最新刊期
      卷 43 ， 期 6 ， 2020
      • Wang Yongyan,Fan Yipin,Zhang Huamin,Bai Weiguo,Wang Yanping
        Vol. 43, Issue 6, Pages: 445-448(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.001
        摘要：The theoretical statements on epidemic diseases in the two originally-lost later-supplemented chapters inSuwen (Plain Questions) suggest that the five-circuit six-qi theory is still of significant reference to the prevention and treatment of pestilence in modern times. Taking three major historical pandemics as example, i.e. encephalitis B in 1974, influenza in 2009 and COVID-19 in Wuhan in 2019, this paper advocates that the TCM community should take the history as a mirror while shouldering the responsibility of preventing and treating epidemic diseases. The circuit-qi theory of the traditional ancient Chinese civilization needs to be integrated with modern ecology, sociology and other diverse disciplines and perspectives to seek the underlying cause of the spreading of pestilence. This paper also summarizes the essential pattern elements and the priority of treatment. Integrated Chinese and Western medical approach is emphasized in the battle against pestilence. The original thinking of holistic manifestation, numbers and changes needs to be highlighted. Under the guidance of ancient Chinese studies, observing thexiang(manifestation) of the disease to discern the underlyingdao(way) of treatment should be used to guide the clinical practice.  
          
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        发布时间：2021-05-20
      • Ding Xia,Li Yuan,Li Ping,Su Zeqi,Wu Fengzhi,Chu Fuhao,Gu Xiaohong
        Vol. 43, Issue 6, Pages: 449-456(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.002
        摘要：ObjectiveTo analyze the prescription characteristics of consensus formulae for the prevention and treatment of novel coronavirus pneumonia (NCP) also known as coronavirus disease 2019 (COVID-19) with traditional Chinese herbal medicine.MethodsWe collected the following formulae released from the start of NCP outbreak to February 6, 2020: foumulae in the “Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial)” (3rdto 5thed.) issued jointly by the National Health Commission and the National Administration of Traditional Chinese Medicine of PRC; the latest clinically-proven effective prescriptionQingfei Paidu Tang(Lung-clearing and Toxin-expelling Decoction) (February 6, 2020 ed.); formulae in the “Prevention and Treatment Protocol for Novel Coronavirus Pneumonia in Beijing” (1stand 2nded.) issued by the Beijing Municipal Administration of Traditional Chinese Medicine; prescriptions approved and released by varied health commissions, traditional Chinese medicine administrations and hospitals at provincial and municipal levels; and prescriptions made public by various medical schools and several prestigious doctors for the prevention and treatment of NCP. The R software (V 3.6.1) was used to analyze the frequency of occurrence of herbs and association rules in formulae for preventive and therapeutic purposes respectively.Results107 preventive formulae involving 121 herbs were identified. 11 herbs with frequency of occurrence over 20% wereGancao(Licorice RootRadix et Rhizoma Glycyrrhizae), Huangqi(Astragalus RootRadix Astragali), Jinyinhua(Honeysuckle FlowerFlos Lonicerae Japonicae), Jiegeng(Platycodon RootRadix Platycodonis), Lianqiao(Weeping Forsythia CapsuleFructus Forsythiae), Cangzhu(Atractylodes RhizomeRhizoma Atractylodis), Fangfeng(SilerRadix Saposhnikoviae), Baizhu(White Atractylodes RhizomeRhizoma Atractylodis Macrocephalae), Lugen(Reed RhizomeRhizoma Phragmitis), Guanghuoxiang(Cablin PatchouliHerba Pogostemonis),andSangye(Mulberry LeafFolium Mori).The core combinations of herbs includedHuangqi, Gancao, Jinyinhua, LianqiaoandFangfengaccording to association rules. There were 115 therapeutic prescriptions involving 203 herbs, of which the following 7 herbs were the most frequently used with frequency of occurrence over 20%:Gancao, Huangqin(Scutellaria RootRadix Scutellariae), Shigao(GypsumGypsum Fibrosum), Kuxingren(Bitter Apricot KernelSemen Armeniacae Amarum), Mahuang(EphedraHerba Ephedrae), Lianqiao,andJinyinhua.The core combinations of herbs includedMahuang, Kuxingren, Shigao,andGancaoaccording to association rules.ConclusionFor the prevention of NCP, the main method used seems to be boosting qi to consolidate the exterior, supplemented by clearing heat, resolving toxins and drying dampness. The commonly used formulae wereYupingfeng San(Jade Wind-Barrier Powder) andYinqiao San(Lonicera and Forsythia Powder). For therapeutic purpose, clearing heat, resolving toxins, and drying dampness were the major methods adopted. The most frequently used prescription wasMaxing Shigan Tang(Ephedra, Apricot Kernel, Gypsum and Licorice Decoction) plusHuangqin and Lianqiao.Treatment should vary according to the progression and stage of the disease with modifications based on complications.  
        关键词：novel coronavirus pneumonia;traditional Chinese herbal medicine;concensus formula;association rules;prescription characteristics   
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        发布时间：2021-05-20
      • Huang Donghui,Feng Cuiling,Cai Junxiang,Wang Kaiyuan,Xie Dongping,Feng Feng,Song Lin,Wen Minyong,Wang Tonghan,Zhang Zhongde
        Vol. 43, Issue 6, Pages: 457-462(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.003
        摘要：ObjectiveTo report the clinical effectiveness of traditional Chinese medicine (TCM) in the treatment of novel coronavirus pneumonia (NCP) and explore the TCM understanding of this disease including its etiology, pathogenesis and treatment approaches.Methods111 patients diagnosed with NCP from January 29 to February 11, 2020 were enrolled at Hubei Provincial Hospital of Integrated Chinese & Western Medicine in the city of Wuhan and treated by Guangdong TCM medical team with Chinese medicine decoction or granule on the basis of conventional supportive therapy. TCM treatment was individualized based on patient categories of mild, moderate, severe and critical conditions under the guidance of pattern differentiation principle. Global improvement and symptom relief were evaluated after treatment.ResultsAmong the 111 patients, 37 patients were recovered and discharged. 62 patients were improving. Disease conditions of 3 cases remained unchanged. One patient deteriorated and was transferred to ICU, and 8 cases died (among which, 4 cases died within 12 hours since the Guangdong medical team took them over on January 29). Symptoms of patients with mild and moderate conditions were 100% gone. For severe and critical cases, their symptoms like fever, cough, diarrhea, constipation, nausea and vomiting were significantly relieved.ConclusionNCP falls into the category of epidemic diseases in TCM. Epidemic dampness toxin seemed to be the main etiological factor. Pathogenic dampness encumbering the spleen and epidemic toxin blocking the lung are the core pathogenesis while pathogenic dampness is persistent throughout the disease and may easily transform into heat, dryness and occasionally cold during disease progression. TCM therapies based on pattern differentiation should be offered alongside standard care of modern medicine throughout the course of disease as favorable clinical outcomes are now observed with this integrative approach.  
        关键词：novel coronavirus pneumonia (NCP);pattern differentiation and treatment;clinical efficacy evaluation   
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        发布时间：2021-05-20
      • Ma Jiaju,Wang Yuguang
        Vol. 43, Issue 6, Pages: 463-468(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.004
        摘要：Membrane-source (pleurodiaphragmatic interspace) is an important location for the onset of epidemic disease in the body, andDayuan Yin(Membrane-source Decoction, DYY) a typical formula indicated for the disease. However, the clinical application of the formula is limited by its acrid-warm and drying nature. Based on original texts fromWenyi Lun (Treatise on Warm-Heat Pestilence)published in the Ming Dynasty, as well as understanding by physicians in later generations, this article discusses the essence of membrane-source and proposes that DYY is indicated for critical condition caused by pattern of dampness trapping hidden deep-lying heat in the middle energizer. As epidemic disease is highly infectious with sudden onset and high mortality rate, first priority in its treatment should be dispelling pathogens hidden inside the human body. Owing to its acrid-warm and drying property, DYY can soothe and drain the membrane-source and transform the dampness-heat pattern into pure heat pattern, which corresponds to the idea of defeating the pathogen by transmitting and changing it proposed by Wu Youke, a famous Chinese epidemiologist and the author ofWenyi Lun.Such practice is still in line with the therapeutic principle of dispersing and purging pathogens through different channels separately in the treatment of dampness-heat pattern. Meanwhile, it is also proposed that the treatment of warm epidemic disease should always center on the pathogens. Besides, the indications of DDY are summarized. Finally, the theoretical significance of membrane-source and DDY is discussed in the current fight against the novel coronavirus pneumonia, also known as the coronavirus disease 2019 (COVID-19).  
        关键词：membrane-source;Dayuan Yin;Wu Youke;Wenyi Lun;dampness trapping hidden deep-lying heat;novel coronavirus pneumonia   
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        发布时间：2021-05-20
      • Shi Lingsheng,He Juan
        Vol. 43, Issue 6, Pages: 469-474(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.005
        摘要：In modern Chinese medicine, “Zhengqi”often juxtaposed with “Xieqi”is an important concept in the theory of pathogenesis based on exuberance and debilitation ofXieqi(pathogenic factors) andZhengqi(healthy qi).However,inHuangdi Neijing (Huangdi’s Internal Classic), “Zhengqi”originally meant“Zhengfeng”(right wind), essentially referring to wind in the right direction in the right season. Therefore, it was also an external pathogenic factor in modern sense because of its potential capacity to cause diseases. It was in the Wei, Jin, and Southern and Northern dynasties (220 AD-589 AD) when “Zhengqi”began to acquire its physiological sense. Later, it gradually became clear that the term referred to healthy qi.Its connotation of “Zhengfeng” was formally replaced with “healthy qi” in the sentence “when there is sufficientZhengqiinside the bodyXie(pathogen) cannot invade the body” in the chapter “Discussion on Acupuncture Methods”, the original contents of which were lost in history and the present contents were added by scholars in the Song Dynasty toSuwen (Plain Conversation).Since then, it was thoroughly established that “Zhengqi”denoted antipathogenic physiological factors,providing significant theoretical basis for the modern concept of “Zhengqi”.  
        关键词：Zhengqi;wind;Zhengfeng;eight directions;eight kinds of wind;Zhengxie (Zhengpathogen);Zhengqi-Xieqicombination of diseases;Shifeng(invigorating wind)   
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        发布时间：2021-05-20
      • Qi Yuanling,Zhang Qingxiang
        Vol. 43, Issue 6, Pages: 475-481(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.006
        摘要：“The heart governs the mind”originates from the chapter of Discussion on Six-Plus-Six System and the Manifestations of the Viscera in thePlain Conversation:“The Heart is an organ, the function of which is like that of a monarch, which is responsible for the mind(shén míng神明, referring to the higher nervous activities that are governed by the heart including spirit, consciousness, and thinking.”Hence, that the heart governs the mind is a summary of the physiological function of the heart. When exploring the phylogenetic explanation of the origin of the statement, we discovered that the connotation of the mind evolved from the mind (law) of the nature to the mind of the human. Drawing upon the essence of the mind (law) of the nature and the feudal bureaucracy on the basis of“being authorized by the heaven (nature)”,and incorporating ancient Chinese philosophy, Chinese physicians in the ancient times formed the concept that the heart houses the mind, meaning the mind of the heart governs and manifests life, and is also home to spirit, consciousness and emotion. Based on relevant anatomic findings, the formation of the belief that the heart governs the mind also integrated knowledge of the nature and humanity. It resulted from the application of the holistic concept of traditional Chinese medicine in the formation of the zang-fu theory. To explore the phylogenesis of the idea that “the heart governs the mind” is of great significance for the inheritance of traditional Chinese medicine theory, clinical diagnosis and treatment, and clarification of conceptual confusion in the later generations.  
          
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        发布时间：2021-05-20
      • Miao Qing,Fan Yiling,Ma Chong,Cao Qing,Wang Ning
        Vol. 43, Issue 6, Pages: 482-486(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.007
        摘要：As a commonly encountered clinical symptom, cough may easily develop into chronic cough if treated in an inappropriate way. Pathogenic cold is one of the important causes of cough as is well summarized in the quote “the invasion of cold into the body and drinking cold water impair the lung” fromNanjing (The Classic of Difficult Issues).Descriptions of the pattern and treatment of “cold cough” have been scattered in classics of traditional Chinese medicine and records of clinical practice, but a systematic review is lacking. Therefore, we put forward the following ideas and framework of treating cold cough from the perspective of triple energizer and zang-fu organs. (1)When cold pathogen attacks the lungZhisou San(Cough-Stopping Powder)Jinfeicao San(Inula Powder)Mahuang Tang(Ephedra Decoction) and relevant modified formulas should be used according to the severity of the cold pathogen. As for cough caused by cold with fluid retentionXiaoqinglong Tang(Minor Green Dragon Decoction) andLinggui Zhugan Tang(Poria, Cinnamon Twig, Atractylodes Macrocephala and Licorice Decoction) are preferred. (2)If cold pathogen invades the spleen or stomach in the middle energizer, treatment should be tailored to the spleen, stomach and gallbladder respectively. For cough as a result of attack on the spleen from coldLizhong Tang(Center-Regulating Decoction) and similar formulas are suitable. For cough resulting from attack on the stomach by coldXiaobanxia Jia Fuling Tang(Minor Pinellia Decoction Plus Poria)Banxia Xiexin Tang(Pinellia Heart-Draining Decoction) and relevant modified formulas should be adopted. For cough with gallbladder heat and spleen cold, we could chooseChaihu Guizhi Ganjiang Tang(Bupleurum, Cinnamon Twig and Dried Ginger Decoction). (3)As for cough due to cold attack on the kidney in the lower energizer, it is key to warm the kidney and dissipate cold with effective formulas such asErxian Tang(Two Immortals Decoction)Zhenwu Tang(True Warrior Decoction) andJinshui Liujun Jian(Gold Water Six Gentlemen Decoction). In conclusion, when treating cold cough, we should choose formulas and medicinals based on careful pattern differentiation according to the severity and location of the disease and the affected zang-fu organs.  
        关键词：cold cough;triple energizer;zang-fu organs;pattern differentiation framework   
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        发布时间：2021-05-20
      • Zheng Rong,Xu Ruoying,Ke Minhui,Tang Shuihua,Huang Minghan
        Vol. 43, Issue 6, Pages: 487-491(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.008
        摘要：Based on the theory of the “interior-exterior relationship between the lung and large intestine” in traditional Chinese medicine (TCM) and drawing on the research progress in mucosal immunology of modern medicine, the present paper summarizes the pathophysiological relationship between simultaneous lung and large intestine pattern and the function of lung and intestine as well as mucosal immunity. As lung qi disperses and descends, it makes defensive qi flow around the body surface. As large intestine transports and transforms waste substances from the body, the five zang-organs are in peace and stability. While the normal physiological function of the lung and large intestine is the foundation for body defenses against external pathogenic factors, their abnormal functioning will lead to the lung and large intestine pattern. According to modern medicine, such disease is closely related to mucosal immunity. It is believed that immunoglobulins and cytokines in the mucosal immune system might play a role in affecting both the lung and large intestine at the same time, and the selective homing mechanism could explain the transmission of the disease between the two. The present research hopes to shed some light on the clinical treatment of the lung and large intestine pattern by exploring the relationship between the disease and mucosal immunity from the perspective of the TCM theory of the “interior-exterior relationship between the lung and large intestine”.  
        关键词：interior-exterior relationship between the lung and large intestine;simultaneous lung and large intestine pattern;mucosal immunity   
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        发布时间：2021-05-20
      • Shi Guang,Liu Yong,Sun Weiwei,Dong Xiaoying,Han Qian,Bao Meiru,Zhao Ruihua
        Vol. 43, Issue 6, Pages: 492-497(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.009
        摘要：ObjectiveTo investigate the effects ofHuoxue Xiaoyi Fang(Blood-moving and Endometriosis-removing Formula, HXXYF) on the ultrastructure of ovarian granulosa cells in rats with endometriosis.MethodsRats were randomly divided into blank group, sham-operated group, model group, and HXXYF group. The latter two groups were formed in the following way. First, rat models with endometriosis were established by allogeneic endometrial transplantation from donors to recipients and recipients were then randomly divided into model group and HXXYF group. After model establishment, while blank group, sham-operated group, and model groupwere given distilled water, HXXYF group was given HXXYF by gavage for 15 consecutive days. Then ovarian tissues of rats in different groups were taken for HE staining to observe follicular development, FSHR polyclonal antibody immunohistochemical staining to locate ovarian granulosa cells, and transmission electron microscopy to observe ultrastructure of ovarian granulosa cells.ResultsIn model group, the numbers of primordial follicles, primary follicles, secondary follicles, and mature follicles were decreased, the numbers of corpus luteum were increased significantly, and granulosa cells were poorly arranged. In addition, ultrastructure of ovarian granulosa cells was severely damaged, and even demonstrated irreversible organelle damage, such as nucleus chromatin margination, mitochondrial vacuolation, and endoplasmic reticulum degranulation.In blank group, sham-operated group and HXXYF group, follicles were all developed at different levels, ovarian granulosa cells were arranged in a regular way, and organelle structure was complete.ConclusionEndometriosis causes serious damage to organelles of ovarian granulosa cells in rats like mitochondrion and endoplasmic reticulum, and affects follicular development. HXXYF can improve follicular development by reducing ultrastructural damage to granulosa cells in rats with endometriosis.  
          
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        发布时间：2021-05-20
      • Bai Minghua,Wang Ji,Zheng Yanfei,Li Yingshuai,Hou Shujuan,Li Lingru,Zhang Yan,Wang Qi
        Vol. 43, Issue 6, Pages: 498-507(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.010
        摘要：ObjectiveTo collect data of TCM body constitution of Chinese population aged 15 and above, and to analyze and describe the distribution characteristics of their TCM body constitution types.MethodsData of 108 015 cases were collected using Constitution in Chinese Medicine Questionnaire (for Adults) and Constitution in Chinese Medicine Questionnaire (for the Elderly) via the internet and terminal equipment, and distribution characteristics of body constitution types were analyzed from such perspectives as the whole sample population, gender, age and region. In addition, the representativeness and distribution of data were analyzed withχ2test.ResultsThere was statistically significant difference in sex ratio but not in age structure between the sample population and the whole population of China in 2015. In the sample population on the whole, the proportion of people with gentleness (balanced) constitution type was 28.98%, and those with 8 imbalanced constitution types accounted for 71.02%, the top three types being yang-deficiency type (16.41%), qi-deficiency type (13.18%) and wetness-heat (damp-heat) type (10.23%). In the 15-64 age group, those with gentleness constitution type made up 28.80%, and those with 8 imbalanced constitution types 71.20%, the top three types being yang-deficiency type (16.75%), qi-deficiency type (13.57%) and wetness-heat type (11.30%). In the group aged above 64, people with gentleness constitution type added up to 30.25%, and those with 8 imbalanced types 69.75%, the top three types being yin-deficiency type (14.04%), yang-deficiency type (13.97%), and phlegm-wetness (phlegm-damp) type (10.70%), followed by qi-deficiency type (10.39%). There were significant differences in body constitution type distribution between different gender, age and region groups.ConclusionThe age structure of the sample population is consistent with that of the whole population of China in 2015, meaning the former is representative of the latter from this perspective. The proportion of people with gentleness constitution type in each age group was smaller than 1/3 of the whole group and smaller than that 10 years ago, while the proportion of those with imbalanced constitution types increased. The top 3 imbalanced types in the whole sample population were yang-deficiency type, qi-deficiency type and wetness-heat type, the sequence of which was different from that 10 years ago. Constitution distribution patterns were different for different gender, age and region groups.  
        关键词：TCM body constitution;constitution in Chinese medicine questionnaire;distribution characteristics   
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        发布时间：2021-05-20
      • Yu Lu,Yu Zhihua,Tang Weijun,Huang Pinxian,Dong Ying,Wang Jian,Lin Shuimiao
        Vol. 43, Issue 6, Pages: 508-515(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.011
        摘要：ObjectiveTo explore the effects of TCM pattern differentiation and treatment on brain function of patients with severe Alzheimer’s disease (AD) using resting-state functional magnetic resonance imaging (fMRI).MethodsAccording to the internationally recognized NINCDS-ADRDA Alzheimer’s Criteria, fifty patients with severe AD were enrolled in the study and were randomly divided into Chinese medicine group (CMG) (n=25) and Western medicine group (WMG) (n=25). Patients in the CMG were given TCM treatment based on pattern differentiation: patients with heart-qi deficiency receivedTiaoxin Fang(Heart-regulating Formula), patients with kidney-essence insufficiencyBushen Fang(Kidney-supplementing Formula) and patients with patterns complicated by phlegm and blood stasis were additionally givenMengshi Guntan Wan(Chlorite Phlegm-Removing Pill) andXuefu Zhuyu Jiaonang(Blood Mansion Stasis-Expelling Capsule) respectively. Patients in the WMG were treated with donepezil 5 mg once daily. The course of treatment lasted 48 weeks for both groups. Therapeutic effects were observed and compared using Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). Changes in brain function of the AD patients before and after treatment were also examined and compared with resting-state fMRI.ResultsAfter 48 weeks of treatment, 45.00% and 38.89% patients scored higher in MMSE and 30.00% and 22.22% scored higher in CDR in the CMG and the WMG respectively. The results of fMRI demonstrated better connectivity between posterior cingulate gyrus and other brain regions in both groups of patients. In CMG, the improved regions involved primarily the left frontal and parietal lobes, left temporal lobe and occipital lobe, while in WMG, the improved regions included primarily the right hippocampus, the left frontal lobe and the temporal lobes.ConclusionThe heart-regulating and kidney-supplementing TCM treatment based on pattern differentiation is effective in improving cognitive function and reducing disease severity of patients with severe AD and enhancing their brain function by increasing connectivity between posterior cingulate gyrus and specific regions in the brain.  
        关键词：TCM pattern differentiation;Alzheimer’s disease;patients with severe AD;resting-state functional magnetic resonance imaging;clinical study   
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        发布时间：2021-05-20
      • Xing Yu,Lu Qiudan,Shen Lingyu,Liu Haitao,Tong Qing,Huang Haitao,Yang Yan,Zheng Lingqi,Li Hongbo,Xiao Shuangshuang,Xiao Hui,Sun Junjian,Liu Yanxia
        Vol. 43, Issue 6, Pages: 516-521(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.012
        摘要：ObjectiveTo explore the criteria for identifying pattern elements of polycystic ovary syndrome (PCOS), and to provide evidence for setting TCM clinical pattern differentiation criteria for PCOS.MethodsClinical data of 518 PCOS patients were collected. Latent variable analysis was made to establish TCM diagnostic criterion model of PCOS based on pattern element, after which, diagnoses made using the model were compared with clinical diagnoses made by TCM physicians.ResultsBoth goodness of fit index (GFI) and GFI adjusted for degrees of freedom (AGFI) were close to 1, suggesting that the model was well-fitting. The root mean square error of approximation (RMSEA) was 0.063 7, which is≤0.08, indicating that the model was acceptable. The results of consistency test were as follows. TCM diagnosis of the pattern element of disease location or affected zang-fu organ (i.e. kidney, liver, and spleen) could be made when just one symptom in the model manifests itself (i.e. lumbosacral pain, frequent urination at night, and tinnitus for kidney; depression, impatience and irascibility, and frequent or excessive sighing for liver; and poor appetite and digestion, abdominal distention after eating, and diarrhea for spleen, respectively). The rates of consistency between the model diagnosis of disease location and pattern differentiation made by TCM physicians were 71.6%, 88%, and 77% for kidney, liver and spleen, respectively. TCM diagnosis of the pattern element of disease nature (i.e. qi deficiency, qi stagnation, and phlegm-damp) could be made when just two symptoms in one category in the model manifest themselves (i.e. mental fatigue, lack of strength, and spontaneous sweating for qi deficiency; chest tightness, chest and rib-side distending pain, and distending pain of the breasts for qi stagnation; and somnolence, heaviness sensation in the head or dizziness as if the head is wrapped up, and expectoration of phlegm for phlegm-damp, respectively). The rates of consistency between the model diagnosis of disease nature and pattern differentiation made by TCM physicians were 86.3%, 83.2%, and 80.5% for qi deficiency, qi stagnation, and phlegm-damp, respectively.ConclusionThe preliminary diagnostic criteria for PCOS based on pattern elements have been set. After meeting basic diagnostic criteria for PCOS, disease locations such as kidney, liver, and spleen can be diagnosed based on just one symptom in the model, and disease nature like qi deficiency, qi stagnation, and phlegm-damp can be diagnosed based on just two symptoms in one category in the model.  
        关键词：polycystic ovary syndrome;pattern elements;cross-sectional study;latent variable analysis;structural equation modelling   
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        发布时间：2021-05-20
      • Dong Jiazi,Xue Ya’nan,Wei Yuntao,Zhang Yu,Xu Huanyu,Zhang Lide
        Vol. 43, Issue 6, Pages: 522-528(2020) DOI: 10.3969/j.issn.1006-2157.2020.06.013
        摘要：ObjectiveTo observe the interventional effects of electroacupuncture at Zusanli (ST36) on myocardial mitochondrial energy metabolism and mitophagy of rats with spleen deficiency.MethodsForty-eight SD rats were randomly divided into normal control group, model group, ST36 group and non-acupoint group with twelve rats in each group. Rat models with spleen deficiency were established by means of trifactor method lasting 14 days. The rats in ST36 group were treated with electroacupuncture at Zusanli (ST36) for 10 days, and the rats in non-acupoint group received electroacupuncture at non-acupoint on bilateral iliac crest for 10 days. The contents of myocardial ATP, ADP and AMP of the rats were determined with HPLC. The expressions of myocardial AMPK, p-AMPK and microtubule-associated protein 1 LC3-I and LC3-II of the rats were detected by Western blotting. Ultrastructure of myocardial mitochondria and mitochondrial autophagosome of rats was observed using transmission electron microscope.ResultsCompared with normal control group, myocardial AMP/ATP and LC3-II/LC3-I ratios of rats in model group, ST36 group and non-acupoint group all significantly increased (P﹤0.01), myocardial p-AMPK/AMPK ratios of rats in model group increased (P﹤0.05) and myocardial p-AMPK/AMPK ratios of rats in ST36 group significantly increased (P﹤0.01). Compared with model group, myocardial LC3-II/LC3-I ratios of rats in ST36 group significantly increased (P﹤0.01). While rats in model group suffered obvious mitochondrial damage, those in ST36 group experienced some improvement with the emergence of a large number of mitochondrial autophagosomes.ConclusionElectroacupuncture at Zusanli (ST36) may be effective in treating rats with spleen deficiency pattern by activating their myocardial AMPK and regulating their myocardial mitochondrial energy metabolism and mitophagy.  
        关键词：Zusanli (ST36);spleen deficiency;cardiac cells;AMPK;mitochondria;rats   
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