最新刊期
      卷 43 ， 期 2 ， 2020
      • Guo Chunxia,Zhang Qiming,Wang Yiguo,Zhang Jianxiong,XuYang,Zheng Tengfei,Feng Hui,Yuan Xiaohui,Li Xuan
        Vol. 43, Issue 2, Pages: 93-97(2020) DOI: 10.3969/j.issn.1006-2157.2020.02.001
        摘要：The function of “the spleen governing muscles” refers to the function of spleen to produce essence of grain and water to nourish muscles and other affiliated parts all over the whole body. However, the functions of skeletal muscles are not solely governed by the spleen.In this article,the distribution and functions of skeletal muscles in the whole body are observed according to anatomy,then these functions are compared with those of the five zang organs in TCM. The functions of skeletal muscles are supported by the physiological functions of the five organs, i.e. transportation, transformation and fixing and lifting tendency of the spleen (manifested as muscle), the respiratory function of the lung, water metabolism and reproductive function of the kidney, free flow of qi and emotions governed by the liver, and housingshen(mental activity) of the heart. To be more specific,the skeletal muscles involved in digestion corresponds with the spleen’s function of transportation and transformation.The skeletal muscles that produce muscular strength and muscular tension to maintain body movement and posture are in accordance with the spleen’s function of governing muscles in five body constituents. The fascial functions that produce tension to fix the organs and support the skin belong to the fixing and lifting function of the spleen. The skeletal muscles involved in breathing correspondto the lung’s function of governing respiration.The skeletal muscles related to urination and delivery are in accordance to the kidney’s function of governing water metabolism and reproduction.The skeletal muscles involved in the expression of emotions are related to the liver which controls free flow of qi and emotions. The skeletal muscles involved in the manifestation of spiritual activities correspond to the heart’s function of housingshen(mental activity).  
        关键词：skeletal muscle;five zang organs in TCM;functional attribution   
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        发布时间：2021-05-20
      • Chen Hongjing,Li Xiaoli,Liu Haipeng,Lin Liangyin,Diao Huaqiong,Ding Haiyue,Wei Dan
        Vol. 43, Issue 2, Pages: 98-102(2020) DOI: 10.3969/j.issn.1006-2157.2020.02.002
        摘要：“Water cold resulting in inhibition of the wood” refers to that kidney yang deficiency and cold coagulation in the kidney may lead to failune of the kidney to warm the liver and liver qi stagnation. This pathogenesis originated from theHuangdi Neijing (Huangdi’s Internal Classic), and has been developed and applied to diseases of various systems by later physicians. Based on literature research, it is observed that this pathogenesis could possibly be applied in interpreting the mechanism of Parkinson’s disease with depression (PDD) from TCM perspective. For PDD, yang deficiency and cold coagulation of the kidney is the root of the attack, and liver qi stagnation appears in the initial stage. According to various clinical studies, the therapeutic method of warming the kidney yang to relieve liver qi stagnation is effective in treating PDD. Based on such findings, we have developed a formula (composed ofZhifuzi(prepared aconite rootRadix Aconiti Lateralis Praeparata), Bajitian (morinda root,Radix Morindae Officinalis), Chaihu (bupleurum, Radix Bupleuri)) with corresponding effects, which proves to be 70%effective. Pharmacological studies also show that certain traditional Chinese medicinals with the effect of warming the kidney or relieving the liver qi stagnation can show some effect in the treatment of PDD. These research results support the exploration of the pathogenesis of PDD from the perspective of “water cold resulting in inhibition of the wood”. This article has explored such a pathogenesis in PDD based on literature reviews of classical TCM literature, relevant theories and modern studies, in order to provide new ideas and references for the pathogenesis research and clinical treatment of PDD.  
        关键词：Parkinson’s disease;Parkinson’s disease with depression;water cold resulting in inhibition of the wood;pathogenesis   
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        发布时间：2021-05-20
      • Lyu Xiaoxue,Wang Yulin
        Vol. 43, Issue 2, Pages: 103-107(2020) DOI: 10.3969/j.issn.1006-2157.2020.02.003
        摘要：Some medical terms were included inGuang Yaedited by Zhang Yi in the Three Kingdom Period.Guang Ya Shu Zhengwritten by Wang Niansun in the Qing Dynasty, is regarded as the best note ofGuang Ya. Wang Niansun prioritized the use of phonetic correlation and cognate words in his interpretation of word meaning and interlingual relationships.This article uses the medical terms included inGuang Yaas the corpus, and explores the theories and methods used by Wang Niansun in interpretation inGuang Ya Shu Zhengincluding identifying the phonetic loan characters, correlating with cognate words, and integrating commonly used words and medical terminology, etc. Besides, Wang Niansun’s collation methods used in identifying the errors in the text ofGuang Yasuch as clerical error, lipographyand redundant words, were also examined. Thus, this article has explored the possible interpretation methods that can be applied in the study of medical terms in ancient medical literatures.  
        关键词：Guang Ya;medical terms;interpretation   
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        发布时间：2021-05-20
      • Li Ya,Li Ruibai,Shi Fengqin,Chen Xinyi,Lyu Liyuan,Zhao Huan,Li Xiaojie,Hou Li
        Vol. 43, Issue 2, Pages: 108-114(2020) DOI: 10.3969/j.issn.1006-2157.2020.02.004
        摘要：ObjectiveTo investigate the inhibitory effect and its possible mechanism of diosgenin on the proliferation, colony formation, migration and invasion of human gastric cancer cell (AGS).MethodsThe cell proliferation assay was used to detect the inhibition effect of diosgenin on AGS proliferation. The colony formation assay was performed to detect the effect of diosgenin on the colony formation efficiency of AGS cells. The wound healing test and transwell chamber assay were used to detect the effect of diosgenin on the migration and invasion of AGS. The MicroRNA(MiRNA) Target Prediction was used to predict the target genes of miR-34a. The Quantitative real-time PCR(qPCR) method was performed to observe the effect of diosgenin on the expression of miR-34a, E2F1, E2F3 and CCND1 in AGS cells, and analyze the correlation between their expression and the prognosis of gastric cancer patients.ResultsDiosgenin with different concentrations (24 μmol/L,30 μmol/L,36 μmol/L,42 μmol/L,48 μmol/L)could significantly inhibit the proliferation of AGS cells, and there was a positive correlation between the inhibiting effect and the dose and time. In different concentrations of diosgenin (24 μmol/L,30 μmol/L,36 μmol/L,42 μmol/L,48 μmol/L), the colony formation efficiency of AGS cells was significantly decreased (P<0.01), and the migration and invasion of gastric cancer cells were significantly decreased (P<0.01), with the effect positively correlated with time and concentration.Diosgenin(36 μmol/L) significantly increased the expression of miR-34a in AGS cells and decreased the expression of E2F1, E2F3 and CCND1, which were target genes of miR-34a. The expression of E2F1, E2F3 and CCND1 genes was significantly negatively correlated with the prognosis of gastric cancer patients.ConclusionDiosgenin seems to inhibit the proliferation, migration and invasion of AGS cells partly by regulating miR-34a and down-regulating the expression of E2F1, E2F3 and CCND1 genes.  
        关键词：diosgenin;gastric cancer;miRNAs;target genes   
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        发布时间：2021-05-20
      • Song Zhongyang,Wang Gongchen,Zhang Zhiming,Yong Wenxing,Liu Yongqi,Zhang Liying,Li Juan
        Vol. 43, Issue 2, Pages: 115-124(2020) DOI: 10.3969/j.issn.1006-2157.2020.02.005
        摘要：ObjectiveTo study the protective effect of Buyang Huanwu Decoction (BHD) combined with bone mesenchymal stem cells (BMSCs) on myocardial ischemia reperfusion injury (MIRI) in rats and the effect of BMSCs migration.Methods60 Wistar rats were randomly divided into sham operated group, model group, BMSCs group and BHD plus BMSCs group The left anterior descending coronary artery (LAD) was ligated to duplicate Miri rat model in all groups except for the sham operated group. The rats were gavaged with BHD and normal saline for 14 days respectively. The levels of cTnI, CK-MB, LDH,and MDA, the content of nitric oxide (NO) and the activity of SOD in serum were measured by biochemical method. The cardiac function was detected by echocardiography, the pathological morphology of myocardial tissue was detected by HE staining, the migration and distribution of GFP-labeled BMSCs were observed in vivo by Caliper IVIS Lumina II, and the content of myocardial BMSC was detected by immunofluorescence.ResultsCompared with the BMSCs group, in BHD plus BMSCs group, the LVIDd and LVIDs decreased significantly, while EF was increased (P＜0.05); the levels of cTnI, LDH and CK-MB were significantly decresed (P＜0.05); the activity of SOD and the content of NO were increased, while the content of MDA was decreased (P＜0.05). According to HE staining, the muscle fibers were arranged in order; there was slight edema in the intercellular matrix and a little infiltration of inflammatory cells, but the cell boundary was clear. The Caliper IVIS Lumina II in vivo showed that there were no obvious migration and distribution of GFP-labeled BMSCs in the sham operation group and model group, but the expression intensity of GFP in the BHD plus BMSCs group was significantly higher than that in the BMSCs group, and the concentration of BMSCs in the heart was significantly higher than that in the BMSCs group (P<0.05). The results of immunofluorescence showed that the content of BMSCs in the BHD plus BMSCs group was significantly higher than that in the BMSCs group (P<0.05).Conclusions BHD could possibly reduce transplanted BMSCs after myocardial ischemia reperfusion injury in rats, reduce myocardial tissue pathological morphological changes, improve cardiac function. Through improving SOD activity in serum, increasing the NO content, and reducing the CK-MB, LDH, cTnI levels and MDA concentration in serum, it seems to reduce MIRI with the myocardial protective effect. Its mechanism might be related to the reduction of the membrane lipid peroxidation, and protection from the oxidative stress injury of myocardial cells in reperfusion period. It also indicates that BHD could possibly promote the migration of BMSCs into the myocardial tissue of MIRI model rats, increase the number of BMSCs migration, and improve the homing efficiency of BMSCs.  
        关键词：Buyang HuanwuDecoction (BHD);bone marrow mesenchymal stem cells;myocardial ischemia-reperfusion injury;protective effect;migration;rats   
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        发布时间：2021-05-20
      • Li Weili,Hao Lele,Jin Ya,Liu Mingmin,Wu Hua,Yu Xinhui
        Vol. 43, Issue 2, Pages: 125-132(2020) DOI: 10.3969/j.issn.1006-2157.2020.02.006
        摘要：ObjectiveObjective To study the effect ofBushenAntai(BSAT) Granule on Transforming Growth Factor β1(TGF-β1), Phosphatidylinositol-3-kinase(PI3K)and serine/threonine(AKT)related proteins in decidua of mice with recurrent spontaneous abortion, and to explore its mechanism of reducing the rate of embryo abortion.MethodsCBA/J × BALB/c mice were caged to establish normal pregnant mice model. The RSA mice model was established by using DBA/2 × CBA mice, which were randomly divided into model group, progesterone groupBushenAntai(BSAT) high dose groupBushenAntai(BSAT)medium-dose group andBushenAntai(BSAT)low-dose group. Each group was gavaged with the corresponding medicine daily.After 15 days of continuous intervention, mice were executed and samples were collected. in each group, the embryo loss was observed by naked eyes; Pathological changes of decidua were observed by hematoxylin eosinstaining. The contents of E2, P, TGF-β1, PI3K and Akt in serum of mice in each group were detected by enzyme-linked immunosorbent assay (ELISA). The expression of TGF-β1, PI3K and Akt in decidua was detected by immunohistochemistry and Western blot.ResultsCompared with the normal group, in the model group the rate of embryo loss was increased (P<0.01), the contents of E2, P, TGF-β1, PI3K and Akt in serum were decreased (P<0.01), the expression levels of TGF-β1, PI3K and Akt in decidua were decreased (P<0.01). Compared with the model group, after drug intervention, the rate of embryo loss was decreased (P<0.01), the contents of E2, P, TGF-β1, PI3K and Akt in serum were increased (P<0.01), and the expression levels of TGF-β1, PI3K and Akt in decidua were all increased (P<0.01), all of which were most significant in the BSAT high-dose group.ConclusionBSAT Granule is likely to reduce the rate of embryo loss in mice with recurrent spontaneous abortion. Its mechanism may be that through up-regulating TGF-β1/PI3K/Akt signaling pathway, it could promote the formation of blood vessels at the maternal fetal interface of mice with recurrent spontaneous abortion, so as to achieve the purpose of embryo protection.  
          
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        发布时间：2021-05-20
      • Wang Jianzhang,Yu Yunfeng,Zhou Manli,Feng Yu,Guo Zhihua,Jian Weixiong
        Vol. 43, Issue 2, Pages: 133-140(2020) DOI: 10.3969/j.issn.1006-2157.2020.02.007
        摘要：ObjectiveTo study the protein changes in the intervention of the Compound Uncaria Tablets in Spontaneously Hypertensive Rats (SHR) and the potential mechanism of left ventricular hypertrophy in hypertension.Methods16SHRs were divided into two groups. The treatment group was gavaged with the Compound Uncaria Tablets, and the control group was gavaged with distilled water. After 12 weeks of intervention, the myocardial tissue protein was taken and tested by iTRAQ assay analysis. By analyzing the enrichment of pathways, the differential proteins and pathways were obtained, and furtherly mapped using the STRING database.ResultsThe pathway enrichment analysis of the differential protein indicated that there were 11 pathways. The iTRAQ analysis of the differential protein indicated that there were 6 up-regulated proteins: transgelatin, carbonic anhydrase 3, S-phase kinase-associated protein 1, C-reactive protein, fibrin 5, and C-1-tetrahydrofolate synthetase; and there were 12 down-regulated proteins: glutathione S-transferase, Ighg3, histidine trinucleotide binding protein 2, 60S ribosomal protein L4, 40S ribosomal protein S6, 60S ribosomal protein L13, 14-3-3 protein, protein LOC100911337, glutathione peroxidase 1, serine hydroxymethyltransferase, protein kinase B, and ubiquitin -40S ribosomal protein S27A.In the relational network drawn by string: 60S ribosomal protein L4, 40S ribosomal protein S6, 60S ribosomal protein L13, and ubiquitin-40S ribosomal protein S27A are most closely related.ConclusionThe intervention of Compound Uncaria Tablets on hypertensive left ventricular hypertrophy is possibly mainly related to improving blood supply, optimizing energy metabolism, inhibiting abnormal growth of cardiomyocytes and increasing fibrin of blood vessels and heart. The occurrence of hypertensive left ventricular hypertrophy may be related to ribosomal proteins.  
        关键词：Compound Uncaria Tablets;hypertension;left ventricular hypertrophy;ribosomal protein;iTRAQ   
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        发布时间：2021-05-20
      • Ni Yingqun,Fang Zhaohui,Shi Hui
        Vol. 43, Issue 2, Pages: 141-147(2020) DOI: 10.3969/j.issn.1006-2157.2020.02.008
        摘要：ObjectiveTo study the effect and mechanism of Danzhi Jiangtang Capsule (DZC) on angiogenesis based on VEGF-mediated signaling pathway in diabetic rats.Methods10 SD rats were selected as the blank group, 50 GK rats were used to establish the model of lower limb ischemia in diabetes, and were randomly divided into the model group, the Danzhi Jiangtang Capsule high-dose group (H-DZC group), the Danzhi Jiangtang Capsule medium-dose group (M-DZC group), the Danzhi Jiangtang Capsule low-dose group (L-DZC group), and the pioglitazone hydrochloride group. In each group, the GK rats were gavaged correspondingly for 30 days.Then the density of new vessels in blood and vascular tissue of lower limbs was detected under the microscope; the contents of VEGF, Ang1, Ang2, Tie2, NO and NOS inserum were detected by ELISA; Ang1, Ang2 and Tie2 in gastrocnemius muscle were detected by Western Blot.ResultsThe VEGF/Akt/eNOS signaling pathway was inhibited in diabetic rats with lower limb ischemia. After the treatment, serum levels of VEGF, eNOS and NO in the H-DZC, M-DZC and L-DZC groups and pioglitazone group were all significantly increased (P<0.01 orP<0.05). Similar results were also observed in the gastrocnemius muscle. The expression of p-Akt and P-eNOS in H-DZC group and pioglitazone hydrochloride group were most significantly increased(P<0.01).Among the three DZC groups, the expression of p-Akt and P-eNOS was most significantly increased in the high-dose group (P<0.05).In addition,compared with the model group, Ang-2 levels in serum and tissues in all treatment groups were significantly reduced (P<0.05 orP<0.01), and the decrease was more significant in H-DZC group (P<0.01). After the treatment, the expression of Ang-1 and Tie-2 in serum and gastrocnemius muscle tissues of rats in all treatment groups were increased (P<0.05 orP<0.01), and the increase was more significant in H-DZC group (P<0.01).ConclusionDZC seems to activate the inhibited VEGF/Akt/eNOS and Ang/Tie2 signaling pathways in diabetic vascular lesions and promote the dissociation of vascular basement membrane, so as to prepare for and promote the initiation of angiogenesis of vessels in lower limbs.  
        关键词：VEGF;signaling pathway;Danzhi Jiangtang Capsule (DZC);diabetes;angiogenesis;rats   
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        发布时间：2021-05-20
      • Lu Dongbo,Kong Jing,Li Sitong,Fan Yuanyuan,Huang Yujuan,Sun Rendi,Huang Guangwei,Liu Lulu,Chen Siyu,Gao Yuanyuan,Jiang Yanyan,Shi Renbing
        Vol. 43, Issue 2, Pages: 148-162(2020) DOI: 10.3969/j.issn.1006-2157.2020.02.009
        摘要：ObjectiveTo establish the quality representation model, analysis method and quality evaluation based on the effective characteristic spectrum of reference ofperillae foliumso as to evaluate the quality ofperillae foliumeffectively and accurately.MethodsTo determine theperillae foliumwhich has the effect of regulating blood lipid as the standard reference pieces. Taking effective characteristic index component as quality reference point. Using HPLC-PDA method to establish effective characteristic spectrum of reference, and obtained quality characterization information was used as the standard to evaluate the quality ofperillae foliumand to prove the accuracy.ResultsScutellarin, as the reference point, (retention time: 30.342 min; content: 0.573 4%; concentration: 0.057 34 g/L ), represented the quality information of characteristic spectrum of benchmark (S1) which was effective:14 characteristic peak retention time, peak area, relative retention time, relative peak area, six characteristic index components content, relative content and content conversion coefficient (caffeicacid,luteolin-7-O-glucuronide, apigenin-7-O-glucuronide, scutellarin, rosmarinic acid, oleanolic acid), which covers phenolic acids, flavonoids and triterpenoids. And reference substance of scutellarin, as the simulative datum point (rretention time: 29.759 min; concentration: 0.057 3 g/L), represented the quality information. The two results were consistent, and verified the feasibility of the test method and the accuracy of the test results.14 characteristic peaks appeared on the chromatograms of 14 batches ofperillae foliumand the conversion content of six characteristic index components was consistent with the measured content. Using the effective quality representation of reference information to evaluate the quality of 14 batches ofperillae foliumand the quality of S8,S7,S12,S9,S13 were judged to be better.ConclusionThe established quality representation model and analysis method based on the effective characteristic spectrum of reference ofperillae foliumcan be used represent the quality ofperillae foliumsimply, accurately and integrally. The established quality analysis model can be used to analyze the quality ofperillae folium.  
        关键词：perillae folium;effective characteristic spectrum of reference;quality representation;quality standard;quality evaluation   
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        发布时间：2021-05-20
      • Han Yongli,Chen Song,Zhang Yanlin,Chen Ziqin
        Vol. 43, Issue 2, Pages: 163-170(2020) DOI: 10.3969/j.issn.1006-2157.2020.02.010
        摘要：ObjectiveTo observe the effect of pretreatment with electroacupuncture at PC 6 (nei guan) on cell autophagy in myocardial ischemia-reperfusion (I/R) rats, and to clarify its underlying mechanism.Methods50 rats were randomly divided into 5 groups: sham operated group, model group, electroacupuncture pretreatment group (EA group), inhibitor pretreatment group (inhibitor group), and electroacupuncture + inhibitor pretreatment group (EA + inhibitor group) (n=10 in each group). The rats in the sham operated group were directly exposed after thoracotomy without other treatments. The rats in the model group underwent in-vivo myocardial ischemia-reperfusion. Rats in the EA group received electroacupuncture treatment on PC 6 (nei guan) 7 days prior to model establishment. Rats in the inhibitor group were injected with wortmannin (PI3K inhibitor) a week before the model was established, and received myocardial ischemia-reperfusion on the 8th day. Rats in the EA + inhibitor group received both forms of pretreatment. All rats were killed after treatment. The serum CK-MB, iNOS, and T-AOC expressions were detected by ultraviolet spectrophotometry. The expression and localization of ATG13, mTOR, and PI3K in myocardial cells were detected by immunofluorescence on paraffin sections. The pathological changes caused by cardiomyocyte autophagy in the control group were observed by HE staining experiments. Ultrastructural changes of cardiomyocytes in the control group were observed by transmission electron microscopy.ResultsCompared with the sham operated group, the serum CK-MB and the iNOS concentration was significantly increased, T-AOC concentrations were significantly reduced in the control group (P＜0.05). Compared with the control group, in the three pretreatment groups, the CK-MB and the iNOS concentration was decreased, T-AOC concentrations were increased (P＜0.05); among them, the effect in the EA group was the most significant. Compared with the sham operated group, the expressions of mTOR, ATG13 and PI3K in cardiomyocytes in the other four groups were all increased Compared with the model group, in the three pretreatment groups, the expression of mTOR, ATG13, and PI3K in myocardial tissues was decreased. HE staining results showed that compared with the sham operated group, in the model group, myocardial muscle fibers showed lytic rupture or even necrosis, and obvious swelling. In the three pretreatment groups, the myocardial fiber space was slightly widened, the necrotic lesions were reduced, and the myocardial cells were slightly swollen; among them the EA group showed the most obvious changes. The transmission electron microscope observation results showed that compared with the sham operated group, in the model group, the myocardial muscle fibers showed lytic rupture or even necrosis, and there were irregular and missing mitochondria. While in the three pretreatment groups, the myocardial muscle fiber gaps were slightly widened, and the nucleus and mitochondrial structure were basically complete. Among them, there was most significant change in the EA group.ConclusionElectroacupuncture pretreatment could possibly reduce myocardial I/R damage and reduce the formation of autophagosomes by promoting autophagy. While wortmannin (PI3K inhibitor) seems to reverse such a protective effect.  
        关键词：myocardial ischemia;electroacupuncture;pretreatment;autophagy;PI3K-Akt-mTOR pathway;rats   
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        发布时间：2021-05-20
      • Ma Xueyan,Yu He,Wu Liqun,Mei Chencheng,Li Zhuo,Huang Ling,Cui Lijun,Liu Shaoyang,Xu Jingnan,Liu Tiegang,Gu Xiaohong
        Vol. 43, Issue 2, Pages: 171-176(2020) DOI: 10.3969/j.issn.1006-2157.2020.02.011
        摘要：ObjectiveTo develop the evaluation scale for Gastrointestinal Heat Retention Syndrome(GHRS) in children.Methods453 children were enrolled and 38 symptoms and signs of the subjects were collected by medical professionals. Classical Test Theory and Item Response Theory were used to select items. Items were selected through five statistical methods including classical test theory of discrete trends analysis, correlation coefficient analysis, Cronbach’s αcoefficient analysis and factor analysis, as well as item response theory. The items which were tested to be acceptable according to 4 or 5 methods would be kept and enlisted in the evaluation scale under the guidance of professional knowledge.ResultsThe evaluation scale consisted of 26 items, including red complexion, red lips, pharyngeal redness and swelling, red tongue, yellow tongue fur, feverish feeling in palms and soles, rapid pulse, slippery pulse, aversion to heat, halitosis, hot mouth and nasal breath, thirst with preference for cold drinks, abnormal appetite, abdominal pain, smelly flatus,reduced frequency of defecation, dry stool, difficult defecation, smelly stool, yellow urine, sweating at night, restless sleep at night, vexation and irascibility,nasal crust, susceptibility to respiratory tract infection, and symptoms worsened after improper diet. There were 11 binary variables and 15 quadruple variables graded by frequency or severity degree.ConclusionThe evaluation scale for GHRS in children is developed, which can be used in the study of GHRS and GHRS-related diseases in children.  
        关键词：Gastrointestinal Heat Retention Syndrome (GHRS);evaluation scale;classical test theory;item response theory   
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