最新刊期
卷 47 ， 期 4 ， 2024
-
Nine problems for promoting high-quality development of traditional Chinese medicine book publishing 增强出版 AI导读
“中医药图书作为传承和发展中医药文化的重要载体，对于培养专业人才、提升教育质量以及增强文化自信具有不可或缺的作用。面对当前中医药图书出版业存在的挑战，笔者深入剖析了九个关键问题，旨在指明行业未来的发展方向和应对策略。这些建议不仅有助于推动中医药图书出版的高质量发展，更将为整个中医药文化的传承与发展奠定坚实基础。通过解决这些核心问题，我们有望见证中医药图书出版业的良性、有序和可持续进步。”摘要：The traditional Chinese medicine(TCM) book is an indispensable carrier for the implementation of the strategy for invigorating China through science and education. Developing high-quality TCM book publishing industry plays a very important role in training TCM talents, improving the quality of TCM education, and enhancing the confidence in the traditional culture. This paper reviewed the historical process of the TCM book publishing industry from its beginning to the present, and proposed nine problems for promoting the high-quality development of TCM book publishing in the current environment, aiming at the pain points and difficulties existing in the current development of the publishing industry. It fundamentally points out the development direction and coping strategies of the future TCM book publishing, and promotes the high-quality development of the benign, orderly and sustainable publishing.关键词：book publishing;traditional Chinese medicine;developing strategy- 204
- |
- 23
- |
- 0
发布时间：2024-05-22
Voice of Guidance
- “关于糖尿病肾脏疾病的研究取得了重要进展。专家围绕“伏热致癥”的核心病机，深入探讨了该疾病的发生、发展与转归。研究表明，伏热状态在糖尿病肾脏疾病中扮演了关键角色，其贯穿始终的影响促进了疾病的发生与发展。专家指出，糖尿病肾脏疾病的发生涉及多种病机因素，包括环境病机、体质病机等，其中“伏热致癥”是核心病机。根据这些特点，专家提出了针对性的中医药治疗方案，为糖尿病肾脏疾病的治疗提供了新的参考。这一研究不仅为糖尿病肾脏疾病的防治提供了新的思路，也为中医药在该领域的应用提供了有力支持。”摘要：Diabetic kidney disease (DKD) is a severe complication of diabetes. Its incidence increases annually, posing a significant burden on public health. The strategy of symptomatic treatment based on pathogenesis differentiation, focusing on identifying pathogenesis, is particularly meaningful for managing complex and variable chronic diseases like DKD. Within this framework, the state of latent heat persists throughout DKD, with " latent heat causing accumulation" identified as the core pathogenesis affecting and promoting the development and progression of DKD. This paper is centered on the concept of " latent heat causing accumulation" and adopts symptomatic treatment based on pathogenesis differentiation as its guiding principle to explore the role of latent heat in DKD. It highlights that the onset of DKD involves environmental and constitutional pathogenesis associated with " the concealment of latent heat" and " stagnant-heat invading collaterals" as the initial pathogenesis, " latent heat causing accumulation" as the core mechanism, and " secondary turbid heat" as the derivative pathogenesis. These pathogenesis factors collectively influence the symptoms, sequelae, and prognosis of DKD. Moreover, this paper provides commonly used prescriptions for different stages, syndrome types, and complications of the disease, aiming to offer a reference for clinical practice in flexibly addressing changes in disease conditions based on varied pathogenesis.关键词：symptomatic treatment based on pathogenesis differentiation;latent heat causing accumulation;diabetic kidney disease;consumptive thirst involving kidney
- 324
- |
- 20
- |
- 0
发布时间：2024-05-22 - 摘要：ObjectiveWe aimed to study the distribution of traditional Chinese medicine (TCM) constitution and related influencing factors in patients with impaired glucose tolerance (IGT).MethodsA cross-sectional study method was used to enroll IGT patients who attended one of eight collaborating units across China between January and August 2021. Basic information was recorded, physical and laboratory examinations were completed, and the data on TCM constitution were collected according to the " classification and determination table of TCM constitution." Finally, patient information was entered into an Excel table, and the data were analyzed using SPSS 26.0.ResultsAmong the 450 patients, a balanced constitution accounted for 37.3%, yang-deficiency constitution for 15.6%, phlegm-dampness constitution for 14.4%, and dampness-heat constitution for 10.9%. Among the biased constitutions, the proportion of men with dampness-heat constitution was higher than that of women, and the proportion of women with yang-deficiency constitution and blood stasis constitution was significantly higher than that of men (P < 0.05). The triglyceride level of patients with phlegm-dampness constitution was higher than that of patients with yang-deficiency constitution (P < 0.05); the HDL-cholestrol level of patients with yang-deficiency constitution was higher than that of patients with phlegm-dampness constitution (P < 0.05); and the uric acid level of patients with phlegm-dampness constitution, dampness-heat constitution, or yin-deficiency constitution was higher than that of patients with yang-deficiency constitution, and the UA level was the highest in patients with dampness-heat constitution (P < 0.05).ConclusionThe distribution of TCM constitution in IGT patients was dominated by balanced constitution, followed by yang-deficiency constitution, phlegm-dampness constitution, and dampness-heat constitution. Gender, blood lipid levels, and UA levels were the main factors affecting the constitution status of IGT patients.关键词：impaired glucose tolerance;prediabetes;TCM constitution;influencing factors;preventive treatment of disease
- 191
- |
- 17
- |
- 0
发布时间：2024-05-22 - 摘要：Consumptive thirst such as dry mouth and polydipsia, frequent urination polyuria, fear of heat and hyperhidrosis and loss of other body fluids, yin deficiency and internal heat expression, and irritability and other abnormal emotional symptoms are common. The Synopsis of Golden Chamber need to be further explored for the treatment of miscellaneous diseases. The dialectical thought has a high clinical application value. Lily disease treatment recommendations in the Synopsis of Golden Chamber are explored. The symptoms of lily disease are varied and uncertain, which are caused by the scattering and wandering aimlessly of heat pathogen. The pathogenesis of lily disease can be examined through external symptoms such as bitter taste in mouth, red urine, and faint and rapid pulse. Diabetes is also closely related to yin deficiency and internal heat, and the pathogenesis of the two is similar. Mental symptoms are common characteristics of lily disease and diabetes. The method taken from the Synopsis of Golden Chamber and Baihe-like prescriptions for the treatment of diabetes are effective. By identifying different patterns, symptoms, and indicators, we can select lily bulb, common anemarrhena, rhizome, figwort root, unprocessed rehmannia root, and other drugs to treat diabetes, in order to improve our understanding of lily disease and provide new ideas for diabetes treatment.关键词：diabetes;consumptive thirst;lily disease;Synopsis of Golden Chamber;Baihe-like prescriptions
- 244
- |
- 18
- |
- 0
发布时间：2024-05-22 - 摘要：Diabetic lower extremity vascular disease is one of the common chronic complications of diabetes, which has a strong disabling effect, clinically, it is of great significance to actively and effectively control the progression of the disease and improve the quality of life of patients. In Sanxiao Lun, LIU Wansu put forward the theory of " dryness-heat and stagnation" according to the pathogenesis of consumptive thirst, and thought that the dryness-heat and stagnation in the stomach and intestines of sanjiao were too severe, the xuanfu was blocked, and the qi and liquid failed to diffuse, which caused diabetes. Vascular endothelial injury and inflammatory reaction are important factors in the development of vascular disease, the pathogenesis evolution of " dryness-heat and stagnation" conforms to the pathological characteristics of inflammatory reaction in western medicine, and the dryness-heat runs through the diabetic lower extremity vascular disease throughout. In this paper, it is believed that diabetic lower extremity vascular disease belongs to the category of " flaccidity and paralysis" in traditional Chinese medicine, and lung scorched by heat is the cause of flaccidity. " Dryness-heat and stagnation" is the source of invading heat (dryness-heat), lung scorched by heat, pulse failure and vein stasis occurred, which causes diabetic lower extremity vascular disease. Treatment should be based on flaccidity, combined with the viewpoint of LIU Wansu′s Sanxiao Lun, taking yangming as the top priority, regulating the triple diabetes, solving the problem of dryness-heat and stagnation, combined with the method of purging the south and supplementing the north, so that the invading heat is cleared, lung heat is diminished, and flaccidity disease cannot occur, in order to provide new ideas for the clinical prevention and treatment of diabetic lower extremity vascular disease.关键词：dryness-heat and stagnation;lung scorched by heat;diabetic lower extremity vascular disease;flaccidity and paralysis
- 151
- |
- 30
- |
- 0
发布时间：2024-05-22
Special Theme: TCM Prevention and Treatment of Diabetes and Its Complications
- 摘要：We summarize our clinical experience with the use of wind herbs for membranous nephropathy treatment. The pathology of membranous nephropathy is mainly based on the spleen and kidney, with wind pathogen, dampness-heat, and blood stasis as the main pathological factors. The imbalance of the spleen ascending clear and kidney-transforming qi is the fundamental pathogenesis of membranous nephropathy. Wind herbs are light and gentle in nature, and they can dispel wind, assist in raising the spleen yang, aid in kidney qi transformation, and promote the unblocking of qi and blood stasis. This corresponds to the pathogenesis of membranous nephropathy, which involves wind invasion, deficiency of the spleen and kidney, failure to ascend clear yang, and stagnation of qi and blood. In the clinical treatment of membranous nephropathy, the use of wind herbs such as ephedra, cassia twig, mulberry leaf, chrysanthemum flower, and other herbs, along with blood-activating and collateral-opening herbs such as incised notopterygium rhizome and root, rhizome ligustici, zedoray rhizome, and pangolin scales, is proposed. Chinese thorowax root, largetrifoliolious bugbane rhizome, divaricate saposhnikovia, incised notopterygium rhizome and root, and other pungent herbs combined with ginseng, membranous milkvetch root, and other sweet-tonifying herbs can tonify yang and benefit the spleen, enhancing the tonifying effect. Ephedra, cassia twig, fresh ginger, prepared common monkshood branched root, manchurian wildginger, and other pungent-warm herbs can warm the kidney, support yang, and promote qi transformation and water metabolism. In clinical treatment of membranous nephropathy, satisfactory result have been achieved by making use of the characteristics of wind herbs.关键词：wind herbs;membranous nephropathy;expelling wind to relieve superficies;eliminating dampness and resolving phlegm;Promoting blood circulation and removing blood stasis
- 218
- |
- 30
- |
- 0
发布时间：2024-05-22 - 摘要：Gastroparesis is a gastric disease characterized by delayed gastric emptying. " Vomiting" is the main clinical manifestation of this disease, while " atrophy" indicates dysfunction of the stomach. Based on the theory of " atrophy, dyspnea and vomiting are ascribed to the upper part", originating from the Chapter of " Zhi Zhen Yao Da Lun" from the Suwen(Basic Questions) section this paper explored the pathogenesis and treatment idea of gastroparesis from the function of the lung. It is put forward that failure of lung qi in dispersion, so the lung qi cannot maintain the circulation of harmonizing qi and blood, leading to malnutrition of stomach and loss of stomach receiving food and drink function. Melancholy impairing lung, so lung cannot govern diffusion, leading to stomach governing the disfunction of dredging and descending. Impaired depurative descending of lung qi, so the large intestine and stomach are lost in the alternating operation of deficiency and excess, leading to stomach governing the disfunction of transportation and transformation. Therefore, the treatment approach is proposed to improve the stomach's function to receive food and drink, transport and transform and promote the recovery of gastric motility by replenishing and restoring lung qi, regulating emotions and catharsis and smoothing lung. Analyzing the effect of function of the lung on gastric motility is of great value for expanding the application of traditional Chinese medicine in gastrointestinal motility disorders, and digging new connotations of classic theories in modern clinical practice.关键词：Huangdi Neijing;lung;gastroparesis;gastrointestinal motility
- 152
- |
- 19
- |
- 0
发布时间：2024-05-22 - 摘要：Hyperhidrosis is a disease in which excessive sweat is secreted, resulting in an abnormal increase in systemic or local perspiration. In traditional Chinese medicine, hyperhidrosis belongs to the category of sweating disease. It is caused by an imbalance between yin and yang and abnormal excretion of body fluid. Many doctors treat the sweating disease from the perspective of heart, lung, and kidney; in contrast, we discuss the etiology and pathogenesis of hyperhidrosis from the perspective of liver and spleen, explain the significance of harmonizing the liver and spleen to improve the sweating disease, and put forward the key pathogenic factors of stagnation liver qi and spleen deficiency, and disharmony between nutrient qi and defensive qi, and the imbalance between yin and yang are the key pathogenic factor. Most of the clinical treatment start from the liver and spleen. The main treatment principle is based on soothing the liver and relieving depression, invigorating the spleen and nourishing blood, and regulating and harmonizing the nutrient qi and defensive qi, paying attention to the relationship between qi and blood in zangfu organs, invigorating the spleen and replenishing qi to consolidate its foundation, soothing the liver and relieving depression to regulate its qi, and invigorating qi and blood and perspiration. Treatment can be supplemented with Xiaoyao Powder plus-minus, mainly to strengthen liver wood and spleen soil, acquire nourishment, smooth qi, nourish the five zang, reconcile qi and blood, enhance physical strength and peace of mind, ensure sufficient qi to arrest sweating, coordinate the liver and spleen, balance the ascending and descending phases, and harmonize the five zang organs.关键词：hyperhidrosis;sweating disease;harmonzing liver and spleen;Xiaoyao Powder
- 237
- |
- 76
- |
- 0
发布时间：2024-05-22 - 摘要：This article is based on the core pathogenesis of yin-yang poisoning recorded in the Synopsis of the Golden Chamber and clarifies the characteristics of " yin poisoning" and " yang poisoning" as considered during the Han and Tang dynasties. It is found that the classification criteria for the two are based on the manifestation of syndromes rather than the cold and heat of the pathogenesis. By analyzing the syndrome of yin-yang poisoning in the Synopsis of the Golden Chamber and combining the records with people's understanding of the efficacy of various medicinals in Shengma Biejia Decoction during the Han and Tang dynasties, it is demonstrated that the core pathogenesis is stagnation, mainly reflected in three aspects: accumulation of toxins, stagnation of qi and blood, and stagnation of yang qi. Among these, the degree and location of stagnation of yang qi are the reasons for the difference between yin poisoning and yang poisoning. The disease of yang poisoning is characterized by sufficient yang qi in the body, obstruction of pathogenic factors on the surface, and intense competition between vital qi and evil qi. Therefore, yang stagnation on the surface is more severe and leads to heat symptoms. The disease of yin poisoning is characterized by deficient yang qi in the body, an inability to resist pathogen, and the deepening of evil qi. The yang qi is suppressed by depression and is relatively mild, making it unable to circulate and warm the body, resulting in cold symptoms. Therefore, when treating yang poisoning, ZHANG Zhongjing used medicinals that were pungent, warm and dispersed to relieve the yang depression on the surface. If the yang depression was dispersed, the heat would naturally dissipate. When treating yin poisoning, only internal medicine is used to relieve internal yang qi stagnation, and when yang qi is extended, cold will naturally disappear. In summary, we aimed to enhance our understanding of the efficacy of Shengma Biejia Decoction from the perspectives of promoting the dispersion of toxins, promoting blood circulation, and promoting yang stagnation, in order to provide new ideas for the clinical use of this formula and expand its application scope.关键词：yin poisoning;yang poisoning;Synopsis of the Golden Chamber;Shengma Biejia Decoction;stagnation
- 131
- |
- 39
- |
- 0
发布时间：2024-05-22 -
An exploration into the thinking of pattern-differentiation-deduced pathogenesis in
Shanghan Lun AI导读摘要：The basic diagnostic and treatment principles of traditional Chinese medicine are the pattern-differentiation-deduced pathogenesis and treatment based on examination of the pathogenesis. Shanghan Lun established a system of pattern differentiation of six meridians, systematically summarized the evolution laws of exogenous febrile disease, and discussed miscellaneous diseases as exogenous diseases. It contains 112 classic formulas and advocates that " those whose disease corresponds to the formulas should take them accordingly", combining disease differentiation and pattern differentiation, containing not only the knowledge of treatment based on pattern identification, but also the profundity of pattern-differentiation-deduced pathogenesis. Based on the original meaning of " pathogenesis", from the three angles of " subtle meaning", " core meaning", and " appropriate meaning", this paper exemplifies the concept of pattern differentiation for six meridians in Shanghan Lun, analyzes the relationship and connotation of formula patterns of classical formulas in Shanghan Lun by " taking pattern with formulas", and explores the concept of pattern-differentiation-deduced pathogenesis in Shanghan Lun. This paper emphasizes that during the clinical practice of traditional Chinese medicine, it is important (i) to deduce the pathogenesis based on pattern differentiation, understand symptoms upon first onset, and deduce the pathogenesis before symptoms appear, thereby treating the disease at an early stage; (ii) to identify the most important concepts, solve complications with simple method, discern the core of the disease, and treat the entire body; and (iii) to optimize timing, act quickly, take advantage of opportunities, accept outcomes, and provide judicious guidance to patients. This paper serves to interpret Shanghan Lun based on pattern-differentiation-deduced pathological mechanism and provides ideas and inspiration for applying the theory of Shanghan Lun to guide clinical practice.关键词：pattern-differentiation-deduced pathogenesis;see what is coming from one small clue;identify the pivot;give judicious guidance according to circumstances- 111
- |
- 11
- |
- 0
发布时间：2024-05-22
Theoretical Studies
- 摘要：ObjectiveWe aimed to investigate (i) the preventive and therapeutic effects of Huogu Muli Prescription (HGMLP), a Chinese medical compound consisting of epimedii folium, drynariae rhizoma, and ostreae concha, on postmenopausal osteoporosis (PMOP) rats and (ii) whether it exerts its effects by regulating the osteoclast-osteogenesis balance.MethodsForty-eight female Sprague-Dawley rats were randomly divided into the following six groups: (i) the sham-operated group, (ii) the model group, (iii) the Qianggu Capsule group, (iv) the calcium carbonate group, and (v, vi) the HGMLP low-dose and high-dose groups (n = 8 rats per group). After adaptive feeding, rats in all groups except the sham-operated group were treated with bilateral ovarian castration to establish the PMOP model. Each day, rats in the Qianggu Capsule group received 0.054 g/kg Qianggu Capsule suspension intragastrically, rats in the calcium carbonate group received 1.670 g/kg calcium carbonate suspension intragastrically, and rats in the HGMLP low-dose and high-dose groups received 0.188 g/kg and 0.375 g/kg HGMLP intragastrically. Rats in the sham-operated group and the model group received an equal volume of normal saline intragastrically. After 90 consecutive days, serum estradiol (E2), estrogen receptor α (ERα), procollagen typeⅠN propeptide (PINP), and tartrate-resistant acid phosphatase 5b (TRACP-5b) were detected by ELISA. Total antioxidant capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels were measured by colorimetry. Bone mineral density (BMD), trabecular number (Tb.N), trabecular separation/spacing (Tb.Sp), trabecular thickness (Tb.Th), and structure model index (SMI) were measured by Micro-CT, and the microstructure of cancellous bone was observed. The expressions of osteoprotegerin (OPG), receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL), phosphorylation of forkhead box O3 (FoxO3α), Wnt2, β-catenin, and peroxisome proliferator-activated receptor γ (PPARγ) in rat femur tissue were detected by Western blotting.Results(i)The serum levels of E2 and ERα increased in the Qianggu Capsule group and HGMLP groups, compared with the model group(all P < 0.05).(ii)Compared with the model group, the serum levels of PINP, TRACP-5b decreased and PINP/TRACP-5b increased in both the Qianggu Capsule group and HGMLP high-dose group(all P < 0.05).(iii)The activities of T-AOC, AOD, and CAT in the Qianggu Capsule group and HGMLP groups were higher than those in the model group, while the content of MDA lower (all P < 0.05).(iv)Compared with the model group, the femoral BMD, Tb.Th, and Tb.N increased in the Qianggu Capsule group and HGMLP groups, while the femoral Tb.Sp and SMI decreased(all P < 0.05); the femoral BMD increased and the Tb.Sp decreased in the calcium carbonate group(all P < 0.05).(v)The protein expressions of RANKL, RANK, FoxO3α, and PPARγ in the Qianggu Capsule group and HGMLP groups were lower than those in the model group, while the protein expressions of OPG, Wnt2, and β-catenin were higher(all P < 0.05).ConclusionHGMLP can significantly increase estrogen levels, inhibit osteoclast differentiation, and inhibit bone resorption in the PMOP rats. It also alleviates oxidative stress, promotes osteogenic differentiation, inhibits lipogenic differentiation, improves bone formation, and recovers the balance between osteoclasts and osteoblasts, thus achieving prevention and treatment of PMOP. The potential mechanism of HGMLP may be related to regulation via the OPG/RANKL/RANK or FoxO3α/Wnt2/β-catenin/PPARγ pathways.关键词：postmenopausal osteoporosis;Huogu Muli Prescription;estrogen;bone formation;bone resorption;rats
- 137
- |
- 15
- |
- 0
发布时间：2024-05-22 - 摘要：ObjectiveWe aimed to investigate the hemostatic effect and mechanism of modified Sijunzi Decoction (MSJZT), consisting of tangshen, India bread, largehead atractylodes rhizome, liquorice root, milkvetch root, ass hide glue, and India madder root, on the zebrafish intestinal bleeding model through 5-hydroxytryptamine (5-HT) and its receptors (5-HT2aR, 5-HT2bR).MethodsZebrafish at 4 days post fertilization were used as the research object. An intestinal bleeding model was established by induction with 6 μmol/L simvastatin for 24 hours. The zebrafish were divided into normal group, model group, MSJZT low-, mid- and high- concentration groups (55.6, 167, 500 mg/L), and after modeling, the corresponding concentration of MSJZT was administered. The samples were collected after 24 hours. Platelet count (PLT) and bleeding status were observed. The content of 5-HT and Caspase 3/7 activity were detected by colorimetry. The gene expressions of 5-HT2aR, 5-HT2bR and serotonin transporter (SERT) were detected by real-time PCR. The protein expressions of protein kinase B (AKT), phosphorylated AKT (p-AKT), extracellular signal-regulated protein kinase (ERK), and phosphorylated ERK (p-ERK) were detected by Western blotting.ResultsThe intestinal bleeding rate in the model group was 70.0%, and that in the MSJZT low-, mid- and high- concentration groups was 36.7%, 40.0%, and 80.0%, respectively; the intestinal hemostatic effect was 54%, 52%, and 7%, respectively. Compared with the model group, the PLT in the MSJZT low- and mid- concentration groups decreased; the content of 5-HT in all MSJZT groups increased, and the gene expressions of 5-HT2aR and 5-HT2bR were up-regulated. The gene expression of SERT was up-regulated in the low- and mid- concentration groups; the Caspase 3/7 activity in the mid- and high- concentration groups was reduced; the expressions of p-AKT and p-ERK proteins were up-regulated in the low- and mid- concentration groups (all P<0.05).ConclusionMSJZT can reduce the incidence and severity of intestinal bleeding in zebrafish intestinal bleeding models. The mechanism may be achieved by activating AKT and ERK signaling pathways through 5-HT and its receptors.关键词：immune thrombocytopenia;modified Sijunzi Decoction;5-hydroxytryptamine;5-hydroxytryptamine receptors;protein kinase B;extracellular signal-regulated protein kinase;zebrafish
- 154
- |
- 31
- |
- 0
发布时间：2024-05-22 - 摘要：ObjectiveTo observe the protective effect of Zhilong Huoxue Tongyu Capsule (Zhilong Capsule) on myocardial ischemia reperfusion injury (MIRI) in mice, and explore its regulatory mechanism using metabolomics.MethodsUsing a random number table method, 30 C57BL/6J mice were randomly divided into the following three groups: sham operation group, model group, and Zhilong Capsule group (6.24 g/kg), with 10 mice in each group. In mice in the model group and the Zhilong Capsule group, a mouse MIRI model was established by ligating the left anterior descending branch, while mice in the sham operation group underwent threading without ligation. The Zhilong Capsule group began modeling one week after pre-administration and continued to receive intragastric administration for two weeks after modeling once daily. The cardiac function, including the left ventricular ejection fraction (LVEF) and left ventricular fraction shortening (LVFS), was assessed by color echocardiography. The myocardial fibrosis and apoptosis were observed by Masson staining and TUNEL staining, respectively. Enzyme-linked immunosorbent assay was used to measure the serum contents of lactate dehydrogenase (LDH) and brain natriuretic peptide (BNP). Liquid chromatography-mass spectrometry combined with multivariate statistical method was performed for serum metabolite detection and identification analysis.ResultsCompared with the model group, the mice in the Zhilong Capsule group exhibited an increase in LVEF and LVFS, a reduction in cardiac tissue structure disorder, a decrease in myocardial fibrosis, a decrease in cell apoptosis rate, and a decrease in serum LDH and BNP contents (P<0.05). Metabolomics result showed that intervention with Zhilong Capsule significantly regulated 30 differential metabolites related to MIRI. Important metabolic pathways involved 20 pathways related to tyrosine metabolism, arginine and proline metabolism, and vitamin digestion and absorption.ConclusionZhilong Capsule has a protective effect on MIRI, and it may achieve this effect by regulating pathways related to tyrosine metabolism, arginine and proline metabolism, and vitamin digestion and absorption.关键词：Zhilong Huoxue Tongyu Capsule;myocardial ischemia reperfusion injury;serum metabolomics;metabolites;mice
- 179
- |
- 24
- |
- 1
发布时间：2024-05-22
Experimental Studies
- 摘要：ObjectiveTo analyze the distribution of traditional Chinese medicine patterns in metabolic syndrome (MS), with the aim of deriving the attributes and characteristics of patterns in patients with MS more accurately and finely.MethodsThe data of 695 MS patients admitted to Dongfang Hospital, Beijing University of Chinese Medicine from December 2017 to September 2022 were retrospectively analyzed to derive traditional Chinese medicine patterns using latent class analysis and latent structure analysis, and the above results were used to identify the pattern type of each patient according to differentiation of syndromes, to determine the traditional Chinese medicine pattern types of MS patients.ResultsA total of 9, 044 times of the symptoms and signs were included in this study, and the top 10 high-frequency symptoms and signs were dry mouth and polydipsia (77.70%), fatigue (60.58%), greasy fur (59.14%), blurred vision (54.68%), slippery pulse (53.96%), wiry pulse (52.09%), white fur (48.92%), numbness of the limbs (43.60%), yellow fur (39.71%), and cold limbs (36.40%). Based on the result of the latent class analysis, this study determined the main pattern elements of 695 patients with MS. The pathological pattern elements included qi deficiency, phlegm-dampness, dampness-heat, qi stagnation, yin deficiency, fire-heat, and impairment of body fluids; the pathological pattern elements were mainly located in liver, spleen, lung, and kidney; the 695 patients could be classified into three main groups: predominantly deficiency syndrome, predominantly excess syndrome, and deficiency syndrome accompanied with excess syndrome. Through analyzing the latent structure model of the symptoms and signs of 695 patients with MS, six basic syndromes were established, which were the syndromes of hyperactivity of liver yang, deficiency in the spleen with dampness retention, deficiency of both kidney yin and yang, consumption of body fluids due to intense heat, blood stasis due to qi deficiency, and stagnation of liver qi with stomach heat. Combined with the theory of Chinese medicine, the four-diagnosis information of 695 cases of MS was comprehensively integrated, and on the basis of latent class analysis and latent structure analysis, secondary syndrome differentiation of patients was performed. A total of 20 syndromes with a frequency of occurrence of >1% were finally obtained, with the highest frequency being the syndrome of stagnation of liver qi and spleen deficiency, internal retention of dampness-heat (12.66%).ConclusionThe pathogenesis of MS is complex and the pattern types are widely distributed, but in general, the syndrome of stagnation of liver qi and spleen deficiency, and internal retention of dampness-heat is the most common. Therefore, clinically, based on syndrome differentiation and treatment, attention should be paid to combining the application of invigorating the spleen and soothing the liver, and clearing heat to resolve turbidity.关键词：metabolic syndrome;latent class analysis;latent structure analysis;syndrome of stagnation of liver qi and spleen deficiency;syndrome of internal retention of dampness-heat
- 163
- |
- 20
- |
- 0
发布时间：2024-05-22 - 摘要：ObjectiveTo establish a differential model of phlegm and blood stasis pattern and qi deficiency and blood stasis pattern in stable angina pectoris using radiomics.MethodsA total of 91 patients with stable angina pectoris who underwent coronary artery CT angiography in Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2021 to January 2022 were collected, including 47 cases of phlegm and blood stasis pattern and 44 cases of qi deficiency and blood stasis pattern. The patients were divided into train set(64 cases) and test set(27 cases) according to the ratio of 7∶3 by stratified random sampling method. 3D-slicer software was used to extract the radiomics features of pericoronary adipose tissue(PCAT) images. Principal component analysis was used to visualize the distribution of radiomics features of pattern of phlegm and blood stasis and pattern of qi deficiency and blood stasis. The least absolute shrinkage and selection operator regression analysis and support vector machine decreasing feature elimination were used for feature selection.The multinomial logistics regression was used for model construction. The receiver operating characteristic (ROC) curve was used to verify the model in the train set and the test set to evaluate the effectiveness of the radiomics features in differentiating phlegm and blood stasis pattern and qi deficiency and blood stasis pattern. Finally, Spearman coefficient was used to analyze the correlation between the differential features and clinical physicochemical data.ResultsA total of 837 radiomics features were extracted from PCAT images by 3D-slicer software. In the principal component analysis, PC1 and PC2 explained 77.9% and 8.1% of the total variance, respectively, and there was a relatively obvious separation trend between the two pattern groups. After feature screening, 7 radiomics features were used to construct the differential model of phlegm and blood stasis pattern and qi deficiency and blood stasis pattern. The area under the ROC curve (AUC) of the differential model was 0.844 in the train set and 0.834 in the test set. Spearman correlation analysis showed that the differential features were significantly correlated with cTnI, neutrophil, triglyceride, total cholesterol, and leukocyte.ConclusionThe CT radiomics model based on PCAT has a high discrimination efficiency for stable angina pectoris with phlegm and blood stasis pattern and qi deficiency and blood stasis pattern.关键词：stable angina pectoris;radiomics;coronary artery CT angiography;differential diagnosis;phlegm and blood stasis pattern;qi deficiency and blood stasis pattern
- 144
- |
- 25
- |
- 0
发布时间：2024-05-22
Clinical Studies
- 摘要：ObjectiveWe aimed to explore the clinical efficacy of precise electro-acupuncture stimulation in the pterygopalatine fossa for the treatment of chronic sinusitis.MethodsIn total, 40 patients with chronic sinusitis who visited the Xiyuan Hospital, China Academy of Chinese Medical Sciences between January 2022 and January 2023 were selected. The subjects were randomly divided into two groups: the treatment group (receiving precise electro-acupuncture in the pterygopalatine fossa) and the control group (receiving standard western medical treatment), with 20 cases in each groups. The treatments were administered twice a week for a period of 12 weeks. The effectiveness of the treatments was evaluated through computed tomography(CT) of the sinus changes and the Lund-Mackay scoring system.ResultsIn cases of total opacity and partial opacity, there were significant differences between the two patient groups before and after treatment (P < 0.05). Intra-group comparison revealed statistically significant improvements in both groups before and after treatment (P < 0.05). The treatment group exhibited significant improvement in various sinus conditions (P < 0.05), while in the control group, a significant improvement was only observed in the left maxillary sinus (P < 0.05). Inter-group comparison also demonstrated that the treatment group′s improvements were superior to those of the control group across multiple indicators (P < 0.05).ConclusionThe precise electro-acupuncture stimulation technique in the pterygopalatine fossa demonstrated significant therapeutic effects in the treatment of chronic sinusitis, with superior outcomes with respect to radiological changes compared to standard western medicine treatment.关键词：pterygopalatine fossa;precise electro-acupuncture stimulation;western medicine;chronic sinusitis;sinus CT
- 112
- |
- 25
- |
- 0
发布时间：2024-05-22 - 摘要：ObjectiveTo observe the effects of moxibustion on myocardial pathological morphology, α-smooth muscle actin (α-SMA) and chromosome 10 deletion phosphatase and tensin homologous protein (PTEN)/mammalian target of rapamycin (mTOR) signalling pathway in rats with chronic heart failure (CHF), and to explore the possible mechanism of moxibustion in attenuating myocardial fibrosis in rats with CHF.MethodsAccording to the random number table method, 60 male SD rats were divided into the normal group (n=10) and the surgery group (n=50), and the rats in the surgery group were ligated the left coronary artery to replicate the CHF model. According to the random number table method, 40 successfully modelled rats were divided into the model group, the moxibustion group, the bpV(phen) group, and the moxibustion+ bpV(phen) group, with 10 rats in each group. The normal and model groups were not given any intervention; in the moxibustion group, customized moxa sticks were used to moxibrate the bilateral " Feishu" (BL13)and " Xinshu" (BL15) on the back of the rats for 30 min at each point once a day; the bpV(phen) group was injected intraperitoneally with the bpV(phen) solution (0.15 mg/kg) twice a week; the moxibustion+ bpV(phen) group was based on the bpV(phen) group, and moxibustion was applied according to the moxibustion group. The intervention was carried out for 4 weeks. The general conditions of rats, such as feeding and activity were observed; HE staining was used to detect morphological changes of the cardiomyocytes; Masson staining was used to detect myocardial fibrosis; the cardiac echocardiography was used to detect ejection fraction (EF) and fractional shortening (FS); real-time PCR was used to detect the mRNA expressions of PTEN and mTOR in the cardiac muscle tissues; protein expressions of PTEN, mTOR, α-SMA in rat myocardial tissue were detected by Western blotting.ResultsCompared with the normal group, rats in the model group had altered cardiomyocyte morphology, severe damage to myocardial fiber structure, significantly lower EF, FS, and mTOR mRNA and protein expressions, and significantly higher PTEN, α-SMA protein expressions and PTEN mRNA expression (P<0.05). Compared with the model group, myocardial ultrastructural damage was attenuated in the moxibustion group, bpV(phen) group, and moxibustion+ bpV(phen) group, and EF, FS, and mRNA and protein expressions of mTOR were significantly higher, α-SMA protein expression was significantly lower, and mRNA and protein expressions of PTEN were significantly lower (P<0.05). Compared with the moxibustion+ bpV(phen) group, myocardial ultrastructural damage was worsen in the moxibustion and bpV(phen) groups, with significantly lower EF, FS, and mRNA and protein expressions of mTOR, significantly higher α-SMA protein expression, and significantly higher mRNA and protein expressions of PTEN (P<0.05).ConclusionMoxibustion can improve the pathological morphology and function of cardiomyocytes and attenuate myocardial fibrosis in rats with CHF, and its mechanism may be related to the down-regulation of PTEN expression, and then the up-regulation of mTOR expression.关键词：moxibustion;chronic heart failure;PTEN/mTOR signalling pathway;myocardial fibrosis;rats
- 156
- |
- 16
- |
- 0
发布时间：2024-05-22 - 摘要：ObjectiveWe aimed to investigate the effects of electroacupuncture at " Zusanli" (ST36) and " Taichong" (LR3) on gastrointestinal motility, gastrointestinal hormones, and brain-gut axis in rats with functional dyspepsia (FD).Methods48 SD rats were randomly divided into a normal control group, a model group, a cisapride group, and an electroacupuncture group, with 12 rats in each group. A mild tail pinch stimulation combined with intermittent food deprivation was used to establish the FD rat model. Body mass, food intake, and sucrose preference rate were recorded before and after modeling to verify the success of the FD model. After modeling, the normal control group and the model group received no intervention; the cisapride group rats were administered cisapride [0.4 g/(kg·d)] by intragastric perfusion for 6 consecutive days as one course of treatment, with a rest day between each course; the electroacupuncture group rats received electroacupuncture stimulation at bilateral " Zusanli" and " Taichong" (DC, dense-sparse wave, 2/100 Hz, 2-5 mA. Electricity was applied for 30 min), with stimulation every 24 h for 6 consecutive times as one course of treatment, with a rest day between each course. After two courses of treatment, samples were collected to compare gastrointestinal motility indices, blood levels of gastrointestinal hormones [motilin, gastrin, serotonin (5-HT), nitric oxide (NO)], serum and tissue levels of endogenous brain-gut peptides [cholecystokinin (CCK), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY)] in the hypothalamus, gastric antrum, duodenum, colon, and protein expressions of ghrelin and substance P in the hypothalamus, spinal cord, gastric antrum, and colon.ResultsBody mass, food intake, and sucrose preference rate were lower of the model rats than those of the normal rats (P < 0.05). Compared with the model group, rats in the electroacupuncture group and cisapride group had (i) lower gastric residual rates, higher rates of small intestinal propulsion and gastric slow wave main frequency and power (P < 0.05); (ii)levels of motilin, gastrin, and 5-HT increased, while NO level decreased (P < 0.05); (iii) serum CCK content increased, while CGRP and NPY levels decreased (P < 0.05); (iv) CCK protein positive expression increased, while CGRP and NPY protein positive expression decreased in the hypothalamus, gastric antrum, duodenum(P < 0.05); (v)ghrelin protein expressions increased, and substance P protein expression decreased in the hypothalamus, spinal cord, gastric antrum, and colon (P < 0.05). There were no significant differences in these indicators between the electroacupuncture group and the cisapride group.ConclusionElectroacupuncture at " Zusanli" and " Taichong" can effectively alleviate gastrointestinal motility disorders in FD rats, regulate gastrointestinal hormone levels, reverse abnormal brain-gut peptide expression, and regulate brain-gut interaction balance.关键词：electroacupuncture;Zusanli;Taichong;functional dyspepsia;gastrointestinal motility disorder;brain-gut peptides;gastrointestinal hormones;rats
- 131
- |
- 11
- |
- 0
发布时间：2024-05-22
Acupuncture Moxibustion and Tuina
- 关键词：diabetic kidney disease;consumptive thirst involving kidney;integration of traditional and Western medicine;guildline
- 592
- |
- 141
- |
- 0
发布时间：2024-05-22
Standard & Guidelines
- Postal code：100029
- Tel：(010)53911857 Email：jbutcm@bucm.edu.cn
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
0