最新刊期
      卷 44 ， 期 11 ， 2021

        Prestigious Forum

      • Yongyan Wang
        Vol. 44, Issue 11, Pages: 965-968(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.001
        摘要：This article explains that people should grasp the law of agreeable or reverse activity of qi-circuit by following the law of the heaven and earth as well as integrating the images, numbers and changes. Taking xinchou year as an example, the climate in the first half of the year pertains to the wetness earth energy of Taiyin, while the climate in the second half of the year pertains to the cold water energy of Taiyang. The water energy is not sufficient and the qi movement is smooth. However, from Light Snow to Greater Cold, if the stage of the terminal qi energy encounters an extremely cold climate, strict, prudent and active prevention should be adopted to control the rebound of the epidemic. Therefore, it is a major event that must be taken seriously to fulfill the principle of integrity and innovation of TCM fundamental theories to integrate Yi theory with medical theory, turn the advantages of clinical syndrome differentiation and treatment and consensus curative effect info the experience reconstruction of technical philosophy, reshape the philosophy of traditional Chinese medicine, understand the ideology of Yi theory, integrate the new technology of big health, high concept and big data of contemporary scientific and technological civilization, and strengthen the basic theoretical research of traditional Chinese medicine.  
        关键词：Yi theory;medical theory;qi-circuit;Huangdi Neijing;COVID-2019   
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        发布时间：2021-12-02

        Expert Opinion

      • Xiaohong Gu
        Vol. 44, Issue 11, Pages: 978-981(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.003
        摘要：Traditional Chinese medicine (TCM) plays a significant role in human fights against epidemic diseases, contributing greatly to the prosperity of the Chinese nation. In response to the state’s strategic needs and people’s health needs, it’s essential to establish and develop TCM epidemiology as a discipline and promote the inheritance and innovation of TCM in epidemic disease prevention, diagnosis, treatment and rehabilitation by taking TCM’s merits and demerits into full consideration. Against the backdrop of the state policy of integrating Chinese and Western medicine, this paper clarifies misunderstandings of TCM epidemiology, analyzes its development dilemma, characteristics and advantages, and proposes to build the TCM epidemiology discipline in the "TCM Plus" era, thereby providing references for accelerating the high-standard establishment of TCM epidemiology discipline.  
        关键词：TCM epidemiology;discipline;Integrated Chinese and Western medicine;Yibing;epidemic disease   
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        Theoretical Studies

      • Tianyu Qin,Shilei Ma,Juan He
        Vol. 44, Issue 11, Pages: 982-986(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.004
        摘要：In modern surgery of traditional Chinese medicine, Yong (carbuncle) and Zhong (swelling) are thought to be caused by the six external pathogenic factors, or poisonous pathogenic factors infection due to wound, or fire and toxin converted from excessive intake of greasy and surfeit food. Heat clearing and detoxification methods and drugs are often used in the treatment. However, in Huangdi Neijing (Huangdi’s Internal Classics), the classic of traditional Chinese medicine, it’s put forward that "if ying qi does not normally circulate in the vessel, instead, it penetrates into the flesh, carbuncle and swelling will be seen" . The discussions on pathogenesis of carbuncle and swelling vary in Huangdi Neijing: fire/ heat is regarded as the cause in the seven chapters on Yun Qi, while the stagnation of ying and wei qi is more frequently mentioned in other chapters.Such a contradiction makes it necessary to trace the core pathogenesis of carbuncle and swelling in order to provide theoretical basis and ideas for clinical treatment and drug usage. This paper compares and distinguishes the original meaning and disease characteristics of Yong (carbuncle), Ju (gangrene), Zhong (swelling), Chuang (sore) and Yang (ulcer), systematically combs Huangdi Neijing and later generations’ understanding of the pathogenesis of these disorders, and reviews the treatment principles and methods of carbuncle and swelling by doctors in previous dynasties. It’s found that the characteristics of carbuncle, gangrene, and swelling are similar. They all refer to the diseases of skin swelling caused by obstruction, which are often seen together in Huangdi Neijing.Sore and ulcer are similar, both referring to lesions that are easy to break. Carbuncle and sore (also ulcer) are different diseases, with the former stressing the pattern of swelling caused by obstruction, while the latter emphasizing the pattern of ulceration. Huangdi Neijing elucidates the theory of obstruction pathogenesis of carbuncle and swelling, based on the ancient people’s understanding of the meaning of Yong (carbuncle): According to Huangdi Neijing, carbuncle and swelling, due to either cold or heat, can be caused by both internal and exogenous pathogenic factors. Among the above, carbuncle and swelling caused by exogenous pathogenic factors is mainly characterized by cold, instead of heat; but ying and wei qi stagnation is the common pathogenesis no matter it is due to cold, heat, or stagnant heat.Later generations of doctors mostly follow such an explanation as in Huangdi Neijing in elucidating the pathogenesis of carbuncle and swelling. Different from carbuncle and swelling, Huangdi Neijing thinks that sore and ulcer are caused by external fire and heat with the pathogenesis of fire and heat rotting flesh, and the symptoms should be local redness, swelling, purulence and even ulceration. Accordingly, the treatment is mainly clearing heat and detoxification. However, due to the development characteristics of emphasis on fire and heat in medicine, and the fact that some carbuncles do fester and break down in the late stage, the later generations have gradually confused the ulcer and carbuncle, and advocated the unified method of clearing heat and detoxification as the main treatment. However, the unique pathogenesis of qi and blood stagnation of carbuncle and swelling are covered up. In terms of treatment carbuncle and swelling are usually treated by promoting blood circulation and dispersing blood stasis, including Dahuang Mudan Decoction, Yiyi Fuzi Baijiang Powder and Qianjin Weijing Decoction which are recorded in Jingui Yaolue(Essentials from the Golden Cabinet), the famous surgical prescription Liuqi Decoction of Sixteen Ingredients, Huoluo Xiaoling Pill recorded in Records of Tradition Chinese Medicine with Reference to Western Medicine, and interior-lifting exterior-resloving method. Therefore, re-grasping the core pathogenesis of carbuncle and swelling, i. e. ying and wei qi stagnation, is the key to clinical curative effect.  
        关键词：Huangdi Neijing;carbuncle and swelling;pathogenesis;qi stagnation and blood stasis;sore and ulcer   
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        发布时间：2021-12-02
      • Ya Wen,Yongkai Xu,Meiling Sun,Yongsheng Guo,Sichao Zhang
        Vol. 44, Issue 11, Pages: 987-991(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.005
        摘要：Because people nowadays are addicted to eating too much fat, sweet food with thick taste, the incidence of stroke with damp-heat pattern is constantly increasing. Through combing the theoretical connotation and origins of "turbidity", "clear orifice", and "turbid evil invading the clear orifice", this article clarifies that damp heat is an important cause that cannot be ignored in the occurrence and development of stroke. The causes of damp-heat include external contraction and internal injury. Damp-heat obstructs the qi movement in the middle jiao, and blocks clear orifice in the upper part of the body, leading to the symptoms of the head and face, and even inducing the occurrence of stroke. Ye Tianshi’s theory of "turbid evil invading the clear orifice" can be regarded as a general exposition of "damp-heat leading to stroke", so the diagnosis, treatment and prevention of damp-heat pattern should be emphasized. Based on the hypothesis of "brain-intestine interlinkage", the core organs affected for the disease of stroke with damp-heat pattern are the brain, spleen, stomach and intestine. To prevent stroke due to damp-heat, the above-mentioned organs should be addressed by clearing dampness and heat, unblocking the fu organs and clearing orifices. The theory of "turbid evil invading the clear orifice" and the above-mentioned therapeutic methods are all derived from the theory and treatment experience of febrile disease. Besides, therapies such as "differentiating and dispelling pathogenic factors from the three jiao" and "nourishing yin and promoting generation of body fluids" are also used in the treatment of stroke. Therefore, the theory and experience of febrile disease may provide new ideas and methods for the prevention and treatment of stroke.  
        关键词：turbid evil;clear orifice;theory of "turbid evil invading the clear orifice";damp heat causes stroke;stroke;Damp-Heat   
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        发布时间：2021-12-02
      • Yaxing Zhang,Tianxing Zhang
        Vol. 44, Issue 11, Pages: 992-996(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.006
        摘要："Xigu", an original concept in Huangdi Neijing(Huangdi’s Internal Classics), has been used in many chapters. There are two representative views on Xigu among ancient doctors: "gap between bones" and "gap between muscles" . On this basis, contemporary scholars deepen the empirical research on Xigu in the aspects of shape and quality. This paper puts forward an innovative view on the connotation of Xigu. It holds that Xigu(literally meaning valley) and Sunluo (also known as Sunmai, referring to minute collaterals) are juxtaposed concepts. Both of them are branches separated from meridians at certain acupoints. The branch leading to deeper portions (bones) is Xigu, and the branch leading to ashallower portion(skin) is Sunluo. Xigu and Sunluo are the terminal structures of meridians, and also the key places for the generation of blood from ying qi.This understanding can help reasonably interpret the various chapters in Huangdi Neijing involving the concept of Xigu, and is consistent with the empirical evidence on biology.  
        关键词：Xigu;Huangdi Neijing(Huangdi’s Internal Classics);Sunmai;Sunluo;acupoint   
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        Textual Research

      • Lin Lin,Jingwen Liu,Qi Jin,Ran Ma,Xuenian Ji,Lin Zhang
        Vol. 44, Issue 11, Pages: 997-1001(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.007
        摘要："Qian" and "Qianbi" are the most common measuring unit used in formula books in the Song Dynasty. During the period between the late Tang Dynasty and early Song Dynasty, "Qian", which originated from Kai Yuan Tong Bao, developed into a unit of measurement. In the Song Dynasty, there existed two kinds of measuring unit systems about "Qian", namely "Liang-Fen-Qian" system and "Liang-Qian-Fen" system, the former of which was used by most of the TCM formula books in the Song Dynasty. Converted into the current measuring unit, 1 Qian is approximately 4 g. The unit "Qianbi" originated from the Han and Tang Dynasties, which was sometimes abbreviated as "Qian" at the same time and generally used for measuring powders. In the Song Dynasty, this usage could be seen more frequently than before, and also had been used in TCM formula prescriptions and tea-blended formula in the meantime. According to the techniques of blending tea in the Song Dynasty, it could be inferred that 1 Qianbi is approximately 0.6 g. On the basis of the statistical comparison of "Qian" and "Qianbi" in tea-blended formula in 12 TCM formula books of the Song Dynasty, it’s found that both units have the same application conditions and value range. In terms of their usage in the prescription of tea-blended formula in the Song Dynasty, "Qian" is actually the abbreviation of "Qianbi" in formula, while "Qian" appears as the same concept in "Liang-Fen-Qian" system when it comes to the dosage. Thus confusion between the usage of "Qian" and "Qianbi" could be clarified by differentiating the different contexts with the characteristics, dosage and preparation of the medicinal comprehensively into consideration.  
        关键词：tea-blended formula;Qianbi;Qian;conversion of the measuring unit   
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        Chinese Medicinal Pharmacology

      • Qi Zhang,Manzhong Li,Xuefeng Feng,Mingcong Li,Hui Zhao
        Vol. 44, Issue 11, Pages: 1002-1010(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.008
        摘要：ObjectiveTo observe the effect of Buyang Huanwu Decoction on the proliferation and differentiation of cortical newborn cells and the expression of Wnt/β-catenin signaling pathway in the newborn cells of cerebral ischemia-reperfusion rats.MethodsThe rats were randomly divided into the sham group, the model group and the Buyang Huanwu Decoction group (BYHWD group) with 9 rats in each group. Cerebral ischemia-reperfusion model was established by middle cerebral artery embolization in rats. 24 hours after modeling, the rats in the BYHWD group were gavaged with Buyang Huanwu Decoction 16.1 g/kg, once a day for 30 days successively. On the 3rd day after modeling, 5-bromodeoxyuridine (BrdU) was injected intraperitoneally to label new cortical cells around the infarction. The positive cells of BrdU, and double labeled BrdU/GFAP, BrdU/MAP-2, BrdU/Wnt, BrdU/β-catenin and BrdU/Dishevelled cells in the cortex around the infarction were detected by immunofluorescence staining.ResultsCompared with the model group, the number of BrdU+ cells in the cortex around the infarction was significantly increased (P<0.01), and the number of double labeled BrdU+ /GFAP+ cells was significantly decreased in the BYHWD group on the 9th, 15th and 30th day after ischemia. The number of double labeled BrdU+ /MAP-2+ cells in the cortex around the infarction in the BYHWD group was higher than that in the model group on the 9th and 15th day after ischemia-reperfusion (P<0.01). Compared with that at the simultaneous point of the model group, the number of double labeled BrdU+ /Wnt+ cells was significantly increased in the BYHWD group on the 9th day after ischemia (P<0.05). The number of double labeled BrdU+ /Dishevelled+ and BrdU+ /β-catenin+ cells was significantly increased in the BYHWD group on the 15th day after ischemia (P<0.05). The number of BrdU+ /Wnt+, BrdU+ /Dishevelled+ and BrdU+ /β-catenin+ cells were significantly increased in the BYHWD group on the 9th, 15th and 30th day after ischemia (P<0.05 or P<0.01).ConclusionBuyang Huanwu Decoction seems to activate the proliferation of new cells, inhibit the differentiation of new cells into glial cells, promote the differentiation of new cells into neurons, and increase the expression of Wnt, β-catenin and Dishevelled proteins in new cells.  
        关键词：Buyang Huanwu Decoction;brain ischemia;neurogenesis;Wnt/β-catenin signaling pathway;cell proliferation;rats   
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        发布时间：2021-12-02
      • Jiawen Wang,Lu Song,HuaKui Zhan
        Vol. 44, Issue 11, Pages: 1011-1019(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.009
        摘要：ObjectiveTo observe the effect of Bushen Huoxue Qufeng (Kidney-tonifying Blood-invigorating and Wind-dispelling) (BHQ) Formula on the expression of nuclear factor-κB (NF-κB) and interleukin-18 (IL-18) in the renal tissue of rats with adriamycin nephropathy, and explore the possible mechanism of BHQ Formula in treating nephrotic syndrome.Methods60 SD male rats were randomly divided into 5 groups: blank group, model group, prednisone group, BHQ group and BHQ + prednisone group. The blank group and the model group were given distilled water by gavage every day; the prednisone group was given the prednisone acetate tablet suspension by gavage at a dose of 6 mg/kg; the BHQ group was given the BHQ decoction by gavage at a dose of 17.19 g/kg; the BHQ+ prednisone group was given prednisone acetate tablet suspension 6 mg/kg by gavage in the morning, and BHQ decoction 17.19 g/kg in the afternoon.All groups were gavaged continuously for 4 weeks. The pathological changes of renal tissue were observed with light microscope and electron microscope; the average optical density of NF-κB-p65 and IL-18 in renal tissue was detected by immunohistochemical method; the mRNA expression of NF-κB-p65 and IL-18 was detected by Real-time PCR method.ResultsCompared with that of the blank group, in the model group the extensive fusion of podocytes was observed, the average optical density of NF-κB-p65 and IL-18 was up-regulated (P< 0. 05), and the mRNA expression of NF-κB-p65 and IL-18 was up-regulated under the electron microscope (P< 0. 05). Compared with that of the model group, in the prednisone group, BHQ group and BHQ+ prednisone group, the podocyte fusion was reduced under electron microscope, with segmentary fusion being found in most groups, the mean optical density of NF-κB-p65 and IL-18 were down-regulated(P< 0. 05), and the mRNA expression of NF-κB-p65 and IL-18 was down-regulated (P< 0.05). The degree of podocyte fusion was the least in the BHQ+ prednisone group under electron microscope.The mean optical density of IL-18 in the BHQ+ prednisone group was lower than that in the BHQ group and prednisone group respectively(P< 0. 05).ConclusionPrednisone group, BHQ group and BHQ + prednisone group may reduce the expression of NF-κB-p65, IL-18 mRNA and their protein to improve the degree of podocyte fusion, thereby alleviating renal inflammation and delaying disease progression, and the BHQ + prednisone group probably have the best curative effect.  
        关键词：nephropathy syndrome;Bushen Huoxue Qufeng (Kidney-tonifying Blood-invigorating and Wind-dispelling) Formula;NF-κB;IL-18;rats   
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        发布时间：2021-12-02

        Science & Technology Theme

      • Mingyue Ma,Xiaohong Wei,Hongcai Shang,Changming Zhong,Haie Pan,Qianqian Dai,Yuhong Wang
        Vol. 44, Issue 11, Pages: 1020-1028(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.010
        摘要：ObjectiveTo explore the effect and mechanism of hyperlipidemia on depression-like behavior in rats with chronic heart failure.MethodsThirty-two male SD rats were divided into sham operation group, hyperlipidemia (HLP) group, chronicheart failure (CHF) group, and hyperlipidemia combined with chronic heart failure (HLP + CHF) group (n=8). The HLP+ CHF group was gavaged with fat emulsion 10 mL/kg daily for 2 weeks to induce hyperlipidemia.After 2 weeks, the left anterior descending coronary artery was ligated, and fat emulsion was intragastric administrated after operation for another 4 weeks to establish a rat model of chronic heart failure after myocardial infarction. In the HLP group, the rats were gavaged with fat emulsion 10 mL/kg daily, and the suture was only threaded without ligation. The sham group and CHF group were given the same volume of normal saline, and the surgical treatment was as same as that of the HLP and HLP+ CHF groups respectively.After 4 weeks, echocardiography, sucrose preference test, open field test, ELISA, immunofluorescence staining and Western blot were used to evaluate heart failure degree, depression-like behaviors, blood lipids and inflammation levels, and degree of astrocyte activation, etc.ResultsCompared with that of the sham group, plasma TC and TG in the HLP group and HLP+ CHF group were significantly increased (P<0.05), and in the CHF and HLP+ CHF groups, plasma BNP content was significantly increased (P<0.05), the LVEF and LVFS were decreased (P<0.05), and the sucrose preference index and total distance and average speed of autonomous activity were significantly lower (P<0.05), the contents of plasma tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β)and interleukin-6 (IL-6) and the expression of glial fibrillary acidic protein (GFAP) in hippocampus were increased (P<0.05). Compared with that of the CHF group, the sucrose preference index and total distance and average speed of open field test were decreased, while plasma TNF-α, IL-1β, IL-6 content and GFAP expression were increased in the HLP + CHF group (P< 0.05).ConclusionChronic heart failure could induce depression-like behavior to a certain extent in rats. Hyperlipidemia seems to aggravate depression-like behavior in rats with chronic heart failure, which may be related to neuroinflammation caused by the activation of astrocytes and the release of inflammatory factors.  
        关键词：hyperlipidemia;chronic heart failure;depression-like behavior;astrocytes;neuroinflammation;rats   
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        Acupuncture & Moxibustion

      • Jieyi Liang,Shoulan Bing,Huangan Wu
        Vol. 44, Issue 11, Pages: 1029-1033(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.011
        摘要：As the development of science and technology accelerates the pace of modern life, insomnia has become a haunting problem. Tracing back to the past, traditional Chinese medicine has a unique view on the treatment of insomnia and has achieved good results. According to Huangdi Neijing(Huangdi’s Internal Classics), the pathogenesis of insomnia is explained as follows: "if wei qi (defensive qi) cannot enter the yin aspect, it will reside in the yang aspect, resulting in excessive yang qi and exuberant yangqiaomai (yang heel vessel), and relatively deficient yin qi. That’s how insomnia occurs." The doctors of later dynasties have summarized it as "yang failing to enter yin" and regarded it as the general pathogenesis of insomnia. Any deficiency or excess of either yin or yang may cause imbalance, resulting in "yang failing to enter yin" . Such an imbalance can be summarized as the following four aspects: excessive yang, excessive yin, deficient yang, and deficient yin. The treatment of insomnia with acupuncture lies in restoring the balance between yin and yang by leading yang into yin, which seems to be an effective green therapy and worth deep exploration and clinical promotion.  
        关键词：sleeplessness;insomnia;Huangdi Neijing (Huangdi’s Internal Classics);yang failing to enter yin;acupuncture and moxibustion   
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        Clinical Studies

      • Yixin Zhang,Xiaoke Zhang
        Vol. 44, Issue 11, Pages: 1034-1038(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.012
        摘要：Diabetic peripheral neuropathy corresponds to the category of bi pattern in TCM, which is characterized by deficiency of internal organs and obstruction of collaterals by blood stasis, phlegm and toxin. Xuanfu(pores) and collaterals are the microstructures that maintain the orderly movement of qi, blood and body fluids in the whole body, and are also the key disease sites for the production of blood stasis, phlegm and toxin. Therefore, based on the "Xuanfu-collaterals" theory in TCM, it is proposed that the basic pathogenesis of diabetic peripheral neuropathy lies in the disordered opening and closing of Xuanfu and the obstruction of collaterals.In the initial stage of diabetic peripheral neuropathy, closed pores cannot distribute the essence, which accumulates inside to transform into toxin. Various pathogenic factors accumulate inside the body to generate toxin and damage the collaterals, forming the key pathogenesis of the disease. Although diabetic peripheral neuropathy is difficult to cure, by following the therapeutic principle of "opening pores and unblocking collaterals", rattan medicinals in TCM prove to be effective in the treatment of the disease, thus providing a new idea for the understanding and treatment of diabetic peripheral neuropathy from the microscopic structure of TCM.  
        关键词：Xuanfu (pores);Collaterals;diabetic peripheral neuropathy;rattan medicinal;opening pores and unblocking collaterals   
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      • Yuan Hou,Sheng Yang,Shuo Han,Peiyou Yang,Zhaoyang Meng,Huaman Liu
        Vol. 44, Issue 11, Pages: 1039-1043(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.013
        摘要：The theory of qi transformation is an important concept in TCM to explain the process of material metabolism and energy transformation in the natural environment. With qi movement as the basis, qi transformation is driven by the interaction between yin and yang, and guaranteed by the harmonious function of organs to promote the normal life activities of the human body. Autophagy is the mechanism of providing material basis for the metabolism of human body through degradation of damaged organelles, protein folding, and formation of small molecules such as amino acid. According to modern TCM scholars, cell autophagy is a microscopic behavior of qi transformation/metabolism at the cellular level; the orderly transmission of autophagy pathway signaling relies on qi movement; and the autophagy steady-state is maintained with yin and yang as the original force. Meanwhile, autophagy is also one of the important mechanisms of idiopathic pulmonary fibrosis (IPF). In TCM, IPF is regarded as lung wei (atrophy), in which disordered qi transformation function leads to the lung dysfunction, and phlegm and blood stasis bind in the lung, so without enough nourishment lung atrophy is seen.In this paper, combined with the qi transformation theory and the relationship between the autophagy mechanism of IPF, it’s proposed that qi transformation disorder is the main pathogenesis of IPF; accordingly, the therapeutic principle should be enhancing defensive qi, resolving phlegm and stasis, and tonifying the kidney and lung. Thus, the qi movement of the lung can be regulated, yin-yang harmony of the human body can be restored so as to delay the process of IPF and improve clinical symptoms.  
        关键词：qi transformation;autophagy;idiopathic pulmonary fibrosis;lung wei (atrophy)   
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      • Hui Zhang,Yunsong Zhang,Lu Jiang,Hui Li
        Vol. 44, Issue 11, Pages: 1044-1048(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.014
        摘要：Collateral disease theory originates from Huangdi Neijing (Huangdi’s Internal Classics), and forms an important part of the TCM theory. It has been developed into a comprehensive system by doctors of later dynasties to guide clinical diagnosis and treatment. Ulcerative colitis belongs to the category of "intestinal colla-teral disease" . This paper discusses the similarities between ulcerative colitis and "collateral disease" from the aspects of cause, course of disease, scope of lesion, characteristics of pathogenesis and clinical manifestations. Ulcerative colitis is deficiency in root and excess in branches, with deficiency of qi and blood, and lack of nourishment of collaterals as the root cause, and stagnant phlegm, turbidity and blood stasis obstructing the intestinal collaterals as branches. Ye Tianshi’s Linzheng Zhinan Yi’an (Case Records as a Guide to Clinical Practice) puts forward the common treatment method of collateral disease: "unblocking the collaterals" . So in terms of treatment, according to the etiology, pathogenesis and disease characteristics of ulcerative colitis, we advocate the basic treatment principle of "unblocking the collaterals", and the corresponding therapeutic methods of clearing heat and dampness, regulating qi and blood, and tonifying deficient collaterals in hope to provide new ideas and directions for the treatment of ulcerative colitis.  
        关键词：ulcerative colitis;collateral diseases;deficiency of collaterals;obstruction of intestinal collaterals;collateral-unblocking method   
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      • Chen Wu,Yujie Yin,Zhenhua Jia
        Vol. 44, Issue 11, Pages: 1049-1056(2021) DOI: 10.3969/j.issn.1006-2157.2021.11.015
        摘要：ObjectiveTo provide reference for the prevention, diagnosis and treatment of pulmonary nodules through the statistical analysis of clinical data, four diagnostic information and chest imaging features, as well as the observation of the distribution of traditional Chinese medicine (TCM)constitutions.Methods424 patients with pulmonary nodules with complete general information admitted to Hebei Yiling Hospital and Hebei Yiling Health Management Center from May 2019 to May 2020 were retrospectively collected. The clinical data and four diagnosis information were collected. Based on "the Constitution in Chinese Medicine Questionnaire", "the Classification and Judgment Questionnaire of Chinese Medicine Constitutions", "the Classification of 9 Basic TCM Constitution Types", and "TCM Terms for Clinical Diagnosis and Treatment: Patterns", the patients’ TCM constitutions were identified, and their distribution was statistically analyzed with SPSS 24.0.ResultsThe clinical data of 424 patients with pulmonary nodules were analyzed as follows: Basic information: in terms of age, the patients ranged from 11 to 102 years old, with an average of (63.91±14.86) years old. The incidence of pulmonary nodules was mainly concentrated in the 61~70 years old session. In terms of gender distribution, 199 cases were females and 225 cases were males.Besides, males had significantly more smoking history, occupational exposure history, drinking history and tumor history than females.There was no significant difference in family tumor history between women and men. Constitution distribution: Among all the subjects, 46 cases (10.85%) had balanced constitution.For the rest with bias constitutions, 161 subjects (37.97%) were with qi deficiency constitution, 47 (11.08%) with yang deficiency constitution, 42 (9.91%) with damp-heat constitution, 37 (8.73%) with blood stasis constitution, 36 (8.49%) with yin deficiency constitution, 32 (7.55%) with qi stagnation constitution, and 23 (5.42%) with phlegm-dampness constitution. Characteristics of nodules: Patients with blood stasis constitution were more likely to have burr sign (P<0.05), and the diameter of the nodule was larger (P<0.05). Patients with damp-heat or blood stasis constitution were more likely to have ground glass sign, compared with patients with other biased constitutions (P<0.05).ConclusionThe formation of pulmonary nodules might be related to qi deficiency and yang deficiency constitutions, and the occurrence of malignant pulmonary nodules is probably related to blood stasis constitution.  
        关键词：pulmonary nodules;traditional Chinese medicine pattern differentiation;constitution;nodule characteristics   
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        发布时间：2021-12-02
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