. Twelve rabbits were randomly divided into three groups with hair removed and skin damaged,systemic poisoning situation was observed after patching blank matrix cataplasm and Majie Pingchuan cataplasm. 2Skin irritation test. Sixteen rabbits were randomly divided into four groups with hair removed and skin damaged,one twelfth of one sheet of blank matrix cataplasm and Majie Pingchuan cataplasm were separately patched on left or right side skin,erythema and edema were observed in single and repeated stimulation tests. 3Skin allegy test. Thirty guinea pigs were randomly divided into three groups,one twelfth of one sheet of blank matrix cataplasm,Majie Pingchuan cataplasm,0. 2 m L of 2,4-dinitrochlorobenzene were patched on the left side skin. On 28 thday allergic reaction was observed after patching the same excitants six hours continuously on the right skin. Results In the acute toxicity test,there was no death and abnormal physiological conditions in rabbits. In the single stimulus test,erythema and edema did not appear. In the repeated stimulation tset,there was slight erythema disappearing in 48 h,and no edema. In allergy test,Majie Pingchuan cataplasm group did not appear erythema and edema,the sensitization rate was 0. Conclusion Majie Pingchuan Cataplasm had no acute toxicity and irritation on intacted or injured skin of rabbits. There was no allergic reaction in guinea pig skin. Majie Pingchuan cataplasm is safe and non-toxic.
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发布时间：2021-05-20 -
Literature study on fecal class Chinese medicines and their application in the ancient prescriptions
摘要：Objective To summarize the basic characteristics of fecal class Chinese medicines in modern clinical practice,and to find out the application of them in ancient prescriptions. Methods Taking "feces"（ Chinese: 粪便; pinyin: fènbiàn） and "Chinese medicines"（ Chinese: 中药; pinyin: zhōngyào）as the keywords,we searched CNKI,Wangfang,CQVIP and CBM databases of relevant articles published since the time of establishment. Then the fecal class Chinese medicines were screened. What we obtained were where the official names came from,what their alternative names were at different times,which creatures they were excreted from,what property and flavor,meridian tropism,efficacy and indications they had. Furthermore,we searched the ancient prescriptions involving fecal class Chinese medicines using the database platform of Dictionary of Chinese Medicine Prescriptions,institute of Chinese Materia Medical of China Academy of Chinese Medical Sciences to get the common compatibility and potential rules of clinical application. Results Total eleven fecal class Chinese were common used in modern clinical practice,which were recorded in various monographs of Chinese medicine by numerous names,and were excreted from birds,mammals and worm. The nature of the medicines were hot or cold;the flavor coved sour,bitter,sweet,bitter,salty; the meridian tropism lied in meridian of liver（ gall bladder）,heart（ cardiac）,spleen（ stomach）,lung（ intestine） and kidney（ bladder）; the various effects were listed as the following: resolving superficies,clearing heat,dispelling pathogenic wind and removing dampness,resolving stagnation,expelling blood stasisfor removing obstruction in collaterals,removing phlegm,relieving cough,calming endogenous wind,inducing resuscitation,removing toxicity,destroying parasites,relieve itching,eliminating necrotic tissues and promoting granulation. In addition,we extracted relevant 1 550 relevant prescriptions containing the eleven medicines which had the internal pharmaceutical compatibility and association rules. Conclusion The application of fecal class Chinese medicines has a long history. The further study and innovating application will be much of value of research and application in the intestinal microecology and the diagnosis and treatment of various diseases.关键词：traditional Chinese medicine;prescription;intestinal flora;fecal microbiota transplantation- 9
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发布时间：2021-05-20 - 摘要：Objective To study the antioxidant activities and chemical compositions of Thymus quinquecostatus Celak（ dijiao）. Methods The antioxidant activities of five polar fractions of dijiao were screened and evaluated using DPPH and ABTS free radical scavenging assays. After the chemical compositions were separated and purified by using silica gel chromatography,Sephadex LH-20 chromatography and MCI GEL CHP-20 P column chromatography,the chemical compositions were identified by MS and NMR spectrometers,and records of literature. Results From the Et OAc and n-Bu OH fractions which showed high antioxidant activity,total 18 compositions were separated and identified: scutellarin（ "1 "short for peak No. 1,the same below）,scutellarein（ 2）,5,6,7-trihydroxy-4’-methoxyflavone（ 3）,xanthomicrol（ 4）,apigenin（ 5）,4’-methoxyluteolin（ 6）,luteolin-7-O-β-D-glucopyranoside（ 7）,luteolin（ 8）,and rutin（ 9）,danshensu（ 10）,vanillic acid（ 11）,protocatechuic acid（ 12）,chlorogenic acid（ 13）,caffeic acid（ 14）,ferulic acid（ 15）,2,6-dihydroxy-4-isopropylphenyl-β-D-glucopyranoside（ 16）,olenolic cid（ 17） and daucosterol（ 18）. Conclusion The composition 1,2,3 and 16 were the first reported in the genus Thymus,and 4 8,10 12,14 15 and 17 18 were found first in dijiao.关键词：Thymus quinquecostatus Celak;antioxidant activity;scutellarin;scutellarein;xanthomicrol
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发布时间：2021-05-20 - 摘要：Objective To improve the quality standard of Jinlian Qingre Capsule. Methods Chinese Globeflower Flower（ Trollii Chinensis Flos,Jinlianhua）,Dyers Woad Leaf（ Folium Isatidis,Daqingye）,Figwort Root（ Srophulariae Radix,Xuanshen） and Bitter Apricot Seed（ Semen Armeniacae Amarum,Kuxingren） in Jinlian Qingre Capsule were identified using thin layer chromdograph（ TLC）. The content of vitexin was detected using HPLC with a Phenomenex Luna C18（ 2） 100 A column（ 250 mm × 4. 6 mm,5μm）,a mobile phase of acetonitrile- 0. 4% ammonium acetate（ 15∶ 85） at the flow rate of 1. 0 m L /min,detection wave length at 340 nm and the column temperature at 25 ℃. Results Main spots of Chinese Globeflower Flower,Dyers Woad Leaf,Figwort Root and Bitter Apricot Seed in TLC were clear and separated well. A good linearity was obtained for vitexin in the range of 0. 06 0. 57 μg（ r = 0. 999 9） with mean sample recovery rate of 99. 7% and RSD of 2. 1%. Conclusion Method of TLC and HPLC established in this study which appears to be highly specific,accurate and repeatable can be used in the quality control of the Jinlian Qingre Capsule.关键词：TLC;HPLC;Jinlian Qingre Capsule;vitexin;quality standard
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发布时间：2021-05-20 - 摘要：<正>国医大师李士懋先生对脉学有深刻的认识,本文从浮脉未必主表证说、沉脉未必主里证说、数脉未必主热证说、迟脉未必主寒证说、弦脉未必主肝胆说、紧脉未必主寒证说、涩脉未必主瘀血说等7个方面,论述了国医大师李士懋先生对这些脉象的创新性的认识和独特性的见解,以期对临床实践起指导关键词：国医大师;李士懋;脉诊;新说
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发布时间：2021-05-20 - 摘要：Objective To study the different prescriptions of eletcro-acupuncture（ distal-proximal acupoints,proximal acupoints and distal acupoints） on pain-related behaviors and expression of microglia marker OX42 and cyclooxygenase 2（ COX2） in spinal dorsal horn in rat model of transplantation of autologous nucleus pulposus,so as to provide experimental basis for the mechanism of the different prescriptions. Methods 54 healthy male SD rats were randomly divided into six groups（ each n = 9）-normal group,model group,sham operation group,distal-proximal acupoint group,proximal acupoint group,distal acupoint group. After modeling,the rats in three acupuncture groups were treated for 20 minutes,once daily for consecutive 7 days. Those in distal-proximal acupoint group were needled at bilateral "L5Jiajixue"（ Ex-B2）,"Dachangshu"（ BL 25）,"Weizhong"（ BL 40） and "Kunlun"（ BL 60）; those in proximal acupoint group were needled at bilateral "L5 Jiajixue"（ Ex-B2） and "Dachangshu"（ BL 25）;the rats in distal acupoint group rats were needled at bilateral "Weizhong"（ BL 40） and "Kunlun"（ BL60）. Thermal withdrawal latencies were evaluated. The expressions of OX42 and COX2 in the left spinal dorsal horn were detected using immunohistochemical methods. Results Thermal withdrawal latencies and the expression of OX42 and COX2 increased in rat model of transplantation of autologous nucleus pulposus. After treatment,thermal pain threshold was improved（ P < 0. 05）,and the expression of OX42 and COX2 were inhibited（ P < 0. 05）. The inhibitory effects of distal-proximal acupoint group and proximal acupoint group were superior to that in distal acupoint group. Conclusion Each acupuncture prescription reduced anti-inflammatory effects by inhibiting inflammatory signaling pathways in spinal dorsal horn,with the prescription of distal-proximal acupoints and proximal acupoints superior to distal acupoints.
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发布时间：2021-05-20 - 摘要：Objective To study the role of nucleus tractus solitarii（ NTS） on the protective effects of moxibustion on gastric mucosa lesion in the nervous pathway by investigating the effects of moxibustion at " Zusanli"（ ST 36） on endogenous protective factors and gap-associated protein expression of gastric mucosal lesion rats after damaging their nucleus tractus solitarii（ NTS）. Methods 48 healthy SD rats,SPF grade,were divided into four groups using random number table（ each n = 12） : normal group,model group,moxibustion group,moxibustion + NTS damaged group. Three days after bilateral NTS damaged in moxibustion + NTS damaged group,gastric mucosal lesion rat model was induced by intragastrical（ i.g.） administration of anhydrous ethanol at dose of 6 m L / kg and aspirin mixed suspension at dose of 200 mg / kg for consecutive three days. The next day,rats in moxibustion group and moxibustion + NTS damaged group were treated by moxibustion at Zusanli（ ST 36） twice daily for consecutive three days.All rats were sacrificed,then their serum and gastric tissue were collected. Ulcer index（ UI） was calculated,and the expressions of epidermal growth factor（ EGF）,nitric oxide（ NO）,Bcl-2 anti-apoptotic proteins（ Bcl-2） and pro-apoptotic protein（ Bax） were detected. Results Compared with normal group,UI in model group increased significantly（ P < 0. 05）,decreased in moxibustion group（ P < 0.05）. Compared with model group,content of EGF and NO in serum and gastric tissue increased remarkably in moxibustion group（ P < 0. 05） which were higher than those in moxibustion + NTS damaged group（ P < 0. 05）. Protein expression of Bcl-2 increased significantly in moxibustion group and moxibustion +NTS damage group compared with model group,while expression of Bax protein decreased with increasing of AI（ P < 0. 05）. Conclusion Treatment of moxibustion at Zusanli（ ST 36） can regulate the expression of endogenous protective factors and proteins to protect rats’ gastric mucosa,which was affected by damaging NTS. It is suggested that NTS be the important regulatory location in the signaling pathway of protective effects of moxibustion at Zusanli on gastric mucosal.
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发布时间：2021-05-20 - 摘要：Objective To study the difference of plantar pressure before and after needle-knife surgery on patients with calcaneodynia,so as to evaluate its efficacy and provide evidence to the clinical application of needle-knife therapy. Methods A total 70 patients with calcaneodynia were divided into two needle-knife therapy groups（ treatment group,each n = 35）. After local anesthesia,the needle-knife was inserted into quickly guided by the plantar fascia scale,perpendicular to the direction of metatarsal fascia,then cut and separated the ligaments and fascia attached to the bone spur three to five times. In treatment group 1,the needle-knives were inserted to half of the scale,and in the treatment group 2,the needle-knives were inserted to quarter of the scale. 35 more patients were assigned to the control group who received blocking therapy. Peak pressure values of medial forefoot（ MFF）,lateral forefoot（ LFF）,midfoot（ MF）,medial heel（ MHEEL） and lateral heel（ LHEEL） were measured before and after treatment using Footscan USB2 System manufactured in RSscan Co. Ltd. Results There was no difference of MFF pressure in the two treatment groups before and after need-knife therapy,but pressures of LFF,MF,MHEEL and LHEEL showed significant differences between after and before treatement（ P < 0. 05）. In control group,the pressures of MFF,MF and MHEEL had no significant differences between before and after treatment,while that of LFF and LHEEL showed differences（ P < 0. 05）. Conclusion Needleknife surgery can effectively attenuate the plantar stress changes of the patients with calcaneodynia,and be benefit for recovery the normal lines of force of patients’ feet.关键词：needle-knife surgery;plantar pressure;arch of the foot;calcaneodynia
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发布时间：2021-05-20 - 摘要：Objective Based on the distribution rules of TCM patterns of bronchogenic carcinoma patients at first visit,the correlation between TCM patterns and bronchoscopy manifestation was studied to attempt to expand the TCM theory of Microscopic Syndrome Differentiation in the field of bronchoscopy.Methods Before treatment,176 patients were diagnosed using TCM Four Diagnostic Methods. Then the distribution of TCM patterns was got by using cluster analysis and factor analysis. 98 of 176 patients undergoing bronchoscopy were further studied to find out the correlation between their TCM patterns and bronchoscopy manifestation. Results The leading patterns of primary bronchogenic carcinoma were deficiency of qi and yin（ 35. 2%）,qi stagnation,blood stasis with dampness retention（ 24. 4%）,qi deficiency with phlegm- dampness（ 22. 2%）,yin deficiency（ 18. 2 %）. There were statistical differences of bronchoscopy manifestation in different patterns（ P < 0. 05） —hyperplasia in pattern of qi deficiency with phlegm-dampness and pattern of qi stagnation,blood stasis with dampness retention,infiltration in pattern of yin deficiency and pattern of deficiency of qi and yin. Conclusion The differences of bronchoscopy manifestation in different TCM patterns were proved.关键词：bronchogenic carcinoma;TCM pattern;bronchoscopy
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发布时间：2021-05-20 - 摘要：Objective To combine the functional quantitative indicators with the morphological imaging diagnosis by quantitative CT on chronic obstructive pulmonary disease（ COPD） patients,so as to provide the objective and quantitative indicators for TCM differentiation and for degrees of lung parenchyma injury. Methods A total of 75 COPD patients at stable stage with syndrome of lung-qi deficiency were divided into three groups（ mild,moderate,severe） in accordance with Clinical Guideline of New Drug for Traditional Chinese Medicine,and 20 more healthy people were recruited into healthy group. After lung CT scan,the multi-range imaging quantitative analysis was carried using the post-proceeding three-dimension technology. Then the CT quantitative indicators and the integral and rating of symptoms of patients were compared with the healthy subjects. Results Compared with the healthy group,the mean volume of each lung lobe,and proportion of emphysema volume increased in all three COPD groups. Furthermore,the more serious the symptoms were,the larger volumes of lung lobes and the more proportion of emphysema volume were. The proportion of emphysema volume in upper lobes or in right middle lobe were larger. Conclusion The correlation between the volume of lung lobes and emphysema and the degrees of integral of TCM symptoms were proved. And the introduction of the quantitative indicators could increase the objectivity and reliability of TCM treatment on COPD.关键词：chronic obstructive pulmonary disease;lung volume;integral of symptoms;CT technology
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发布时间：2021-05-20 - 摘要：<正>2015年10月21日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2014年"百种中国杰出学术期刊"称号,这是《北京中医药大学学报》连续第三次获得"百种中国杰出学术期刊"称号。2014年《中国科技期刊引证报告》（核心版）共收录中国科技核心期刊2 312种,《北京中医药大学学报》
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发布时间：2021-05-20 - 摘要：Objective To systematic review on Chinese medicines for recurrent spontaneous abortion（ RSA） by meta-analysis. Methods The literature was collected by computer retrieval on domestic database,manual retrieval on conference proceedings and information of pharmaceutical factories. According to the inclusive and exclusive criteria,tests were selected,data were extracted and evaluated and the systematic review was carried out by description analysis,the meta-analysis was conducted using Rev Man 5.3 software from Cochrane Collaboration. Results 15 studies with 1 051 cases were included. The following indicators in Chinese medicine group（ experiment group） were superior to those of control group（ P= 0. 00） —clinical efficiency[OR = 3. 92,95% CI（ 2. 11,7. 28） ],improvement of symptom score[WMD= 1. 83,95% CI（ 1. 77,1. 89） ],successful tocolysis rate[OR = 5. 55,95% CI（ 2. 29,13. 41） ],HCG levels[WMD = 10 791. 66,95% CI（ 8 644. 24,12 939. 08） ],negative rate of ACA[OR = 4. 13,95% CI（ 2. 05,8. 33） ],negative rate of Em Ab[OR = 3. 13,95% CI（ 1. 53,6. 39） ],CD3 antibody[WMD =-2. 48,95% CI（- 4. 73,- 0. 23） ],CD8 antibody[WMD = 0. 98,95% CI（ 0. 16,1. 79） ]. However,there was no significant difference in CD4 antibody[WMD = 1. 04,95% CI（- 0. 13,2. 22） ]（ P = 0. 08）.Conclusion Current evidence proves that Chinese medicine has advantages in treating RSA. Due to the bias from selection and detection,the argumentation intensity was loosen inevitably. So much more high quality randomized double-blind controlled trials are needed to provide more high quality evidence.关键词：Chinese medicines;recurrent spontaneous abortion;Meta-analysis;randomized controlled trial
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发布时间：2021-05-20 - 摘要：Objective To make a preliminary exploration on TCM syndrome elements of elderly patients with multi-system diseases. Methods A total 124 medical records of elderly patients with multi-system diseases were analyzed using SPSS software,of which count data were represented by the raw data and analyzed using Student’s test and the measurement data were represented by figure "0"or "1"and analyzed using Chi-square test. And TCM syndrome were input separately according to disease nature or disease location-"0"for none,otherwise "1". Results The frequency of disease nature elements from high to low was listed as the following: yin deficiency syndrome（ 65. 3%）, qi deficiency syndrome（ 58. 1%）,heat syndrome（ 41. 1%）,blood stasis syndrome（ 37. 9%）,qi stagnation syndrome（ 36. 3%）; that of disease location elements was listed as: spleen（ 54. 8%）,kidney（ 49. 2%）,liver（ 24. 2%） and lung（ 23. 4%）. 75% patients over 80 years suffered form qi deficiency,higher than50% patients less than 80 years old. The mean age of patients with qi deficiency syndrome was 77. 65 ±9. 98,while that of heat syndrome patients was 73. 14 ± 8. 44. The patients with qi deficiency syndrome were older than those without qi deficiency syndrome,and the patients with heat syndrome were younger than those without heat syndrome. The quantity of the disease in phlegm syndrome group was the most（ 6. 00 ± 1. 83）,and there was a significant difference compared with other groups. The elderly patients suffered from diabetes,coronary heart disease or chronic lung disease had more TCM syndrome elements and more complicated syndromes,and the patients with chronic gastritis had less TCM syndrome elements and less complicated syndromes. Conclusion The rule of TCM syndrome elements of elderly patients with multi-system disease is characterized by complexity,uncertainty and particularity.关键词：geriatrics;multi-system disease;TCM syndrome elements
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发布时间：2021-05-20 - 摘要：<正>为规范本刊作者投稿中参考文献的著录格式,根据2015年5月15日发布2015年12月1日开始实施的GB/T 7714—2015《信息与文献参考文献著录规则》和有关编辑出版的规定和要求,结合本刊长期以来采用的《顺序编码制》的特点,特制订《北京中医药大学学报》参考文献著录格式,希望作者遵照执行。
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发布时间：2021-05-20
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