最新刊期
卷 40 ， 期 11 ， 2017
- 摘要：In order to summarize and discuss the current situation of speculative organon applied in theoretical research of traditional Chinese medicine（TCM）,the article analyses the characteristics of speculative organon,application status,research results,misunderstanding and a series of problems caused by these misunderstanding in TCM theoretical research. Although speculative organon has played a huge role in promoting the development of TCM theoretical research,there are still four problems:abuse of speculation; absence of justice and consensus inducing concept confusion; inaccurate grasp in applied range of speculative organon; and confusion with qualitative research method. It is conductive to choose correct research methods in scientific work,and it also has a positive significance for collating TCM textbooks,studying on TCM theory,TCM education and TCM theory development.关键词：speculative organon;traditional Chinese Medicine（TCM）;theoretical research
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发布时间：2021-05-20 - 摘要：Male reproductive system,especially the testicles,is highly sensitive to radiation rays. Small dose of ionizing radiation will lead to testicular injury,which results in spermatogenesis obstacle,and then causes temporary or permanent infertility. The theory of "preventive treatment of disease " in Chinese medicine,namely the ideas of prevention,has important guiding significance to prevent the reproductive system from being injured by radiation and to promote restoration. Before being radiated,the basic principle is to reinforce healthy qi and improve disease-resistant and recovery capability. The Chinese therapiesl with effects of tonifying Qi and blood,nourishing Yin and moistening dryness,replenishing kidney and nourishing essence are mainly used,and simultaneously assisting by medicinal with effects of purging heat and relieving toxin,clearing heat and engendering fluid,and cooling blood and stopping bleeding. After being injured by radiation,in order to prevent from deterioration and improve recovery,Chinese therapies which can invigorate kidney and liver,nourish essence and blood,soothe liver and strengthen spleen,and restore coordination between heart and kidney should be used with a view to the overall,at the same time,medicinal with effects of clearing heat and relieving toxin,engendering fluid,and activating blood and resolving stasis can be used complementally. Health care after being cured is very important as well,and a healthy life style should be maintained.关键词：radiation injury;preventive treatment of disease;male reproductive function
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发布时间：2021-05-20 - 摘要：The constitution of yang deficient is characterized by insufficiency-cold manifestations,and ranks the third position in biased constitution. The theory of yang-deficient constitution is sorted out from causes, physiological and psychological characteristics, distribution in people groups, incidence tendency,and formulas and medicinal for adjusting constitution on the base of achievements in the research of yang-deficient constitution for resent 10 years. The advancements and weaknesses in the study of yang-deficient constitution are found,which will provide reference for further studies.关键词：yang-deficient constitution;epidemiology investigation;document research;genomics;metabonomics
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发布时间：2021-05-20 - 摘要：There were in-depth studies and discussions on phlegm-fluid retention by many physicians at ancient times,among them Zhu Danxi’s doctrine of phlegm-fluid retention was the most famous with a considerable influence on later generations. Zhang Jingyue realized the quintessence of Zhu’s doctrine and dared to innovate. He put forward his own unique understandings on phlegm-fluid retention combined with his clinical experience and Zhu ’s doctrine, and had made a tremendous contribution to the development of diagnosis and treatment of phlegm-fluid retention. This paper discusses the exposition about phlegm-fluid retention in Danxi Xinfa（Danxi ’s Experiential Therapy） and Jingyue Quanshu（Complete Works of Jingyue）,and sorts out the similarities and differences between them after comparing and integrating their academic thought and features. The authors hope to get the true essence of doctrine of phlegm-fluid retention and provide guide for treatment of phlegm-fluid retention diseases in clinical practice.关键词：phlegm-fluid retention;Zhu Danxi;Zhang Jingyue
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发布时间：2021-05-20 - 摘要：About the pathogenesis of dawn diarrhea,medical experts of all dynasties consider that dawn diarrhea is induced by spleen-kidney yang deficiency,and fire failing to warm earth,so dawn diarrhea is also called "renal diarrhea",which can be treated with Sishen Wan（Four Miracle Pills） as a basic formula in clinical practice. However,after more thought,the authors fully understand the influence of liver on the occurrence of dawn diarrhea,which is the key of treatment from the chronomedicine perspective,though kidney has close relationship with the disease. The five watches of the night are in Yin Mao,which is subsumed to wood in the five elements,belongs to qi of shaoyang. At the time of five watches,qi of shaoyang sends up,and because of insufficiency of spleen,wood severely restricts earth,then dawn diarrhea occurs.关键词：dawn diarrhea;time medicine;Sishen Wan（Four Miracle Pills）;effulgent liver fire
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发布时间：2021-05-20 - 摘要：By comparing the formulas one by one between the Song’s revision edition and newly carved edition of Qianjin Yaofang（Essential Prescriptions Worth a Thousand Gold）,the authors find out that the Song’s people had adjusted the arrangement order of formulas in original book according to indications,changes of their realization to disease causes and classification,and new understanding on efficacy of formulas and medicinal. This repartition of formulas and indications reflected that the Song Dynasty had developed a deeper understanding on the therapeutic effect of Chinese medicinal,and given a more normative therapeutic system and more completed academic framework of Qianjin Yaofang,which showed the evolution of academic thought of Chinese medicine in the Song Dynasty.关键词：Song’s people;Qianjin Yaofang（Essential Prescriptions Worth a Thousand Gold）;compile style;academic system
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发布时间：2021-05-20 - 摘要：Objective To observe the stability of orthostatism and weight-bearing position,and range of motion（ROM） of vertical plane and coronal plane of thoracic vertebrae through measuring spinal forms before and after standing exercise, and explore the corrective effect of standing exercise on spine unbalance. Methods The university students（n = 30） were chosen as subjects,and divided into test group and control group. After standing exercise,the changes of thoracic intervertebral angles of spinal orthostatism and weight-bearing position,anterior flexion and posterior extension of vertical plane,and left bending and right bending of coronal plane were measured by using spinal measurement apparatus in2 groups. The measurement results were compared. Results The comparison results showed that the stability of 2 spinal positions and ROM of vertical plane and coronal plane had significant differences between 2 groups（P < 0. 05）. The ROM of coronal plane had greatly significant difference in test group before and after standing exercise（P < 0. 001）,and that has no difference in control group at the same time points. Conclusion The differences in the stability and ROM of thoracic vertebrae indicate that standing exercise can adjust the form of spine and correct spine unbalance.关键词：spine unbalance;standing exercise;thoracic measurement;qigong
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发布时间：2021-05-20 - 摘要：<正>10月31日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2016年"百种中国杰出学术期刊"称号,这是《北京中医药大学学报》连续第5次（2012、2013、2014、2015、2016年）获得"百种中国杰出学术期刊"称号。2016年《中国科技期刊引证报告》（核心版）自然科学卷共收录中国科技核心期刊1912种中文期刊和96种英文期刊,《北京中医药大学学报》2016年核心影响因子1.038,核心总被引频次2 659,综合评价总分
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发布时间：2021-05-20 - 摘要：Objective To discuss the effect and mechanism of Wuzi Yanzong Wan（Five Seeds for Multiplying Pills） in the proliferation of Sertoli cells in infant rats. Methods The Sertoli cells were separated from male SD rats（20 d old） and cultured,and then randomly divided into normal group,lowdose Wuzi Yanzong Wan group（5 g/L,low-dose group）,mid-dose Wuzi Yanzong Wan group（10 g/L,mid-dose group） and high-dose Wuzi Yanzong Wan group（15 g/L,high-dose group）. The changes of optical density（OD） of Sertoli cells were detected by using methyl thiazolyl tetrazolium test（MTT） in all groups. The expression of Ki67 positive granules in Sertoli cells were detected by using immunohistochemistry technique in all groups. The expressions of Akt and p-Akt in Sertoli cells were detected by using Western blot method. Results Compared with normal group,the proliferation of Sertoli cells treated with Wuzi Yanzong Wan was promoted significantly（P < 0. 05 or P < 0. 01）. The expression of Ki67 positive granules increased significantly（P < 0. 05 or P < 0. 01）,and relative expression of p-Akt increased significantly（P < 0. 05 or P < 0. 01）. Conclusion Wuzi Yanzong Wan can possibly promote the proliferation of Sertoli cells in infant rats through activating Akt signal transduction pathway and up-regulating p-Akt expression.关键词：Wuzi Yanzong Wan（Five Seeds for Multiplying Pills）;Sertoli cells;culture in vitro;proliferation;Akt signal transduction pathway;rats
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发布时间：2021-05-20 - 摘要：Objective To study the influence of Yiqi Huoxue Tongluo Fang（Qi-Replenishing BloodActivating Collateral-freeing Decoction） on signal pathway of c-jun N-terminal kinase（JNK） and inflammatory factors in mice with diabetic peripheral neuropathy（db/db mice）, and discuss its mechanism in protecting peripheral nerve. Methods The db/db mice（n = 40） were randomly divided into 5 groups: model group,lipoic acid group,high-dose Yiqi Huoxue Tongluo Fang group（6. 4 g/kg,high-dose group）,mid-dose Yiqi Huoxue Tongluo Fang group（3. 2 g/kg,mid-dose group） and low-dose Yiqi Huoxue Tongluo Fang group（1. 6 g/kg,low-dose group）,and other db/m mice（n = 8） were chosen into normal group. All groups were intragastrically given corresponding drugs once a day for 8 weeks. After the last administration of drugs, the plantar thermal response time and motor nerve conduction velocity（MNCV） were detected. The levels of interleukin-1β（IL-1β） and tumor necrosis factor-α（TNF-α） were detected by using enzyme-linked immunosorbent assay（ELISA）. The protein expressions of JNK and phosphorylase JNK（p-JNK） in dorsal root ganglion（DRG） were detected by using Western blot method. Results Compared with normal group,MNCV was slower,plantar thermal response time was longer,levels of IL-1β and TNF-α increased,and protein expressions of JNK and pJNK are stronger in model group（P < 0. 01 or P < 0. 05）. Compared with model group,Yiqi Huoxue Tongluo Fang promoted MNCV,shortened plantar thermal response time,decreased levels of IL-1β and TNF-α and down-regulated protein expressions of JNK and p-JNK to some extent（P < 0. 01 or P <0. 05）. Conclusion Yiqi Huoxue Tongluo Fang can inhibit the abnormal activation of JNK signal pathway and relieve inflammatory reaction to protect peripheral nerve in db/db mice.关键词：Yiqi Huoxue Tongluo Fang（Qi-Replenishing Blood-Activating Collateral-freeing Decoction）;db/db mice;diabetic peripheral neuropathy;JNK signal pathway;inflammatory factors
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发布时间：2021-05-20 - 摘要：Objective To investigate the influence of velvet antler polypeptides（VAP）-PLGA compound membrane formed from VAP and copolymer（PLGA） of polylactic acid（PLA） and polyglycolic acid（PGA） on regeneration of sciatic nerve in rats. Methods Healthy male Wistar rats（n = 36） were randomly divided into 4 groups（each n = 9）. The sciatic nerve of rat was revealed by operation,and was not treated in sham-operation group after isolating the nerve and sewed up directly broken ends in model group after cutting the nerve. The sciatic nerve of rat was sewed up and wrapped up with PLGA compound membrane in control group and the nerve was sewed up and wrapped up with VAP-PLGA compoundmembrane in treatment group. The samples were collected respectively on the 2 nd,4 thand 6 th weeks after the operation and given histological and immunohistochemical observation and detection.Results The histological observation showed that nervous axon was normal in sham-operation group at 3 time points. The quantity of medullated fibers was significantly more,and axon regeneration rate and maturity of regenerated axon were significantly higher in treatment group than those in model group and control group（P < 0. 05） at 3 time points. The immunohistochemical detection showed that the antigen staining and antigen expressions of transforming growth factor β（TGF-β） and insulin-like growth factor （IGF）in regenerated nerve fiber axon and myelin sheath were significantly higher in treatment group than those in sham-operation group,model group and control group（P<0.05）.ConclusionVAP-PLGA compound membrane can provide a microenvironment and neuroactive factors required by neural restoration,and promote the regeneration of peripheral nerve,which is an ideal biological material for neural restoration.关键词：velvet antler polypeptides;PLGA;peripheral nerve;nerve regeneration;rats
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发布时间：2021-05-20 - 摘要：Objective To investigate the protective and mechanism of tanshinone ⅡA（TS ⅡA） in oxidative stress damage of endothelial cells induced by oxidized low-density lipoprotein（ox-LDL） based on PI3K/Akt/mTOR autophagy pathway. Methods EA. hy926 cells were cultured in vitro,and then randomly divided into normal group,model group,ox-LDL + TSⅡAgroup,ox-LDL + TSⅡA+ LY294002 group,TS ⅡAgroup and LY294002 group. The content of malondialdehyde（MDA） and activity of superoxide dismutase（SOD） were detected by using chromatoptometry,autophagy status was observed by using FITC-LC3 fluorescence microscope and Naolive 3 D Cell Explorer Real-time Microscopic Imaging System,and meanwhile, expressions of autophagy-related proteins and PI3K/Akt/mTOR pathway proteins were detected by using Western Blotting. Results Compared with normal group,MDA content increased,SOD activity decreased and content of LC3-I/LC3-II protein increased in model group（P <0. 01）,and after TS ⅡAintervention,MDA content decreased,SOD activity increased and content of LC3-I/LC3-II protein increased（P < 0. 01）. Compared with normal group,protein expressions of PI3K,p-Akt and p-mTOR decreased significantly in model group（P < 0. 05 or P < 0. 01）. Compared with model group,protein expressions of PI3K,p-Akt and p-mTOR decreased significantly after TS ⅡA intervention（P < 0. 05 or P < 0. 01）. Compared with ox-LDL + TSⅡAgroup,content of LC3-I/LC3-II protein decreased and autophagy level decreased（P < 0. 01） after applying LY294002,an inhibitor of PI3K. Conclusion Tanshinone ⅡAmay improve autophagy through regulating PI3K/Akt/mTOR pathway to relieve the oxidative stress damage of EA. Hy926 cells and prevent atherosclerosis.关键词：tanshinone ⅡA;oxidized low-density lipoprotein;atherosclerosis;oxidative stress;autophagy
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发布时间：2021-05-20 - 摘要：ObjectiveTo observe the influence of Bugan Jianyao Fang（Liver-tonifying Lumbarinvigorating Decoction）on expressions of intervertebral disc matrix metalloproteinase-3（MMP-3）and tissue inhibitor of metalloproteinase-1（TIMP-1）in rats with lumbar disc degeneration.MethodsSD rats（n=75）were randomly divided into sham-operation group,model group,Yaobitong（Waist Impediment-Freeing Capsules）group,doxycycline（DOX）group and Bugan Jianyao Fang group（each n=15）.After establishing successfully the model of lumbar disc degeneration in rats,all groups were,respectively,given orally Yaobitong,DOX and Bugan Jianyao Fang.The expressions of intervertebral disc MMP-3 and TIMP-1 were detected in all group after and 20 d and 4 d after intervention.Results After intervention for 20 d and 40 d,the expressions of intervertebral disc MMP-3 and TIMP-1 decreased in Yaobitong group,DOX group and Bugan Jianyao Fang group compared with model group（P<0.05）.The difference in expressions of intervertebral disc MMP-3 and TIMP-1 had statistical significance in Yaobitong group,DOX group and Bugan Jianyao Fang group after intervention compared with those in the same groups before intervention（P<0.05）.The comparison among Bugan Jianyao Fang group,Yaobitong group and DOX group showed that the difference had no statistical significance（P>0.05）at all time points.ConclusionBugan Jianyao Fang can reduce the expressions of intervertebral disc MMP-3 and TIMP-1 in rats with lumbar disc degeneration,which may be one of mechanisms of Bugan Jianyao Fang preventing and curing lumbar disc degeneration.关键词：Bugan Jianyao Fang（Liver-tonifying Lumbar-invigorating Decoction）;intervertebral disc;degeneration;matrix metalloproteinase-3;tissue inhibitor of metalloproteinase-1;rats
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发布时间：2021-05-20 - 摘要：ObjectiveTo analyze the content of active components in fresh Danshen（Radix Salviae Miltiorrhizae,Red Sage Root）from different producing areas,and review reasonably the medicinal quality of fresh Danshen.Methods The content of 5 salvianolic acids and 12 tanshinones in fresh Danshen,from 7 different producing areas,were determined by applying LTQ-Orbitrap XL high-resolution mass spectrometer.On this basis,all content were analyzed by using principal component analysis（PCA）and partial least square（PLS）analysis.ResultsThe content of active components in fresh Danshen from the same producing area were basically the same,and difference was significant in content of active com-ponents among fresh Danshen from different producing areas. The content of salvianolic acids was the highest in fresh Danshen from Hubei,and content of tanshinone I and tanshinone IIAwere the highest in fresh Danshen from Sichuan and Henan. The analysis results of PCA and PLS showed that the distribution of most active components had a distinct regional specificity. Conclusion The difference is significant in quality of fresh Danshen from different producing areas,and they have a distinct regional specificity. Using fresh Danshen as quality evaluation materials,that is a useful supplement to review quality of raw medicinal materials based on dry herbs. It explored a new and more comprehensive approach for reviewing other Chinese medicinal materials.关键词：Danshen(Radix Salviae Miltiorrhizae;Red Sage Root);content determination;principal component analysis;partial least square analysis;variation
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发布时间：2021-05-20 - 摘要：<正>2017年10月31日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》入选"第四届中国精品科技期刊"即"中国精品科技期刊顶尖学术论文（F5000）"项目来源期刊。有效期:2017年10月-2020年2月。中国科学技术信息研究所根据中国精品科技期刊遴选指标体系综合评价结果,以《中国科技论文与引文数据库（CSTPCD）》中的论文和引文数据为基础,计算不同期刊的相关指标,采用定量分析和定性分析相
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发布时间：2021-05-20 - 摘要：Objective To probe into the influence of polysaccharides of Luotuopeng（Peganum harmala L.,Herb of Common Peganum） on toxicity of Poly Q accumulation in the muscle cells of AM141 strain of Caenorhabditis elegans（C. elegans）. Methods The polysaccharides of Luotuopeng were extracted by using water extraction followed by sequential alcohol deposition method, and the content of each precipitation was determined by using phenol-sulfuric acid method. The polysaccharides were added to medium,and then samples were collected for counting the number of fluorescence dots due to Poly Q-YFP accumulation in the muscle cells of C. elegans. The influence of the polysaccharides on toxicity of Poly Q accumulation in AM141 strain of C. elegans was reviewed. The precipitation precipitated by 60% ethanol with higher activity was purified by using macroporous resin for re-reviewing the activity. Results The mass fractions of the polysaccharides precipitated by 30% ethanol,60% ethanol or 80% ethanol were,respectively,20. 07%, 21. 80%, 19. 98%. The inhibition rates of the polysaccharides on the fluorescence dots due to Poly Q-YFP accumulation in the muscle cells of C. elegans were,respectively,7. 9%,17% and-1. 72%. After the precipitation precipitated by 60% ethanol purified with macroporous resin,the mass fractions of the polysaccharides,in 10% and 20% ethanol elution with higher mass fractions,were,respectively,49. 76% and 38. 26%,and the inhibition rates were,respectively,35. 25% and 18. 03%. Conclusion The method for reviewing the influence of the polysaccharides on toxicity of Poly Q accumulation through model of AM141 strain of C. elegans is easy,stable and reliable.The polysaccharide precipitated by 60% ethanol has the highest inhibitory effect on Poly Q accumulation with a dose-effect relationship.关键词：polysaccharides of Luotuopeng（Peganum harmala L. Herb of Common Peganum）;content determination;Caenorhabditis elegans;Huntington’s diseases;Poly Q
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发布时间：2021-05-20 - 摘要：Objective To investigate the typing characteristics of TCM excess pattern of primary bronchogenic lung cancer. Methods The diagnostic criteria for primary bronchogenic lung cancer were formulated after referring past relevant criteria and literature and combining past research achievements by Professor Zhang Peitong ’s research team. The unified pattern differentiation and classification were carried out in the patients with primary bronchogenic lung cancer（n = 135）. Results All 135 patients had manifestations of excess pattern,and the frequency of manifestations of excess pattern were,in an descending order,qi stagnation pattern,qi counterflow pattern,phlegm congealing pattern,and blood stasis pattern. There were 2（1. 48%） patients with single pattern and 133（98. 52%） with combination of 2 or more patterns. The frequency of 4-pattern combination,3-pattern combination and 5-pattern combination were higher. The frequency of in-pairs excess patterns,were qi stagnation pattern + qi counterflow pattern,qi counterflow pattern + phlegm congealing pattern,qi stagnation pattern + phlegm congealing pattern,qi stagnation pattern + blood stasis pattern,qi counterflow pattern + blood stasis pattern,and blood stasis pattern + phlegm congealing pattern. Conclusion Qi stagnation pattern and qi counterflow pattern dominate the occurrence and development of primary bronchogenic lung cancer. The combinations of multi-pattern are common and 4-pattern combination is the most common in the patients.The in-pairs excess patterns are qi stagnation pattern,qi counterflow pattern,phlegm congealing pattern and blood stasis pattern.
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发布时间：2021-05-20 - 摘要：Sjogren’s syndrome（SS）,named as dry impediment in Chinese medicine,has complex clinical symptoms. It is mostly caused by constitutional insufficiency,emotional disorder and improper diet combining external pathogen attack,resulting in dysfunction and interaction of five zang-organs,overconsumption and distribution dysfunction of yin,blood and fluid-humor,and failing to arrive at all limbs,bones and orifices. The paper elucidates the pathogenesis and diagnostic and therapeutic characteristics of dry impediment,and indicates the disease is related to all five zang-organs（heart,liver,spleen,lung,kidney） while most closely related to kidney,spleen and liver. The pathogenesis of the disease is based on deficiency of kidney yin and essence,and mainly dominated by dysfunction of spleen in transportation and block of liver’s free activity. The treatment of the disease,based on pattern differentiation,commonly use therapies of nourishing yin and tonifying kidney,fortifying spleen and tonifying qi, soothing liver and activating blood, clearing lung-heat and moistening dryness, and nourishing heart and tranquilizing mind,meanwhile matched with nourishing blood and engendering fluid,freeing collateral vessels and relieving pain,and clearing heat and eliminating dampness. Among these therapies,nourishing yin,tonifying qi and activating blood are keys in treatment.关键词：dry impediment;Sjogren’s syndrome;five zang-organs;pathogenesis;diagnosis and treatment
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发布时间：2021-05-20 - 摘要：<正>为规范本刊作者投稿中参考文献的著录格式,按照2015年5月5日发布2015年12月1日开始实施的GB/T 7714-2015《信息与文献参考文献著录规则》和有关编辑出版的规定和要求,结合本刊长期以来采用的《顺序编码制》的特点,特制订出《北京中医药大学学报》参考文献著录格式,希望作者遵照执行。1文内引用参考文献的标注和著录原则与方法参考文献应限于作者直接阅读过的、最主要的、最新发表在正式出版物上的文献。未公开发表的内
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发布时间：2021-05-20
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