最新刊期
卷 42 ， 期 1 ， 2019
- 摘要：<正>以下为2018年1月—2018年12月为本刊审阅稿件的专家名单,感谢你们对本刊的支持和帮助（以姓氏笔画为序in order to surname strokes）:
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发布时间：2021-05-20 - 摘要：The current ear is a time of agriculture civilization,industrial civilization and information intelligence in parallel.In this time traditional Chinese medicine（TCM）is much valued but it is still in an opportunity period of transformation from a vulnerable science.TCM development should comply with development direction of big science,and keep pace with the times based on image thinking and original creativity.Aiming at 2 important issues in medical development-medical moral education and clinical research,the authors propose that the characteristics of high concept age should be grasped,medical ethics should be remodeling according to benevolence and virtue concepts,humanistic care should be blended in medicine,innovative academic team should be built,and harmonious academic atmosphere should be constructed.Medical research should be based on clinical practice,and clinical practice should be guided by original derivation and development of sciences.The talents of general medicine should be cultivated through early and frequent clinical practice.Basic and clinical researches should be guided by TCM original thinking.It is historical inevitability to integrate TCM and Western medicine.The update of disciplinary framework should be mobilized by curative effect of TCM pattern differentiation and treatment,and medical system will be completed with philosophic wisdom of Chinese ethnic peoples.关键词：medical ethics;clinical research;Chinese medicine
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发布时间：2021-05-20 - 摘要：The pathogenesis of essence depletion and collateral impediment can summarize the characteristics of core pathogenesis of diabetic nephropathy（DN）and guide clinical treatment effectively.The pathogenesis of essence depletion emphasizes that kidney lesions is the core of five viscera lesions.Kidney deficiency indicates the consumption of kidney essence and deficiency induces the production of stagnation,dampness,stasis and turbidity.The pathogenesis of collateral impediment indicates that dampness,stasis and turbidity due to deficiency obstruct kidney collateral,even aggregation-accumulation is produced.Therefore collateral impediment is characterized by excess due to deficiency.The therapy of filling essence and freeing collaterals is proposed for DN treatment in the paper.The filling essence refers to nourishing kidney essence,and freeing collaterals refers to eliminating pathogens to free collaterals.It is a kernel therapy for DN.The nourishing kidney essence is a cornerstone in DN treatment,especially in middle or late stages of DN treatment.In early stage eliminating pathogens to resolve impediment（eliminating-freeing therapy）is stressed,and in late stage reinforcing healthy qi and eliminating pathogens（nourishing-freeing therapy）is emphasized.The healthy qi will not be damaged during eliminating pathogens.关键词：diabetic nephropathy;core pathogenesis;essence depletion;collateral impediment;kidney essence
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发布时间：2021-05-20 - 摘要：In order to properly understand the physiological characteristics of children and apply principles of recuperative medical care,chun-yangis textually studied from etymology and the original intention of Taoism.Etymologically,both chun and yang have their original meaning and derived meanings.Chun involves tiny,pure and powerful meanings,while yang is about ferventness,quickness and activity.In Taoist internal elixir,chun-yang has 3 meanings,including the boundary between fairyland and earth,congenital yin and yang,and virginity.However,chun-yang is not powerful yang or pure yang.Children’s chun-yangis firstly seen in Luxin Jing,which is indeed influenced by Taoism.The view of chun-yang equaling to powerful yang conflates the original and derived meanings of chun and yang,which is also a misunderstanding of Taoist chun-yang.There are two aspects of chun-yang theory in Taoism:jeune yang and energetic yang.In this regard,children’s chun-yang should also have the dual meanings.关键词：children;chun-yang;physiological characteristics;Taoist internal elixir
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发布时间：2021-05-20 - 摘要：There are many disease names conserved in ancient dictionaries.The ancients’ knowledge on diseases can be inferred through annotation on these names.However,corruption cannot be avoided in the process of literature handing-down,so that the descendants can not accurately understand the original meaning of these disease names.Some disease names with large question in Guangya,including"zhou（疛）","wen（殟）","zi（■）","zi（■）"and"xian（痫）",are combed and analyzed combining with the relevant ancient literature for textually researching on the meanings of these disease names.The purpose is to reflect the importance of explanation on special ancient books to medical lexicological study,and to supplement and correct the interpretation with doubts in contemporary large-scale dictionaries.关键词：zhou（疛）;wen（殟）;zi（■）;xian（痫）;textual research
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发布时间：2021-05-20 - 摘要：Objective To investigate the effect and possible mechanism of extracts of Xuanshen（Scrophularia Root,Radix Scrophulariae）on liver metabolome in rat model of hyperthyroidism.Methods The rat liver metabolites spectrums effected by Euthyrox and Xuanshen extracts were analyzed by using ultra high performance liquid chromatography-time of-flight-mass spectrometry（UPLC-TOF-MS）.The difference in metabolites spectrums was studied between blank group and model group by using orthogonal partial least squares-discriminant analysis（OPLS-DA）.The potential biomarkers were found in liver through variable importance projection（VIP）.The interventional effects of Xuanshen extracts were discussed through comparing the difference in content of potential biomarkers.Results There were 21 potential biomarkers found in rat liver in model group,and among them14 metabolites were significantly called back by Xuanshen extracts.The biosynthesis of glycosylphosphatidylinositol（GPI）-anchor,and metabolisms of arachidonic acid,purine,α-linolenic acid,linoleic acid,glutathione and glycerophospholipid were significantly improved by Xuanshen extracts in Euthyrox-induced hyperthyroidism rat model.Conclusion Xuanshen extracts can play a role of treating hyperthyroidism through improving relevant liver potential biomarkers and metabolism pathways in hyperthyroidism rat model.关键词：Xuanshen（Scrophularia Root,Radix Scrophulariae）;Euthyrox;hyperthyroidism;liver metabonomics;rats
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发布时间：2021-05-20 - 摘要：Objective To establish a new-type virtual screening predictive model of Chinese medicinal compounds with anti-fibrosis effects,and to verify the predictive performance of the model.Methods The dimension reduction and characteristic optimization of molecular fingerprints were implemented by using random forest（RF）algorithm and gradient boosting decision tree（GBDT）algorithm.A hybrid model of characteristic optimization-machine learning was established,and optimized characteristics were input into logistic regression（LR）and machine learning algorithm of artificial neural network（ANN）for training.Precision,recall rate and F1 value were used for reviewing the performances of various model combinations.The virtual screening predictive model of Chinese medicinal compounds with anti-fibrosis effect was determined according to results of model performance reviewing.The predictive results of anti-fibrosis activity of Chinese medicinal compounds were compared between the virtual screening predictive model and molecular docking model for further verifying the predictive efficiency of the virtual screening predictive model.Results The precision of RF model was 0.76,recall rate was 0.75 and F1 value was 0.74（AUC=0.818）.The precision that of GBDT model was 0.76,recall rate was 0.74 and F1 value was 0.72（AUC=0.829）.The precision of ANN model was 0.75,racall rate was 0.75 and F1 value was 0.75（AUC=0.802）,and that of model of RF+LR was 0.77,recall rate was 0.76 and F1 value was 0.75（AUC=0.840）.The precision of model of RF+LR was 0.74,recall rate was 0.84 and F1 value was 0.79（AUC=0.850）,and that of model of GBDT+LR was 0.80,recall rate was 0.80 and F1 value was 0.79（AUC=0.872）.The precision of model of GBDT+ANN was 0.73,recall rate was 0.91 and F1 value was 0.81（AUC=0.837）.The results of molecular docking activities of Chinese medicinal compounds including curcumin,glycyrrhizic acid,hydro-xysafflor yellow A,emodine and gypenoside were accordance with the predictive results of the virtual screening predictive model.Conclusion The model based on RF+LR is better than the models established based on other methods.The virtual screening predictive model has good performance in prediction of Chinese medicinal compounds through comparing with molecular docking model.The method has feature of highthroughput screening and can make up the shortage of compound screening efficiency in molecular docking.It provides a new way for virtual screening prediction of Chinese medicinal compounds with anti-fibrosis effects.关键词：organ fibrosis;machine learning;molecular fingerprinting;Chinese medicinal compound screening
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发布时间：2021-05-20 - 摘要：Objective To investigate the relative mechanism of Maimendong Tang（Ophiopogon Decoction）in amelioration of lung function and endoplasmic reticulum stress（ERS）in rats with bleomycin-induced pulmonary fibrosis.Methods Male healthy SD rats were randomly divided into normal group,model group,Maimendong Tang group 1 and Maimendong Tang group 2.The rat model of pulmonary fibrosis was established by bleomycin pulverization via tracheal intubation.On the 14 t h d after modeling,Maimendong Tang was intragastrically given to Maimendong Tang group1 and Maimendong Tang group 2 twice a day for 20 d continuously.The general conditions were observed,and pathological changes of lung tissue were observed after HE and Masson staining.The forced vital capacity（FVC）,0.4 second rate（FEV0.4/FVC）,mass FVC,inspiratory resistance（Ri）,expiratory resistance（Re）and dynamic pulmonary compliance（Cydn）were detected by using spirometer.The expressions of glucose regulated protein 78（GRP78）and C/EBP homologous protein（CHOP）protein in lung tissue were analyzed by using Western blotting assay and immunohistochemistry staining technique.Results Compared with normal group,FVC,FVC/lung mass and Cydn decreased,and 0.4 second rate increased in model group.Compared with model group,FVC increased and 0.4 second rate decreased and Cydn increased in Maimendong Tang group 1 and Maimendong Tang group 2,and mass FVC increased in Maimendong Tang group 2.Pathological sections showed that there were chronic inflammatory cell infiltration in consolidation zone of lung tissue and massive collagen deposition,GRP78 and CHOP with high expressions were mainly positioned in vesicular type Ⅱ alveolar epithelial cells（AECⅡs）.The inflammation was relieved,collagen deposition was decreased,protein expressions of GRP78 and CHOP were reduced and in Maimendong Tang group 2.Conclusion Maimendong Tang can significantly improve lung function and reduce lung interstitial collagen deposition,which may be related to regulation of protein expressions of GRP78 and CHOP in AECⅡs in consolidation zone of lung tissue,relief of ERS,and recovery of normal AECⅡs function.关键词：Maimendong Tang（Ophiopogon Decoction）;endoplasmic reticulum stress;type Ⅱ alveolar epithelial cells;glucose regulated protein 78;C/EBP homologous protein;rats
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发布时间：2021-05-20 - 摘要：Objective To study and compare the molecular mechanism of SiniSan（Cold-Limbs Powder）and Suanzaoren Tang（Spine Date Seed Decoction）in treatment of insomnia based on network pharmacology method.Methods A database of active compounds of Sini San and Suanzaoren Tang was established through searching the databases of Chinese medicinal compounds including traditional Chinese medicinal system pharmacology platform（TCMSP）,and the predictive analysis of the compounds was conducted by using machine learning algorithm.Based on the analyses of KEGG pathway,gene ontology（GO）enrichment and disease association of therapeutic target database（TTD）,Cytoscape software was used to construct complex network of active constituent-target-disease and topological analysis of the pharmacological mechanisms of Sini San and Suanzaoren Tang.Results There were 145 active constituents obtained from Sini San and among them saikoside and kaempferol had higher binding activities.There were 1 306 target proteins obtained and among them22 were significantly correlated to diseases,and 49 significant KEGG pathways and 72 significant GO enrichment pathways obtained from Sini San.There were 139 active constituents obtained from Suanzaoren Tang and among them jujuboside and timosaponin had higher binding activities.There were 1 386 target proteins,52 significant KEGG pathways and 84 significant GO enrichment pathways obtained from Suanzaoren Tang.Conclusion The potential network pharmacological mechanisms and active constituents of Sini San and Suanzaoren Tang in insomnia treatment are studied at the molecular biology level through complex network graph calculation and bioinformatics analysis.The purpose is to provide new ideas for further revealing the mechanism of treating insomnia with Chinese medicinal based on principle of different treatments for the same disease.关键词：network pharmacology;Sini San（Cold-Limbs Powder）;Suanzaoren Tang（Spine Date Seed Decoction）;insomnia;molecular mechanism
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发布时间：2021-05-20 - 摘要：Objective To study the interventional effect of Yangyin Yiqi Heji（Yin-nourishing Qireplenishing Mixture）to alveolus epithelial-mesenchymal transition in rats with bleomycin-induced pulmonary fibrosis.Methods Wistar rats in SPF class（n=120）were randomly divided into normal group,model group,prednisone group and low-dose,mid-dose and high-dose Yangyin Yiqi Heji groups.The rat model of pulmonary fibrosis was copied by using intratracheal instillation of bleomycin,and all groups were orally given corresponding medicinals for 28 d after modeling for 1 d.The rats were executed respectively on the 14th d and 28th d to collect lung samples for detection of left lung pathological changes by using HE and Masson staining.The mRNA expressions ofα-smooth muscle actin（α-SMA）,E-cadherin,collagen I（Col I）and laminin（LN）were detected in rigth lung by using real-time fluorescence quantitative polymerase chain reaction（RT-PCR）.Results The mRNA expressions ofα-SMA,Col I and LN increased,and E-cadherin expressions decreased in model group compared with normal group（P<0.05）.After treatment,the mRNA expressions ofα-SMA,Col I and LN decreased,and mRNA expression of E-cadherin increased in all treatment groups（P<0.05）.On the 28 th d,mRNA expression of E-cadherin increased in high-dose Yangyin Yiqi Heji group compared with prednisone groups（P<0.05）,and mRNA expression of LN deecresed in high-dose,mid-dose and low-dose Yangyin Yiqi Heji groups（P<0.05）.Conclusion Yangyin Yiqi Heji can inhibit the epithelial-mesenchymal transition in rats with bleomycin-induced pulmonary fibrosis,and the mechanism may be related to down-regulation of genes ofα-SMA,Col I and LN and up-regulation of E-cadherin gene.关键词：Yangyin Yiqi Heji（Yin-nourishing Qi-replenishing Mixture）;pulmonary fibrosis;epithelial-mesenchymal transition;rats
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发布时间：2021-05-20 - 摘要：Objective To study the anti-fatigue effects of aqueous extracts from Xianye Jinquehua（Rooibos,Aspalathus Linears）and Zanghonghua（Saffron,Crocus sativus L.）through classic behavior test（loaded swimming）and detections of blood lactic acid,liver glycogen and muscle glycogen.Methods At first 32 mice were randomly divided into blank control group,Xianye Jinquehua group and Zanghonghua group,and were orally given corresponding medicinals once a day.The test of loaded swimming was conducted in all groups after 14 d.Then 46 mice were randomly divided into blank control group and low-dose XianyeJinquehua+Zanghonghua group,and were orally given corresponding medicinals once a day.The test of loaded swimming and detection of blood lactic acid were conducted in all groups after 14 d.According to above test results,100 mice were randomly divided into blank control group,low-dose Xianye Jinquehua+Zanghonghua group,middose Xianye Jinquehua +Zanghonghua group and high-dose Xianye Jinquehua +Zanghonghua group.After oral medication for 14 d,the content of liver glycogen and muscle glycogen was detected.Results The time of loaded swimming was not improved in Xianye Jinquehuagroup and Zanghonghua group,and it was prolonged（P<0.05）and content of blood lactic acid was decreased（P<0.05）in low-dose Xianye Jinquehua+Zanghonghua group.The content of liver glycogen and muscle glycogen was increased in low-dose Xianye Jinquehua+Zanghonghua group,mid-dose Xianye Jinquehua+Zanghonghua group and high-dose Xianye Jinquehua+Zanghonghua group compared with blank control group（P<0.05 or P<0.01）.Conclusion The single administration of single Xianye Jinquehua or single Zanghonghua has no anti-fatigue effect,while combination of them has this effect.关键词：Xianye Jinquehua（Rooibos,Aspalathus Linears）;Zanghonghua（Saffron,Crocus sativus L.）;loaded swimming;blood lactic acid;liver glycogen;muscle glycogen;anti-fatigue effect;mice
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发布时间：2021-05-20 - 摘要：Objective To detect the species and diversity of fungi on surface of tortoiseshell decocting pieces and provide reference for medication safety of tortoiseshell decocting pieces.Methods The decocting pieces of tortoiseshell（8 batches）were collected from retail pharmacies in Beijing,and species and diversity of fungi on surface of tortoiseshell decocting pieces were estimated by using method of high-throughput sequencing（HTS）.At the same time,fungi on surface of tortoiseshell decocting pieces were cultured by using plate method,and then were purified by using top purification method for obtaining a single fungus strain.The fungi on the surface of tortoiseshell decocting pieces were identified according to colony morphology,microstructure,and DNA barcodes.Results The results of HTS showed that there were 2 lines,5 doors,21 classes,56 orders,123 families,173 genera and 201 species of fungi on surface of tortoiseshell decocting pieces summed up totally,including mainly Aspergillus,Cordyceps,Wickerhamamyces,Cladosporium,Alternaria,Candida,Wallemia and Penicillium.The results of plate method showed that there were 42 strains of 10 species of fungi on surface of tortoiseshell decocting pieces summed up totally,including mainly Penicillium oxalicum,Aspergillus fumigates,Aspergillus niger,Aspergillus amstelodami,Penicillium sp.,Mucor racemosus f.racemosus,Aspergillus candidus and Eurotium sp.Conclusion The fungi on surface of tortoiseshell decocting pieces can be separated and purified by using plate method.HTS is rapid and efficient.The combination of plate method and HTS can identify scientifically,accurately and comprehensively the species of fungi on surface of tortoiseshell decocting pieces,and provide a detection method for medication safety of tortoiseshell decocting pieces.
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发布时间：2021-05-20 - 摘要：Objective To analyze the variation types kaunene synthase-like（KSL）gene in Danshen（Salvia Root,Radix Salviae Miltiorrhizae）from different producing areas in China,and investigate primarily the influence of KSL gene polymorphism on enzyme-catalyzed reaction of its codases.Methods Specific primers were designed,and full-length KSL genes of Danshen from different producing areas（Henan,Shandong,Sichuan,Hubei,Shanxi,Neimonggu,Hebei）in China were homologously cloned.The variation types were compared and mutation samples were selected to establish a prokaryotic expression system and inducible expression in vitro.The enzyme-catalyzed products of KSL gene were detected by using gas chromatography-mass spectrometer（GS-MS）,and influence of KSL gene polymorphism of Danshen on protease catalytic efficiency was further analyzed.Results The full-length KSL gene was 1 788 bp,and there were totally 595 amino acid residues encoded.The sequencing results showed that there were polymorphisms in KSL gene of Danshen from different producing areas in China,which could cause synonymous and non-synonymous mutations.The catalytic efficiency of different genotypes of KSL was significantly different,which was the highest in Shanxi and the lowest in Inner Mongolia.The KSL gene containing A-type variation mutated at 1 047 bp in Danshen from4 producing areas including Shanxi,Hubei,Shandong,and Sichuan,and the catalytic efficiency of which was significantly higher than those containing no Atype variation in Danshen from4 producing areas including Henan,Hebei and Inner Mongolia.Conclusion KSL genes have gene polymorphisms indeed in Danshen from different producing areas.The non-synonymous mutations induced by polymorphisms can further lead to changes of amino acid sequences and finally resulting in difference in the catalytic efficiency of encoded enzymes.The polymorphisms of key enzyme genes in the synthesis pathway of tanshinones can be taken as a starting point to provide further reference for revealing the accumulation mechanism of tanshinones and breeding the excellent germplasm of Danshen.关键词：Danshen（Salvia Root,Radix Salviae Miltiorrhizae）;kaunene synthase-like gene;key enzyme;gene polymorphism;catalyzed efficiency
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发布时间：2021-05-20 - 摘要：Objective To discuss the influence of exogenous Gibberellin（GA3）and abscisic acid（ABA）on genetic expressions of key enzymes in ethylene synthesis in Taizishen（Pseudostillaria Root,Radix Pseudostellariae）,and provide reference for intelligent use of growth regulators during cultivation of Taizishen.Methods The genes of key enzymes in ethylene synthesis of Taizishen were screened and identified from transcriptome database by using local Blast method.Hai’ershen in full-bloom stage was treated with exogenous GA3 and ABA,and samples were collected at different time points(20 d,40 d,50 d and 60 d.The genetic expressions of key enzymes in ethylene synthesis of Taizishen were detected by using real-time fluorescence polymerase chain reaction（RT-PCR）.Results There were totally 6 genes of key enzymes in ethylene synthesis in roots of Taizishen obtained,and they were named PhACO1,PhACO2,PhACO3,PhACS1,PhACS2 and PhSAMS.GA3 and ABA could regulated the expressions of above 6 genes,and expressions of PhACO1,PhACO2,PhACS1 and PhSAMS were up-regulated after treated with GA3,and expressions of PhACO3 and PhACS2 were up-regulated after 20 d to 40 d and down-regulated after 50 d to 60 d.The expressions of genes of key enzymes in ethylene synthesis in Taizishen showed down-regulation at first and then up-regulation after treated with ABA,but different genes had different demonstrations.The expression of PhACO1 was up-regulated after 20 d to 60 d,and down-regulated after 40 d to 50 d.The expressions of PhACO2 and PhACO3 were down-regulated after 20 d to 50 d,and up-regulated after 60 d.The expression of PhACS1 was down-regulated after 20,up-regulated after 40 d to 60 d.The expressions of PhACS2 and PhSAMS were down-regulated.Conclusion GA3 and ABA may control the ethylene signaling pathway to regulate plant growth through affecting the ethylene biosynthesis of Taizishen.It is speculated that Taizishen is treated with suitable concentration of GA3 in adventitious root growth period and treated with ABA treatment in root thickening period,the yield of Taizishen will be increased.关键词：Taizishen（Pseudostillaria Root,Radix Pseudostellariae）;Gibberellin;abscisic acid;key enzymes in ethylene synthesis;genetic expressions
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》已入编《中国学术期刊（光盘版）》。为此郑重声明如下:一、凡在《北京中药大学学报》发表的文章,如作者事先未表示异议,则相应地被编入《中国学术期刊（光盘版）》。《中国学术期刊（光盘版）》免收作者版面费。二、《中国学术期刊（光盘版）》免费向作者提供引文率统计资料。作者可通过所在单位设立的中国学术期刊文献检索咨询站查询,检索本人在《中国学术期刊（光盘版）》中发表论文的被引用情况;如本单位未设立
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发布时间：2021-05-20 - 摘要：The evaluation on sinews and bones in tuina of traditional Chinese medicine（TCM）re-fersto a systematic approach to evaluate the patient’s physical state,so as to select appropriate tuina therapies and achieve safe and efficient goals.Through summarizing the characteristics of evaluation on sinews and bones in main schools of modern TCMtuinaincluding assessments of bone landmarks,soft tissues and pain,and Western manual therapies including assessments of palpation of spine,postures（positions）,pain and surrounding soft tissues,the key elements of promotion mode of evaluation on sinews and bones in TCM tuina are proposed,namely the ev alu-ation on muscle tissue morphology,postures,tenderness points and joint motions.The purpose is to provide a reference for establishing a scientific,standard and feasible mode of evaluation on sinews and bones.关键词：traditional Chinese medicine;tuina;theory of sinews and bones;evaluation on sinews and bones
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发布时间：2021-05-20 - 摘要：<正>《北京中医药大学学报》是由教育部主管、北京中医药大学主办的高级中医药学术期刊,主编为中国中医界学术权威王永炎院士。本刊分别属于中国自然科学核心期刊,中国中文核心期刊,全国中医药优秀期刊,全国优秀科技期刊,国内6大检索系统10余种检索刊物的主要刊源,美国《化学文摘》（CA）、美国《剑桥科学文摘》（CSA）、美国《国际药学文摘》（IPA）、美国《乌利希期刊指南》（Ulrich PD）、
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发布时间：2021-05-20
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