最新刊期
      卷 43 ， 期 1 ， 2020
      • Wang Yongyan,Zhang Huamin,Ji Xinyu
        Vol. 43, Issue 1, Pages: 5-7(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.001
        摘要：The chapter entitiledDiscussion on the Changes of Qi-ConvergenceinPlain Questionsis about the excess and insufficiency of five-motion qi and changes ofde(function)hua(transformation)zheng(administration)ling(order), to elaborate the relation between nature, disorder and phenomena. This paper analyzes the chapter from the following three aspects: Firstly, the pathogenesis of patterns due to excessive or insufficient yearly qi helps to comprehend the general mechanism of five qi excess or insufficiency, the relations of engendering, restraining, over-restraining and counter-restraining among them. Therefore manifestation observation should be the premise of pattern diagnosis and disease treatment. Secondly, the elucidated rule of Daoism follows the law of nature and thus manifestations are for us to consider; No reckless action is to be taken without any careful account. Thirdly, innovation is the priority to inheritance of past knowledge and development of new theories. Based on the author’s research and clinical experiences against infectious diseases and H1N1 influenza in the earlier years, this paper emphasizes that independent thinking originates from the cultural awareness and that exploring the origins of the discipline is the source of innovation.  
          
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        发布时间：2021-05-20
      • Wang Hong,Zheng Ruoyun,He Juan
        Vol. 43, Issue 1, Pages: 8-11(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.002
        摘要：Model thinking is an important way of original thinking in traditional Chinese medicine (TCM). Examples like three yin and three yang, Yellow River MapLo ShuSquare, as well as the Stems-and-Branches, are all original thinking models that have played an important part in constructing the theoretical system ofHuangdi Neijing (Huangdi’s Internal Classic).It is very important to analyze the influence of different original thinking modals on medical theories in order to understand them. Later heaven eight diagrams(houtian bagua)is an important thinking model in both traditional culture and TCM. It contains the double connotations of time and space, which has important influences on the regional division of nine palaces and eight winds inHuangdi Neijing,and the positioning of human viscera, especially in the proposal of the “earth pivot and four images” and the theory of human body corresponding to the nine geographical divisions. It is also an important demonstration of the “unity of man and nature”.  
        关键词：houtian bagua;nine palaces and eight winds;human body corresponding to the nine geographical divisions;Yellow Emperor’s Inner Cannon   
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        发布时间：2021-05-20
      • Li Jiwu,Cheng Wenhui,Meng Lifeng,Tang Aihua,Li Shuanglei,Wang Zhengang
        Vol. 43, Issue 1, Pages: 12-16(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.003
        摘要：This paper analyzes the “turning point” of six-meridian disorders inShanghanlun (Treatise on Cold Damage Disease) from the perspective of qi ascending and descending movement based on yin-yang qi transformation so as to shed light on the mechanism, pattern diagnosis, formulae and herbs prescribed for six-mendian disorders. It starts with reviewing the relations between original qi and yin-yang qi, yin-yang qi and constrained transformation of ascending and descending, ascending-descending disorder and yin-yang qi disorders, yin-yang ascending and descending and turning point in six-meridian disorders to elaborate on ascending and descending of original qi, six-meridian yin-yang qi transformation. Then the paper continues to discuss on the pathomechanism, pattern diagnosis, formulae and herbs prescribed for three-yang and three-yin (six meridians) disorders from the perspective of ascending and descending disorder. This paper is written with the objectives of understanding how to diagnose and treat six-meridian disorders by using the traditional theory of yin-yang ascending and descending qi transformation, so that we could inherit the qi-transformation theory, grasp the TCM classics, use the classic formula flexibly and improve clinical competency.  
        关键词：syndrome differentiation of six meridians;yin and yang;ascending and descending;qi transformation;therapeutic method and prescription herbs;Shang Han Lun   
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        发布时间：2021-05-20
      • Zhang Tianxing
        Vol. 43, Issue 1, Pages: 17-20(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.004
        摘要：The statement of “extreme yin turning into yang, extreme yang turning into yin” came from the chapter entitledYinyang Yingxiang Dalun (Major Discussion on the Theory of Yin and Yang and the Corresponding Relationships Among All the Things in Nature)inSuwen (Plain Questions).Based on the annotations of ancient doctors, this paper put forward the viewpoint of interpreting yin and yang from the aspect of interior and exterior. “Extreme yang turning into yin” means that when the exogenous pathogens are too strong or the exterior is repeatedly influenced by six pathogenic factors, the disease will transmit from the exterior to the interior, injuring qi movement of five zang-organs. “Extreme yin turning into yang” means that when the internal injury is too severe, which leads to deficiency or disorder of internal qi, the exterior will also be involved, resulting in the recurrence of exogenous diseases. The statement that “happiness and anger injure the qi, while heat and cold injure the appearance” describes the law of how endogenous and exogeous pathogens cause diseases, while “extreme yin turning into yang, extreme yang turning into yin” describes the valatility of diseases. The essence of “extreme yin turning into yang, extreme yang turning into yin” is to explain the relationship between exogenous and endogenous disorders. This idea is the theoretical basis for clinical understanding of the causes, analysis of pathogenesis, and pattern differentiation, and it merits forther exploring and developing.  
          
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        发布时间：2021-05-20
      • Gu Jianjun
        Vol. 43, Issue 1, Pages: 21-26(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.005
        摘要：With the rise of Neo-Confucianism in Song and Ming Dynasties, medical theories tended to become philosophical since Song Dynasty, and the concept of viscera gradually separated from the existence of the entity and presented as conceptual and metaphysicalones. In the visceral manifestation of the kidney system, Kidney was gradually referred to as the life gate(mingmen).Functions of the kidney become metaphysiral as kidney stores essence, qi, water and fire; extension of renal functions and unity of liver and kidney; function exchange between the kidney and life gate as well as ontology of life gate concept; and the dematerialization of deficiency pattern identification and treatment. The construction of the ontological system of life-gateTaijishows that the interaction of heart and kidney is the basic mechanism of life movement, and this system was the key turning point in visceral manifestation system’s philosophizing.  
        关键词：Visceral manifestation of the kidney;life gate;ontology;Tai chi;heart and kidneys interact   
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        发布时间：2021-05-20
      • Liu Fan,Wei Fengqin
        Vol. 43, Issue 1, Pages: 27-31(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.006
        摘要：This paper focuses on the formation and development of Liu Wansu’s fire theory to shed light on its influence on the inheritance and innovation of TCM. Firstly, the paper elaborates on the forming process of Liu Wansu’s fire theory, which mainly includes his own practice, collection of classics, and integration of neo-confucianism into the theory. Secondly, from the perspectives of TCM practitioners in the Jin and Yuan dynasties, of warm pathogen diseases and modern scholars, the paper further summarizes the thread of inheritance. Finally, influence of Liu Wansu’s fire theory (formation and development) on the inheritance and innovation of modern Chinese medicine is expounded. To sum up, focusing on classics and learning from various sources are the prerequisite for successful inheritance and innovation.  
        关键词：Liu Wansu;fire theory;inheritance   
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        发布时间：2021-05-20
      • Li Yu,Zhang Xueliang,Zhang Min,Wang Qingguo
        Vol. 43, Issue 1, Pages: 32-34(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.007
        摘要：The statement “tongue is the orifice of heart”, also known as “heart opens into the tongue”, comes from theHuangdi Neijing (Huangdi’s Internal Classic).The physiological function and pathological changes of the heart are closely related to the tongue. As the orifice of the heart, tongue is connected with the heart on meridians and channels. Tongue expresses the heart by helping articulate, while the heart dominates mind by opening into the tongue. By observing the tongue, doctor can underst and the functional state of the heart’s governing blood vessels and mind. Clinically, the theory of “tongue being the orifice of the heart” can guide the diagnosis and treatment of such diseases as orifice occlusion.  
        关键词：tongue being the orifice of heart;heart opening into the tongue;orifice;clinical application   
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        发布时间：2021-05-20
      • Liang Xiao,Tong Xue,Du huilan,Duan Yancang
        Vol. 43, Issue 1, Pages: 35-42(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.008
        摘要：ObjectiveTo study the effects of sequential administration ofBushen Tiaojing FangII and III (Kidney-invigorating and Menstruation-regulating Decoction II and III, BSTJF II & BSTJF III) on cumulus-oocyte complex (COCs), the levels of cumulus expansion and related parameters of cumulus expansion (HAS2 and TNFAIP6) in mice.Methods120 mice were randomly divided into normal group, model group and BSTJF group (n=40 in each group). From the 1stday to the 9thday, model group and BSTJF group were injected with GnRHa intraperitoneally, and on the 9thday, PMSG was injected simultaneously, and hCG was injected after 48 hours, while equal volume of normal saline was injected to the normal group. BSTJF group was given BSTJF II through gavage administration from the 1stday to the 9thday, and was given BSTJF III from the 10thday to the 11thday, while equal volume of distilled water was given to the normal group and the model group. The COCs were taken out under the microscope at 6 h, 9 h and 12 h after saline or hCG injection. The cumulus expansion was graded and counted, and COCs were collected. Protein expression of cumulus expansion related factors (HAS2 and TNFAIP6) was detected by immunofluorescence staining, and the mRNA expression of cumulus expansion related factors (HAS2 and TNFAIP6) was measured by using real-time fluorescent quantitative PCR.ResultsCompared with the normal group, there was no statistically significant difference in the level of cumulus expansion and the mRNA expression level of HAS2 and TNFAIP6 in the model group (P>0.05). Compared with the normal group and the model group, the cumulus expansion level of the BSTJF group showed a reduction of low-level expansion rate and an increase of high-level cumulus expansion rate (P<0.05). There was no statistically significant difference in the mRNA expression level of HAS2 among the normal group, model group and BSTTF group at 6 h after saline or hCG injection (P>0.05). The mRNA expression levels of HAS2 in the BSTJF group were higher than those in the normal group and the model group at 9 h and 12 h after saline or hCG injection (P<0.05). The mRNA expressions of TNFAIP6 in the BSTJF group at 6 h, 9 h, and 12 h after saline or hCG injection were higher than those of the normal group and the model group(P<0.05).ConclusionThe sequential administration ofBushen Tiaojing FangII and III could promote the cumulus expansion of COCs in mice, and it is speculated that the possible mechanism is related to the up-regulation of mRNA expression levels of cumulus expansion related factors HAS2 and TNFAIP6.  
        关键词：Bushen Tiaojing FangII;Bushen Tiaojing FangIII;COCs;cumulus expansion;HAS2;TNFAIP6;mice   
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        发布时间：2021-05-20
      • Yu Huizhen,Chen Cheng,Chen Junming,Zhu Pengli
        Vol. 43, Issue 1, Pages: 43-49(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.009
        摘要：ObjectiveWe used isolation of density gradient centrifugation and culture on rat bone marrow-derived endothelial progenitor cells (EPCs) to observe the effect of resveratrol on the proliferative capacity of EPCs.MethodsThe rat bone marrow-derived mononuclear cells were isolated by using density gradient centrifugation. Nonadherent cells were removed. Adherent cells were cultured for 14 days to obtain EPCs. The cell markers of CD31, vWF, FLK-1, and CD45 were measured by using immunofluorescence. The uptake of Dil-Acetylated Low Density Lipoprotein (DiL-AC-LDL) and FITC-Ulex europaeus agglutinin-1(FITC-UEA-1) and the Matrigel tube formation assay were conducted to identify EPCs. The influence of resveratrol at different concentrations(5, 10, 25, 50, 100 μmol/L)for 48 h and at different time periods (24~72 h) of culture on the proliferative capacity of EPCs were detected by using CCK8 assay.ResultsIsolated bone marrow derived-mononuclear cells with a cobblestone and pavement stone appearance were cultured after 2 weeks. The immunofluorescence demonstrated that more than 90% cells expressed CD31, vWF and FLK-1. Moreover, the cells could take in DiI-AC-LDL and FITC-UEA-1. In addition, these cells could develop well-formed tube networks when plated in matrigel. According to the morphological, immunophenotypic and functional characteristics, the cells in the study were verified to be rat EPCs. Compared with the control group, after incubated with resveratrol for 48h, the EPCs’ proliferative capacity were improved in concentration (5~50 μmol/L) of resveratrol dependence(P＜0.01 ). Compared with the control group, incubated with 50 μmol/L resveratrol for 24, 48 or 72 h, the EPCs’ proliferative capacity were improved in a time (24~72 h)-dependent way(P＜0.05,＜0.01,＜0.01).ConclusionThese cells isolated by density gradient centrifugation and detected by immunofluorescence were identified as rat bone marrow-derived endothelial progenitor cells. Furthermore, resveratrol could improve the proliferative capacity of rat bone marrow-derived endothelial progenitor cells. These may establish the foundation for the research in the cardiovascular protection mechanism of resveratrol in the future.  
        关键词：resveratrol;endothelial progenitor cells;proliferation;bone marrow;rat   
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        发布时间：2021-05-20
      • Zhang Ningning,Wu Liqun,Huo Jingwei,Zhu Ke
        Vol. 43, Issue 1, Pages: 50-55(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.010
        摘要：ObjectiveTo observe the effects ofJiawei Liu’an Jian(Supplemented Six-Ingredient Decoction, JWLAJ) on airway inflammation and pathological changes of pulmonary tissue remodeling in rats with cough variant asthma (CVA), and to explore its mechanism in treating CVA, so as to provide evidence for clinical treatment.MethodsA total of 60 Wistar rats were randomly allocated into normal group, model group, Montelukast sodium (MS) group, and treatment groups including low-dose, mid-dose and high-dose JWLAJ groups. The rats were sensitized with albumin and aluminium hydroxide, and then inhaled albumin to replicate CVA rat models. The infiltration of pulmonary inflammatory cells, the degree of collagen deposition (collagen area and collagen volume fraction) and morphological changes of airway in the lung tissues of rats in each group were observed.ResultsCompared with the normal group, inflammatory cell infiltration, hyperemia and edema could be observed in the lung tissues under the microscope in the model group. Compared with the model group, the amount of inflammatory cells in the lung tissues were reduced in all treatment groups, and the degrees of hyperemia and edema were also reduced. Collagen area: Compared with the normal group, the collagen area of the model group was increased (P<0.05); compared with each other in the treatment groups, the collagen area decreased most significantly (P<0.05) in the low-dose JWLAJ group; there was no statistically significant difference between the treatment groups and the MS group (P>0.05). Collagen volume fraction: Compared with the normal group, the collagen volume fraction of the model group was increased (P<0.05); compared with each other in treatment groups, the collagen volume fraction decreased most significantly (P<0.05) in the low-dose JWLAJ group; there was no statistically significant difference between the treatment groups and MS group (P>0.05). The airway morphological parameters: Compared with normal group, there was a significant increase in smooth muscle area/bronchial basement membrane diameter (Wam/Pbm), as well as airway wall area/bronchial basement membrane diameter (Wai/Pbm) in the model group (P<0.05). Compared within the treatment groups, the Wam/Pbm, Wai/Pbm ratios were the lowest in low-dose JWLAJ group (P<0.05). There was no statistically significant difference between the MS group and treatment groups (P>0.05).ConclusionJWLAJ could be used to prevent and treat CVA, probably by reducing infiltration, hyperemia and edema of inflammatory cells in lung tissues, reducing collagen deposition surrounding the airway, as well as interfering in airway remodeling.  
        关键词：Jiawei Liu’an Jian(Supplemented Six-Ingredient Decoction);cough variant asthma;inflammatory cells;airway remodeling;rats   
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        发布时间：2021-05-20
      • Chu Fuhao,Li Yuan,Wang Yan,Gao Ying,Zhang Beibei,Su Zeqi,Ding Xia
        Vol. 43, Issue 1, Pages: 56-65(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.011
        摘要：ObjectiveTo explore the main active compositions and their targets ofCansha (Faeces Bombycis)in the prevention and treatment of rheumatoid arthritis combined with diabetes, and to reveal its characteristics of multi-composition, multi-target and multi-channel.MethodsThe main ingredients ofCanshawere sorted out combining literature search and database mining, and the targets of main active compositions were predicted by using Parm Mapper reverse molecular docking method. The names of predicted protein were revised by using UniProt database and the information of related-diseases were revised by using Therapeutic target database (TTD). The targets, related to rheumatoid arthritis and diabetes, were screened out. The composition-target-disease networks ofCanshaand protein-protein interaction (PPI) networks were constructed by using Cytoscape software. Functional annotation analysis of Gene Ontology (GO) and signaling pathway enrichment analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed on the related targets ofCanshain treatment for rheumatoid arthritis and diabetes.ResultsAfter screening and analysis, the main active compositions ofCanshaincluded beta-Carotene, beta-Sitosterol, cholesterol and euchrenone A7. Network pharmacology analysis showed that 37 targets related to rheumatoid arthritis and/or diabetes, among which 6 targets related to both rheumatoid arthritis and diabetes, such as SEC14-like protein 2 (S14L2), dipeptidyl peptidase 4 (DPP4), corticosteroid 11-beta-dehydrogenase isozyme (DHI1), caspase-1 (CASP1), peroxisome proliferator-activated receptor gamma (PPARG) and alpha-tocopherol transfer protein (TTPA). Through GO functional annotation analysis 7 GO items were obtained (P<0.05), of which three involved biological processes items and four molecular function items. And there were 4 signaling pathways (P<0.05) in the KEGG signaling pathway analysis, involving prolactin signaling pathway, Osteoclast differentiation signaling pathway, Th17 cell differentiation signaling pathway and PPAR signaling pathway.ConclusionCanshais characterized by multi-composition, multi-target and multi-channel in the clinical prevention and treatment of rheumatoid arthritis combined with diabetes. This study provided a reference for further expounding on the mechanism of clinical prevention and treatment of diseases ofCanshaand the scientific basis for the study of homotherapy for heteropathy ofCansha. However, further experiments are warranted to verify key targets and regulatory mechanisms.  
        关键词：network pharmacology;Cansha (Faeces Bombycis);homotherapy for heteropathy;mechanism;reverse molecular docking   
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        发布时间：2021-05-20
      • Zhu Xiaoling,Li Binxin,DONG Yu
        Vol. 43, Issue 1, Pages: 66-73(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.012
        摘要：ObjectiveTo study the chemical compositions and gastritis-related targets in Mongolian medicineShudage-4 based on molecular docking, and to explore the interaction between chemical compositions and related targets.MethodsA total of twenty-eight compounds and seven targets related to gastritis were selected based on previous study of network pharmacology and were docked separately. The binding free energy was determined and the interaction between receptor and ligand was analyzed.ResultsThe compounds with anti-gastritis activity screened fromShudage-4 were found to have low binding free energy and high binding activities to cyclooxygenase-2 (COX-2). Moreover, stigmasterol, oleanolic acid, sitosterol, isoalantolactone, costunolide, alpinia trimethyl ether, quercetin, alantolactone, rhamnetin, dehydrocostus lactone, alpinia, kaempferol, kaempferide, and curcumin have lower binding free energy with targets such as COX-2.ConclusionThis paper provides reference for further study on material basis of Mongolian medicineShudage-4 in the treatment of gastritis through the molecular docking investigation of chemical compositions and targets related to gastritis.  
        关键词：Shudage-4;chemical compositions;interaction;molecular docking   
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        发布时间：2021-05-20
      • Wu Jing,Zhang Zhichen,Li Zhonghao,Liu Chongchong,Dong Xiaoke,Liu Jinmin
        Vol. 43, Issue 1, Pages: 74-78(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.013
        摘要：ObjectiveTo study the distribution of pattern elements and their evolution over time in patients with acute cerebral infarction undergoing intravenous thrombolysis within 14 days of onset.Methods56 patients with rt-PA intravenous thrombolysis within 6 hours after the onset of cerebral infarction were included. The information of TCM pattern elements was collected on the 1st, 3rd, 5th, 7th and 14th day after the onset of disease. Various information and data were synthesized for statistical analysis.ResultsIn the evolution of the pattern elements of patients, the wind pattern was the dominart one on the 1st day; the proportion of blood-stasis pattern and phlegm-dampness pattern was also high. As the disease progressed, the proportion of internal wind pattern rapidly decreased on the 3rd day and disappeared on the 14th day; the proportion of phlegm-dampness pattern and blood-stasis pattern showed a downward trend but still maintained high. As time passed, the proportion of qi-deficiency pattern gradually increased and became the highest one on the 7th day. The proportion of internal-fire pattern rised on the 5h day and tended to the initial level; the proportion of yin-deficiency pattern was always low with a downward trend over time.ConclusionIn the early stage of cerebral infarction, excess pattern dominated the pattern elements of patients. Among them, wind pattern seems to be the main factor. The combination of every two of wind, phlegm and stasis patterns topped the list, followed by that of all three basic patterns. Compared with previous studies on the evolution of pattern elements of cerebral infarction, the patients’ clinical pattern form in this study gradually reduces after thrombolytic therapy, with decreasing excess pattern and more prominent qi-deficiency pattern.  
        关键词：cerebral infarction;pattern elements;intravenous thrombolysis   
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        发布时间：2021-05-20
      • Liu Yujia,Wang Shenzhi,Kuang Huitao,Fan Fuyuan
        Vol. 43, Issue 1, Pages: 79-83(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.014
        摘要：ObjectiveTo provide a reliable basis for the diagnosis and standardized treatment of rheumatoid arthritis by summarizing its patterns and pattern elements.MethodsCases of the inpatients and outpatients from May 2016 to December 2017 in the rheumatology department of the First Hospital of Hunan University of Chinese Medicine were collected, and the included cases were analyzed for pattern analysis and pattern element extraction, and their clinical characteristics were analyzed.ResultsA total of 12 patterns were obtained in 217 patients diagnosed as rheumatoid arthritis, which were divided into 5 pattern elements of disease locations and 10 pattern elements of disease characters. Clinical common patterns from high to low were liver-kidney deficiency, dampness-heat obstruction, cold-dampness obstruction, qi-blood deficiency, phlegm and blood stasis obstruction, cold-heat complex, wind-dampness obstruction, qi-yin deficiency, pattern elements of disease locations from high to low were meridians and channels, kidney, liver, spleen, superficies, and pattern elements of disease characters from high to low were dampness, heat, cold, qi deficiency, blood deficiency, blood stasis, phlegm, wind, yin deficiency, yang deficiency.ConclusionLiver-kidney deficiency, dampness-heat obstruction, cold-dampness obstruction are the common patterns of rheumatoid arthritis; and meridian, kidney, liver, dampness, heat, cold are the common pattern elements. Establishing pattern differentiation system with pattern elements as the core could play a role of controlling complexity in clinical diagnosis and treatment of rheumatoid arthritis.  
        关键词：rheumatoid arthritis;patterns;pattern elements;clinical research   
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      • Zhang Xinyue,Huang Xunying,Ha Lue,Hui Xin,Wang Hao,Zhao Baixiao
        Vol. 43, Issue 1, Pages: 84-88(2020) DOI: 10.3969/j.issn.1006-2157.2020.01.015
        摘要：ObjectiveTo observe symptoms and changes in sleep quality before and after moxibustion on Xinshu (BL15), Neiguan (PC6), Danzhong (RN17), Zhongwan (RN12), Zusanli (ST36) in clopidogrel-resistant patients with coronary heart disease (CHD).MethodsThe project planned to enroll 100 patients in total. In this trial study, 30 CHD patients with clopidogrel resistance and insomnia have been enrolled. All patients filled in the Pittsburgh Sleep Quality Index (PSQI) scale by themselves and recorded accompanying symptoms of coronary heart disease that caused physical discomfort during the past one month. For each treatment session, the operation sequence of“back to belly, top to bottom” was followed. Moxibustion was perforned first on the bilateral Xinshu (BL75) points, then on the Neiguan (PC6) points and Danzhong (RN17) points, and then on Zhongwan (RN12) points, finally on bilateral Zusanli (ST36) acupoints. PSQI scores before and after the treatment were collected. Complications of coronary heart disease were also evaluated.ResultsPSQI scores significantly improved (P<0.05) both at 2 weeks and 4 weeks after the treatment. CHD related symptoms were also alleviated.ConclusionMoxibustion can significantly improve insomnia and relieve the symptoms of coronary heart disease. It could benefit the prognosis and recovery of CHD patients.  
        关键词：moxibustion;insomnia;coronary heart disease;clopidogrel resistance;Pittsburgh sleep quality index   
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