最新刊期
卷 39 ， 期 7 ， 2016
- 摘要：<正>我出生在城市,为避战乱随母返乡,有3年的农村生活。5岁学做农活,亲历种子萌芽、间苗、中耕锄草、拔麦子、割谷子、掰玉米等,有过日出而做日落而息的务农体验,有与自然融合的感受。古代先贤有称"务农以成明医"之论确有道理。我是首届学中医的大学生。在读期间的教务长祝谌予先生,系京城名医施今墨的门婿,他幼承家学,青年时期东渡日本,就读帝国大学医科。建院初关键词：整合医学;中西医结合;中医现代化
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发布时间：2021-05-20 - 摘要：<正>2015年10月21日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2014年"百种中国杰出学术期刊"称号,这是《北京中医药大学学报》连续第三次获得"百种中国杰出学术期刊"称号。2014年《中国科技期刊引证报告》（核心版）共收录中国科技核心期刊2 312种,《北京中医药大学学报》2014年核心影响因子0.722,核心总被引频次2 235,综合评价总分78.30,总排名第102位,位居中医药大学
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发布时间：2021-05-20 - 摘要：Blood stasis pattern is a commonly-seen pattern in TCM clinical practice. The specific symptoms and diagnosis of blood stasis pattern were recorded in two TCM classics,Treatise on Febrile Diseases（ Shang Han Lun） and Synopsis of Golden Chamber（ Jin Gui Yao Lüe）,both written by Zhang Zhongjing,which provided important foundation for clinical research of blood stasis pattern. To provide a clear train of thought about the characteristics of blood stasis pattern described by Zhang Zhongjing,and to study the development and changes of blood stasis pattern diagnosis from Han Dynasty to modern times,this study systematically generalized statements about blood stasis pattern from those two books according to modern TCM diagnostics,summarizing and analyzing characteristics of blood stasis pattern by Zhang Zhongjing,and compared the diagnosis principles of blood stasis pattern in Treatise on Febrile Diseases（ Shang Han Lun） and Synopsis of Golden Chamber（ Jin Gui Yao Lüe） with reference to modern principles.关键词：blood stasis pattern;Treatise on Cold Damage（Shang Han Lun）;Synopsis of Golden Chamber（Jin Gui Yao lüe）;traditional Chinese medicine diagnosis
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发布时间：2021-05-20 - 摘要：This paper proposes a new theoretical system for pattern identification of warm diseases,which consists of causal pattern identification and mechanism pattern identification. Mechanism pattern identification can be further divided into basic mechanism,systematic and symptomatic pattern identification.Basic mechanism of warm diseases arises from conflict（ between healthy and pathogenic qi） and damage（ to healthy qi）. Heat is divided into flaming heat and stagnating heat in the former pathogenesis while it is divided into warm heat and damp heat in the latter one. Pattern identification methods such as the Defense,Qi,Nutrient,and Blood pattern identification and the Triple Energizer pattern identification should be integrated with the basic mechanism and symptomatic pattern identification,so that a more comprehensive theoretical system for pattern identification of warm diseases would be achieved,which would also help its clinical application.关键词：causal pattern identification;mechanism pattern identification;basic mechanism pattern i dentification;systematic pattern identification;symptomatic pattern identification
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发布时间：2021-05-20 - 摘要：<正>咳嗽是呼吸科患者最常见的症状,临床根据咳嗽发病的时间分为急性咳嗽、亚急性咳嗽和慢性咳嗽,其中咳嗽时间超过8周,且胸部X线检查无明显异常,以咳嗽为主要或惟一症状者,即所谓不明原因慢性咳嗽（简称"慢性咳嗽"）[1]。中医学认为慢性咳嗽属于"久咳""久嗽"范畴,外感六淫邪气迁延不愈、饮食不节、情志失调、他脏久病及肺或素体肺气不足等均可导致肺气失宣而作。临床表现为咳嗽关键词：慢性咳嗽;叶天士;脾胃;中医辨治
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发布时间：2021-05-20 - 摘要：Objective To provide theoretical basis for clinical treatment of diseases caused by dryness pathogen and to offer a new understanding of "yin-yang attribute of dryness pathogen"in traditional Chinese medicine（ TCM） by collecting and analyzing ancient and modern literature on yin-yang attribute of dryness pathogen using bibliometric methods. Methods After determining search terms and search criteria,literature before 1949 was retrieved from the electronic Chinese Medical Classics（ Fifth Edition）,and contemporary literature was collected from the CNKI database and Super Mobile Library to conduct statistics analysis. Results There were 36 entries identified in Chinese Medical Classics（ Fifth Edition） and34 entries from CNKI and Super Mobile Library,in which statements about the "yin-yang attribute of dryness pathogen"were varied. Conclusion According to the analysis,the viewpoint of "dryness pathogen belongs to yin"is better received than the opposite view,"dryness pathogen belongs to yang",and this study also offers supports for this view. Although the latter view is less popular,it still has clinical value.关键词：dryness pathogen;yin-yang attribute;bibliometric methods
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发布时间：2021-05-20 - 摘要：<正>为了更好地服务作者、读者,提高工作效率,《北京中医药大学学报》编辑部自2011年1月1日起开通网上采编系统（http://xb.bucm.edu.cn）,请广大作者和读者登陆本刊网址,随时通过此系统投稿、查稿、修改稿件或浏览最新目录等,首次登陆需先行注册。本刊创刊以来所有内容均可在线全文阅读。本刊不再接收电子邮件与纸版投稿,请作者、读者相互转告。
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发布时间：2021-05-20 - 摘要：<正>《证治心传》是一部几乎被湮没的温病学重要文献[1],该书在中国医学史上无记载,在温病学发展史上几乎无人提及。其为明代袁体庵遗著,史可法于崇祯十六年（公元1643年）作序,故推测其成书时间在1643年以前[2]（吴有性《温疫论》成书时间为公元1642年,2书成书时间相近）。继清代赵观澜加评后,民国年间刊行于《三三医书》。叶天士是温病学理论的重要奠基人之一,与《证治心传》在温病学理论思想及用药规律上有不关键词：证治心传;温病学;渊源
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发布时间：2021-05-20 - 摘要：Objective To investigate the anti-postmenopausal osteoporosis mechanism of Zhuanggu Zhitong Capsule（ Bone-strengthening Pain-relieving Capsule,ZGZTC） in regulating Treg / Th17 balance in bone tissue. Methods Seventy-two 8-month-old SD female rats were allocated randomly into sham operation group,model group,estradiol group（ 0. 21 mg / kg）,ZGZTC high-dose group（ 1. 28 g / kg）,ZGZTC medium-dose group（ 0. 64 g / kg） and ZGZTC low-dose group（ 0. 32 g / kg）. There were 12 rats in each group. Bilateral ovariectomy was performed on rats in all groups except for the sham operation group. After administration for 18 weeks,all rats were anaesthetized intraperitoneally with hydrazine hydrate. The content of E2,IL-10 and IL-17 A was measured with ELISA in left femur. Gene expression of Foxp3,RORγt,IL-17 A and IL-10 in right femur was detected by using RT-PCR,and the number of cell with RORγtor Foxp3 was counted with immunohistochemistry in left tibia. Results Zhuanggu Zhitong Capsule significantly increased E2 and IL-10 levels in bone tissue（ P < 0. 01）,reduced the level of IL-17 A in bone tissue（ P < 0. 05 or P < 0. 01）. It significantly increased the Foxp3 and IL-10 mRNA expression and inhibited the RORγtmRNA expression in bone tissue（ P < 0. 05）. The percentage of cell with Foxp3 was significantly increased by ZGZTC in bone tissue（ P < 0. 05）,and the percentage of cell with RORγtwas significantly reduced（ P < 0. 05 or P < 0. 01）. The ratio of Foxp3 to RORγtpresented a positive correlation with the E2level（ r = 0. 990 5,P < 0. 01）. Conclusion Zhuanggu Zhitong Capsule could downregulate the number and function of Th17,upregulate the number and function of Treg in bone tissue in ovariectomized rats partly via improving the E2 level.关键词：Zhuanggu Zhitong（Bone-strengthening Pain-relieving） Capsule;Treg / Th17;postmenopausal osteoporosis;rats
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发布时间：2021-05-20 - 摘要：Objective To analyze the effects of different kinds of Image Thinking on brain functional area by measuring alpha band electroencephalograph（ EEG） power. Methods 48 college students were enrolled and divided into two groups. Subjects in the experiment group received three kinds of Image Thinking intervention,while those in the control group did not receive any intervention. Alpha band absolute power of two groups was measured to compare and analyze. Results The alpha band absolute power value of the experiment group was higher than that in the control group at occipital lobe,parietal lobe,and temporal lobe in both active and resting state（ P < 0. 05）. The power in α frequency range was significantly different in three kinds of Image Thinking status. When imagining"I am rambling in the rose bushes",there was statistically significant difference in contralateral lead in（ FP1-FP2）,（ F7-F8）,（ C3-C4）,（ P3-P4）,（ T5-T6）,and（ O1-O2）（ P < 0. 05）. Moreover,power in the right hemisphere was higher than left hemisphere,and after active stage the power of occipital lobe reduced. When imagining "the spring sunshine is warm on my body""My every pore is breathing freely",there was statistically significant difference in contralateral lead in（ F7-F8） and（ P3-P4）（ P < 0. 05）. The alpha band absolute power increased at occipital lobe after active stage,then the power increased to peak at final resting state. Conclusion Image thinking exhibits a significant tranquilizing effect according to the reflection of the high power of alpha band at occipital lobe and parietal lobe. Different kinds of feeling effect caused by Image Thinking maybe related to the function of every brain area.关键词：Image Thinking;qigong;alpha band of EEG;tranquilization;brain area
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发布时间：2021-05-20 - 摘要：Objective To observe the effects of Mahuang（ Herba Ephedra） and Wuweizi（ Fructus Schisandrae） combined with dexamethasone（ DXM） on expression of angiogenic factors and inhibitors in rats with idiopathic pulmonary fibrosis（ IPF）. Methods Wistar male rats of SPF level（ n = 106） were divided randomly into sham operation group,model group,Mahuang group,Wuweizi group,Mahuang +DXM group,Wuweizi + DXM group and DXM group. The model of IPF was established by using instillation of bleomycin（ 7 mg / kg） except for the sham operation group. Each group was administered intra-gastrically of corresponding drug. All rats were sacrificed on the 7thand 28 thday via abdominal aorta blood-letting,and the pathological changes of lung tissue were evaluated with HE staining and the expression of hypoxia-inducible factors 1α（ HIF-1α）,platelet derived growth factor（ PDGF）,pigment epithelium-derived factor（ PEDF） and endostatin in rat serum were also measured with ELISA. Results Compared with the sham operation group,the expression of HIF-1α,PDGF,PEDF and endostatin in model group significantly increased（ P < 0. 01）; the HIF-1α content on the 28 thday was higher than that on the7 thday,and the PEDF and endostatin content were lower than that on the 7thday. The expression of HIF-1α and PDGF significantly decreased in Mahuang group and Wuweizi group compared with the model group,and the expression of PEDF and endostatin increased（ P < 0. 05）. Compared with Mahuang group on the 28 thday,the expression of HIF-1α and PDGF on the 7thday increased markedly,but the expression of PEDF and endostatin on the 28 thday was lower than those on the 7thday. In the Wuweizi group the changes in the expression of HIF-1α,PDGF,PEDF and endostatin were opposite to Mahuang group. The expression of HIF-1α and PDGF significantly decreased in Mahuang + DXM group and Wuweizi + DXM group compared with the model group（ P < 0. 05）,and the expression of PEDF and endostatin increased.In Wuweizi + DXM group the HIF-1α content was significantly higher than those in DXM group while the PEDF content was significantly lower（ P < 0. 05）. Conclusion Regulatory factors on angiogenesis lose their balance in rats with IPF. Mahuang and Wuweizi could achieve inhibition of the expression of HIF-1α and PDGF,and selectively promote the expression of PEDF and endostatin. When combined with DXM,the selectivity might be weakened in different pathological stages.关键词：Mahuang（Herba Ephedra）;Wuweizi（Fructus Schisandrae）;dexamethasone;idiopathic pulmonary fibrosis;angiogenesis;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the effects of Bushen Yifei Xiaozheng Decoction（ kidney-tonifying lung-boosting stasis-resolving decoction） on the expression of key genes and proteins in Casepase-12 signaling pathways in rats with idiopathic pulmonary fibrosis（ IPF）. Methods IPF was induced with bleomycin in rats except for the normal group. Pirfenidone was used as positive control,while Bushen Yifei Xiaozheng Decoction（ TCM） was administered during（ TCM preventive group） and after（ TCM treatment group） the model established and throughout the whole experiment（ TCM preventive and treatment group）. Pathological change in the rat lungs was observed with Masson staining,meanwhile the expression of molecular genes and proteins involved in Caspase-12 signaling pathways was detected by using Western blot and Real-time PCR. Results Masson staining revealed that the degree of fibrosis in TCM groups improved significantly and alveolar structure changed little. Protein and gene expression of Caspase-12 pathway in the model group was higher than those of normal group（ P < 0. 05）. In addition,the protein and gene expression of pirfenidone group and TCM groups were less than the model group（ P< 0. 05 or P < 0. 01）,especially TCM preventive and treatment group. Conclusion Bushen Yifei Xiaozheng Decoction could inhibit the process of pulmonary fibrosis via acting on the gene expression of Caspase-12 pathway and releasing the endoplasmic reticulum stress.关键词：Bushen Yifei Xiaozheng Decoction（kidney-tonifying lung-boosting stasis-resolving decoction）;idiopathic pulmonary fibrosis;endoplasmic reticulum stress;apoptosis pathways;Caspase-12;rats
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发布时间：2021-05-20 - 摘要：Objective To explore the immunoregulatory effect of Oldenlandia（ Hedyotis diffusa Villd.）,by investigating on the expression of macrophage cytokines and on TLR-4 inflammatory signal transduction pathway,aiming to propose a new experimental and theoretical evidence for the use of oldenlandia.Methods Three common cytokines,such as IL-6,MCP-1 and Cxcl1 in macrophage cells were detected by using RT-PCR after treatment with oldenlandia solution. Autodock software was used to analyze the correlation between the main components and TLR-4 so as to explore the mechanism of expression changes of the cytokines. Results Oldenlandia solution could upregulate the expression of Cxcl1,which might depend on the combination of TLR4 and stigmasterol-beta-D-glucoside,trans-4-methoxycinnamyl alcohol,and asperulosidic acid. Conclusion Oldenlandia could activate TLR-4 signal pathway and thus affect the expression of Cxcl1 and function of macrophage. It can be inferred that oldenlandia could regulate immunity,which could serve as the theoretical rationale for the development of new drugs in the laboratory.
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发布时间：2021-05-20 - 摘要：Objective To study the inhibitory effects on α-glucosidase（ AG） and aldose reductase（ AR） extracted from Potentilla parvifolia in different solvents,and to find out natural inhibitors of AG and AR. Methods With a combined vitro and vivo experiment design,this study measured the in vitro inhibitory effects of AG and AR extraction from Potentilla Parvifolia in three solvents: ethyl acetate（ total flavonoids）,petroleum ether and water through AG inhibitors and AR inhibitory activity screening models. In vivo effects of total flavonoids from Potentilla Parvifolia on impaired glucose tolerance of mice were also measured. Results Extraction of Potentilla Parvifolia in total flavonoids demonstrated a stronger inhibitory effect on AR and AG. Its inhibitory effect on AG was higher than that of acarbose. Meanwhile,both high and low dose of total flavonoids improved glucose tolerance in mice. Conclusion Total flavonoids in Potentilla parvifolia exhibits inhibitory effects on AG and AR.关键词：Potentilla parvifolia;α-glucosidase;aldose reductase;inhibitory activity;glucose tolerance
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发布时间：2021-05-20 - 摘要：Objective To investigate the influence of different decomposed combinations of Simiao Yong’an Decoction（ four-ingredient health-restoring decoction） on the extraction rates of liquiritin,hyperoside and luteoloside. Methods The extraction rates of liquiritin,hyperoside and luteoloside were determined with HPLC using a SunfireTMC18 analytical column（ 4. 6mm × 150 mm,5μm） in decomposed formula of Simiao Yong ’an Decoction. The mobile phase was composed of aqueous phosphoric acid（ 0. 1%） and acetonitrile using anisocratic elution. The column temperature was 35℃. The flow rate was1. 0 m L / min while the detection wavelength was set at 276 nm（ liquiritin） and 350 nm（ hyperoside and luteoloside）. The contents and the extraction rates of liquiritin,hyperoside and luteoloside from the original and dismantled formula were detected and analyzed. Results Compared with the single herb,the more ingredients it contained,the higher extraction rates of liquiritin,hyperoside and luteoloside. When the whole ingredients were stewed together,the extraction rates of these 3 components reached the peak.Conclusion The different decomposed Simiao Yong’an Decoction can significantly improve the extraction rates of liquiritin,hyperoside and luteoloside,which indicated the validity and rationality of compound compatibility from the extraction rates of chemical compositions.关键词：Simiao Yong’an Decoction（four-ingredient keeping health decoction）;prescription dismantlement;liquiritin;hyperoside;luteoloside;extraction rate
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发布时间：2021-05-20 - 摘要：Objective To evaluate the efficacy and safety of Shenfu injection in the treatment of bradycardia. Methods Randomized controlled trials（ RCT） on Shenfu injection treating bradycardiawas retrieved from CNKI database,Wanfang Database,VIP Database,CBM,Pub Med,EMbase,and Clinical Trials. gov. Cochrane Handbook was used to assess methodological quality,and data were analyzed using Rev Man5. 3 Software. Results 13 trials involving 978 patients were included into the analysis. The overall methodological quality was low as most studies were evaluated as B level and one study was C level.Meta- analysis showed that Shenfu injection was better than atropine（ RR = 1. 27,95% CI 1. 09 1. 48,P = 0. 002） in terms of the overall effect（ relief of symptoms and improvement of heart rate）,but there were no statistic difference between using atropine alone andusing Shenfu injection and atropine together（ RR = 0. 84,95% CI 0. 73 0. 97,P = 0. 30）. Compared with Shenfu injection in polarized solution,Shenfu injection can improve the clinical symptoms better（ RR = 0. 52,95% CI 0. 40 0. 67,P = 0. 01）,but there was no difference in the heart rate increase（ RR = 0. 57,95% CI 0. 32 1. 20,P = 0. 06）.Safety: Adverse reactions were reported in four studies,with dry mouth being the most common one.Conclusion In view of the quality of the current research,the efficacy of treating bradycardia with Shenfu injection cannot be ensured. In the future,high quality studies are needed to confirm the efficacy of Shenfu injection.关键词：Shenfu injection;bradycardia;systematic review;evidence-based medicine
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》已入编《中国学术期刊（光盘版）》。为此郑重声明如下:一、凡在《北京中药大学学报》发表的文章,如作者事先为表示异议,则相应地被编入《中国学术期刊（光盘版）》免收作者版面费。二、《中国学术期刊（光盘版）》免费向作者提供引文率统计资料。作者可通过所在单位设立的中国学术期刊文献检索咨询站查询,检索本人在《中国学术期刊（光盘版）》中发表论文的被引用情况;如本单位未设
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发布时间：2021-05-20 - 摘要：Objective To observe changes in the stimulating effects of micro-invasion catgut embedding on different acupoints in healthy human over time and location,providing reference data for interval period of micro-invasion catgut embedding,and To study the feasibility of MRI T2-mapping technology used to measure stimulating effect of embedding material. Methods Before and after the left acupoints sanyinjiao（ SP 6） and zusanli（ ST 36） were treated with micro-invasion catgut embedding on 8 healthy subjects,8 echo sequence images were collected by using MRI scan. Sources of 8-echo sequence images were sent to the work station to get T2-mappings,and test the T2 value on T2-mappings,analyzing the characteristics of T2 value with time variation while comparing the difference of catgut absorption in SP 6and ST 36. Results In both two acupoints,T2 values on the 8thhour,the 3th,the 7thand the 14 thday after being catgut-embedded were all higher than those at the time before catgut-embedding（ P < 0. 01）,T2 valuse on the 21 th,the 28 thand the 35 thday after being catgut-embedded presented with no significant difference compared with the time before catgut-embedding（ P > 0. 05）. After being catgut-embedded,the peaks of T2 value appeared on the 3thday. Peak of T2 value in ST 36 was higher than that in SP 6,and T2 value in ST 36 decreased in a curve steeper than that in SP 6. It both took 21 days for T2 value in two acupoints to decrease to the level before catgut-embedding. Conclusion Catguts absorption period in ST 36 and SP 6 are the same. If applying micro-invasion catgut-embedding in acupoints on normal body limbs at the same condition,the catgut-embedding interval period is probably about 21 days. MRI T2-mapping technology could be applied to observe stimulating effect of embedding material after acupoint embedding.关键词：embedded material;acupoints on normal body;stimulating effect;Catguts absorption period;magnetic resonance imaging（MRI） T2-mapping
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发布时间：2021-05-20 - 摘要：Objective To analyze the relationship between the clinical manifestations of TCM patterns and high-resolution CT（ HRCT） imaging features in primary Sjogren’s syndrome（ p SS） patients with interstitial lung disease（ p SS-ILD）. Methods A retrospective study on 75 cases with p SS-ILD was conducted to analyze the distribution of TCM patterns and chest HRCT staging and their correlation.Results Among 75 cases,there were three principal TCM patterns,which were deficiency pattern,excess pattern and deficiency-excess complex pattern. They could be further divided into 8 patterns in which and lung qi and yin deficiency pattern were the most frequent（ 29. 3%）,lung qi and yin deficiency with phlegm obstructing lung pattern（ 28%）. Correlation analysis showed that the more severe the lesion degree of HRCT imaging was,the more frequent the lung qi and yin deficiency pattern was（ 85. 7%,P =0. 020）. Conclusion TCM pathogenesis of p SS-ILD is a deficiency-excess complex pattern with a deficiency root and excess manifestation. There is certain relevance between TCM pattern and the lesion degree in HRCT imaging.关键词：Sjogren’s syndrome;interstitial lung disease;TCM patterns;chest high-resolution CT
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发布时间：2021-05-20 - 摘要：<正>为了实现科技期刊编辑、出版发行工作的一电子化,推进科技信息交流的网络化进程,我刊现已入网"万方数据——数字化期刊群"。所以,向本刊投稿并录用的稿件文字,将一律由编辑部统一纳入"万方数据——数字化期刊群",提供网络信息服务。凡有不同意者,请另投他刊。本刊所付稿酬包含刊物内容上网服务报酬,不再另付。"万方数据——数字化期刊群"是国家"九五"重点科技攻关项目,由国家科技部组织实施,原中国科技
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发布时间：2021-05-20 - 摘要：<正>随着中医药科研的发展,动物实验越来越显示出重要地位,也得到了迅速发展。近年来,动物实验报告在各期刊所占比重越来越大,但有研究[1]显示国内中医药动物实验报告存在较多问题,在一定程度上影响了其学术价值和社会价值。虽然目前中医药动物实验报告尚无标准,但2010年由国际实验动关键词：ARRIVE指南;动物实验报告;规范化;中医药
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发布时间：2021-05-20 - 摘要：<正>为规范本刊作者投稿中参考文献的著录格式,根据2015年5月15日发布2015年12月1日开始实施的GB/T 7714—2015《信息与文献参考文献著录规则》和有关编辑出版的规定和要求,结合本刊长期以来采用的《顺序编码制》的特点,特制订《北京中医药大学学报》参考文献著录格式,希望作者遵照执行。1文内引用参考文献的标注和著录原则与方法参考文献应限于作者直接阅读过的、最主要的、最新发表在正式出版物上的文献。未公开发表的内部文件和资料、二次文献不宜作参考文献引用。
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发布时间：2021-05-20
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