最新刊期
卷 46 ， 期 11 ， 2023
- 摘要：ObjectiveThis study aimed to analyze the clinical characteristics and distribution rules of TCM patterns of patients with fibromyalgia syndrome (FMS) and provide a basis for the TCM diagnosis and treatment of FMS.MethodsA prospective cross-sectional study was conducted in the Department of TCM Rheumatology at China-Japan Friendship Hospital, recruiting 148 FMS patients from April 2022 to April 2023. The observation indexes included pain triggering and exacerbating factors, pain VAS scores, pain locations, pain characteristics, and other major symptoms. Relevant TCM patterns were analyzed.ResultsFMS patients’ pain induced by fatigue, emotional stimulation, and climate change accounted for 52.0%, 48.6%, and 39.2% of the FMS patients’ pain, respectively; these factors aggravated pain in 64.9%, 49.3%, and 54.1% of patients, respectively. Mild, moderate, and severe pain were reported by 11.5%, 47.3%, and 41.2% of the patients, respectively. The upper left region, upper right region, lower left region, lower right region, and central axis region accounted for 89.2%, 88.5%, 90.5%, 86.5%, and 93.2% of the patients’ pain respectively. Regarding pain sites, the back, lumbar area, right scapular region, right upper arm, and left scapular region were more commonly affected, accounting for 84.5%, 81.8%, 76.4%, 75.0%, and 75.0% respectively. Regarding the nature of pain, heavy, aching, and distending pain accounted for 69.6%, 63.5%, and 52.7%, respectively. Regarding the common symptoms, fatigue, waking unrefreshed, cognitive symptoms, sleep disorder, emotional disorder, and chronic headache accounted for 95.9%, 91.2%, 67.6%, 88.5%, 93.2%, and 71.6%, respectively. Patients with combined migraine, irritable bowel syndrome, and osteoarthritis accounted for 29.1%, 16.9%, and 14.2% respectively. The major types of TCM patterns with FMS, using cluster analysis, were liver depression transforming into fire (98.6%), dampness accumulated due to spleen deficiency (95.3%), and deficiency of both the liver and kidney(16.9%). Patients with FMS often have a combination of TCM patterns, in which liver depression transforming into fire combined with dampness accumulated due to spleen deficiency (77.7%) is the most common.ConclusionFMS is often characterized by fatigue and emotional disorder, easily aggravated by exertion, emotional stimulation, and climate change. The most common TCM pattern is liver depression transforming into fire combined with dampness accumulated due to spleen deficiency.关键词：fibromyalgia syndrome;clinical characteristics;cross-sectional study;liver depression transforming into fire;dampness accumulated due to spleen deficiency;deficiency of both the liver and kidney;traditional Chinese medicine pattern
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发布时间：2023-12-08 - 摘要：ObjectiveThis study aimed to evaluate the efficacy and safety of Bushen Qingre Runzao Decoction (rehmanniae radix, ophiopogonis radix, dendrobii caulis, moutan cortex, lophatheri herba, forsythiae fructus, mori folium, and amomi fructus) in treating primary Sjögren syndrome (PSS) with yin deficiency and dryness-heat pattern.MethodsA randomized controlled trial was conducted. PSS patients with yin deficiency and dryness-heat pattern who were admitted to TCM Department of Rheumatism of China-Japan Friendship Hospital from September 2020 to January 2023, were enrolled. Patients were randomized 1∶1 into the treatment and control groups. The treatment group was treated with Bushen Qingre Runzao Decoction, and the control group was administered hydroxychloroquine sulfate tablets. The duration of intervention in both groups was 12 weeks. The differences in Vision Analog Scale (VAS) scores of dry mouth, dry eyes, fatigue, body pain, overall dry symptoms, and European League Against Rheumatism (EULAR) Sjögren Syndrome Patient-Reported Index (ESSPRI), Sjögren Syndrome Disease Activity Index (ESSDAI), salivary flow rate, Schirmer’s test, and immune inflammation index [serum immunoglobulins (IgG, IgA, IgM), complements(C3, C4), erythrocyte sedimentation rate, C-reactive protein] between the two groups were compared, and adverse reactions were observed.ResultsA total of 96 patients were included, with 48 cases per group. After 12 weeks of intervention, the VAS scores of dry mouth, dry eyes, and overall dryness symptoms were lower in the treatment group than those in the control group (all P<0.05). In the treatment group, after 12 weeks of intervention, the VAS scores of dry mouth, dry eyes, and overall dryness symptoms and ESSPRI were significantly lower than those before treatment (all P<0.05), and the Schirmer’s test result and health change scores of SF-36 were significantly higher than those before treatment (both P<0.01). In the control group, after 12 weeks of intervention, the VAS score of fatigue(P<0.01) was lower than that before treatment, and serum levels of IgA, C3, C4, and health change score of SF-36 were higher than those before treatment(all P<0.05). There was only one case of diarrhea and one case of loose stool in the experimental group, and one case of rash and one case of skin color darkening in the control group. No serious adverse reactions were observed in both groups.ConclusionBushen Qingre Runzao Decoction has a high safety profile and can effectively improve dryness symptoms such as dry mouth and eyes and increase tear secretion in PSS patients with yin deficiency and dryness-heat pattern.关键词：primary Sjögren syndrome;yin deficiency and dryness-heat pattern;Bushen Qingre Runzao Decoction;hydroxychloroquine sulfate;randomized controlled trial
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发布时间：2023-12-08 - 摘要：Rheumatoid arthritis is a chronic, symmetrical, erosive autoimmune disease based on synovitis as the pathological basis. Clinically, rheumatoid arthritis presents as multiple joint swelling, pain, morning stiffness, and in later stages, it can manifest as joint deformities and systemic involvement. The collateral disease theory is one of traditional Chinese medicine theories. Collateral disease refers to diseases caused by the collaterals being affected by pathogenic factors, disrupting the normal flow of qi and blood, thus impacting the normal physiological functions of the meridians, limbs, and zang-fu organs. In recent years, the collateral disease theory has been widely applied in the clinical diagnosis and treatment of rheumatoid arthritis. Insect drugs are known for their properties in dispelling wind and traveling through meridians, entering and unblocking collaterals. Their therapeutic effects can be categorized as activating blood circulation, resolving blood stasis, and unblocking the collaterals; expelling wind, unblocking the collaterals, and relieving pain; and nourishing and replenishing the original qi. Modern pharmacological studies have shown that insect drugs can treat rheumatoid arthritis from multiple perspectives, such as anti-inflammation and analgesic, immune regulation, anticoagulation, antioxidation, improving bone metabolism, protecting vascular endothelial cells, and inhibiting angiogenesis. This article explores the application of insect drugs in rheumatoid arthritis based on the collateral disease theory, in order to broaden the therapeutic approaches to rheumatoid arthritis.关键词：rheumatoid arthritis;Collateral Disease Theory;insect drugs;traditional Chinese medicine
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发布时间：2023-12-08 - 摘要：Polymyalgia rheumatica is a clinical syndrome characterized by stiff pain in neck, scapular and pelvic muscles. Arterial inflammation often occurs with vascular involvement as the disease progresses. Polymyalgia rheumatica can be classified as "muscle arthralgia" in traditional Chinese medicine. If the syndrome differentiation is accurate, the intervention effect will be satisfied in the early stage.According to the characteristics of polymyalgia rheumatica, our team can discuss its pathogenetic mechanism from the point of view "dampness-heat invading the channels at early stage, static-heat invading the collaterals at later stage". The main cause of polymyalgia rheumatica is the combination of internal and external pathogenic factors. Among them, the external evil qi invasion is the manifestation, and the internal dampness-heat is the root. All in all, when the evil qi invades the defensive qi, it can obstruct the skin surface. Hence, static-heat can’t be resolved, and then transfers into the ying blood gradually. Finally, it leads to the formation of static-heat invading the collaterals. In view of its manifestations and deteriorated cases, it can be treated in different stage from the following three angles. In the acute stage, venting the exterior and clearing out interior-heat should be chosen, in order to dispel the evil qi by decoction. In the stable stage, harmonizing the exterior and interior should be chosen in a gentle treatment way. And in the deteriorated stage, the treatment method should be based on the manifestations, so cooling the blood and dissolving stasis is necessary. In addition, rheumatism is chronic, recurrent and refractory. The most important thing is not to change the original formula after the formula takes effect.关键词：polymyalgia rheumatica;combination of internal and external pathogenic factors;dampness-heat invading the channels;static-heat invading the collaterals;treatment by stages
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发布时间：2023-12-08
Special Theme: TCM Prevention and Treatment of Rheumatism
- 摘要：Chronic pain is persistent, difficult to treat, and often accompanied by pain emotions, such as depression and anxiety, seriously affecting patients’ quality of life and substantially harming individuals, families, and society. Therefore, chronic pain has received considerable attention. This article explains the etiology and pathogenesis of chronic pain according to the "pain is caused by accumulation of body fluids" theory in Huangdi Neijing and clarifies the traditional Chinese medicine connotation of tuina treatment for chronic pain. The unique advantages of tuina treatment for chronic pain and pain emotions through the "treatment for both the body and mind" approach are summarized. It is hoped that the exploration of the "pain is caused by accumulation of body fluids" theory here will provide ideas for relevant basic research, clinical diagnosis, and treatment.关键词：pain is caused by accumulation of body fluids;chronic pain;pain emotion;tuina;treatment for both the body and mind
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发布时间：2023-12-08 - 摘要：Metabolic syndrome is a cluster of metabolic disorders associated with obesity, hyperglycemia, hypertension, and dyslipidemia. Central obesity is an important initiating factor and clinical manifestation of metabolic syndrome, while an imbalance in the intestinal flora can induce metabolic inflammation and insulin resistance. Lipid metabolism disorder also plays an important role in the occurrence and development of metabolic syndrome. Phlegm is an important pathological factor of metabolic syndrome that correlates with the intestinal microbiota and lipid metabolism disorders. Therefore, this paper systematically investigated the pathological mechanisms underlying metabolic syndrome with phlegm syndrome from the perspective of "intestinal microbiota-lipid metabolism", and proposed that metabolic syndrome with phlegm syndrome is closely related to lipid metabolism disorder mediated by intestinal microbiota. Combining the two diseases and machine learning furthers our understanding of the biological basis of metabolic syndrome with phlegm syndrome and provides a mechanism for microscopically differentiating the syndromes, acting as a theoretical reference for scientific research into disease prognoses and treatment targets.关键词：metabolic syndrome;phlegm syndrome;microscopic syndrome differentiation;gut microbiota;lipid metabolism
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发布时间：2023-12-08 - 摘要：The three-dimensional hierarchical differentiation and treatment view of qi, blood, and essence level reflects the evolution of diseases from organ dysfunction to tissue structure damage and even organ failure. This view can better explain the dynamic process of disease occurrence and progression and has practical guiding significance in the differentiation and treatment of internal medicine diseases. Interstitial lung disease is a clinically refractory disease, with the initial invasion to qi, followed by damage to ying blood, and then depletion of lung essence. Because the flow of qi is not smooth, it first affects lung qi. Then it leads to blood stasis and obstruction along the lung collateral. The depletion of essence destroys and penetrates the form and substance of the lungs. Interstitial lung disease, as a chronic progressive disease, has evolved from qi level syndrome characterized by organ dysfunction to essence level syndrome characterized by organic structural damage. The dynamic development of pathology and location of interstitial lung disease runs through the three-dimensional hierarchical differentiation and treatment view of qi, blood and essence level.The occurrence and development of interstitial lung disease are related to the depletion of qi, blood, and essence. This article explores the dynamic development of interstitial lung disease pathogenesis from a shallow to a deep perspective based on the three-dimensional hierarchical differentiation and treatment view of qi, blood, and essence level, providing new ideas and references for the differentiation and treatment of interstitial lung disease.关键词：interstitial lung disease;qi, blood and essence;hierarchical differentiation and treatment;dynamic development
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发布时间：2023-12-08
Theoretical Studies
- 摘要：ObjectiveThis study aimed to observe the effect of Yishen Tongluo Formula, which consists of prepared rehmannia root, milkvetch root, asiatic cornelian cherry fruit, danshen root, rhubarb root and rhizome, ramuli euonymi, and draconis resin, on podocytes in db/db mice and the murine renal podocytes cell line(MPC-5), and to explore the potential mechanism of Yishen Tongluo Formula in improving podocyte injury in diabetic kidney disease.Methods(ⅰ)In vivo. The db/db mice and littermate control db/m mice were used as the study objects. The db/db mice were divided into five groups according to their bodyweights, in which four groups were treated with Yishen Tongluo Formula (1.0, 2.5, 5.0 g/kg) or valsartan (10 mg/kg) once a day. The model group and the control group were given the same amount of distilled water. After 8 weeks of treatment, the number and morphology of podocytes in the kidney were assessed by transmission electron microscopy, and the podocyte marker protein (WT-1) was visulized by immunofluorescence and TUNEL staining. The serum levels of interleukin-1β (IL-1β) and interleukin-18(IL-18) were measured by enzyme-linked immunosorbent assay. The mRNA and protein expression and activation of NLRP3, CASP1 and GSDMD were measured by Q-PCR and Western blotting. (ⅱ)In vitro. MPC-5 cells induced with advanced glycation end products (AGEs). CCK-8 and lactate dehydrogenase (LDH) release detection techniques were used to detect LDH and evaluate the cell survival rate and membrane integrity. The mRNA levels of NLRP3, CASP1 and GSDMD in MPC-5 cells were measured by Q-PCR and Western blotting.Results(ⅰ) In vivo. Compared with the renal podocytes of db/m mice, those of db/db mice were fused, the basement membrane was thickened and the percentage of TUNEL-positive cells was increased, the positive expression rate of WT-1 was decreased, IL-1β and IL-18 levels in the serum were increased, the mRNA levels of NLRP3, CASP1 and GSDMD were upregulated, the protein expression of NLRP3 was upregulated, and CASP1 and GSDMD were activated(P<0.05). Compared with the model group, the podocyte injury in renal tissue was alleviated, the number of TUNEL positive cells in renal tissue was decreased, and the serum IL-1β and IL-18 levels decreased. NLRP3, CASP1, GSDMD, IL-1β and IL-18 mRNA levels reduced, the protein expression of NLRP3 and inhibited CASP1 and GSDMD pathway activation(all P<0.05). (ⅱ) In vitro. Compared with the control group, the survival rate of MPC-5 cells in the AGEs model group decreased, LDH release increased, the mRNA levels of NLRP3, CASP1 and GSDMD were upregulated, the protein expression of NLRP3 was upregulated, and CASP1 and GSDMD were activated(all P<0.05). After administration of Yishen Tongluo Formula, podocyte injury was improved, LDH release decreased, the mRNA levels of NLRP3, CASP1, GSDMD, IL-1β and IL-18 and the expression of NLRP3 protein decreased and CASP1 and GSDMD were inhibited(all P<0.05).ConclusionYishen Tongluo Formula can improve podocyte injury in mice with diabetic kidney disease by inhibiting the activation of the NLRP3/CASP1/GSDMD signaling pathway and reducing podocyte scorch death.关键词：Yishen Tongluo Formula;diabetic kidney disease;podocyte;pyroptosis;cysteinyl aspartate specific proteinase 1;murine renal podocytes;db/db mice
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发布时间：2023-12-08 - 摘要：ObjectiveTo investigate the effect of ginsenoside Rb1, berberine, and their combination on the intestinal flora in obese mice induced by a high-fat diet.MethodsForty-two male SPF grade C57BL/6J mice were fed on a high-fat diet for 12 consecutive weeks to establish an obese mice model. The 32 up to the standard obese mice were randomly divided into four groups: the control group, ginsenoside Rb1 group (20 mg/kg), berberine group (50 mg/kg), and ginsenoside Rb1+ berberine group (ginsenoside Rb1 20 mg/kg+ berberine 50 mg/kg), with eight mice in each group. The mice in each group received the corresponding drugs by gavage for 8 consecutive weeks, and the mice were fed with high-fat diet during the administration period. The body weight of the mice in each group was recorded every week, and the fasting blood glucose of mice in each group was detected every 2 weeks. After the experiment, fecal samples were collected for 16 S rDNA sequencing to observe the changes in the intestinal flora in each group of mice.ResultsCompared with the control group, the body weight from 4 to 6 weeks in the ginsenoside Rb1 group, the berberine group and the ginsenoside Rb1+ berberine group were reduced, and the fasting blood glucose at 4, 6 and 8 weeks were reduced (P<0.05). Furthermore, the imbalanced intestinal flora induced by the high-fat diet were improved, manifesting as an increased ratio of Bacteroides/Firmicutes, and the relative abundance of harmful bacteria, such as Deferribacteres, Mucispirillum, Helicobacter, Dorea, Ruminococcus, and Odoribacter were reduced.ConclusionGinsenoside Rb1, berberine, and their combination could reduce the body weight of mice with diet-induced obesity, and this effect is likely mediated through the modulation of the intestinal flora composition.关键词：ginsenoside Rb1;berberine;obesity;intestinal flora;mice
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发布时间：2023-12-08
Experimental Studies
- 摘要：ObjectiveTo explore the curative effect of Xiaoke Tongbi Formula in treating painful diabetic peripheral neuropathy(PDPN).MethodsSixty-eight patients with PDPN were recruited from August 2018 to December 2020 in Guangdong Prorincial Hospital of Chinese Medicine. They were randomly divided into the control group(n=34) and observation group(n=34); after applying the exclusion criteria, the final sample of the control group comprised 31 patients, and the observation group contained 29. The control group received pregabalin, and the observation group was treated with Xiaoke Tongbi Formula. The Brief Pain Inventory for patients with PDPN (BPI-DPN) score, numerical rating scale-11 (NRS-11), daily sleep interference diary (DSID), patients’ global impression of change (PGIC), traditional Chinese medicine(TCM) syndrome score, sensory nerve conduction velocity (SNCV), motor nerve conduction velocity (MNCV), incidence of adverse reactions and curative effects were compared between the two groups.ResultsAfter treatment, the total effective rate, as determined by the BPI-DPN score, was 75.9% in the observation group and 54.8% in the control group (P=0.019). The total effective rate determined by the PGIC score was 44.8% in the observation group and 9.7% in the control group (P=0.002); The total effective rate demonstrated by the syndrome score was 58.6% in the observation group and 41.9% in the control group (P=0.049). During the treatment period, no adverse events occurred in the observation group, while the control group experienced adverse events such as dizziness, drowsiness, and lower limb weakness, with a statistically significant difference (P<0.05).ConclusionXiaoke Tongbi Formula effectively treats PDPN and can safely and effectively improve patients' pain symptoms.关键词：painful diabetic peripheral neuropathy;Xiaoke Tongbi Formula;pregabalin;nerve function;brief pain inventory-diabetic peripheral neuropathy
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发布时间：2023-12-08 - 摘要：ObjectiveTo identify changes in metabolites in patients with stable angina pectoris(SAP) with qi stagnation and blood stasis, explore the differential metabolites and metabolic pathways associated with SAP, and determine the therapeutic mechanisms associated with Suxiao Jiuxin Pills.MethodsPatients and healthy recruited from September 2019 to September 2021 in Dongzhimen Hospital and other departments. The experimental group included 30 SAP patients with qi stagnation and blood stasis, and the control group included 30 healthy individuals. Serum metabolomics analysis was performed on both groups using liquid chromatography/mass spectrometry (LC/MS), and the VIP values of the first two principal components of the multivariate partial least squares-discriminant analysis model combined with a univariate analysis of difference fold-change and P values were used to screen differentially expressed metabolites. Metabolic pathway enrichment analysis of differential metabolites was performed using the Kyoto Encyclopedia of Genes and Genomes database.ResultsA total of 18 significant differential metabolites were identified in the experimental and control groups; the levels of 4-hydroxycinnamimide, biliverdin-Ⅸ-β, and 2-methylene glutamic acid were lower in SAP patients than in healthy individuals, and the L-carnitine, vitamin BT, agmatine, citraconic acid, guanine, and menthol levels were higher. Twenty-one significant differential metabolites were identified in the experimental group before and after the administration of Suxiao Jiuxin Pills. The levels of bacterial chlorophyll-a, sphingosine, 4-oxoretinol, ceramide, 1-methylguanine, and other metabolites decreased after administration, while those of 6-ketoprostaglandin E1, resin toxin, and prostaglandin G2 increased. The abnormal changes in differential metabolites suggest that numerous metabolic pathways are disordered in SAP patients, including amino acids, lipids, retinol, purines, porphyrins, chlorophyll, inflammatory mediator regulation of transient receptor potential channels, and serotonergic synapses.ConclusionThere are significant differences in metabolites between patients with SAP with qi stagnation and blood stasis and healthy people, and Suxiao Jiuxin Pills have positive and negative effects on regulating serum metabolites in vivo, thus regulating intestinal flora, maintaining the normal intestinal barrier, improving blood lipid levels, increasing the stability of vascular endothelial function, reducing tissue cell inflammation response, and inducing antioxidant effects.关键词：Suxiao Jiuxin Pills;stable angina pectoris;qi stagnation and blood stasis;metabolomics;liquid chromatography/mass spectrometry (LC/MS)
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发布时间：2023-12-08 - 摘要：ObjectiveTo study the characteristics of traditional Chinese medicine (TCM) syndromes in male patients with androgenetic alopecia (AGA).MethodsThe clinical data of 1, 000 male patients with AGA admitted to the Hair Medicine Center of China-Japan Friendship Hospital from January 2020 to December 2020 were retrospectively collected. A self-designed TCM symptom questionnaire was used to collect clinical information of the four examinations. Descriptive frequency analysis, factor-cluster analysis, and Chi-square test were performed using Excel and SPSS 26.0 software. The clinical data were combined to summarize the main TCM syndromes and symptoms.ResultsThe top five symptoms ranked by frequency were scalp oil (94.6%), scalp scurf(73.0%), scalp pruritus(71.2%), depression(67.5%), and fatigue (66.3%). Four TCM syndromes were derived using factor-cluster analysis: syndrome of internal retention of dampness-heat (34.6%), syndrome of liver depression and spleen deficiency(28.7%), syndrome of blood heat and wind-dryness(22.2%), and syndrome of liver-kidney deficiency (14.5%). Men aged 20 to <30 years were mainly syndrome of internal retention of dampness-heat, those aged 30 to <40 years were mainly syndrome of liver depression and spleen deficiency, and those aged 40 to <50 years were mainly syndrome of internal retention of dampness-heat. There was a significant difference in the distribution of TCM syndromes in patients aged 30 to <40 years (P<0.05).ConclusionMale AGA syndromes are mainly syndrome of internal retention of dampness-heat and syndrome of liver depression and spleen deficiency, and the distribution of syndromes differs across age groups. It is feasible to evaluate TCM syndromes with factor-cluster analysis combined with experts’ experiences for the clinical syndrome differentiation and treatment of male AGA.关键词：androgenetic alopecia;traditional Chinese medicine;syndrome;factor-cluster analysis
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发布时间：2023-12-08 - 摘要：In recent years, an increasing number of reports have been made on drug-induced liver injury (DILI) caused by Chinese materia medica, which has negatively influenced the development of traditional Chinese medicine (TCM). This article aims to analyze the current literature database on DILI reports related to Chinese materia medica, highlight the problems and deficiencies in the process of reporting DILI by Chinese materia medica, and suggest recommendations for a rational reporting procedure for this complication. Research findings indicated that published studies on DILI by Chinese materia medica contain incomplete information on Chinese materia medica sources, an absence of analysis of concurrent medication, alcohol consumption, and use of dietary supplements, and a clear violation of the basic principles of adverse drug reaction (ADR) reporting, leading to excessive reporting of DILI by Chinese materia medica. Additionally, to clarify the causative drugs, this article proposes the definition of Chinese materia medica-related DILI, and suggests a standardized reporting procedure for Chinese materia medica-related DILI. This article clarifies the true etiology of DILI and by referring to both domestic and international standards for handling ADR reporting, establishes standardized procedures for reporting Chinese materia medica-related DILI. These efforts are intended to further optimize the clinical application of Chinese materia medica and promote the healthy development of the TCM.关键词：traditional Chinese medicine;Chinese materia medica;drug-induced liver injury;adverse drug reaction
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发布时间：2023-12-08
Clinical Studies
- 摘要：Childhood autism is a common mental and behavioral disorder in children. In the Key to Therapeutics of Children’s Diseases, Qian Yi suggested that "although children have a voice and can swallow medicine, but can not speak, this is not aphasia, for the kidney timidity". Based on the theory of "kidney timidity and aphasia", combined with the physiological and pathological characteristics of childhood autism, this paper tries to introduce it into the syndrome treatment of childhood autism. Through divergent thinking of the same treatment of different diseases and the holistic concept in traditional Chinese medicine(TCM), it is proposed here that the pathogenesis of childhood autism is kidney yin and essence deficiency, and the disease is located in the brain, and related to the heart, liver, spleen and kidney. Qian Yi created Liuwei Dihuang Pill on the basis of Shenqi Pill to treat children’s diseases related to kidney timidity.According to the pathogenesis of childhood autism combined with the analysis of Qian Yi Liuwei Dihuang Pill, this paper analyzed and discussed the treatment for childhood autism, increasing our understanding of childhood autism from the perspective of TCM and in the hope of bringing therapies closer to clinical application and finding practical and effective treatment methods for this disorder to explore the methods of TCM treatment of autism.关键词：childhood autism;Qian Yi;Key to Therapeutics of Children’s Diseases;kidney timidity and aphasia;Liuwei Dihuang Pill
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发布时间：2023-12-08 - 摘要：The heart-spleen correlation theory originated from Huangdi Neijing, a part of the holism of the five zang organs in traditional Chinese medicine. Numerous recent studies have shown that Helicobacter pylori (Hp) is potentially associated with the occurrence and development of atrial fibrillation through inducing abnormal inflammatory and immunology response, destroying intestinal flora, affecting brain-gut interaction, and increasing blood viscosity. This study begins with the heart-spleen correlation theory and indicates that "ying-wei insufficiency, bacterial pathogen invasion", "ying-wei disordered regulation, abnormal mind", "ying-wei abnormal operation, qi and blood disharmony", "ying-wei loss of constraints, heart and spleen mutual injury" are the traditional Chinese medicine pathogenesis and evolution processes of atrial fibrillation resulting from Hp. And the "insufficiency", "disordered regulation", "abnormal operation" and "loss of constraints" of ying-wei are all under the category of "ying-wei disharmony". "Nutrient-defense disharmony" is the core pathogenesis throughout. From the perspective of "heart-spleen correlation, ying-wei harmony", this paper analyzes the syndrome differentiation and treatment of different stages of the process from the beginning of Hp infection to the development of Hp-induced atrial fibrillation, with a view to providing new ideas for the prevention and treatment of atrial fibrillation patients.关键词：heart-spleen correlation;heart-spleen correlation, ying-wei harmony;Helicobacter pylori;atrial fibrillation;pathogenesis;treatment
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发布时间：2023-12-08 - 摘要：Cholestatic pruritus is a common hepatobiliary disease caused by inhibited bile flow and bile stasis due to intrahepatic or extrahepatic causes. It is in the "Yangfeng" category in traditional Chinese medicine. This paper discusses the etiology, pathogenesis and treatment of cholestatic pruritus, based on the theory that "inside diseases show signs outside" in traditional Chinese medicine. The pathogenesis includes dampness-heat accumulation and steaming out, blood deficiency with wind intrusion and dryness damaging striae and interstices, and static blood blocking collaterals, resulting in pruritus and unsmooth skin. The treatment approach is based on the manifestation of the "external" disease to eliminate the internal pathogenesis, focusing on clearing heat and resolving dampness, cooling blood and regulating the mind, with formulas such as Longdan Xiegan Decoction and Mahuang Lianyao Chixiaodou Decoction; nourishing yin and enriching blood, dispelling wind and moisturizing dryness, using formulas like Siwu Decoction, Danggui Yinzi, and Zizao Yangrong Decoction; promoting blood circulation and dredging collaterals, harmonizing yin and yang, with formulas like Taohong Siwu Decoction and Dahuang Zhechong Pill being considered. Furthermore, psychological symptoms such as anxiety and depression need to be taken seriously and treated by clearing heart fire, cooling the blood and calming the mind. Wind drugs also play an essential role in the treatment of pruritus, such as Jingjie (schizonepetae herba), Fangfeng(Saposhnikoviae Radix) and so on. The treatment should pay attention to the holistic nature of all "internal" and all "external", only in this way can we solve the worries of the disease and alleviate the sufferings of patients.关键词：inside diseases show signs outside;cholestatic pruritus;treatment of traditional Chinese medicine
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发布时间：2023-12-08 - 摘要：Under the modern "biology-psychology-society" medical model, coronary heart disease with depression has become a research focus, and its core pathogenesis elements can be summarized as "deficiency, depression, and toxin", that is, depression due to deficiency, toxin due to accumulation of depression, and heart damage due to toxin. "Deficiency" mainly refers to the qi deficiency of heart and gallbladder, the fundamental internal cause of the disease. "Depression" includes both the broad sense of qi stagnation and the narrow sense of three depression-related emotions (anger, depressive thinking, and anxiety), which are key factors in the progression of the disease. "Toxin" refers to the accumulation and transformation of pathological products, such as phlegm and static blood, into the "latent toxin". Toxins emerge under the stimulation of emotional depression and damage the heart channels, corrupt the shape, and cause irreversible cardiac functional lesions, the final outcome of coronary heart disease with depression. The main treatment methods include supplementing qi, strengthening heart, regulating the mind and strengthening the gallbladder, regulating qi to relieve depression, strengthening mental therapy, treating phlegm, stasis, and toxins together to smooth the blood vessels. We hope to provide new ideas for the clinical diagnosis and treatment of coronary heart disease with depression.关键词：coronary heart disease with depression;qi deficiency of heart and gallbladder;three depression-related emotions;endogenous toxins;toxin damages the heart channels
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发布时间：2023-12-08
Thought and Method
- 摘要：Based on the qi transformation of yin and yang and ascending or descending among five zang organs in Huangdi Neijing, the theory of "qi circle in round" is the dynamic circulation of qi movement taking the central earth as the axis surrounded by the four elements in the visceral aspect, while the qi-blood movement with Yangming pivoting and yangqi leading in the meridian aspect, highlighting the importance of the circulation of qi and blood, yin being calm and yang being sound, and the balance of body and spirit. According to the theory of "qi circle in round", the pathogenesis of post-stroke hemiplegia is circulation disorder due to "yin-ascending and yang-descending" and "left-blood and right-qi" resulting in obstructed meridians and brain collateral, mainly due to the dampness of the spleen with phlegm leading to a lack of nutrient qi and defense qi, liver and lung failure to transport and transform, causing qi deficiency and blood stasis, and the non-interaction between the heart and the kidney accompanied with brain collateral damage. Considering its substantial "physical injury" and functional "mental injury", the acupuncture and moxibustion therapy based on syndrome differentiation should focus on regulating Yangming qi movement to improve the shape, balancing yin and yang to recover spirit, and integrating the four elements to smooth qi and blood, so as to restore qi circulation and the unity of body and spirit. This paper provides new ideas for improving the efficacy of acupuncture and moxibustion for post-stroke hemiplegia.关键词：qi circle in round;stroke;hemiplegia;acupuncture and moxibustion;efficacy;mechanism
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发布时间：2023-12-08
Acupuncture Moxibustion and Tuina
- 摘要：Breast cancer is the most prominent malignant tumor in women and the most common cause of cancer-related deaths in women worldwide. Breast cancer is a focus of cancer prevention and treatment programs in China. With the progress of breast cancer treatment, traditional Chinese medicine(TCM) has played a unique role in the integrated TCM and western medicine treatment model for breast cancer, and has become one of the main ways to treat breast cancer. Here, the recent clinical research, experience, diagnosis, and treatment consensus regarding breast cancer treated with TCM are summarized to review the current situation and prospects of TCM in treating breast cancer, analyze the problems existing in clinical research, and put forward suggestions to provide direction and ideas for better future clinical treatment and research.关键词：breast cancer;traditional Chinese medicine;treatment;review
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发布时间：2023-12-08 - 摘要：The traditional Chinese medicine (TCM) theory of weak pulse at yang and wiry pulse at yin in the Synopsis of the Golden Chamber is used to explain the etiology and pathogenesis of chest bi or chest painful impediment. Cardiac toxicity due to chemotherapy belongs to the TCM category of "chest bi". Thus, it is believed that the theory of Yang Wei Yin Xian can provide guidance in the occurrence, development, prognosis, and treatment of this complication. The basic pathogenesis of chemotherapy-induced cardiac toxicity is the deficiency of yang in tumor patients caused by illness and medication. Turbid phlegm, blood stasis, and drug toxicity are the pathological basis for cardiac toxicity occurrence or exacerbation. During chemotherapy, the pathogenesis and clinical characteristics of cardiac toxicity at different stages are analyzed based on the characteristics of the patients, which includes the steps "exuberance of yang, gradual deficiency of yang, decline of yang" and "insufficiency of yin pathogen, different gradually exuberance of yin pathogen, yang deficiency and yin excess". Different treatment method in phases are proposed according to these characteristics, such as supplementing qi and strengthening the spleen to prevent disease, dispelling phlegm and resolving stasis against disease changes, and warming yang and promoting urination to improve vital qi. This study provides a reference for TCM in the prevention and treatment of chemotherapy-induced cardiac toxicity.关键词：cardiac toxicity;chemotherapy;adverse reactions;Synopsis of the Golden Chamber;weak pulse at yang and wiry pulse at yin
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发布时间：2023-12-08
Hematology and Oncology
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