最新刊期
卷 46 ， 期 3 ， 2023
- 摘要：Acupoint compatibility is an important part of the acupuncture treatment system, which has a direct impact on clinical efficacy. Based on years of clinical experience and clinical research, the author believes that practitioners treating patients by acupuncture and moxibustion should pay attention to syndrome differentiation of channel theory and acupoint matching along meridians. The acupoint compatibility characteristics of superficial disease and visceral disease are different. Superficial disease is superficial and related to meridian circulation; practitioners should pay attention to the distribution along the meridian and mainly combine local-distal acupoints. When treating visceral diseases, with visceral dysfunction as the main pathogenesis, practitioners should pay attention to surface infusion and combine specific acupoints. Based on the characteristics of acupuncture and moxibustion, selecting the appropriate differentiation and acupoint compatibility method is beneficial to building a clinical practice fit acupuncture treatment system to improve the clinical efficacy of acupuncture.关键词：acupoint compatibility;syndrome differentiation of channel theory;acupoints along meridians;superficial disease;visceral disease
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发布时间：2023-04-07 - 摘要：There are a variety of acupoint stimulation method for acupuncture and moxibustion to treat irritable bowel syndrome (IBS), involving 58 acupoints, but the main acupoints used have some commonalities. Ten of the most commonly used acupoints are mainly distributed in the dominant area of nerve segments closely related to the colon. The segmental connection between the acupoints and target organs determines the specificity of the acupoint effect. There is a limit to the number of acupoints in a prescription; selection of more acupoints will not necessarily lead to better effects. The acupuncture and moxibustion treatment effect in IBS did not show a significant improvement as the number of acupoints increased, it has little advantages to selected more than 6 acupoints, so the number of main acupoints used for acupuncture and moxibustion treatment of IBS can be controlled at 4~6. The significance of the compatibility of Tianshu(ST25) and Zusanli(ST36) may lie in some complementary effects produced by their different action targets, rather than the enhancement or superposition of the effect on common action targets.关键词：acupoint;acupoint selection rule;compatibility rule;irritable bowel syndrome;dose-effect relationship;modern acupuncture and moxibustion
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发布时间：2023-04-07 - 摘要：By summarizing the relationship between body parts of human beings and the acupoint compatibility of Zangfu diseases, meridian diseases, similar diseases, as well as special acupoint compatibility, it was found that: (i) the matched acupoints for treating different types of diseases show a certain body part-distribution pattern; (ii) acupoints of special acupoint compatibility also display a consistent or corresponding relationship on body parts. The study of body part theory provides a wide range of ideas for acupuncture treatment to select or match acupoints, supports the search for more "effective stimulation" and it can also enrich and improve the existing acupuncture theory system.关键词：body part;acupoint compatibility;matching acupoint;acupuncture effect;acupuncture theory
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发布时间：2023-04-07
Special Theme: Rules of Acupoint Compatibility
- 摘要：Sjögren syndrome, a systemic autoimmune disease that is characterized by dry mouth and eyes, on which treatment decision remain challenging, while traditional Chinese medicine (TCM) has advantages and is widely used in China. However, the lack of consensus on standardized TCM patterns diagnosis and treatment based on evidence-based evidence, limits the further improvement of clinical efficacy and scientific research level. Rheumatology Branch, Chinese Academy of Chinese Medicine organized more than 50 experts from 48 hospitals across the country to form Expert Consensus for TCM Patterns of Sjögren Syndrome: (ⅰ) pattern of yin deficiency and depletion of fluid; (ⅱ) pattern of deficiency of both qi and yin; (ⅲ) pattern of endogenous heat due to yin deficiency (pattern of yin deficiency and heat-poison, included); (ⅳ) pattern of intermingled dryness and blood stasis; (ⅴ) pattern of intermingled dryness and dampness. According to the patterns, principles of treatment and prescriptions are also on the same page. The formation and promotion of this consensus is of importance in the TCM course of diagnosis and treatment of Sjögren syndrome.关键词：Sjogren syndrome;arthralgia caused by dryness pathogen;patterns of traditional Chinese medicine;expert consensus
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发布时间：2023-04-07
Standards & Guidelines
- 摘要：Precision medicine refers to implement "tailored" health care and clinical decision-making based on the patient’s intrinsic biological information and clinical signs. Major breakthroughs have been made not only in targeted therapy of gastric cancer and in the analysis and identification of biological markers, but also in the development of minimally invasive and precise surgery. Traditional Chinese medicine is a system that is characterized by a high degree of "individualized medicine" , where attention is paid to the influence of various factors such as constitution, environment, and lifestyle on individual differences. "Inflammation cancer transformation" of chronic gastritis is a complex process that encompasses the digestology and oncology, involving a dynamic evolution that spans multiple pathological stages. Guided by the ideology of "preventive treatment" , Chinese medicine pays special attention to the precise prevention and treatment across the whole process and all factors involved in "inflammation cancer transformation" of chronic gastritis. The ultimate aim is to provide (i) targeted and precise management for different pathological stages, different syndrome characteristics, and different population characteristics; and (ii) active intervention based on "principle, methodology, formula, medication" at each pathological stage, so as to block disease progression and reduce the incidence of gastric cancer. This paper discusses the advantages of traditional Chinese medicine in precision medicine, from the perspective of accuracy in theory, prevention, differentiation, and treatment, in order to provide a reference for delaying, blocking, or even reversing the process of "inflammatory cancer transformation" of chronic gastritis.关键词：precision medicine;chronic gastritis;gastric cancer;inflammation cancer transformation;traditional Chinese medicine
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发布时间：2023-04-07 - 摘要：" Strengthening and consolidating body resistance" is the basic principle of traditional Chinese medicine (TCM) in the prevention and treatment of tumors. After nearly 60 years of development, the academic inheritance venation of " strengthening and consolidating body resistance - strengthening vital qi and removing toxicity - consolidating body and clearing resource" has been gradually formed. Based on the exploration of the evolution law of the core pathogenesis in the tumor whole cycle, our team proposed the " Evolution of Five Phases" , and condensed the " Five Method of Strengthening Vital Qi" to highlight the prevention and treatment advantages of TCM in phased sequential differentiation, which are divided into strengthening vital qi and resolving stagnation, strengthening vital qi and lifting collapse, strengthening vital qi and removing toxicity of irradiation and chemotherapy, strengthening vital qi and removing residul toxicity, strengthening vital qi and activating blood circulation to remove blood stasis. Attach importance to precancerous negative emotions, pay attention to susceptible constitution, to strengthening vital qi and removing toxicity to prevent and treat tumorigenesis; optimize the pathogenesis of postoperative qi collapse, separate three sources(pectoral qi, middle qi, and kidney qi) of differentiation and treatment, to strengthening vital qi and lifting collapse to promote postoperative rehabilitation; refining adverse reactions (AEs) prevention and treatment strategies, pay attention to drug toxin yin and yang property, to strengthening vital qi and removing toxicity to improve AEs; anchor residual toxicity is not done, pre-resolve cancer, to prevent and treat postoperative recurrence and metastasis; clarify the clinical value of strengthening vital qi and activating blood circulation in advanced tumors, in order to improve long-term survival. The establishment of " Five Methods of Strengthening Vital Qi " is the inheritance and innovation of the treatment method of " strengthening and consolidating body resistance" , which is in line with the current law of TCM understanding of tumors, hoping to guide and optimize clinical treatment, improve the level of TCM prevention and treatment, and improve the TCM tumor differentiation and treatment system.关键词：Five Methods of Strengthening Vital Qi;strengthening and consolidating body resistance;Evolution of Five Phases;traditional Chinese medicine;tumor
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发布时间：2023-04-07 - 摘要：Pancreatic diseases are mostly caused by disorders of the spleen. Treatment of pancreatic cancer caused by the spleen based on traditional Chinese medicine can effectively delay its evolution, but there is a lack of theoretical support, which is worthy of further discussion. Based on the elucidation of the connotation of "spleen acting as the guard for the five zang viscera and six fu viscera" , this paper states that "spleen acting as the guard for the five zang viscera and six fu viscera" is a summary of the body’s security function, which depends on "spleen dominant digestion" . The secretory functions of pancreatic cancer patients are abnormal, so the obstruction of bile and pancreatic juice excretion leads to "spleen failing to digest" , which leads to the pathological transformation from "spleen acting as the guard for the five zang viscera and six fu viscera" to "spleen lossing of guard" , or it may be the main cause of the evolution of pancreatic cancer. The pathological evolution process of "spleen injury-spleen failure-spleen collapse" is highly consistent with the evolution of pancreatic cancer based on modern research, which reasonably explains the significant curative effect of spleen treatment on the delay of the progression of pancreatic cancer. It is pointed out that the key to delaying the progression of pancreatic cancer is to maintain and restore the function of the "spleen acting as the guard for the five zang viscera and six fu viscera" in order to reshape the tumor microenvironment of pancreatic cancer. Combined with modern research, this paper summarizes the three spleen-regulating strategies of clearing spleen to restore defensive qi, invigorating spleen to run defensive qi, and tonifying spleen to replenish defensive qi, in order to provide a useful reference for clinical diagnosis and treatment of pancreatic cancer.关键词：pancreatic cancer;spleen acting as the guard for the five zang-organs and six fu-organs;digestion;exocrine function;treating spleen;defensive qi
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发布时间：2023-04-07 - 摘要：WU Youke discussed the treatment of epidemic diseases in Wenyi Lun(Treatise on Warm Pestilence), proposing that various kinds of qi are the pathogenic factors of diseases and emphasizing the importance of healthy qi by stating that sufficient healthy qi can prevent the invasion of pathogenic qi. Reinforcing healthy qi is key to epidemic treatment, and treatment varies according to age, sex, constitution, and syndromes. During the struggle between healthy qi and pathogenic qi, healthy qi must be reinforced and pathogenic factors must be simultaneously and appropriately removed. For a combined deficiency and excess pattern, reinforcement and reduction method should be used alternately. He also proposed tonifying method that should not be used, such as ginseng and largehead atractylodes rhizome. He also emphasized the regulation and tonification of epidemics in later stages, the nourishment of stomach qi, the need for a proper diet, and the need to secure body fluids to nourish yin and strength healthy qi. His theory serves as a reference for the prevention and treatment of COVID-19.关键词：Treatise on Warm Pestilence;epidemic disease;reinforce healthy qi and remove pathogenic factors simultaneously;Nourish yin;COVID-19 infection
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发布时间：2023-04-07 - 摘要：This paper reconstructs the theory of "stasis of metal should be adjusted" combined with functional principles from the theory of traditional Chinese medicine and discusses the pathogenesis and treatment of pulmonary nodules. It is believed that "stasis of metal" reflects deviation in spatial operation, imbalance and stagnation of the visceral structure, and the function of the five elements belonging to gold; "adjusted" is a general term to describe treatment method that make the lung structure and function adapt to each other through the method of propaganda, dredging, penetration, and dispersion. It is suggested that "stasis of metal" is the general pathogenic mechanism underlying the occurrence and development of pulmonary nodules; functional retardation is an important factor and structural retardation is the pathological basis. In the clinical treatment of pulmonary nodules, this theory can be combined with wind-drugs which open the lung xuanfu and the lung collateral microstructure on the basis of dialectical treatment, and regulate pulmonary function to treat pulmonary nodules.关键词：stasis of metal should be adjusted;pulmonary nodules;Xuanfu;lung collaterals;wind-drugs
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发布时间：2023-04-07
Theoretical Studies
- 摘要：Isolation measures for COVID-19 not only effectively cut off viral transmission, but also affected the on-site monitoring of the third party in traditional Chinese medicine (TCM) clinical research. Therefore, remote data quality control has become an urgent problem in clinical research. The present research is based on the Major Program of "the 13th Five-Year Plan" for the prevention and treatment of severe infectious diseases with TCM and the experiences of remote data quality control during the COVID-19 epidemic. Based on the relevant regulatory requirements of clinical research in China and abroad, according to the clinical research quality standards of ALCOA (attributable, legible, contemporaneous, original, accurate) and CCEA (complete, consistent, enduring, available), and from a practical perspective, in the present study we elaborate on the plan, key points, and method of data verification, as well as two methods of data quality assessment. We introduce the advantages of the intensive electronic data platform and discuss how to use the platform to remotely control the trial progress and data quality management method , in order to provide an opportunity for clinical researchers to reduce on-site contact with patients and effectively improve data quality through an electronic data platform and mass electronic data processing.关键词：traditional Chinese medicine;COVID-19;clinical research;remote monitoring;data quality
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发布时间：2023-04-07 - 摘要：ObjectiveWe aimed to explore the symptom-herb relationships and the evolution law implied in the development of stroke treated by traditional Chinese medicine (TCM).MethodsBased on ancient books on TCM, a stroke symptom-herb network was constructed, and its temporal evolution was analyzed by network topology and node ranking feature calculation, community discovery, subnetwork similarity calculation, and other method.ResultsThe changes in the structure and scale of the symptom-herb network of stroke and evolution analysis of the node sorting characteristics revealed the key symptoms and core herbs used to treat stroke in different historical periods, which confirmed the changes in the theoretical understanding of stroke in TCM and the gradual maturity of symptom differentiation and treatment. Subnetwork similarity analysis showed that stroke can be roughly divided into three categories: true stroke, analogous stroke, and acute stroke. Community discovery and evolutionary analysis uncovered symptom and drug combinations that were closely linked in different historical periods.ConclusionThe temporal evolution analysis of complex networks serves as a new method for studying the complex relationship and evolution law between stroke-related symptoms and herbs used. The result can be used as a reference for combining the source and flow of stroke and clinical symptom differentiation and treatment.关键词：stroke;symptom-herb relationship;ancient chinese medicine books;complex network;community discovery
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发布时间：2023-04-07
TCM Informatics
- 摘要：ObjectiveWe aimed to explore the effect of myocardial infarction (MI) on the intestinal absorption of the active ingredients of Qishen Yiqi Dripping Pills (QSYQ).MethodsTwenty-five male Sprague-Dawley rats were used. Fifteen rats were randomly selected to establish the MI model by ligating the left anterior descending coronary artery; the remaining rats were used as the normal group. Seven-day postoperative MI model rats were taken to confirm the model was successfully established and to determine the physiological status of the intestinal mucosal barrier by electrocardiography (ECG), by analyzing myocardial and intestinal tissue sections, and by measuring the levels of the serum biomarkers 5-hydroxytryptamine (5-HT) and lipopolysaccharides(LPS). In normal and seven to nine day postoperative MI model rats, the intestinal absorption of the active ingredients of QSYQ was studied by the single-pass intestinal perfusion method. The final concentration of perfusate was 30 g/L. Values and differences of parameters related to intestinal absorption such as the effective permeability coefficient, absorption rate constant, and absorption fraction were obtained by the weight difference method.ResultsThe ECGs of MI model rats showed 6-8 Q waves and ST-segment elevation. Cytomorphological changes in HE-stained pathological sections of myocardial and intestinal tissues of rats were observed in the model group, with more inflammatory cell infiltration. The serum concentrations of 5-HT and LPS were higher in the model group (P<0.05). The rate and extent of absorption of the different components varied in MI rats compared to normal rats. The trans-intestinal membrane absorption rates of danshensu, protocatechualdehyde, tanshinone IIA, calycosin, ginsenoside Rb1, and trans-nerolidol were higher in MI rats (P<0.05), and the in vivo absorption fractions of ginsenoside Rb1 and trans-nerolidol were also simultaneously increased (P<0.05). Danshensu and calycosin changed from low to high permeability. There were no significant differences in parameters related to intestinal absorption of salvianolic acid A, rosmarinic acid, ginsenoside Rg1, notoginsenoside R1, and astragaloside Ⅳ in the disease state.ConclusionThe MI rat model was established successfully after ligating the left anterior descending coronary artery. Morphological changes in myocardial and intestinal tissues of rats were observed. MI changed the mucosal barrier function of the intestine. The effects of the infarct state on the absorption of different types of components were complex and non-specific.关键词：Qishen Yiqi Dripping Pills;myocardial infarction;the single-pass intestinal perfusion method;intestinal absorption;permeability;rats
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发布时间：2023-04-07 - 摘要：ObjectiveWe aimed to investigate the molecular mechanism by which vascular softening pill regulate the activation of the p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway and the vascular inflammatory response to prevent atherosclerosis by long-stranded non-coding RNA taurine upregulated gene 1 (lncRNA-TUG1).MethodsIn vitro, a high-fat diet was used to establish an atherosclerosis mouse model. Seventy-five ApoE-/- mice were randomly divided into the model group, the TUG1 inhibitor group (10 μL TUG1-interfering lentivirus), the negative control group (10 μL empty lentivirus), the vascular softening pill group (43.2 g/kg) and the combination group (10 μL TUG1-interfering lentivirus + 43.2 g/kg vascular softening pill), 15 mice in each group. The intervention was continued for 8 weeks. Protein expression of TUG1 were measured by immunohistochemistry; the levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) in peripheral serum were measured by ELISA; the mRNA expression levels of TUG1 and total p38 protein (T-p38) in mouse aorta were detected by real-time PCR. In vivo, a vascular endothelial cell (VEC) dysfunction model was established and the vascular softening pill drug serum was used for intervention. After the intervention, survival rate of cell was measured by MTT assay, the cell ultrastructure was observed by transmission electron microscopy, the levels of ICAM-1, VCAM-1, IL-8 and MCP-1 in the serum were measured by ELISA, the mRNA expression levels of TUG1 and T-p38 were measured by real-time PCR, and the protein levels of T-p38 and phosphorylated p38 (p-p38) were measured by Western blotting.ResultsAfter the intervention, Immunohistochemical detection showed that the positive signal of TUG1 mean optical density was brown yellow or brown. The most obvious atherosclerotic plaque formation and the most obvious positive signal of TUG1 protein expression were found in the model and negative control groups. Compared with the model group, the aortic TUG1 mean optical density was reduced in the vascular softening pill group (P<0.05), the peripheral serum levels of ICAM-1, VCAM-1, IL-8 and MCP-1 were reduced (P<0.05), and aortic TUG1 and T-p38 mRNA expression levels were reduced (P<0.05). Cell culture experiments revealed that the survival rate of VEC cells was increased in the vascular softening pill serum group compared with the model group (P<0.05). Transmission electron microscopy showed that the distance between mitochondria in the cells in the vascular softening pill serum group was smaller than that in the model group, and the arrangement of intracellular fibers was more orderly than that in the model group. Compared with the model group, the levels of ICAM-1, VCAM-1, IL-8 and MCP-1 in the cell sap of the vascular softening pill serum group were reduced (P<0.05), the cellular TUG1 and T-p38 mRNA expression levels were reduced (P<0.05) and the cellular T-p38 and p-p38 protein expression levels were reduced (P<0.05).ConclusionThe molecular mechanism by which vascular softening pills protect against atherosclerosis may be related to the regulation of the p38 MAPK signaling pathway through lncRNA-TUG1, inhibition of the vascular inflammatory response, inhibition of vascular endothelial cells apoptosis and protection of vascular endothelium.关键词：vascular endothelial cells;vascular softening pill;inflammatory response;lncRNA-TUG1;p38 MAPK signal pathway;mice
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发布时间：2023-04-07
Experimental Studies
- 摘要："Life cycle health" has become an important part of the national health strategy. The "life process theory" of traditional Chinese medicine (TCM) constitution (Tizhi) is the theoretical basis for carrying out whole life cycle constitution (Tizhi) health management. In the "Three Key Issues" of TCM constitution (Tizhi), constitution (Tizhi) is the basis of individualized health management, correlation between constitution and disease is the basis of health management, and constitution (Tizhi) adjustment is the purpose of health management. People in different life cycles can formulate appropriate health management plans according to these three aspects. Based on the three key problems of constitution (Tizhi), this paper summarizes the current situation of health management in the whole life cycle. We also propose that the concept of "three levels of prevention" should be used to examine the "whole life cycle health." In addition to focusing on the health of each stage of the life cycle, attention should be paid to the impact of the previous life cycle stage on the subsequent life cycle stages. Attention should be paid to the dynamics and phases of the life cycle, and the concept of "three levels of prevention throughout the life cycle" should be established. The life cycle sequence of children-adults-elderly should be taken as the time chain of health management for disease prevention, and this could even be extended to embryonic health management. According to this, we can reveal the physical law of the whole life cycle and establish a dynamic and complete health management system based on the whole life cycle.关键词：TCM constitution;key scientific issues;life cycle health management
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发布时间：2023-04-07
TCM Constitutions
- 摘要：ObjectiveWe aimed to verify the efficacy of integrated Chinese and Western medicine in the treatment of patients with metastatic colorectal cancer (mCRC).Methods733 mCRC patients who visited Xiyuan Hospital of Chinese Academy of Chinese Medical Sciences, Beijing Cancer Hospital and Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine between August 1, 2013 and December 31, 2015 were enrolled. A cohort study design was adopted, and "receiving continuous traditional Chinese medicine (TCM) for ≥3 months" was taken as the exposure factor. Patients who met this criterion were classified into the integrated Chinese and Western medicine cohort, and patients who did not meet this criterion were classified into the Western medicine cohort. Overall survival (OS) and the 1-, 3- and 5-year survival rates were compared between the two cohorts. A multivariate risk proportional regression model was used to explore the factors affecting the prognosis of mCRC patients.ResultsA total of 335 patients with mCRC were included in this study, including 129 patients in Chinese and Western medicine cohort and 206 patients in Western medicine cohort. The median overall survival (mOS) in the Chinese and Western medicine cohort was 28.0 months and that of the Western medicine cohort was 20.3 months. The difference was statistically significant (HR=0.748, 95%CI=0.587-0.950, P<0.05). The 1-, 3- and 5-year survival rates of the Chinese and Western medicine cohort were 96.0% (120/125), 36.8% (46/125) and 10.4% (13/125), respectively. The 1-, 3-, and 5-year survival rates of the Western medicine cohort were 79.9% (159/199), 23.1% (46/199) and 6.0% (12/199), respectively. The 1-, 3-year survival rates of Chinese and Western medicine cohort was higher than Western medicine cohort(P<0.01). Subgroup analysis showed that there was a significant difference in mOS between the two cohorts in the female, right-side colon, RAS mutation, no targeted therapy, and non-chemotherapy subgroups (P<0.05, P<0.01). Multivariate analysis showed that right-side colon, non-chemotherapy, RAS mutation, and low differentiation were independent prognostic factors for poor prognosis of mCRC and integrated of Chinese and Western medicine was a protective factor (HR=0.529, 95%CI=0.386-0.714, P<0.01), which reduced the risk of death by 47.1%.ConclusionIntegrated of Chinese and Western medicine can prolong the OS of mCRC patients, and the benefits are more obvious in women and in patients with right-side colon cancer and RAS mutation. Integrated of Chinese and Western medicine can significantly reduce the risk of death in mCRC patients. At the beginning of Western medicine treatment, the early integrated of traditional Chinese medicine will bring greater survival benefits to mCRC patients.关键词：metastatic colorectal cancer;combination of Chinese and Western medicine;cohort study;cox multifactor analysis
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发布时间：2023-04-07 - 摘要：Interstitial lung disease associated with Sjögren syndrome belongs to the category of "arthralgia caused by dryness pathogen" in traditional Chinese medicine, and it is generally believed that its pathogenesis is centered on internal dryness, which is caused by internal heat and burning of body fluid due to the lack of innate endowment or external dryness. The metabolism of water and grain essence is slow, and excessive accumulation of grain essence or abnormal transportation and transformation can lead to turbidity, and the accumulation of turbidity is the basis for the development of turbid poison. Turbid poison has the characteristics of poisonous evil, its nature is harsh, it is more likely to consume qi and blood, and it has the characteristics of agglutination, stagnation and filth. Turbid poison can be classified as a class of original poison. The original base of its transformation is turbidity from the grain essence. If the grain essence is transformed into a mellow and moist essence, alienation is brewed into the turbidity of corruption. The formation of turbid poison caused by spleen deficiency is a process of gradual accumulation, which can damage the internal organs and is complex and easily recurring. We believe that deficiency of the spleen and stomach is the source of dryness and that turbid poison with phlegm and blood stasis in the middle jiao and lung channels is the key factor aggravating the dryness. The theory of turbid poison of spleen and stomach covers the whole disease process. In the early stage, the spleen and stomach are deficient and the turbidity gathers at the beginning, which hinders qi and injures body fluid. In the middle stage, the turbidity breeds turbid poison, which leads to heat with phlegm and blood stasis. In the late stage, the turbid poison accumulates to form a mass, which can damage various organs. Clinical treatment should be based on the degree of turbid poison, blocking the source of turbid poison in the early stage, paying attention to the protection of body fluid, dredging the meridians by detoxification in the middle and late stage and taking in energy to restore the vital qi. The symptoms and signs of interstitial lung disease associated with Sjögren syndrome are consistent with the characteristics of turbid poison invading the human body. The theory of turbid poison of spleen and stomach can provide a new idea for the differentiation and treatment of this disease in traditional Chinese medicine.关键词：Sjogren syndrome;deficiency of spleen and stomach;turbid poison;interstitial lung disease
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发布时间：2023-04-07 - 摘要：ObjectiveBy analyzing the traditional Chinese medicine syndrome and cerebral glucose metabolism of dementia with lewy bodies(DLB) and Alzheimer's disease (AD), this study intends to find the features of effective differential diagnosis of DLB and AD.MethodsFrom January 2020 to December 2020, a total of 60 patients meeting the criteria were included, including 30 patients with DLB and 30 patients with AD.The general demographic data of the patients were collected. The total score of the Clinical Dementia Rating Scale (CDR) was used to assess the severity of dementia and the dementia syndrome factor weighting scale was used to determine the syndrome types of the patients. Positron emission computer tomography was performed after intravenous injection of the tracer 18F-fluorodeoxyglucose.ResultsYin deficiency and yang hyperactivity, qi deficiency of lung and kidney, liver-kidney deficiency were the most common syndromes in DLB patients.The syndromes of spleen deficiency and phlegm turbid, heat-toxity and blood stasis, spleen-kidney deficiency were the most common in AD patients. The changes of brain metabolism in DLB patients with suspected dementia were mainly reduced in the parietal lobe and temporal lobe. The metabolism of frontal, parietal and temporal lobes was decreased in DLB patients with mild and moderate dementia. In AD patients with non-severe dementia, the metabolism of the parietal lobe, temporal lobe and frontal lobe is decreased, while in some AD patients with moderate dementia, the metabolism of the occipital lobe is decreased.In patients with DLB, the changes in brain metabolism in patients with syndrome of yin deficiency and yang hyperactivity were mainly reduced metabolism in frontal lobe, parietal lobe, temporal lobe and occipital lobe; the changes in brain metabolism in patients with syndrome of qi deficiency of lung and kidney were mainly reduced metabolism in frontal lobe, parietal lobe and temporal lobe; the changes in brain metabolism in patients with liver-kidney deficiency syndrome were mainly reduced metabolism in parietal lobe and temporal lobe. However, patients with AD with different TCM syndromes mainly have low metabolism in frontal lobe, parietal lobe and temporal lobe.ConclusionThere are significant differences in TCM syndrome and cerebral glucose metabolism characteristics between DLB and AD patients, which is helpful for the differential diagnosis of DLB and AD. The brain metabolic characteristics of DLB patients with different syndromes are different, which is conducive to the precise treatment of DLB.关键词：dementia with Lewy bodies;Alzheimer’s disease;TCM pattern;positron emission tomography and computed tomography
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发布时间：2023-04-07 - 摘要：ObjectiveWe aimed to (i) explore the proportion of complication of cardiovascular risk-related diseases, the degree of thickening of the carotid intima media thickness (IMT) the detection rate of plaques, and the distribution law of traditional Chinese medicine (TCM) syndrome elements in different coronary artery lesions, (ii) analyze the factors influencing coronary artery lesions, and (iii) explore the theory of blood vessels.MethodsA cross-sectional retrospective analysis including 227 patients admitted to the Department of Cardiovascular Medicine of The First Affiliated Hospital of Guangzhou University of Chinese Medicine between August 2021 and October 2021 who were diagnosed by coronary angiography because of chest pain was conducted.The patients were divided into four groups according to the Gensini score: the no stenosis group, the mild stenosis group, the moderate stenosis group and the severe stenosis group.The proportion of cardiovascular risk-related diseases, the distribution law of TCM syndrome elements, the carotid IMT thickening degree and the distribution law of plaque in different degrees of coronary stenosis were analyzed, and the factors related to coronary stenosis were analyzed by multi-classification logistic regression.ResultsThe proportion of moderate coronary artery disease with diabetes and dyslipidemia was the highest in the moderate stenosis group.The analysis of syndrome elements showed that the factors related to disease location were all in the heart.Among the TCM syndrome elements, the proportion of heat toxin in the moderate stenosis group was the highest, while the proportions of phlegm-turbidity, qi stagnation and qi deficiency were the highest in the no stenosis group.Among the 227 patients who underwent coronary angiography, only 139 patients underwent carotid artery ultrasound examination.There are differences in the distribution of the degree of thickening in left IMT and right IMT and in the presence of plaques, which difference is statistically significant (P<0.01).In the no stenosis group, the proportion of left IMT and right IMT<1.0 mm and without plaques was the highest.In the severe stenosis group, the proportion of right IMT 1.0~1.5 mm or left and right IMT>1.5 mm, with plaques was the highest, and decreased gradually in the moderate, mild and no stenosis groups.The proportion of left IMT 1.0~1.5 mm was the highest in the moderate stenosis group, next to that in the severe stenosis group, decreased gradually in the mild and no stenosis groups.Multi-classification logistic regression showed that the main factors affecting coronary artery stenosis were complicated with dyslipidemia, heat toxin and right IMT.ConclusionDyslipidemia, Carotid artery and coronary artery plaques damage due to the blood vessels.Dyslipidemia, heat toxin, right IMT thickening are factors influencing coronary artery stenosis.The concept of disease prevention and treatment based on blood lipid level, carotid ultrasound combined with TCM syndrome differentiation is put forward, which aims to identify the disease in a non-invasive way, prevent it before it aggravates, and prevent it from spreading.关键词：blood vessel theory;carotid artery;coronary artery;syndrome elements
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发布时间：2023-04-07 - 摘要：Cardiac diseases are closely related to mitochondrial dysfunction. In traditional Chinese medicine (TCM), the heart, spleen, and kidney play important roles in cardiac diseases. There is evidence indicating that TCM exert its effects through regulating mitochondrial function. Based on the theory of TCM, clinical trials, and animal experiments, it is found that "loss of heart kidney interaction and imbalance of heart and spleen" is not only the key pathogenesis in the evolution of cardiac diseases, but also the macro expression of mitochondrial related functional disorders. A review of relevant literature revealed that cardiac diseases caused by abnormal mitochondrial function are treated through addition and subtraction of prescriptions such as nourishing kidney and benefiting qi, nourishing qi and warming yang, warming and benefiting heart and kidney, strengthening spleen and nourishing heart, or nourishing qi and strengthening spleen. The "heart kidney interaction" theory is the macro-control of mitochondrial dynamics (fusion and lysis); the theory of "heart spleen mutual generation" is a steady-state regulation of mitochondrial energy metabolism. The functions of mitochondria are various and complex, and TCM plays an important guiding role in the treatment of cardiac diseases through its related theories. Therefore, it is of great significance to explore the role of mitochondrial function in the treatment of cardiac diseases from the perspective of "heart kidney interaction, heart spleen mutual generation" , so as to provide more possibilities for TCM-based treatment of cardiac diseases.关键词：heart kidney interaction;heart spleen mutual generation;cardiac disease;mitochondrial function;mitochondrial dynamics;mitochondrial energy metabolism
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发布时间：2023-04-07 - 摘要：By consulting the ancient Chinese medicine classics and analyzing the theoretical connotation of "strengthening vital qi and removing toxicity" and "removing toxicity and recuperating vital qi" , this paper explores the similarities and differences between "strengthening vital qi and removing toxicity" and "removing toxicity and recuperating vital qi" in the treatment of malignant tumors. "Strengthening vital qi and removing toxicity" and "removing toxicity and recuperating vital qi" are both based on "vital qi" and "toxin" , which are the two bases of tumor growth and prognosis. "Strengthening vital qi and removing toxicity" emphasizes strengthening vital qi, correcting deviation, and dispersing toxin, and takes "strengthening vital qi" as the priority. The specific method include nourishing yin and warming yang, regulating qi and dispersing depression, and invigorating the spleen and kidney. "Removing toxicity and recuperating vital qi" pays attention to removing toxicity, eliminating pathogens, and recuperating health, with the key objective being "removing toxicity" . The specific method include attacking excessive pathogens, finding the cause and removing toxicity, and using toxic medicines to enhance the effects on tumors. Through the application of clinical events, this paper demonstrates the feasibility and efficacy of the two methods, providing new ideas for clinical tumor treatment, which is of great guiding significance.关键词：malignant tumor;strengthening vital qi and removing toxicity;removing toxicity and recuperating vital qi;vital qi;cancerous toxicity
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发布时间：2023-04-07
Clinical Studies
- 摘要：ObjectiveTo inquire into the mechanism of acupuncture in the treatment of depression.MethodsSprague-Dawley rats were randomly divided into the normal group, the model group, the acupuncture group, and the fluoxetine group (n=8 rats in each). The depression model was established by using chronic unpredictable mild stress method. The "Baihui" (GV20) and "Yintang" (GV29) acupoints were selected in the acupuncture group. Acupuncture treatment was given before modeling each day, with needle retention for 10 minutes, six times a week. Fluoxetine was given intragastrically before modeling each day (10 mg/kg), once daily. The behavior tests, including the body weight and the sucrose preference test were performed. The hippocampal protein expression levels of NLRP3, ASC, and Caspase-1 were measured by Western blotting. The hippocampal gene expression levels of IL-1β and IL-18 were measured by real-time fluorescent quantitative PCR. The hippocampal contents of IL-1β, IL-18, IL-4, and IL-10 were measured by ELISA.ResultsCompared with the normal group, the body weight and the percentage of sucrose preference test were decreased in the model group (P<0.05, P<0.01), the hippocampal expression levels of NLRP3, ASC, and Caspase-1 were increased (P<0.01), the hippocampal gene expression of the pro-inflammatory factors IL-1β and IL-18 were increased (P<0.01, P<0.05), and the protein levels of IL-1β and IL-18 in the hippocampus were increased (P<0.01, P<0.05), and the levels of anti-inflammatory factors IL-4 and IL-10 were decreased (P<0.01, P<0.05). Compared with the model group, there was no statistical difference in the body weight in the acupuncture and fluoxetine groups (P > 0.05), while the percentage of sucrose preference was increased in both the acupuncture and fluoxetine groups (P<0.05). Compared with the model group, the expression levels of hippocampal NLRP3, ASC, and Caspase-1 were decreased (P<0.01), the gene expression levels of the pro-inflammatory factors IL-1β and IL-18 (P<0.01, P<0.05) and the protein levels of IL-1β and IL-18 were reduced (P<0.01, P<0.05), and the content of the anti-inflammatory factor IL-10 in the hippocampus was increased (P<0.05). However, there was no statistical difference in the content of IL-4 (P>0.05). In addition, there was no statistical difference between the acupuncture and fluoxetine groups (P>0.05).ConclusionAcupuncture treatment could alleviate depressive behavior and exert antidepressant effects, possibly by inhibiting the NLRP3 inflammasome activity and the related inflammatory response, reducing pro-inflammatory cytokine levels, and increasing anti-inflammatory cytokine levels in the hippocampus.关键词：acupuncture;depression;chronic unpredictable mild stress;NLRP3 inflammasome;inflammatory cytokines;rats
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发布时间：2023-04-07 - 摘要：ObjectiveWe aimed to observe the effect of acupuncture combined with umbilical cord mesenchymal stem cells on ovarian reserve function in rats with premature ovarian failure.MethodsSeventy female Sprague-Dawley rats were divided into the modeling group and the normal group. Modeling group rats were injected intraperitoneally with vinyl cyclohexene (80 mg/kg) to establish a rat model of premature ovarian failure. After the model was successfully established, the rats were divided into the model group, the acupuncture group, the stem cell group, and the combined treatment group (12 rats per group). The remaining 12 normal rats served as the blank group. The acupuncture group was treated with acupuncture at RN4, RN6 and ST36. In the stem cell group, 0.5 mL human umbilical cord mesenchymal stem cell fluid was injected into the tail vein of rats on the first and eighth days of intervention (2.5×106 cells). Rats in the combined treatment group received acupuncture and tail vein injection of human umbilical cord mesenchymal stem cell fluid. After the intervention, wet ovarian weight and the ovarian index were determined. The contents of serum testosterone (T), estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), anti-Mullerian hormone (AMH) and the contents of antioxidant indices malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD) were detected by ELISA. HE staining was used to detect the morphological changes of ovaries in each group. The relative expression levels of Akt, p-Akt, Bcl-2 and Bax in ovaries were detected by immunohistochemistry and Western blotting.ResultsCompared with the blank group, the wet ovarian weight and ovarian index of the model group were decreased significantly (P<0.01). The serum levels of LH, T, FSH, and MDA were increased (P<0.05, P<0.01), while the levels of E2, AMH, GSH and SOD were decreased (P<0.05, P<0.01). HE staining showed that the number of mature follicles in the ovary was decreased and the number of atretic follicles was increased. The relative expression of Akt, p-Akt and Bcl-2 in ovarian tissue was decreased (P<0.05, P<0.01), and the relative expression of Bax was increased (P<0.01). Compared with the model group, the wet ovarian weight and ovarian index of rats in the acupuncture group, stem cell group and combined treatment group were increased (P<0.05, P<0.01). The serum levels of T and FSH were decreased (P<0.05, P<0.01). The serum levels of E2, AMH, GSH and SOD were increased (P<0.05, P<0.01). HE staining showed a decrease in ovarian abnormalities. In ovarian tissue, the positive expression of p-Akt and Bcl-2 and the relative expression of these proteins were increased (P<0.05, P<0.01), while the positive expression of Bax and the relative expression of this protein were decreased (P<0.05, P<0.01). Compared with the acupuncture group and the stem cell group, the wet weight of ovaries in the combined treatment group was increased significantly (P<0.05), the serum levels of T and FSH were decreased significantly (P<0.05, P<0.01), the level of AMH was increased significantly (P<0.05, P<0.01), and the positive expression of Akt was increased significantly (P<0.05). Compared with the acupuncture group, the levels of SOD and GSH in the combined treatment group were increased significantly (P<0.01), and the relative expression of Bax was decreased significantly (P<0.01). Compared with the stem cell group, the serum MDA level in the combined treatment group was decreased significantly (P<0.05).ConclusionAcupuncture, stem cell treatment, and combined treatment can play an active role in the treatment of premature ovarian failure rats, improve the ovarian reserve function of premature ovarian failure rats, promote the proliferation of ovarian granulosa cells, and inhibit apoptosis in follicles. The effect of combined treatment is better than that of acupuncture or stem cell therapy only.关键词：acupuncture;umbilical cord mesenchymal stem cells;premature ovarian failure;stem cell transplantation;rats
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发布时间：2023-04-07
Acupuncture Moxibustion and Tuina
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