最新刊期
      卷 40 ， 期 5 ， 2017
      • CHEN Guang,GAO Jialiang,WANG Jie
        Vol. 40, Issue 5, Pages: 357-361(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.001
        摘要：In order to illustrate the application principles and methods of the theory of life gate in hypertension treatment,following opinions were presented through analyzing ancient literature and summarizing clinical experience. Hypertension,in early stage,is related to excited state in the aspects of physiological function,pathological changes and pathogenesis,while the excited state can be induced by life gate deficiency failing to control fire in the body. The life gate deficiency failing to control fire in the body is divided into deficiency of genuine yin leading to frenetic stirring of the ministerial fire and floating upward of life gate brontosaurus fire. The former can be treated with Liuwei Dihuang Wan for nourishing life gate,inhibiting fire and guiding water,and the latter can be treated with Bawei Wan for warm-tonifying life gate and conducting fire back to its origin. And purifying one’s heart and limiting one’s desires as well as cherishing and nourishing one’s genuine yin and yang really make sense in prevention.  
        关键词：life gate;essential hypertension;Liuwei Dihuang Wan;Shenqi Wan;preventive treatment of disease   
        11
        |
        299
        |
        1
        <HTML>
        <引用本文> <批量引用> 9366060 false
        发布时间：2021-05-20
      • LI Xin,LIU Wei,TENG Jialin
        Vol. 40, Issue 5, Pages: 362-365(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.002
        摘要：The theory of assistant medications,proposed by Professor WANG Xinlu,is a new idea for the innovation of TCM theory under the environment of modern science and technology. The evolution,connotation,specific content and future direction and significance of assistant medications and theory of assistant medications have been systematically expounded. The direction of further research on theory of assistant medications has been pointed out in order to develop TCM basic theory,and obtain legal support in Chinese clinical medicine.  
        关键词：theory of assistant medications;WANG Xinlu;precision medicine;preventive treatment of disease   
        8
        |
        266
        |
        4
        <HTML>
        <引用本文> <批量引用> 9366047 false
        发布时间：2021-05-20
      • WANG Min,LI Yuhang
        Vol. 40, Issue 5, Pages: 366-370(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.003
        摘要：Ganmai Dazao Tang is a famous formula for hysteria in Jinguiyaolue（ Synopsis of the Golden Chamber）. The connotation of hysteria has been explored in the paper through summing up relative knowledge of medical practitioners in the successive dynasties. The pathogenesis of hysteria lies in function disorder of five viscera resulting in that five viscera fail to restrain their spirits,viscera spirits float and heart spirit is uneasy. Hysteria reflects the clinical pathological features of estrangement among qi,blood,yin and yang,and viscera spirits failing to be restrained and floating in the exterior. The combining and medicating laws of Ganmai Dazao Tang,and pathological features hysteria have been further analyzed according to principle of correspondence between formula-syndrome factors. The pharmacodynamic material basis of Ganmai Dazao Tang has been analyzed and the opinion of placebo efficacy has been negated according to the progresses in modern pharmacological research and clinical research. The combination of Ganmai Dazao Tang is rigorous,and similar to Guizhi Tang,the first one of all TCM formulas. These two formulas both are based on regulating yin and yang and widely applied in the clinic with significant curative effects.  
        关键词：Ganmai Dazao Tang;hysteria;correspondence between formula and syndrome factors   
        9
        |
        543
        |
        3
        <HTML>
        <引用本文> <批量引用> 9366038 false
        发布时间：2021-05-20
      • MA Fangfang,PAN Shixia,LIN Yin,XI Xi,ZHANG Cong,LIAO Yan,WANG Jing,LI Bing,WANG Yichen,KE Xiuhui
        Vol. 40, Issue 5, Pages: 371-375(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.004
        摘要：This article has analyzed the source and clinical significance of statement of "if keeping health,Zusanli（ ST36） frequently being given moxibustion"based on philology and medical principles.The statement was recorded in Suosuilu（ Trivial Details of Traditional Chinese Medicine） written in early Southern Song Dynasty,which was originally designed for preventing and curing wind diseases. The moxibustion on ST36 is to diffuse and unblock qi and blood of zang-fu organs,but is not to give festering moxibustion. If the statement is explained as repeated festering moxibustion,Yubaizhuang moxibution recorded in Beijiqianjinyaofang（ Essential Prescriptions Worth a Thousand Gold for Emergencies） and Bao moxibution recorded in Zhenjiuzishengjing（ Classic of Nourishing Life with Acupuncture and Moxibustion）used only in the condition of excessive yang deficiency will be misunderstood. Acupressure,frottage and foot bath can be selected in ST36 healthcare. Considering safety,some mild moxibustion therapies are recommended,such as suspended moxibustion and sandwiched moxibustion,in patients with obvious cold symptoms.  
        关键词：Zusanli（ST36）;wind diseases;moxibustion;health care   
        9
        |
        357
        |
        3
        <HTML>
        <引用本文> <批量引用> 9366020 false
        发布时间：2021-05-20
      • LIU Wenchen,GUO Shuwen,ZHENG Chenglong,WANG Hui,ZHANG Lu,WU Jiani,LIU Jun-li,HUANG Xiaolou,LI Fanghe,TAN Xiaobo,CAI Qian
        Vol. 40, Issue 5, Pages: 376-384(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.005
        摘要：Objective To investigate the myocardial expressions of protein kinase B（ Akt）/mammalian target of rapamycin（ m TOR） signaling pathway and effective mechanism of Yiqi Huoxue Fang depending on model of myocardial ischemia. Methods The model of acute myocardial infarction（ AMI） was established through ligation of left coronary anterior descending branch in SD rats,and randomly divided into model group,perindopril group,Qishen Yiqi Gutta Pills group,Yiqi Huoxue Fang group and shamoperation group,and all groups were given orally corresponding medications respectively 2 d afteroperation. The observation time points were set on the 7th d and 28 th d. The changes of heart function and structure were detected by using ultrasonic testing,changes of myocardial pathomorphology were observed after HE staining,and expressions of Akt,m TOR,p-Akt and p-m TOR in infarction marginal zone were detected by using Western blot test,real-time fluorescence quantitative polymerase chain reaction（ RTPCR） and immunohistochemistry technique in all groups. Results The level of left ventricular ejection fraction（ LVEF） and left ventricular fraction shortening（ LVFS） decreased significantly in model group compared with sham-operation group on the 7th d and 28 th d（ P < 0. 01）. The level of left ventricular end-systolic volume（ LVESV） increased significantly on the 7th d（ P < 0. 01）,and levels of LVESV and left ventricular end-diastolic volume（ LVEDV） increased significantly（ P < 0. 01） on the 28 th d in model group. The levels of LVEF and LVFS increased and levels of LVEDV and LVESV decreased significantly in all medicated groups compared with model group（ P < 0. 01）. The thinner ventricular wall,less cardiomyocytes,disorder myocardial cells arrangement and inflammatory cell infiltration were observed in infarction marginal zone in model group, and disorder myocardial cells arrangement and less cardiomyocytes were observed in all medicated groups. The ratio of p-Akt/Akt and p-m TOR/m TOR increased（ P < 0. 05）,expressions of Akt m-RNA and m TOR m-RNA increased significantly（ P <0. 01）,and levels of p-Akt and p-m TOR positive cell rates increased significantly（ P < 0. 01） in model group. The ratio of p-Akt/Akt and p-m TOR/m TOR increased（ P < 0. 05）,expressions of Akt m-RNA and m TOR m-RNA increased（ P < 0. 05 or P < 0. 01）,and levels of p-Akt and p-m TOR positive cell rates increased significantly（ P < 0. 05） in all medicated groups. Conclusion Yiqi Huoxue Fang can improve heart function and protect myocardial cells through activating cardiac self-protective mechanismAkt/m TOR signaling pathway in rats with myocardial infarction.  
        关键词：acute myocardial infarction;Yiqi Huoxue Fang;Akt/mTOR signaling pathway;rats   
        9
        |
        306
        |
        4
        <HTML>
        <引用本文> <批量引用> 9366000 false
        发布时间：2021-05-20
      • LIU Xiao,ZHANG Geng,LIU Tao
        Vol. 40, Issue 5, Pages: 385-391(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.006
        摘要：Objective To investigate the influence of medicated cerebrospinal fluid of modified Sanjia San on inflammatory reactions of BV2 microglia cells induced by lipopolysaccharide（ LPS）. Methods BV2 microglia cells were divided into blank control group,model group,three modified Sanjia San groups and huperzine group. After the cells cultured and adhered to wall,modified Sanjia San groups and huperzine group were,respectively,given medicated cerebrospinal fluid（ 10. 0%,5. 0%,2. 5%,10.0%） and incubated at 37 ℃ for 2 h. Except of blank control group,all groups were given LPS（ 1 mg/L as final concentration） and incubated continuously for 24 h,and then supernatant was collected for extracting protein samples. The content of nitric oxide（ NO） in supernatant was detected by using nitrate reductase method in all groups. The content of inducible nitric oxide synthase（ NOS）,interleukin-1β（ IL-1β） and tumor necrosis factor-α（ TNF-α） in supernatant were detected by using enzyme-linked immunosorbent assay（ ELISA） in all groups. The expressions of c-Jun N-terminal kinase（ JNK） and phospho-c-Jun N-terminal kinase（ p-JNK） were detected by using Western blot test in all groups. Results The content of supernatant NO,i NOS,IL-1β and TNF-α increased significantly,and expression of pJNK was up-regulated in model group. The content of supernatant NO,i NOS,IL-1β and TNF-α decreased significantly,and expression of p-JNK was down-regulated in 10. 0% and 5. 0% modified Sanjia San groups. Conclusion The medicated cerebrospinal fluid of modified Sanjia San has the regulative effect on inflammatory reactions of BV2 microglia cells induced by LPS,and the mechanism may be related to the controlling of p-JNK expression and reducing of generation of inflammatory media.  
          
        9
        |
        204
        |
        2
        <HTML>
        <引用本文> <批量引用> 9365988 false
        发布时间：2021-05-20
      • Liu Jian,WANG Yuhong,Han Yuanshan,XU Yalan,Liu Lin,Yang Hui,LI Wei,XIANG Yun
        Vol. 40, Issue 5, Pages: 392-398(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.007
        摘要：Objective To investigate the influence of Zuogui Jiangtang Jieyu Fang（ ZJJF） on hippocampus neuron synaptic plasticity related proteins-Ca MKⅡ and Syn Gap in rats simulated diabetes complicating depression DD. Methods The hippocampus neurons were primitively isolated,purified and cultured in SD rats. The DD model was established by applying intervention of high glucose and cortisone. The cultured hippocampus neurons were randomly divided into normal group,model group,medicated serum of ZJJF（ ZJJF group）,medicated serum of positive drug（ fluoxetine and metform）group（ positive drug group） and blank group. The damages of hippocampus neurons were detected by using Nissl’s staining in all groups,and expressions of Ca MKII and Syn Gap were detected by using immunofluorescence staining and high-content analysis（ HCA） after drug intervervention for 18 d.Results Compared with normal group and blank group, the quantity of Nissl bodies decreased significantly,neural network and dentritic spines ruptured or disappeared,and expressions of Ca MKII and Syn Gap were significantly down-regulated in model group（ P < 0. 01）. Compared with model group,the quantity of Nissl bodies, neural network and dentritic spines, and synaptic connection were significantly recovered,and expressions of Ca MKII and Syn Gap were un-regulated in positive drug group and ZJJF group（ P < 0. 01 or P < 0. 05）. Conclusion ZJJF had significant regulative effect on Ca MKII and Syn Gap in simulated condition of diabetes complicating depression,which may be one of important mechanisms of ZJJF antagonizing cellular damage and neural degeneration.  
        关键词：diabetes complicating depression;cell culture;hippocampus neurons;Zuogui Jiangtang Jieyu Fang;calmodulin dependent protein kinase Ⅱ;SynGap;rats   
        8
        |
        271
        |
        3
        <HTML>
        <引用本文> <批量引用> 9365967 false
        发布时间：2021-05-20
      • WANG Lin,PEI Ling-yan,KE Yushi,CUI Jian,LI Shucun
        Vol. 40, Issue 5, Pages: 399-404(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.008
        摘要：Objective To discuss the influence of Mongolia medicine-Garidi San on helper T cell 1（ Th1） and helper T cell 17（ Th17） in rats with ulcerative colitis（ UC）. Methods All rats were randomly divided into normal group,model group,low-dose Garidi San group（ low-dose group）,mid-dose Garidi San group（ mid-dose group）,high-dose Garidi San group（ high-dose group）,sulfasalazine group（ SSZ group） and Bupi Yichang Wan group. The UC model was induced and established by using immune method and TNBS. Garidi San was orally given to,respectively,low-dose group（ 1. 76 g/kg）,mid-dose group（ 3. 51 g/kg） and high-dose group（ 7. 02 g/kg）,SSZ was given to SSZ group（ 3. 60 g/kg）,and Bupi Yichang Wan was given to Bupi Yichang Wan group（ 1. 62 g/kg）. After 4 weeks the samples of peripheral blood were collected from all groups. The ratio of Th1 to Th17（ Th1/Th17） in peripheral blood was observed by using flow cytometry,and levels of PB transforming growth factor β（ TGF-β）,interleukin-6（ IL-6）,interleukin-17（ IL-17） and interferon-γ（ IFN-γ） were detected by using enzyme-linked immunosorbent assay（ ELISA）. Results The level of TGF-β was decreased significantly in mid-dose group,low-dose group and SSZ group. The levels of serum IL-6 and IL-17 were decreased significantly（ P < 0. 05）,level of IFN-γ was increased（ P < 0. 05）,and Th1/Th17 was increased（ P < 0. 05） in all medication groups. Conclusion Garidi San can regulate the differentiation direction of helper T cell 0,and recover the balance of Th1/Th17 in UC rats,which may be one of mechanisms of Garidi San curing UC.  
        关键词：Garidi San;ulcerative colitis;helper T cell 1;helper T cell 17;rats   
        10
        |
        119
        |
        2
        <HTML>
        <引用本文> <批量引用> 9368088 false
        发布时间：2021-05-20
      • JIN Xiaofei,ZHOU Xiaohong,WU Mishan,ZHANG Ying,ZHAO Yanmeng,LI Yuan,WU Zeng,GAO Weijuan
        Vol. 40, Issue 5, Pages: 405-412(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.009
        摘要：Objective To study the inhibitory effect of astragaloside IV（ AST） on the apoptosis of PC12 cells induced by oxygen-glucose deprivation/oxygen-glucose rehabilitation（ OGD/OGR） through activating autophagy. Methods PC12 cells in logarithmic phase were collected and randomly divided into normal group,OGD/OGR group（ model group）,AST solvent control group（ DMSO group）,AST group,AST + autophagy inhibitor group（ AST + 3-MA group）,3-MA group and autophagy activator group（ RAPA group）. Except of normal group,all other groups were given treating of OGD for 3 h and then OGR for 12 h and simultaneous medication treating. The morphological changes of autophagosomes were observed by using transmission electron microscope（ TEM）,expressions of LC3 II,Beclin1 and Caspase-3were detected by using Western blotting,and apoptosis of PC12 cells were detected by using flow cytometry after TUNEL staining. Results Compared with normal group,the typical autophagosomes were observed,expressions of LC3 II,Beclin1 and Caspase3 increased,and apoptosis rate and apoptosis increased（ P < 0. 05）. Compared with model group,the quantity of autophagosomes and expressions of LC3 II and Beclin1 increased（ P < 0. 05）,and expression of Caspase3 and apoptosis rate and apoptosis decreased in AST group and RAPA group（ P < 0. 05）. Compared with model group,the quantity of autophagosomes and expressions of LC3 II and Beclin1 decreased（ P < 0. 05）,and expression of Caspase3 and apoptosis rate and apoptosis increased in 3-MA group（ P < 0. 05）,while DMSO group and model group had no significant difference（ P > 0. 05）. Compared with AST group,the quantity of autophagosomes and expressions of LC3 II and Beclin1 decreased（ P < 0. 05）,and expression of Caspase3 and apoptosis rate and apoptosis increased in AST + 3-MA group and 3-MA group（ P < 0. 05）. Conclusion AST play a neuroprotective role through activating autophagy and inhibiting apoptosis of PC12 cells induced by OGD/OGR.  
        关键词：astragaloside;autophagy;apoptosis;PC12 cells;oxgen-glucose deprivation/oxgenglucose rehabilitation   
        13
        |
        382
        |
        4
        <HTML>
        <引用本文> <批量引用> 9365949 false
        发布时间：2021-05-20
      • GUO Xiao,GUO Rongjuan,XING Jia,WANG Jialing,YUAN Qingjie,WANG Jianwei,GAO Wei
        Vol. 40, Issue 5, Pages: 413-419(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.010
        摘要：Objective To study the therapeutic effect of Ningxin Anshen Fang on insomnia,and regulative mechanism to the metabolic loop of glutamic acid（ Glu）/γ-aminobutyric acid（ GABA）-glutamine（ Gln）. Methods The model of insomnia was established by using modified multiple water platform sleep deprivation method in rats,and then all rats were randomly divided into normal group,model group,diazepam group,Ningxin Anshen Fang low-dose group（ low-dose group）,Ningxin Anshen Fang mid-dose group（ mid-dose group） and Ningxin Anshen Fang high-dose group（ high-dose group）. The general conditions were observed,sleep latency and sleep duration were observed by applying pentobarbital sodium（ PS） cooperative sleep test,and model and curative effect of Ningxin Anshen Fang on insomnia were reviewed. The content of Glu and GABA in brainstem and hypothalamus was detected by using high performance liquid chromatography（ HPLC）. The expressions of glutamic acid decarboxylase（ GAD） and astrocyte glutamine synthetase（ GS） in brainstem and hypothalamus were detected by using Western blot experiment. Results The sleep latency was significantly shortened,sleep duration was prolonged,GABA level in brainstem and hypothalamus was increased and ratio of Glu to GABA（ Glu/GABA） was decreased by Ningxin Anshen Fang in insomnia rats. The expression of GAD in brainstem and hypothalamus was significantly promoted in all Ningxin Anshen Fang groups. Conclusion Ningxin Anshen Fang can affect the synthesis and decomposition Glu and GABA and expressions of Glu and GABA,and normalize the excitotary/inhibitory metabolic imbalance of Glu/GABA through regulating Glu/GABAGln metabolic loop,which may be related to that Ningxin Anshen Fang has the curative effects of calming heart and tranquillizing mind,and sedation and hypnosis.  
        关键词：glutamic acid;γ-aminobutyric acid;calming heart and tranquillizing mind;insomnia;rats   
        14
        |
        611
        |
        14
        <HTML>
        <引用本文> <批量引用> 9365932 false
        发布时间：2021-05-20
      • KONG Jing,HE Jing,TAN Li,SHEN Lifeng,LI Qian,ZHANG Yuanyuan,LV Shan,WU Qi-uhong,CHEN Mengjie,LIU Lu,LI Wenxia,LU Dongbo,SHI Renbing,JIANG Yanyan
        Vol. 40, Issue 5, Pages: 420-427(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.011
        摘要：Objective To establish a method of high performance liquid chromatography（ HPLC） for simultaneously determining of 7 nucleoside（ uracil,cytidine,uridine,adenine,guanosine,adenosine and 2’-deoxyadenosine） in Aurea helianthus,and conduct the relevant analysis and review on quality of Aurea helianthus. Methods HPLC-PDA was applied for determining 7 nucleosides in Aurea helianthus.The quality representation of 11 batches of Aurea helianthus was carried out and representation results were given relevant analysis based on the content of index components and index component adducts from7 nucleosides. Results The linear relations of 7 nucleosides were good,and precision,stability,repeatability and sample recoveries were all accorded with the requirements of methodology determination.The content of 7 nucleosides in 11 batches of Aurea helianthus was determined by using the established method. Taking batch lot 1 of Aurea helianthus as criterion material,the content of index components was higher in batch lot 2,6,9,10 and 4,and relevancy was the highest among criterion Aurea helianthus and batch lot 6,9,8,4,3 and 11. The comprehensive review showed that excellent degrees of batch lot1,2,6,9 and 4 were in the lead. Conclusion The established method for determining content of nucleosides in Aurea helianthus and correlation analysis mode of quality representation can analyze overall quality relevancy and application validity,which provides the reliable evidence for quality control and review of Aurea helianthus.  
        关键词：Aurea helianthus;nucleosides;high performance liquid chromatography;content determination;relevant analysis;quality review   
        11
        |
        245
        |
        3
        <HTML>
        <引用本文> <批量引用> 9365906 false
        发布时间：2021-05-20
      • BU Zhengxiang,LUO Xiaozhou,TANG Chunzhi
        Vol. 40, Issue 5, Pages: 428-435(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.012
        摘要：Objective To analyze the curative effect of acupuncture-moxibustion on optic atrophy by applying network Meta-analysis model based on frequency-statistic data filling strategy. Methods The databases of Cochrane Library,Pub Med,EMbase,AMED,Nature,Science Online,World Sci Net,CBM,CNKI and Wan Fang Database were retrieved with computer for collecting RCT/CCT literature from database establishing time to Jun. 2016. The review on quality and bias risk of every included study were conducted by 2 researchers according to 5. 1. 0 standard in Cochrane Handbook. Results There were totally 16 studies involving 1 369 samples included. The results of network Meta-analysis showed that the possibility of the best curative effect of each therapy was respectively as follows: Western drug（ 10. 5%）,acupuncture（ 5. 9%）,acupuncture + moxibustion（ 4. 4%）,ear acupoints + Chinese medications（ 4. 7%）,electro-acupuncture（ 8. 0%）,acupuncture + Chinese and Western medications（ 4. 9%）,moxibustion + Western medications（ 3. 2%）,electro-acupuncture + Chinese and Western medications（ 4. 3%）,Chinese and Western medications（ 10. 1%）,Chinese medications（ 6. 7%） andacupuncture + Western medications（ 3. 4%）. The results indicated that the curative effect of Western medications was the best. Acupuncture + Western medications had advantages compared with only Western medications,and difference in odds ratio had statistical significance. In terms of safety,the safety evaluation could not be confirmed because none of the included literature described the occurrence of adverse events. The modern medical studies on the mechanism of acupuncture in treatment of optic atrophy were relatively less,so it was unable to judge the modern medical mechanism. Conclusion Western medications, Chinese and Western medications and electro-acupuncture may be the best therapies for optic atrophy,but the exact conclusion still needs to be verified further by high-quality clinical researches.  
        关键词：optic atrophy;acupuncture-moxibustion;network Meta-analysis   
        8
        |
        836
        |
        2
        <HTML>
        <引用本文> <批量引用> 9365896 false
        发布时间：2021-05-20
      • LU Zhengyu,LU Lingdan,ZHU Dongyu,XU Qiang,CHEN Jie,ZHAO Hong
        Vol. 40, Issue 5, Pages: 436-441(2017) DOI: 10.3969/j.issn.1006-2157.2017.05.013
        摘要：Objective To observe the clinical efficacy of Pingchan Yisui Fang on Parkinson’s disease complicated with mild cognitive impairment（ PD-MCI） of type of marrow sea deficiency. Methods The patients with Parkinson ’s disease complicated with mild cognitive impairment（ PD-MCI） of type of marrow sea deficiency（ n = 103） were randomly divided into control group and Chinese medicine group（ CM group）,and control group was given basic treatment of Western medicine and CM group was additionally given Pingchan Yisui Fang for 36 weeks. The curative effect was reviewed by using Unified Parkinson ’s Disease Rating Scale（ UPDRS）,Montreal Cognitive Assessment Scale（ Mo CA） and Minimum Mental State Examination（ MMSE） before and after treatment. Results The scores of UPDRSwere significantly lower（ P < 0. 05）,and scores of Mo CA and MMSE were significantly higher（ P <0. 01） in CM group than those in control group after treatment. The factor scores of attention,abstract ability,delayed recall and orientation in Mo CA,and orientation,memory ability,attention and recall ability in MMSE were significantly higher in CM group than those in control group（ P < 0. 05 or P <0. 01） after treatment. Conclusion Pingchan Yisui Fang can effectively relieve motor symptoms and cognitive disorder on the base of standardized treatment of Western medicine in patients with PD-MCI.  
        关键词：Parkinson’s disease;mild cognitive impairment;treatment integrated Chinese and Western medicine;Pingchan Yisui Fang   
        8
        |
        245
        |
        2
        <HTML>
        <引用本文> <批量引用> 9364664 false
        发布时间：2021-05-20
      0