最新刊期
卷 41 ， 期 10 ， 2018
- 摘要：The triple burners（ Sanjiao） and the four qi paths（ Sijie） are the major cavities and spaces in the human body. They are the most important spaces to accommodate and distribute the defensive qi（ weiqi）. Triple burners are body cavities: the upper burner（ Shangjiao） is the mediastinum; the middle burner（ Zhongjiao） is the peritoneal cavity; and the lower burner（ Xiajiao） is the general term for the retro-peritoneal cavity. Consistent with modern anatomical nomenclature,Huangdi Neijing（ Huangdi’s Internal Classic） named the retro-peritoneal cavity in two terms: lower burner（ Xiajiao） and Sanjiao.Xiajiao referred to the perirectal space and Sanjiao referred to retro-peritoneal space. The retroperitoneal space is renamed as "retro-Sanjiao"in this article in order to differentiate the general term of Sanjiao when it refers to the three body cavities. The lower burner is the base of the generation,accumulation and distribution of the defensive qi. Four qi paths are the extension of the upper and lower burners. The abdominal qijie corresponds to extraperitoneal fascia,and the leg qijie refers to the anterior and posterior osteofascial sheathes. The pectoral qijie is equivalent to the endothoracic fascia,and the head qijie refers to retropharyngeal space and prevertebral space etc. Triple burners and meridians are the spaces and routes for the distribution and circulation of defensive qi. Once there is an obstruction in the four extremities,one of the four qi path will open and engage to relieve the pressure of defensive qi,and eventually will involve all of four qi paths. Therefore,it is necessary not only to stimulate the points related to four qi paths,but also has to resolve the obstruction in the body extremities in order to regain the normal circulation of the defensive qi.关键词：triple energizers;four qi paths;defensive qi;qi thoroughfare
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发布时间：2021-05-20 - 摘要：<正>2017年10月31日,中国科学技术信息研究所（ISTIC）在北京召开中国科技论文统计结果发布会,《北京中医药大学学报》荣获2016年"百种中国杰出学术期刊"称号,这是《北京中医药大学学报》连续第5次（2012、2013、2014、2015、2016年）获得"百种中国杰出学术期刊"称号。2016年《中国科技期刊引证报告》（核心版）自然科学卷共收录中国科技核心期刊1 912种中文期刊和
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发布时间：2021-05-20 - 摘要：With regard to "exterior",it is generally considered that this entity refers to the muscle and surface of human body. In fact,according to the depth of human tissue and the connection with the outside world,the exterior can be further refined into "the surface of exterior","the lining of exterior","the surface of interior". The skin,hair and muscle are in direct contact with the outside world. The outermost layer of the human body is "the surface of exterior"; the meridians,bones,and blood vessels is deeper than the surface of the exterior,and it is not directly connected with the outside world. So it is the human body "the lining of exterior"; human internal organs that communicate directly with the outside world are the"the surface of interior". The defensive function of the"exterior"is the embodiment of the defensive qi（ weiqi） function,and the function of the defensive qi depends on the "exterior"of the tangible entity. This "exterior"entity division can broaden the scope of application of exterior-resolving method and wind-expelling medicinals,and enrich the theory of external treatment.关键词：exterior;the surface of exterior;the lining of exterior;the surface of interior;wind-expelling medicinals
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发布时间：2021-05-20 - 摘要：This paper discusses the relationship with the manifestations of granulomatous lobular mastitis and phlegm dampness constitution in traditional Chinese medicine based on the "phlegm pathogen causing diseases"and features of phlegm pathogen. The clinical manifestations of granulomatous lobular mastitis are varied. Phlegm is involved in the whole process of granulomatous lobular mastitis. The authors conclude that granulomatous lobular mastitis is a mass disease caused mainly by phlegm affecting the skin. In clinical practice,diagnosis should be focused on phlegm,treating the kidney,spleen and liver. The combination of pattern diagnosis and constitution differentiation could ensure a better clinical efficacy. This paper could be used as references for the theory development and clinical treatment of granulomatous lobular mastitis.关键词：granulomatous lobular mastitis;phlegm pathogen causing disease;disease development
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发布时间：2021-05-20 - 摘要：Prescription worth thousand gold（ Beiji Qianjin Yaofang） contains numerous data of pattern,medicinals,and formulae. This paper summarizes how Chinese medicinals are used in 30 formulae in the chapter of amenorrhea by using data mining and literature analysis. The key mechanism of amenorrhea is accumulation of static blood with pathogens of cold,heat,phlegm or qi stagnation. Qi and blood deficiency is often combined as well. The symptoms are amenorrhea,abdominal qi stagnation or masses,abdominal pain and abnormal leucorrhea. Treatment method used is breaking and expelling blood stasis mainly. The following treatment methods may also be combined depending on the manifestations:warming meridians to dissipate coldness,resolving and dissipating masses and binds,clearing pathogenic heat,expelling phlegm and draining water,tonifying qi and blood. Preparing and administering methods corded in the book are of guidance in clinical practice.关键词：Prescription worth thousand gold;amenorrhea;characteristics of herb and formula used
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发布时间：2021-05-20 - 摘要：<正>2016年10月26日中国高校科技期刊研究会发布《关于公布2016年度中国高校杰出·百佳·优秀科技期刊入选名单的通知》,按照2016年度中国高校杰出·百佳·优秀科技期刊遴选方案,经中国高校科技期刊研究会常务理事会议审定,共选出中国高校杰出科技期刊20种（其中英文科技期刊10种）、中国高校百佳科技期刊104种、中国高校优秀科技期刊254种。《北京中医药大学学报》被评为中国高校百佳科技
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发布时间：2021-05-20 - 摘要：The concept and historical evolution of meridian theory in the Song Dynasty and dynasties before Song are clarified. After investigating the chapters of meridian theory in Tongren Shuxue Zhenjiu Tujing（ Illustrated Manual of Acupuncture Points of the Bronze Figure） and comparing them with those in Huangdi Neijing（ the Yellow Emperor’s Internal Classic）,Nanjing（ Classic of Difficult Issues） and some other works,The evolution of meridian theory in Tongren Shuxue Zhenjiu Tujing is summed up as follows:Nutrient qi transforms into blood qi running in the meridian to moisten the whole body. The naming methods of the meridians changes from zang（ fu） hands（ feet） vessels to hands（ feet） zang（ fu） meridians.The theory of shidong and suoshengbing in Nanjing is inherited and developed,and pulse-taking methods on renying and qikou acupoints in Huangdi Neijing are developed to present the concept of conception vessel（ CV） being the sea of yin vessels. The related concepts and origins of some problems of meridian theory before the Song Dynasty are clarified,which is helpful for us to grasp deeply the development characteristics of meridian theory.关键词：Tongren Shuxue Zhenjiu Tujing（Illustrated Manual of Acupuncture Points of the Bronze Figure）;meridian theory;evolution
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发布时间：2021-05-20 - 摘要：Objective To observe the effects of shenzhiling（ SZL） oral liquid on learning,memory and synaptic structure of APPswe/PSldE9 mice. Methods Seventy-five APPswe/PSldE9 mice were randomly divided into model group,donepezil group（ 0. 92 mg/（ kg·d））,high-dose SZL（ 50 g/（ kg·d）） group,mid-dose SZL（ 25 g/（ kg·d）） group,and low-dose（ 12. 5 g/（ kg·d）） SZL groups（ n =15 in each group）. 15 C57/BL6 J mice were used as the normal control group. For the model and normal group,mice were administered oral gavage of distilled water while the interventional groups received corresponding medicine for three months. Learning and memory was evaluated by using Morris water maze test,and the ultrastructure of the synapses were observed with transmission electron microscope.Results Compared with the normal group,mice in the model group had a longer escape latency and swimming distance（ P < 0. 01）; reduced times across the platform and stay in the target platform quadrant（ P < 0. 01）. After SZL treatment,escape latency was reduced and the swimming distances was shorter（ P < 0. 05）; times across the platform and stay in the target platform quadrant were increased,especially in the mid-dose and low-dose groups（ P < 0. 01）. The ultrastructure of the synapses was improved in the SZL groups than that in the model group,especially in the mid-dose and lowdose groups.Conclusion SZL oral liquid could improve learning and memory ability,and improve ultrastructure of the synapses in APPswe/PSldE9 mice. This may be one of the important mechanisms of improving cognitive function.关键词：Alzheimer’s disease;Morris water maze;synapses;APPswe/PSldE9 mice
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发布时间：2021-05-20 - 摘要：Objective By investigating the effects of Chaibei Zhixian（ Radix Bupleuri and Bulbus Fritillariae Thunbergii anti-epilepsy,CBZX） decoction,a Chinese herbal compound,on the expression and distribution of multidrug resistance protein（ P-glycoprotein,P-gp） in intractable epileptic rats,to explore the possible molecular pathogenesis mechanism of intractable epilepsy. Methods 80 Wistar rats were intraperitoneally injected lithium chloride-pilocarpine hydrochloride to establish intractable epilepsy model,and 12 rats at the same week age were used as the normal control. 59 rats were selected as successful model and randomly divided into model group（ n = 14）,CBZX group（ n = 15; 8. 1 g/kg intragastric gavage）,and carbamazepine（ CBZ） group（ n = 15; 36 mg/kg intragastric gavage） and combination treatment group（ n =15; CBZX plus CBZ intragastric gavage）. The average duration of seizures and the Racine’s grade of epileptic seizure were evaluated after 2 weeks’ intervention. Immunohistochemical method and Western blotting assay were used to compare the expression and distribution of P-gp in the hippocampus and cerebral cortex of the rats. Results Compared with the normal group,the expression of P-gp increased significantly in all epileptic groups（ P < 0. 05）. Conclusion CBZX decoction combined with carbamazepine is superior to using single therapy. The Chinese herbal compound CBZX decoction seems to show some effects in inhibiting P-gp drug transporters.关键词：intractable epilepsy;multidrug resistance protein;Chai Bei Zhi Xian Decoction;carbamazepine;rats
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》由教育部主管,北京中医药大学主办,中国工程院院士王永炎教授担任主编,创刊于1959年,国内刊号CN11-3574/R,国际刊号ISSN1006-2157。由北京报刊发行局向全国发行,国内代号82-414;国内发行由中国国际图书贸易总公司（北京399信箱）办理,国外代号M734。近期,陆续发现假冒《北京中医药大学学报》开设的网站,这些侵权网站盗用我刊网站标识、页面布局和
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发布时间：2021-05-20 - 摘要：Objective To establish the in vitro and in vivo HPLC profiles of Mongolian drug compound Xieriga-4,and assign and identify its chemical composition in vitro and in vivo. Methods To take SD rats and intragastrically administer a certain amount of Mongolian medicine compound Xieriga-4 to prepare in vivo serum and metabolic urine,and measure with HPLC. comparing the effective components in drug-containing serum and urine,an in vitro and in vivo HPLC profile of Mongolian drug compound Xieriga-4 was established. Results The in vitro HPLC profiles of Mongolian medicine compound Xieriga-4 were analyzed,and a total of 53 peaks were found. There were 35 blood components after in vivo administration of Mongolian Medicine Compound Xieriga-4,and 25 blood components were directly injected into the blood. The other 10 were considered new metabolites. Peaks 7,9,12,14,15,17,26,27,30,33,51,53 originated from turmeric,Peaks 18 and 19 came from Cork; the peaks 1,2,3,10,and 16 from lice; the peaks 8,18,31, and 32 from earthworms. Four incoming chemical constituents were identified through in vitro and in vivo chemical composition comparisons. Three of them were identical to those in metabolism and it was assumed that they may act as prototype components and be excreted. Conclusion Blood components and metabolites may be effective components of compound effects. This article speculates that the composition of blood components of the compound into the blood to speculate the mechanism of its treatment,in order to provide further evidence to explore the mechanism of Mongolian medicine compound Xieriga-4 treatment of diseases.关键词：Mongolian Medicine Compound Xieriga-4;characteristic map;blood components;metabolic components;chemical composition in vitro and in vivo;rats
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发布时间：2021-05-20 - 摘要：Objective To explore suitable clinical research methods for traditional Chinese medicine by comparing the advantages and disadvantages of the three clinical methods in traditional Chinese medicine,including single-case randomized controlled trial（ n-of-1）,randomized controlled trial（ RCT）,and real world study（ RWS）. Methods Relevant literature including latest guideline at home and abroad were searched to compare and contrast for analysis. Results Traditional Chinese medicine is featured by individualized treatment. N-of-1 trial seems to align with scientific and TCM rationale in clinical diagnosis and treatment. Conclusion N-of-1 trial is a scientifically refined case study in TCM. Systematic evaluation of data obtained could facilitate scientific evaluation of efficacy and validation of individualized treatment. Its application has great prospective in TCM clinical studies.关键词：randomized controlled trial;TCM;RCT;real world study
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发布时间：2021-05-20 - 摘要：Objective To establish a diagnostic scale of TCM pattern elements of type 2 diabetes mellitus（ T2 DM） by introducing the scale development method into the diagnosis of TCM patterns and to explore the standardization of TCM pattern by developing relevant scale. Methods Data obtained with TCM four diagnostic methods was collected from 249 qualified patients with T2 DM in five grade 3 and first-class hospitals around the country by using a multi-center clinical epidemiology survey. Pattern differentiation was centrally made after all the information was collected. The entry pool of four TCM diagnostic methods of each pattern was initially identified on the basis of literature research. Correlation coefficient,stepwise regression and factor analysis methods were jointly used to do entry screening on the data of 179 samples.Logistic regression was conducted to do entry assignment,and ROC curve was used to determine the diagnostic threshold to establish the diagnosis scale of T2 DM TCM pattern elements. 70 samples were used to do reliability and validity evaluation of the scale. Results There were nine pattern elements in T2 DM Diagnostic Scale of TCM patterns,namely,pattern of qi deficiency,yin deficiency,internal dampness,dryness-heat, yang deficiency, blood stasis, liquid depletion, phlegm turbidity and qi stagnation,whose diagnostic threshold were: 11 points,9 points,8 points,13 points,8 points,10 points,12 points,7 points and 4 points respectively. The split-half reliability of the scale was 0. 878,and its Cronbach’sα was 0. 844. Three common factors were extracted with factor analysis. The cumulative variance contribution rate was 69. 123% and the correlation coefficient of the score of each pattern element to the total score was 0. 471-0. 794. Conclusions There are nine pattern elements in the diagnostic scale of T2 DM TCM factors,which is of good reliability and validity,and can be used for clinical or research pattern diagnosis. It provides new ideas and methods for the study of TCM pattern standardization.关键词：type 2 diabetes;scale;reliability;validity;TCM syndrome
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发布时间：2021-05-20 - 摘要：Objective To investigate the correlation of tongue manifestations and FibroScan value in patients with post-hepatitic cirrhosis and provide objective evaluation of illness severity and pathogenesis.Methods The clinical information extraction table of hepatitis cirrhosis was used to collect the general information of the patient’s condition,the FS value of the tongue image and etc. The data were inputted into Excel,and grouped according to whether there was any tongue picture or not. SPSS 20. 0 software was used to analyze the clinical information of patients with descriptive statistical analysis,including t test,chi-square test,and rank sum test. Results In 108 patients with post-hepatitic cirrhosis,the minimum value of FS was 4. 10 kPa and the maximum value was 75. 00 kPa. The mean value was（ 24. 07 ± 18. 43） k Pa; compensatoed stage（ 16. 18 ± 10. 06） k Pa,decompensated stage（ 38. 03 ±21）. There was significant difference between the two stages（ P < 0. 05）. FS of the crimson tongue was highest in the color of tongue. In tongue shape,Fs of thin tongue was higher than other tongues. In tongue coating,dry and yellow coating were higher than others. Among all the groups,only the bulgy tongue group,the cracked tongue group and the dry fur group had significant differences（ P < 0. 05）,but there was no significant difference between other groups. Conclusion FS value appears to ke higher in the patients with thin tongue,fissured tongue and dry coating. It shows that the higher the FS value of heat syndrome,yin deficiency,blood deficiency and injury,the more serious the condition of liver cirrhosis is when the above three tongue signs appear in the patients with hepatitis and liver cirrhosis. This indicates that FS value has a certain correlation with tongue changes.关键词：post-hepatitic cirrhosis;FibroScan;tongue changes;inspection
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发布时间：2021-05-20 - 摘要：Objective To study the distribution of TCM constitution in patients with primary insomnia,and the correlation between TCM constitution and sleep quality. Methods Cross-sectional survey was used. The Pittsburgh sleep quality index（ PSQI） and the Chinese Medical Constitution Scale were evaluated,and the data were collected to analyze the patients’ constitution distribution,sleep quality and the association between the constitution and the sleeping quality. Results A total of 308 cases（ 104 male & 204 female） were observed; the youngest was 20 years old,the oldest was 75 years old,with an average age of（ 46. 32 ± 16. 23） years old. There were 162 cases of single constitution and 146 cases of combined constitution. The mean score of PSQI was（ 12. 65 ± 3. 04）. Symptoms of insomnia include poor sleep quality,shorter sleep time and longer time to falling asleep. The main symptoms were difficulty of falling asleep. Secondary symptoms of each constitution were as follows: early awakening in the phlegm dampness and yang deficiency constitutions; profuse dreaming in the blood stasis constitution;easy awakening in the yin deficiency constitution; shallow sleeping in the qi stagnation constitution,qi deficiency constitution,damp heat constitution and special constitution. Secondary symptoms of combined constitution were profuse dreaming. Conclusion The most common constitution in insomniacs were qi deficiency constitution,yin deficiency constitution and phlegm dampness constitution; and three kinds of combined constitution were qi deficiency and yang deficiency constitution, qi deficiency and yin deficiency constitution,yang deficiency and phlegm dampness constitution. There was no difference in the sleep quality between the single and combined constitutions,and the main symptom was difficulty in falling asleep. The secondary symptoms were correlated with the constitution of TCM.关键词：insomnia;constitution of traditional Chinese medicine;sleep quality
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发布时间：2021-05-20 - 摘要：Objective To evaluate the effectiveness of traditional Chinese medicine in the treatment of oligospermia and asthenospermia. Methods Randomized controlled trials（ RCTs） were retrieved from CNKI,Wanfang database,VIP,CBM,PubMed,Cochrane library,EMbase,Web of Knowledge. The date of publication was January 2004 to March 2017. RCTs about traditional Chinese medicine in the treatment of oligospermia and asthenospermia were included. Treatment group received traditional Chinese medicine,while the control group was treated with Western medicine. The quality of included studies was evaluated and performed by using the statistical software STATA12. 0. Results A total of 44 RCTs involving 4779 patients were included. Meta-analysis showed that total effective rate [RR = 1. 15,95% CI（ 1. 07-1. 23）,P = 1. 00],semen volume [MD = 0. 57,95% CI（ 0. 44-0. 70）,P < 0. 000 01],sperm density [MD = 0. 82,95% CI（ 0. 73-0. 91）,P < 0. 000 01],percentage of class A sperm [MD= 0. 72,95% CI（ 0. 60-0. 84）,P < 0. 000 01],percentage of class A + B sperm [MD = 0. 85,95%CI（ 0. 74-0. 96）,P < 0. 000 01]. Conclusion Traditional Chinese medicine was superior to Western medicine in improving semen volume,sperm density,percentage of class A sperm,percentage of class A+ B sperm,and total effective rate.
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发布时间：2021-05-20 - 摘要：Objective To evaluate the efficacy and safety of compound Zaofan pills alone or combined with Western medicine in the treatment of blood diseases. Methods The researchers retrieved the seven authoritative databases commonly used,and searched published randomized controlled clinical trials on compound Zaofan pills alone or combined with Western medicine in the treatment of blood diseases from the establishment of the library to January 2018,and carried out data extraction and quality evaluation,and then the Review Manager 5. 3 software was used for Meta analysis. Results Finally,15 qualified clinical studies were included,among which 11 were aplastic anemia,3 were myelodysplasia syndromes,and 1 was immune thrombocytopenia. Meta-analysis showed that:（1） The overall efficacy evaluation showed that the compound Zaofan pills alone or combined with Western medicine was superior to Western medicine alone（ P < 0. 000 01）.（2） The efficacy of compound Zaofan pills alone or combined with Western medicine in the treatment of aplastic anemia was better than that of Western medicine alone（ P< 0. 000 01）.（3）The efficacy of compound Zaofan pills alone or combined with Western medicine in the treatment of myelodysplastic syndrome was better than that of Western medicine alone（ P = 0. 002）.（4）Six studies reported treatment-related adverse reactions,mainly mild gastrointestinal reaction and mild liver function damage,but all of them occurred in the combined treatment group,so it could not be determined as the result of compound Zaofan pills. Conclusion Compound Zaofan pills alone or combined with Western medicine seems to be more effective than Western medicine alone in the treatment of aplastic anemia and myelodysplastic syndrome with safety.关键词：Compound Zaofan Pill;aplastic anemia;myelodysplastic syndromes;Meta analysis
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发布时间：2021-05-20
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