最新刊期
      卷 43 ， 期 5 ， 2020
      • Dong Fei,Liu Hongliang,Gu Xiaohong
        Vol. 43, Issue 5, Pages: 357-362(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.001
        摘要：The novel coronavirus pneumonia is mainly characterized by involvement of pulmonary interstitial lesions. Among patients with increased expression of virus in the kidney, lung-kidney impairment tends to manifest from the early stage after onset. For patients with older age and underlying diseases, their lung and kidney seem to be both involved at later stages, which may then develop into multiple organ failure syndrome (MOFS). The “lung-sanjiao(triple energizer)moyuan(membrane source)-kidney” theory in traditional Chinese medicine (TCM) considers that lung mesenchyme and kidney mesangial membranes are the material basis for triple energizer membrane source to play its role, which is highly consistent with the pathogenesis theory of “[epidemic] pathogens lurking in the membrane source” proposed by Wu Youke in book titledOn Epidemic Diseases (Wen Yi Lun).This paper articulates the model theory of “lung-triple energizermoyuan-kidney”, to reason how and why the treatment methods of “treating the upper, [middle] and lowerjiaorespectively (fen xiao shang xia)” by Ye Tianshi in the book titledOn Warm & Heat Diseases (Wen Re Lun)are widely used and also effective in clinical practice. This model theory may serve as reference for the further application of the TCM classic theories in the treatment of emerging and emergent infectious diseases.  
        关键词：novel coronavirus pneumonia;sanjiao moyuan;lung-kidney impairment;divide and resolve the upper and lower(fen xiao shang xia)   
        412
        |
        5
        |
        5
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360811 false
        发布时间：2021-05-20
      • Yang Xianzhao,Du Hongbo,He Weili,Zhang Jingfeng,Liu Ning,Cui Jie,Chen Zhengguang,Du Yong,Ye Yong’an
        Vol. 43, Issue 5, Pages: 363-367(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.002
        摘要：It has been more than two months since the outbreak of Corona Virus Disease 2019 (COVID-19), and the overall epidemic situation is now under effective control with the number of cured discharged cases surpassing existing confirmed ones. Although the general condition of discharged patients has been improved to a certain extent, quite a number of them still have clinical symptoms and organ injury. Therefore, follow-up rehabilitation treatment for these patients is of great importance. Our team went to Wuhan, the center of epidemic regions, to assist clinical treatment using traditional Chinese medicine. From our experience, we found the course of the disease is relatively long, and that the problem of pulmonary fibrosis is more prominent during the recovery period. Most COVID-19 patients at the recovery stage tend to present with a complicated state of multiple patterns, characterized by dominant qi deficiency, increasing severity of blood stasis together with remaining excess of pathogens. Based on field observations, we hold that the qi deficiency and blood stasis is the core pathogenesis. Therefore, management of COVID-19 patients during the recovery period should target at pulmonary fibrosis as the key pathology by using qi-tonifying blood-activating treatment as the basic principle, combined with methods of clearing away the remaining pathogenic factors. Flexible medicinal modification could help patients recover better.  
        关键词：COVID-19;recovery period;traditional Chinese medicine;prevention and preatment strategy   
        358
        |
        4
        |
        8
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360793 false
        发布时间：2021-05-20
      • Wang Yuguang,Cheng Jinlian,Yan Shiyan
        Vol. 43, Issue 5, Pages: 368-372(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.003
        摘要：There has been no specific treatment for coronavirus disease 2019 (COVID-19). Quite a number of ongoing clinical trials are conducted to search for efficacious medicine against COVID-19. Meanwhile there are concerns about study design rigor,non-specific target and adequate oversight of these trials.This paper analyzed the problems observed in current COVID-19 clinical trials investigating the efficacy of traditional Chinese medicine (TCM) therapies and then offered suggestions for possible solutions. Design of COVID-19 clinical trials should be based on the nature of COVID-19 as an emergent and acute epidemic disease.Investigators should discern the TCM understanding of COVID-19 in terms of its pathogenic factors and mechanism, combining the stage characteristics of the course of acute infectious diseases, while following TCM general understanding of pestilential diseases. Multiple clinical study designs could be employed for different objective set at different stage of epidemic disease, including epidemiological study of TCM patterns, observational study, randomized controlled trials and case studies, etc. TCM should be properly positioned in playing its effective role in intervention with severe and critical cases and not limited to mild or common types only. Meanwhile, surveillance with unified deployment needs to be in place to ensure strong ethical grounds and rigorous scientific research attitude.  
        关键词：COVID-19;clinical trial;traditional Chinese medicine   
        314
        |
        5
        |
        1
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360782 false
        发布时间：2021-05-20
      • Vol. 43, Issue 5, Pages: 373-376(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.004
        关键词：epidemic;stress;traditional Chinese medicine;psychosomatic medicine;guideline   
        273
        |
        2
        |
        0
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360775 false
        发布时间：2021-05-20
      • Fan Lu,ZENG Feng
        Vol. 43, Issue 5, Pages: 377-380(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.005
        摘要：This thesis explores the text variances in three different versions of Qian Jin Yao Fang (Important Formulas Worth a Thousand Gold Pieces) in terms of the following four aspects: medical principle, therapeutic method, prescription and medicinals. Based on that, the disciplinary differences are analyzed, and concluded that historical medical literature has the characteristic of being complex, and the contents have a certain degree of uncertainty. The text variances in academic thoughts among the three versions of Qian Jin Yao Fang have provided solid evidence for tracing the development history, distinguishing between right and wrong, and sorting the ambiguous issues that have existed for a long time. Therefore, the text variances in different versions of Qian Jin Yao Fang could serve as the pointcut for research of the book in a deeper level, which will not only provide advice for clinical practice, but also provide reference for further research on the academic and thinking development history of TCM.  
        关键词：Qian Jin Yao Fang (Important Formulas Worth a Thousand Gold Pieces);version;text differentiation and analysis   
        302
        |
        4
        |
        0
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360766 false
        发布时间：2021-05-20
      • Huang Yinghua,Liang Yongxuan
        Vol. 43, Issue 5, Pages: 381-385(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.006
        摘要：Euibangyoochui (Yi Fang Lei Ju)is a large-scale medical book compiled by the government of Chosun Dynasty in 1445 AD. It quotes 152 kinds of Chinese medical classics and one kind of Koryo’s medical work. Based on the categories of literature related toShang Han Lun (Treatise on Cold Damage)andJingui Yaolue (Synopsis of Golden Chamber)listed inGeneral Catalog for Chinese Medical Classical in China and Grand Dictionary of Chinese Medical Classics,this paper attempts to explore the citations of medical literatures related to these two books inEuibangyoochui.First, the general information about the book, such as author and its written time, are determined; then it is comprehensively analyzed combined with other materials. Finally, the relevant quotations inEuibangyoochuiare compared to those inXin Bian Jin Gui Fang Lun,which is the existing earliest version of the base copy of Zhang Zhongjing by Deng Zhen in Yuan Dynasty. Thus the citations of 16 kinds of medical literatures related toShang Han Lunand one book related toJingui Yaolueare analyzed and evaluated.  
          
        291
        |
        4
        |
        0
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360758 false
        发布时间：2021-05-20
      • Liu Sijia,Chen Yucai,Hu Suqin,Li Chunrui,Guo Jian
        Vol. 43, Issue 5, Pages: 386-392(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.007
        摘要：ObjectiveTo explore the pharmacological mechanism ofWuzi YanzongPill in the treatment of male spermatogenic dysfunction by network pharmacology in rat sertoli cells.MethodsTargets of anti-spermatogenic dysfunction inWuzi YanzongPill were screened and the biological function and signal pathway were analyzed by online database. The heat stress model was constructed with rat sertoli cells to detect changes in the production of reactive oxygen species (ROS) and the expression of Hsp70.ResultsThe results of network pharmacology showed thatWuzi YanzongPill mainly improved male spermatogenesis dysfunction by regulating ROS level and extracellular stimulus response etc. The ROS fluorescence probe results showed that, compared with the blank group, the ROS production was significantly increased in the model group, and significantly decreased in theWuzi YanzongPill group. Western blot results showed that the expression of Hsp70 inWuzi YanzongPill group was higher than that in the blank group and lower than that in the model group.ConclusionWuzi YanzongPill seems to protect rat sertoli cells under heat stress by reducing ROS production and Hsp70 expression.  
        关键词：Wuzi YanzongPill;heat stress;sertoli cells;network pharmacology;reactive oxygen species (ROS)   
        293
        |
        5
        |
        1
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360744 false
        发布时间：2021-05-20
      • Lyu Yanmin,Xiu Linlin,Liu Haiyan,Zhang Jingxuan,Li Na,Zhang Chen,Xu Wan,Chen Feng,Wang Xin,Ge Chaoran,Chen Shaohong,Zhong Gansheng
        Vol. 43, Issue 5, Pages: 393-401(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.008
        摘要：ObjectiveTo comparative the thyroid hormone level and histopathological changes of the thyroid tissue in PTU-induced goiter rats treated withHaizao YuhuDecoction and its recipe minus antagonistic medicinal combination, and to explore whether eliminating antagonistic medicinal combination inHaizao YuhuDecoction can affect the therapeutic effect.MethodsThe rats were randomly divided into the blank group, model group, positive drug group (euthyrox)Haizao YuhuDecoction groupHaizao YuhuDecoction minus Glycyrrhizae groupHaizao YuhuDecoction minus Sargassum group, andHaizao YuhuDecoction minus Sargassum and Glycyrrhizae group. The rat model of goiter was induced with propylthiouracil. Each group was fed with the corresponding drug or decoction. The concentration of serum related indicators was detected, including the thyroid coefficient, thyroid hormone level and its synthesis, transport and regulation. Under light microscope, pathological changes of thyroid tissue in rats were observed, and nucleic number and follicular area in sections were counted.ResultsLike the positive drugHaizao YuhuDecoction was consistent with the positive drug of euthyrox in maintaining thyroid functions and recovering the pathological damage of thyroid tissue in PTU-induced goiter rats. Comparing the thyroid hormone related indicators,the degree of recovery was listed:Haizao YuhuDecoction group＞Haizao YuhuDecoction minus Glycyrrhizae group＞Haizao YuhuDecoction minus Sargassum group＞Haizao YuhuDecoction minus Sargassum and Glycyrrhizae group. Comparing the histopathological changes of the thyroid tissues, the alleviating degree was listed:Haizao YuhuDecoction group＞Haizao YuhuDecoction minus Sargassum and Glycyrrhizae group＞Haizao YuhuDecoction minus Sargassum group＞Haizao YuhuDecoction minus Glycyrrhizae group.ConclusionThe therapeutic effect ofHaizao YuhuDecoction in regulating thyroid hormone level and improving histopathological changes in goiter rats seems to be better than its recipe minus antagonistic medicinal combination, and theHaizao YuhuDecoction minus Sargassum and Glycyrrhizae tends to have the least effect.  
        关键词：Haizao YuhuDecoction;antagonistic medicinal combination;goiters;thyroid hormone;thyroid morphology   
        302
        |
        4
        |
        2
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360723 false
        发布时间：2021-05-20
      • Xu Huichao,Gao Yan,Chen Hao,Hao Jianheng,Liu Jinfang,Liu Yang,Miao Yuchuan
        Vol. 43, Issue 5, Pages: 402-407(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.009
        摘要：ObjectiveTo explore the new mechanism of changes in TLR4 gene methylation levels in the treatment of liver stagnation and spleen deficiency pattern in non-alcoholic steatohepatitis (NASH) in rats withXiaoyao San (XiaoyaoPowder).Methods30 male SD rats were randomly divided into blank group, model group andXiaoyao Sangroup (n=10). Rats in the blank group were given normal diet for 28 weeks. followed by injection of normal saline for 4 weeks. In the model group andXiaoyao Sangroup, liver stagnation and spleen deficiency pattern model was established by feeding the rats with a high-fat and high-sugar diet with stimulations of chronic stress and irregular diets for 28 weeks In the last 4 weeks, the model group andXiaoyao Sangroup were injected with normal saline andXiaoyao Sansolution respectively. At the end of 28 weeks, urine was collected from the three groups, and the liver and hippocampus tissues were taken to make pathological sections. The corresponding indicators were detected by real-time fluorescence quantitative PCR (qPCR), enzyme-linked immunosorbent assay (ELISA), and hydrogen sulfite sequencing PCR (BSP), etc.ResultsCompared with the model group, the symptoms of liver stagnation and spleen deficiency pattern were significantly alleviated with a decreased pattern score in theXiaoyao Sangroup. The numbers of fat vacuoles and infiltration degree of inflammatory cells in liver cells were significantly reduced. The TLR4 mRNA content in liver tissues was decreased, while the methylation level of TLR4 gene was increased (P<0.05).ConclusionXiaoyao Sanmay up-regulate the TLR4 gene methylation level and down-regulate the TLR4 mRNA expression in rats with liver stagnation and spleen deficiency pattern in non-alcoholic steatohepatitis, thus improving the degree of liver steatosis and alleviating inflammation and other symptoms. This seems to be the new mechanism for the treatment of such condition withXiaoyao San.  
        关键词：Xiaoyao San (XiaoyaoPowder);nonalcoholic steatohepatitis (NASH);liver stagnation and spleen deficiency pattern;DNA methylation;TLR4   
        281
        |
        4
        |
        3
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360707 false
        发布时间：2021-05-20
      • Zhang Xiuli,Lei Chang,Liu Yang,Ge Jinwen,Meng Pan,Zhang Junyu,Ren Yongzhen,Zi Dong,Zhu Wei
        Vol. 43, Issue 5, Pages: 408-413(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.010
        摘要：ObjectiveTo investigate the influence of medicated serum ofNaotaifangⅡ on the morphology, M1/M2 polarization markers and inflammatory factors of HAPI cells induced by LPS.MethodsThe inflammation model of HAPI cell was induced by LPS. The cultured cells were divided into: blank group, model groupNaotaifangⅡ group, and minocycline group. Morphology and quantity of microglia were observed by High Content Imaging System. mRNA expression of M1-type markers (MCH II, iNOS, MCP-1, CD11b) and M2-type markers (Arg1, Mrc1, Ym1), pro-inflammatory factors (IL-1β, IL-6, IL-12, TNF-α) and anti-inflammatory factors (IL-4, IL-10, TNF-β) was detected by qRT-PCR.ResultsCompared with the blank group, in the model group, microglia cell body became larger while showing multipolarization or amoeba type with coarser and shorter synapse; the mRNA level of M1 markers and pro-inflammatory increased significantly(P< 0.01); moreover, the expression of M2 marker Mrc1 and anti-inflammatory factors IL-4 and TNF-β decreased dramatically (P<0.01). Compared with the model group, inNaotaifangⅡgroup, the cell swelling recovered, the synapses became longer, and the microglia increased. Besides, in NaotaifangⅡgroup, the mRNA expression of M1 markers MHCⅡ, iNOS and CD11b and the pro-inflammatory factors were significantly decreased (P<0.01), and the mRNA expression of M2 markers and anti-inflammatory factors were significantly increased (P<0.01). Compared with the minocycline group, the Naotaifang Ⅱ group showed no significant advantage in reducing the expression of M1 markers (P>0.05), while better effect on lowering the expression of pro-inflammatory factors IL-6, IL-12 and TNF-α (P<0.01) except IL-β. Besides, NaotaifangⅡcould better increase mRNA expression of M2 markers Mrc1, Ym1 and anti-inflammatory factors IL-4, TGF-β compared with the minocycline group.ConclusionNaotaifangseems to inhibit M1 polarization, promote M2 polarization by regulating cell morphology, M1/M2 markers and inflammatory factors. It could possibly enhance M2 markers and anti-inflammatory factors better than minocycline.  
        关键词：NaotaifangⅡ;microglia polarization;M1 markers;M2 markers;pro-inflammatory factors;anti-inflammatory factors   
        301
        |
        4
        |
        2
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360685 false
        发布时间：2021-05-20
      • Wang Xiao,Lin Zhijian,Zhang Bing,Wang Yu,Mao Qiuyue,Jiang Zhuoxi
        Vol. 43, Issue 5, Pages: 414-422(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.011
        摘要：ObjectiveTo explore the safety risk ofDanshen (danshenroot, Radix et Rhizoma Salviae Miltiorrhizae) preparation in the treatment of breast cancer.MethodsBioinformatics technology was used to screen and analyze the gene chip GSE85871 in the GEO database. The intervention effect of main chemical components of theDanshenpreparation on the differentially expressed genes of human breast cancer cells MCF7 was analyzed with the GO function and the KEGG pathway, combined with the literature mining method to sort out the adverse reactions/events ofDanshenpreparation.ResultsWhenDanshenpreparation interferes with the MCF7 cells, it could regulate genes such as nerve ligand signal pathway, thyroid pathway, immune regulation, and the expression of CHRM2. The abnormality of this pathway would cause abnormal neurological receptor function, hypothalamic dysfunction (thyroid), and respiratory function (asthma).ConclusionWith the approaches of bioinformatics and literature mining, thisarticle explores the early warning of the potential safety risk ofDanshenpreparation in the adjuvant treatment of breast cancer. In the treatment of breast cancer withDanshenpreparation, more attention should be paid to monitor the patient’s neurological, thyroid and respiratory functions. Thus, this article attempts to provide ideas for further study of the safety issue of TCM preparation.  
          
        267
        |
        4
        |
        0
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360671 false
        发布时间：2021-05-20
      • Wang Yongyan,Zou Yihuai,Xie Yingzhen
        Vol. 43, Issue 5, Pages: 423-426(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.012
        摘要：In order to reduce the morbidity and recurrence rate of stroke, the statement of "to record the clinical manifestations of patient before the occurrence of disease” in the second volume of Wang Qingren's Yi Lin Gai Cuo (Correction of Errors in Medical Works) was reviewed. Based on that, more attention should be paid to the observation of symptoms of stroke aura. By observing Xiang (external signs), the disease can be detected and pattern differentiated. The pathogenesis mainly involves depleted yuan qi, resulting in stagnation of deficient qi, which would be induced to internal wind. The mainly medicinals include Puhuang (cattail pollen, Pollen Typhae), Tianma (tall gastrodis tuber, Rhizoma Gastrodiae) and Foshou (finger citron fruit, Fructus Citri Sarcodactylis), etc. Besides, a prescription for secondary prevention of stroke is put forward.  
          
        296
        |
        4
        |
        1
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360659 false
        发布时间：2021-05-20
      • Fang Ge,Ren Qi,Wang Bin,Zhou Xiaowen,Li Xiantao
        Vol. 43, Issue 5, Pages: 427-431(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.013
        摘要：ObjectiveTo explore the distribution characteristics of TCM patterns of stable coronary heart disease with abnormal lipid metabolism.MethodsThrough clinical epidemiological investigation, the distribution characteristics of TCM patterns of stable coronary heart disease with dyslipidemia were analyzed with the multivariate statistical method.ResultsThe principal component analysis of patterns in patients with stable coronary heart disease and abnormal lipid metabolism was carried out. The principal component with eigenvalue greater than 1 was selected, and its cumulative contribution rate was 61.81%. In the factor analysis, 10 common factors were extracted and clustered into four characteristic groups under cluster analysis.ConclusionBy frequency analysis, principal component analysis, factor analysis and cluster analysis, the distribution of TCM patterns of stable coronary heart disease with abnormal lipid metabolism can be classified into four types. Most of them are a mixture of deficiency and excess, with deficiency of yin or both qi and yin, and excess including blood stasis and phlegm-dampness, mainly involving the heart, spleen and kidney. This study could provide relevant references for improving TCM pattern differentiation, treatment and clinical efficacy.  
        关键词：coronary heart disease (CHD);abnormal lipid metabolism;patterns;distribution   
        264
        |
        4
        |
        2
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360646 false
        发布时间：2021-05-20
      • Lin Xiaoli,Tan Weihan,Zhu Fengyi,Liang Dan,Yan Ran,You Fengming
        Vol. 43, Issue 5, Pages: 432-435(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.014
        摘要：There exist significant differences in epidemiology, molecular biology, histology, genetics and pathological features between left-sided and right-sided colon carcinoma, so the treatment and prognosis differ too. InHuangdi Neijing (Huangdi’s Internal Classic)a theory of “Left-Blood and Right-Qi” states that the left side of the body pertains to blood, and its disorders are mostly related to blood deficiency or blood stasis; while the right side pertains to qi, and its disorders are mostly related to qi deficiency or qi stagnation. Based on that theory, in this paper the pathogenic difference between left-sided and right-sided colon cancer is explored, and suggestion of formula selection is put forward accordingly, Thus providing theoretical evidence for more accurate pattern differentiation of colon cancer.  
        关键词：“Left Blood and Right Qi” Theory;left- and right-sided colon;pathogenic laterality   
        299
        |
        4
        |
        1
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360632 false
        发布时间：2021-05-20
      • Yang Yang,Ma Yuexiang
        Vol. 43, Issue 5, Pages: 436-440(2020) DOI: 10.3969/j.issn.1006-2157.2020.05.015
        摘要：In recent years, with the acceleration of life pace and the improvement of living standards, the incidence of acne has increased year by year, with an increasingly more complicated pathogenesis. From the perspective of body constitution, modern medical practitioners have combined the differentiation of constitution, disease and pattern to explore a new approach in its diagnosis and treatment. Studies revealed that in patients with acne, the proportion of qi deficiency constitution had gradually increased. Thus, in this study, in order to improve the efficacy of treatment of patients with qi deficiency constitution, pattern differentiation for patients with acne was explored, as well as the theories on qi deficiency constitution. On basis of that, the survey results of qi deficiency constitution, and the experience of diagnosing and treating acne from the perspective of qi deficiency constitution were summarized. Thus, it was concluded that there were important clinical basis and therapeutic advantages to treat acne from the perspective of qi deficiency constitution.  
        关键词：qi deficiency constitution;acne;theory;therapy   
        324
        |
        4
        |
        1
        <HTML>
        <L-PDF>
        <引用本文> <批量引用> 9360418 false
        发布时间：2021-05-20
      0