最新刊期
卷 47 ， 期 7 ， 2024
- “耳穴疗法治疗肥胖的研究进展，为降低肥胖发病率提供新方案，推动临床应用，具有广阔前景。”摘要：In recent years, the incidence of obesity has been rapidly increasing, greatly elevating the incidence of hypertension, heart disease, non-alcoholic fatty liver disease, and other diseases. Reducing the incidence of obesity has become the focus of global concern. There is an urgent need to find effective and safe treatment method. More and more evidence support the efficacy of auricular acupoint therapy for obesity. It has the advantages of safety, effectiveness, convenience, and cheap. This article intends to discuss the research status of auricular acupoint therapy for obesity based on theoretical development, mechanism exploration, and technical innovation in order to promote the clinical application of auricular acupoint therapy for obesity. At present, with the help of multiple disciplines, inheriting and enriching the theoretical connotation of auricular point therapy for obesity, confirming its clinical effectiveness and safety, clarifying its effect mechanism in the treatment of obesity, and improving the traditional auricular acupoint therapy are feasible directions to promote auricular point therapy in the treatment of obesity, and it can make auricular point therapy have a broader application prospect.关键词：auricular acupoint;obesity;transcutaneous auricular vagus nerve stimulation;clinical application;mechanism exploration
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发布时间：2024-08-02 - “最新研究揭示了耳穴磁疗法在治疗脑病方面的潜力，通过跨学科技术优化磁刺激参数，为提高疗法安全性和有效性提供了新思路。”摘要：With the integration and application of various disciplines, traditional Chinese medicine′s auricular acupoint therapy has gained new opportunities for development. The effective activation of auricular acupoints is crucial as the initial step in auricular acupoint therapy. To address this issue, advanced techniques for physical stimulation, blending principles from traditional Chinese and Western medicine, have been developed. This paper explores the profound impact of magnetism on the structure and function of organisms from multiple dimensions, focusing on magnetobiology. It provides a comprehensive review of the clinical efficacy, research paradigm, challenges, and future prospects of auricular magnetic therapy. The article emphasizes the magnetic characteristics of organisms, particularly the nervous system′s high sensitivity to magnetic fields. It highlights the potential of modern magnetic stimulation techniques in treating brain diseases through auricular therapy. Additionally, the paper explores the research paradigm of auricular magnetic stimulation in conjunction with physical molecular dynamics simulation, materials engineering, mathematical modeling, and interdisciplinary biomedical technology. This endeavor is expected to provide valuable insights for optimizing the parameters of auricular magnetic stimulation and understanding its underlying principles. The multidisciplinary, cross-system, and multi-scale biophysical research paradigm introduces a new conceptual framework and investigative approach for auricular acupoint therapy, significantly enhancing the safety and efficacy of auricular magnetic stimulation therapy.关键词：magnetic stimulation;auricular point;biophysics;nervous system
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发布时间：2024-08-02 - “最新研究揭示耳穴疗法的历史发展脉络，为非药物疗法融入健康中国及全球卫生事业提供借鉴。”摘要：This article employs a multidisciplinary approach encompassing traditional Chinese medicine, history, philology, and exegetics to comprehensively examine the historical evolution of auricular acupoint therapy and otomedicine. Originating in China, systematized in Europe, and currently advancing through modern research and development led by China, this study traces the historical context of otological practices. It outlines the foundational principles of otomedicine as depicted in the Huangdi Neijing, elucidates the accumulation of ancient otomedical knowledge within this framework, reviews the systematic establishment and theoretical underpinnings of auricular acupoints, and delineates the process of formulating auricular acupoint standards. Through case studies such as " ear-brain interconnection" and " ear treatment of encephalopathy", it illustrates the interdisciplinary nature of ear medicine research and development. The article aims to illuminate the historical transition from ear therapy to ear medicine within the contemporary context and the emergence of auricular point-guided ear medicine. By drawing on historical insights and looking toward the future, it provides a foundation for the ongoing development of the ear medical specialty, offering insights for integrating non-drug therapies into China′s healthcare system and global health initiatives.关键词：ear diagnosis and treatment;auricular acupoint therapy;otology;historical development;auricular acupoint standards
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发布时间：2024-08-02 - “在信息化浪潮推动下，耳穴信息化装置发展迅速，有效辅助精准定位、诊断和治疗。本文分析了其在促进诊治模式变革、实现远程医疗方面的效果，同时指出了当前面临的挑战，并提出了相应的对策，为耳穴信息化装置的进一步发展提供了借鉴。”摘要：The rapid advancement of informatization has opened up new possibilities for the development of auricular acupoint information devices. This paper starts with a discussion between diagnosis and treatment of auricular acupoint and auricular acupoint information devices. It also summarizes the current research and development status of auricular acupoint information devices that assist with precise acupoint localization, diagnosis, and treatment. Furthermore, it explores the impact of these devices on transforming the models of diagnosis and treatment, as well as facilitating telemedicine in auricular acupoint. The analysis highlights existing challenges faced by auricular acupoint information devices globally, such as limited clinical application and promotion, the urgent need for improved level of informatization, and insufficient cross-disciplinary integration. The paper also proposes corresponding measures that emphasize the importance of research, development, and transformation, enhancing the level of informatization, and fostering multidisciplinary exchanges and cooperation. The aim of this study is to provide valuable insights for the development of auricular acupoint information devices.关键词：auricular acupoint;information device;precise acupoint localization;adjuvant diagnosis;adjuvant treatment
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发布时间：2024-08-02
Special Theme: Auricular Point Therapy and Auricular Medicine
- “最新研究揭示了甘草在张仲景方药体系中的核心作用，通过梳理历代本草古籍，总结出甘草的四个基本功效，为深入研究张仲景方药体系提供了新思路和方法。”摘要：Glycyrrhizae Radix et Rhizoma is the most commonly used herb in ZHANG Zhongjing′s Treatise on Cold Pathogenic Diseases and Synopsis of Golden Chamber. It serves as a crucial entry point for understanding ZHANG Zhongjing′s prescription system. The role of Glycyrrhizae Radix et Rhizoma in ZHANG Zhongjing′s prescription system differs from its current recognized efficacy. By analyzing the typhoid prescriptions and referring to ancient materia medica texts from various dynasties, this study categorizes the formulas containing Glycyrrhizae Radix et Rhizoma and identifies four fundamental efficacies associated with it: fluid retention, preservation of gastric qi, support of yang qi, and protection of the triple energizer. These basic efficacy principles align with the core treatment principles implied in ZHANG Zhongjing′s prescription system, suggesting that Glycyrrhizae Radix et Rhizoma is one of the key herbs in constructing ZHANG Zhongjing′s prescription system. To elucidate the logical expansion of prescriptions, formulas containing Glycyrrhizae Radix et Rhizoma are deconstructed and classified into first-order, second-order, tertiary-order, quaternary-order, and other formulas based on the affinity of the paired herbs. Similarly, the corresponding herbs are classified accordingly. Using Cinnamomi Ramulus, Zingiberis Rhizoma, Paeonia lactiflora Pall., and Ephedrae Herba as examples, the study analyzes the principles behind formulas containing Glycyrrhizae Radix et Rhizoma. ZHANG Zhongjing′s prescription system strategically added or subtracted other herbs to fully utilize or extend the four fundamental effects of Glycyrrhizae Radix et Rhizoma, resulting in the majority of existing formulas through continuous expansion. This provides new insights and approaches for further in-depth study of ZHANG Zhongjing′s prescription system.关键词：Glycyrrizae Radix et Rhizoma;classical formula;Zhang Zhongjing;textual research
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发布时间：2024-08-02 -
Discussion on the connotation and clinical application of the " homogeny of dryness and dampness" AI导读
“在中医学领域，深入挖掘“燥湿同源”理论，为现代临床实践提供理论指导，开辟新方向。”摘要：In the theoretical system of traditional Chinese medicine (TCM), the theory of " homogeny" is rich in content and has been extensively discussed by medical scholars throughout history. Various relationships, such as " homogeny of liver and kidney", " homogeny of blood and water", and " homology of ying and wei", have been explored. One relationship that is particularly relevant to the theoretical system of TCM is the connection between dryness and dampness, which is associated with the pathogenesis of many modern diseases. Understanding the relationship between dryness and dampness is crucial in clinical practice. This article examines relevant literature, including classic works like the Huangdi Neijing to explore the theoretical basis for the concept of " homogeny of dryness and dampness". The core connotation of this theory includes the ideas that dryness can generate dampness and dampness can transform into dryness. In clinical practice, it is important for doctors to apply this theory flexibly, addressing dampness when dryness is present and vice versa. For diseases characterized by dampness or dryness pathogens, doctors should consider the coexistence, homology, and mutual transformation of dampness and dryness when conducting syndrome differentiation and treatment. The theory of " homogeny of dryness and dampness" not only enhances the understanding of the etiology and pathogenesis of TCM, but also provides valuable theoretical guidance for modern clinical practice. Further research on this theory will continue to highlight its value in modern clinical applications.关键词："homogeny" theory;homogeny of dryness and dampness;theoretical basis;connotation;clinical application- 137
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发布时间：2024-08-02 - “在中医临床组方用药领域，专家基于病证症结合模式，探索传统方剂君臣佐使原则，提出辨证用药为君、辨病用药为臣、对症用药为佐及调和用药为使的组方原则，为提高临床疗效提供新思路。”摘要：In the context of the complex and ever-changing spectrum of diseases, the traditional Chinese medicine compatibility of prescription and drugs is no longer able to fully meet the needs of clinical diagnosis and treatment. Therefore, this article is based on the diagnosis and treatment model of the combination of disease, syndrome, and symptom, combined with the development achievements of Western medicine, and explores the principles of formulating traditional prescriptions based on the combination of chief, deputy, assistant, and envoy. This article proposes a formulation principle of composing prescriptions with the diagnosis of syndrome as the chief, the diagnosis of disease as the deputy, the treatment of symptoms as the assistant, and the harmonization of medicine as the envoy. This forms a treatment plan with the core link of syndrome differentiation and treatment, disease differentiation and treatment, symptomatic treatment, detoxification, and efficacy enhancement. The purpose of this article is to address the current clinical challenges such as an increasing disease spectrum and the complexity of syndrome patterns and symptom clusters. It aims to provide new insights into traditional Chinese medicine clinical treatment plans and herbal formulation strategies, with the ultimate goal of improving the clinical effectiveness of traditional Chinese medicine.关键词：combination of disease, syndrome, and symptom;compatibility of prescription and drugs;chief, deputy, assistant, and envoy;principles of formulating prescription
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发布时间：2024-08-02 - “最新研究揭示《伤寒杂病论》中“饮食如故”的深层含义，为临床鉴别诊断提供新视角。”摘要：In Treatise on Cold Pathogenic and Miscellaneous Diseases, there are five articles concerning " diet as usual". When many doctors annotate such articles, they mostly interpret " diet as usual" as normal diet or because of stomach qi not affected by disease, ignoring the true significance of " diet as usual" and its role in clinical differential diagnosis. Through sorting out and summarizing the relevant provisions of " diet as usual", combining with the comments of Shuowen Jiezi and various ancient and modern doctors on the relevant provisions of " diet as usual" to explore the meaning behind it, the author believes that " diet as usual" can only be understood as " diet as before". Because it exists in a variety of diseases, it cannot be blindly extended to " normal diet". " Diet as usual" has two functions in clinical differential diagnosis: on the one hand, the stomach is empty, and no solid no drink blocks the qi movement, or there is stagnant heat in the stomach and intestines, but has not yet formed dry feces; on the other hand, when the middle jiao becomes one of the pathogenic factors of the disease, " diet as usual" can exclude the influence of the middle jiao.关键词：Treatise on Cold Pathogenic and Miscellaneous Diseases;diet as usual;pathogenic factors;disease location
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发布时间：2024-08-02
Theoretical Studies
- “最新研究发现，人参-玉竹药对能有效改善慢性应激大鼠的抑郁样行为，其抗抑郁作用可能与抑制脑皮质炎性小体激活及其介导的炎症反应有关。”摘要：ObjectiveTo observe the effect of Renshen (ginseng)-Yuzhu (fragrant solomonseal rhizome) on inflammatory factors and inflammasomes in depression rats, and to explore the antidepressant mechanism of Renshen-Yuzhu.MethodsFifty male SD rats were divided into the blank group, model group, fluoxetine group (2.1 mg/kg), Renshen-Yuzhu low-dose group (1.89 g/kg), and Renshen-Yuzhu high-dose group (5.67 g/kg), with ten rats in each group. Except for the blank group, the rats in the other groups were treated with chronic unpredictable mild stress to establish a depression rat model. On the second day after the end of modeling, the rats in each group were given the corresponding drugs once daily for 14 days. After modeling and dosing, body weight, forced swimming immobility time, and sucrose preference rate were measured. After dosing, hematoxylin-eosin staining was used to detect neuronal damage in the cerebral cortex, enzyme-linked immunosorbent assay was used to detect the contents of interleukin-4 (IL-4), interleukin-23 (IL-23), and interleukin-27 (IL-27) in cortex, real-time PCR was used to detect the mRNA expression of interleukin-24 (IL-24) in cortex, and the protein expressions of nucleotide-binding oligomerization domain-like receptor protein 1 (NLRP1), absent in melanoma 2 (AIM2), and nucleotide-binding oligomerization domain-like receptor protein 4 (NLRC4) were detected by Western blotting.ResultsAfter dosing, compared with the blank group, the body weight of the model group decreased, the sucrose preference rate decreased, the swimming immobility time was prolonged, the neuronal tissue in cortex was destroyed, the content of IL-4 in cortex decreased, the contents of IL-23 and IL-27 in cortex increased, and the protein expressions of NLRP1, AIM2 and NLRC4 in cortex increased (P<0.01). Compared with the model group, the body weight of rats in each administration group increased, the sucrose preference rate increased, the swimming immobility time was shortened, the damage of neuronal tissues in cortex improved, the content of IL-4 in cortex increased, the contents of IL-23 and IL-27 in cortex decreased, and the protein expressions of NLRP1, AIM2 and NLRC4 in cortex decreased (P<0.05).ConclusionRenshen-Yuzhu couplet medicines can improve the depressive-like behavior and exert antidepressant effect in chronic stress rats, and its mechanism may be related to the inhibition of NLRP1, NLRC4, AIM2 inflammasome activation and its mediated inflammatory response in cortex, reducing pro-inflammatory cytokines, and increasing the level of antiinflammatory cytokines.关键词：depression;ginseng;fragrant solomonseal rhizome;inflammatory factors;inflammasomes;rats
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发布时间：2024-08-02
Experimental Studies
- “在男性不育症治疗领域，专家基于叶天士“甘守津还”理论，提出甘味药物可滋阴荣精，补益生殖之精，为提高精子质量和受孕率提供新方案。”摘要：Male infertility, a common condition in andrology, falls under the category of " no son" in traditional Chinese medicine (TCM). Unhealthy eating habits and excessive sexual activity, prevalent due to improved living standards, have contributed to the increasing incidence of male infertility. YE Tianshi proposed the theory of " maintaining with the sweet and restoring the body fluids", which emphasizes the importance of ample body fluid for the nourishment of the male essence chamber. Sufficient body fluid is crucial for normal sperm generation. In TCM, the primary pathogenesis of male infertility involves the loss of body fluids and insufficiency of yin essence. Sweet Chinese herbal medicinal is recommended as it nourishes yin, enriches essence, and replenishes male reproductive essence without producing phlegm and dampness. Therefore, when treating male infertility, attention should be given to the use of sweet Chinese herbal medicinal, adhering to the principle of " abundant body fluids nourish kidney yin, and abundant kidney yin supports semen production". Therapies such as purging fire to preserve body fluids with Zengye Decoction, nourishing yin to enrich essence with Guilu Erxian Decoction, benefiting qi to promote fluid production with Buzhong Yiqi Decoction, and warming yang and transporting fluids with Xianfu Shezi Decoction should be considered. Medication and dosage adjustments should be made based on the specific etiology, pathology, and related symptoms to improve the quality of male sperm and enhance the chances of conception.关键词：male infertility;sweet Chinese herbal medicinal;body fluids;nourishing yin;promoting fluid production
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发布时间：2024-08-02 - “北京大学第一医院胃肠外科及中西医结合科开展的临床试验显示，参苓白术颗粒能有效改善直肠癌低位前切除术后患者的LARS症状，提高生活质量。”摘要：ObjectiveThis study aimed to assess the clinical efficacy of Shenling Baizhu Granules in treating low anterior resection syndrome (LARS) in rectal cancer.MethodsThe study employed a randomized, double-blind, placebo-parallel controlled, single-center, validity-tested clinical trial design. December 2019 to June 2022, the Department of Gastrointestinal Surgery and Integrated Traditional Chinese and Western Medicine of Peking University First Hospital recruited 110 patients who had undergone low anterior resection(LAR) for rectal cancer and subsequently developed LARS. These patients, meeting the enrollment criteria, were randomly assigned into the treatment group (55) and the control group (55) using the double-blind method principle. The randomization table was generated by SAS 9.2 software employing the double-blind method. The treatment group received oral Shenling Baizhu Granules, while the control group received oral placebo granules. Both groups commenced treatment on the 10th day after-surgery for 30 consecutive days. Patients were evaluated using LARS score, traditional Chinese medicine (TCM) symptom grading, and XU Zhongfa score before treatment, on the 15th day of treatment, and on the 1st day after treatment cessation.ResultsOut of 110 patients, 107 were included in the full analysis set for efficacy analysis: 55 patients in the treatment group and 55 patients in the control group. One case in the treatment group was excluded (against protocol), and two cases in the control group were excluded (one lost to follow-up, one against protocol). Baseline data between the two groups were consistent, with no statistically significant difference. Before treatment, LARS scores for the treatment and control groups were 33.0 (31.0, 36.0) and 34.0 (32.0, 37.0) respectively. Patients with TCM symptom scores of grades 2 to 3 accounted for 92.73% and 90.57% in the treatment and control groups, respectively, with no statistically significant difference. After 30 days of treatment, LARS scores for the treatment and control groups were 21.0 (19.8, 23.0) and 26.0 (22.0, 28.0) respectively. The percentage of patients with TCM symptom scores of grades 2 to 3 decreased to 33.33% in the treatment group and 66.04% in the control group, with a statistically significant difference. Shenling Baizhu Granules showed rapid improvement in watery or loose stools in post-operative rectal cancer patients. After 30 days of treatment, Shenling Baizhu Granules significantly improved appetite, stool consistency, abdominal distension, abdominal pain, and eructation symptoms in postoperative rectal cancer patients. Before treatment, the XU Zhongfa scores for the treatment and control groups were 3.0 (2.0, 4.3) and 4.0 (2.0, 4.0) respectively, with no statistically significant difference. After 30 days of treatment, the XU Zhongfa scores for the treatment and control groups were 7.0 (6.0, 8.0) and 6.0 (5.0, 7.0) respectively, with the treatment group significantly higher than the control group (P < 0.01).ConclusionShenling Baizhu Granules can effectively improve LARS symptoms in patients following LAR of rectal cancer within a short period of time.关键词：Shenling Baizhu Granules;rectal cancer;low anterior resection syndrome;traditional Chinese medicine symptom grading;XU Zhongfa scare
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发布时间：2024-08-02 - “最新研究揭示，遗传因素显著影响抽动障碍患儿的临床表现，发病年龄更小，病程更长，病情更严重，更易合并其他精神心理疾病。不同年龄段患儿中医证候分布存在差异，为临床治疗提供重要参考。”摘要：ObjectiveThis study aimed to analyze the impact of genetic factors on the clinical presentation of tic disorder and investigate the pathogenesis of tic disorder considering different sources of genetic influence and generations, along with the distribution characteristics of evidence from Chinese medicine.MethodsInclusion of 474 cases of tic disorder was assembled(from October, 2020 to October, 2023), and clinical data on the children, including gender, age of onset, disease duration, initial symptoms, severity, comorbidities, and family history, and TCM patterns were collected. Firstly, the children were divided into genetic and nongenetic groups based on family history, and their clinical manifestations were observed. Secondly, the age of peak incidence of tic disorder in China(6 or 9 years) was used as the age segmentation point to explore the influence of heredity on clinical manifestations at different ages and the distribution of TCM patterns. Finally, children with genetically-related tic disorder were selected as probands to carry out family studies. The morbidity of the first-degree, second-degree and third-degree relatives of the probands were investigated to analyze the morbidity characteristics and distribution of TCM patterns of children with tic disorder under different genetic types.ResultsOut of 474 children, 226 cases (47.7%) belonged to the genetic group, and 248 cases (52.3%) to the nongenetic group. Compared with the non-genetic group, the genetic group had a younger age of onset (P = 0.013), a longer duration of illness (P = 0.011), a higher degree of severity (P < 0.01), and more comorbid conditions (P = 0.016). Children in the genetic group with an age of onset under 6 years accounted for a larger proportion of the liver-hyperactive and wind-driven pattern(26.5%) and a smaller proportion of the qi depression transforming into fire pattern(17.1%), which were significantly different from those in the non-genetic group (P = 0.016).In the genetic group, 146 cases (64.6%) were inherited from the father, 80 cases (35.4%) from the mother, and there was no significant difference in the developmental characteristics of children with tic disorder from different sources of genetic influence. Furthermore, 183 cases (81.0%) were inherited from the parent-child generation, 26 cases (11.5%) from the second generation, and 17 cases (7.5%) from the third generation; the difference in initial symptoms between different genetic generations was statistically significant (P = 0.042).ConclusionChildren with genetically related tic disorder have a younger age of onset, their condition is more severe, and they are more likely to be comorbid with other psychiatric disorders. The variation in the distribution of Chinese medicine patterns among children with tic disorder of different ages of onset.关键词：tic disorder;genetically-related;family studies;liver hyperactivity and wind-driven pattern;clinical characteristics
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发布时间：2024-08-02 - “最新研究揭示了近视的“脑-目”机制，为中医治疗近视提供了新思路。研究表明，补肾精、充脑髓，补肝血、柔经筋，可充盈脑目精血，增强眼调节功能，延缓眼轴变长，防止近视进展。”摘要：Myopia is a significant global health issue, and its exact causes are still not fully understood, leaving a lack of effective and propaqable treatment options. The prevalence of myopia among children and adolescents in China remains high, posing challenges for prevention and control efforts. According to the " theory of imbalance of essence and tendon", an imbalance in the essential elements and tendons can impede the passage of eye essence and blood, resulting in delayed expansion and contraction of the eye meridians and tendons, leading to blurred vision. Modern research indicates that during the development of myopia, there are notable changes in the microstructure, activation range, and signaling of various brain regions, providing a biological basis for the " brain-eye" mechanism. Moreover, abnormal activity in the brain nucleus contributes to alterations in choroid blood flow and the impairment of eye muscle regulation, thereby accelerating the progression of myopia, this phenomenon represents the manifestation of the brain-eye imbalance. Consequently, strategies for myopia prevention and control should prioritize nourishing kidney essence, replenishing brain marrow, promoting liver and blood health, and softening the meridians. These measures aim to optimize the functioning of the brain and eyes, maintain the flexibility of eye tendons, enhance eye regulation, sustain the strength of eye tendons, and delay the advancement of eye axis growth and myopia. By enriching the scientific understanding of the appropriate application of traditional Chinese medicine techniques to prevent and control myopia through the brain, this research provides valuable insights for future explorations in this field.关键词：myopia;essence;tendon;imbalance;brain science
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发布时间：2024-08-02 - “最新研究揭示，《傅青主女科》中五味合化理论在生殖领域助孕方案中的应用，为提高不孕症患者受孕率提供新思路。”摘要：The combination of sourness, bitterness, sweetness, pungency, and saltness results in different effects. Through the analysis of the theory of combining five flavours in Fu Qingzhu′s Obstetrics and Gynecology, this article explores its application in formulation ideas and the characteristics of Chinese medication, summarized as " primarily sweet, with all four flavors harmonized". FU Qingzhu emphasizes the central role of sweet-flavour medicine in facilitating conception, while incorporating the other four flavours in synergy. For instance, sweet and pungent flavours can boost yang energy, eliminating chilliness and warming the uterus; sour and sweet flavours can nourish yin essence and protect the uterus; bitter and sweet flavours can tonify yin, supporting the kidneys and moistening the uterus; and pungent and salty flavours can eliminate stasis, regenerate blood, and enhance uterine functions. By flexibly utilizing the flavours and meridian affinity of traditional Chinese medicine, along with the theory of combining five flavours, it is possible to enhance drug compatibility, deepen the theoretical connotation of Chinese formulas, and regulate the uterus from both yin and yang aspects to facilitate conception. FU Qingzhu′s integration of multiple Chinese formulas into a single formula allows for comprehensive treatment. Clear differentiation of dosages within the formula highlights the primary and secondary relationships of traditional Chinese medicines. Additionally, the utilization of pharmaceutical processing techniques optimizes efficacy and regulates meridians and collaterals. This article explores FU Qingzhu′s application of the " pure and harmonious traditional Chinese medicines" theory. His prescription thinking enables the attainment of multi-level therapeutic effects, which greatly benefits the optimization of traditional Chinese medicine fertility assistance programs and increases pregnancy rates among infertility patients.关键词：five flavours combination;Fu Qingzhu′s Obstetrics and Gynecology;facilitate conception;medicinal properties of Chinese materia medica;prescription thinking
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发布时间：2024-08-02 - “在泛血管医学领域，专家基于“虚气留滞”理论，探索了内皮细胞功能失调与微炎症状态的病机关键，为疾病防治提供新思路。”摘要：Pan-vascular medicine is an emerging discipline focusing on atherosclerotic diseases, with the concept of multidisciplinary integration, emphasizing on exploring the mechanism of disease development from the whole of the organism′s structure and function. At present, the basic mechanism system of pan-vascular diseases has yet to be perfected. The pan-vascular concept is highly compatible with the idea of Chinese medicine that focuses on the overall view. Deficiency of all qi is the root cause of pan-vascular diseases, while phlegm, blood stasis, and water-dampness and other tangible evils stagnate in the veins and channels as the symptoms of the disease, therefore, the disease mechanism can be highly summarized as " stagnation due to qi deficiency". Deficiency leads to the stagnation, blocking the veins and channels, and the deficiency worsens due to the stagnation and then damages the veins and channels, thus, it develops into a disease. Based on the theory of " stagnation due to qi deficiency", this paper takes endothelial cell dysfunction as the entry point of pan-vascular diseases, and considers that low endothelial cell immunity is the initiating factor of pan-vascular diseases, and that the widespread persistence of microinflammatory state is the key pathology to pan-vascular diseases.关键词：pan-vascular disease;stagnation due to qi deficiency;endothelial cells;immune function;microinflammatory state
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发布时间：2024-08-02 - “最新研究揭示，2型糖尿病患者的失眠和胃肠道症状与血糖控制紧密相关，且这些症状的共存可能显著增加血糖控制难度。”摘要：ObjectiveTo investigate the relationship between insomnia, gastrointestinal symptoms, and glycosylated hemoglobin (HbA1c) levels in individuals diagnosed with type 2 diabetes mellitus (T2DM), as well as the related influencing factors.MethodsA total of 910 T2DM patients treated in our multicenter from January 2022 to December 2022 were enrolled in this study. General information (gender, age, smoking and drinking history, exercise, course of disease, treatment and complications), HbA1c, Athens Insomnia Scale(AIS) scores and Gastrointestinal Symptoms Rating Scale(GSRS) scores of patients were collected. The differences of sleep and gastrointestinal symptoms between groups were analyzed, and the correlation between the differences and HbA1c was analyzed. Furthermore, the risk factors for non-standard HbA1c were analyzed.ResultsThe AIS score and GSRS score in the HbA1c control group were less than those in the non-standard group (P<0.01). Insomnia was reported by 37.0% of T2DM patients, and the HbA1c level in the insomnia group was significantly higher than that in the non-insomnia group (10.00%±2.38% vs. 8.26%±1.73%, P<0.01). Gastrointestinal symptoms were present in 57.5% of T2DM patients, and the HbA1c levels in the group with gastrointestinal symptoms were significantly higher than those in the group without gastrointestinal symptoms (9.26%±2.23% vs. 8.43%± 1.98%, P<0.01). Furthermore, 26.3% of T2DM patients experienced both insomnia and gastrointestinal symptoms. Remarkably, the HbA1c levels in the group with both insomnia and gastrointestinal symptoms were significantly higher than those in the group without either condition (10.18%±2.44% vs. 8.45%±1.86%, P<0.01). Correlation analysis demonstrated a significant association between sleep quality, gastrointestinal function, and HbA1c levels (P<0.01). The logistic regression analysis result revealed that age, GSRS score, AIS score, and the presence of insomnia combined with gastrointestinal symptoms were independent risk factors for predicting HbA1c≥6.5% (P<0.01). Having both insomnia and gastrointestinal symptoms concurrently was the strongest risk factor for substandard HbA1c control, and the risk of blood sugar control may increase about 5 times when both appear together.ConclusionInsomnia and gastrointestinal symptoms are common comorbidities in T2DM patients, showing a cross-interfering relationship, and they appear together with poor blood sugar control, interact causally, and amplify each other.关键词：type 2 diabetes;insomnia;gastrointestinal symptoms;glycosylated hemoglobin;co-management platform of three disciplines of diabetes
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发布时间：2024-08-02
Clinical Studies
- “在恶性肿瘤治疗领域，专家提出“体寒瘤热”病机观，探索寒热平调治疗思路，为改善微环境紊乱、提高临床疗效提供新方向。”摘要：Cancer is a prevalent and challenging disease that is difficult to treat. Western medicine recognizes the disruption of the immune and inflammatory microenvironment as a crucial factor in the development and progression of cancer. According to traditional Chinese medicine, cancer falls into the categories of " accumulation" and " abnormal masses". Based on the attributes of cold and heat in the overall and local conditions as well as the characteristic of the struggle between the vital qi and pathogenic factors at different stages of this disease, this article proposes the concept of " body coldness and tumor heat " to describe the pathogenesis of cancer formation and progression. This pathogenesis aligns with the disruption of the immune and inflammatory microenvironment in modern medical oncology. The article suggests a treatment approach that focuses on balancing cold and heat, nourishing and protecting yang qi, warming the kidneys, and strengthening the spleen to address the " coldness of the entire body". This approach also involves promoting qi circulation, eliminating dampness, phlegm, and stasis, and detoxifying and dispersing nodules to address the " heat in the tumor locally". By addressing deficiencies, eliminating pathogenic factors, and promoting circulation to alleviate stagnation, the aim is to restore the balance of yin and yang and improve the complex state of " coldness of the entire body" and " heat in the tumor locally". These interventions can ameliorate the disorder in the microenvironment and enhance clinical efficacy.关键词：intermingled cold and heat;struggle between vital qi and pathogen;tumor immune microenvironment;tumor inflammatory microenvironment;body coldness and tumor heat
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发布时间：2024-08-02
Hematology and Oncology
- “最新研究发现，电针治疗可显著上调动脉粥样硬化家兔腹腔巨噬细胞中胆固醇逆转运相关蛋白的表达，增强胆固醇逆转运过程，为针刺治疗动脉粥样硬化提供了新的机制解释。”摘要：The objective of this study was to examine the effects of electroacupuncture on the expression of ATP-binding cassette transporter A1 (ABCA1), ATP-binding cassette transporter G1 (ABCG1), and class B type Ⅰ scavenger receptor (SR-BⅠ) genes and proteins in peritoneal macrophages of atherosclerotic rabbits. The study aimed to explore the mechanism underlying the treatment of atherosclerosis (AS) with electroacupuncture.MethodsTwenty-six male New Zealand rabbits were randomly divided into the negative control group (n=7) and the modeling group (n=19) using a random number table method. The negative control group rabbits were fed a regular diet, while the modeling group was induced with a combination of high-fat feed and common carotid artery balloon injury surgery to create an AS model. After successful modeling, the rabbits in the modeling group were further divided into the model group, the electroacupuncture group, and the atorvastatin group, with 6 rabbits in each group. The rabbits in the electroacupuncture group received electroacupuncture at " 'Neiguan’(PC6) ", " 'Zusanli’ (ST36)", and " 'Guanyuan’ (ST25)" acupoints, using a density wave, a current of 1 mA, and a frequency of 4 Hz/20 Hz, once a day. The needle was retained for 20 minutes each time, and a total of 4 courses of treatment were conducted, with 6 days per course. The rabbits in the atorvastatin group were administered atorvastatin calcium tablet suspension (1 mg/kg) orally once a day, for 6 days per course, with a total of 4 courses. After the interventions, HE staining was performed to observe the morphological changes in the common carotid artery tissue of the rabbits. Peritoneal macrophages were collected from the rabbits, and the mRNA expression levels of ABCA1, ABCG1, and SR-BⅠ were measured using real-time fluorescence PCR. The protein expression levels of ABCA1, ABCG1, and SR-BⅠ were detected using Western blotting.ResultsThe negative control group exhibited smooth intima of common carotid artery in rabbits, while the model group displayed damaged intima of common carotid artery, thickened artery walls, and the formation of atherosclerotic plaques. The electroacupuncture group and atorvastatin group showed significant improvements in wall thickening and a reduction in plaque area. Compared with the negative control group, the mRNA and protein expressions of ABCA1, ABCG1, and SR-BⅠ in peritoneal macrophages of rabbits in the model group were reduced (P<0.01). Compared with the model group, the electroacupuncture group and atorvastatin group exhibited increased mRNA and protein expressions of ABCA1, ABCG1, and SR-BⅠ in abdominal macrophages of rabbits (P<0.01). Furthermore, the atorvastatin group demonstrated increased mRNA levels of ABCG1 and SR-BⅠ, as well as increased protein expressions of ABCA1, ABCG1, and SR-BⅠ in peritoneal macrophages of rabbits, in comparison to the electroacupuncture group (P<0.01).ConclusionElectroacupuncture can enhance the expressions of ABCA1, ABCG1, and SR-BⅠ mRNA and protein in abdominal macrophages of AS rabbits, thereby promoting the process of cholesterol reverse transport. This may be one of the mechanisms underlying the effectiveness of acupuncture in the treatment of AS.关键词：atherosclerosis;electroacupuncture;cholesterol reverse transport receptors;rabbits
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发布时间：2024-08-02 - “在中医治疗郁证领域，专家采用针刺疗法，遵循温阳活血原则，选取关键穴位，标本兼顾，攻补兼施，有效促进气血运行，恢复五脏五神功能，为郁证治疗提供新方案。”摘要：The human body′s structure and function are complex, encompassing five viscera, six bowels, as well as differences in qi, blood, yin, and yang. However, the fundamental life activity primarily relies on the body′s yang. Physiologically, when the body has sufficient yang and smooth blood circulation without stagnation, the five organs are nourished, ensuring their proper function. Conversely, pathologically, the deficiency of yang caused by cold injury leads to blood stagnation and prolonged stasis, resulting in inadequate nourishment of the five viscera and subsequent dysfunction. Depression is a condition that can be triggered by cold condensation and blood stasis. Acupuncture treatment follows the principle of warming yang and activating blood circulation. Key acupuncture points such as Baihui (GV20), Dazhui (GV14), Zhiyang (GV9), Mingmen(GV4), Guanyuan(CV4), and Zusanli(ST36) are used to warm yang and replenish qi, while Xuehai (SP10), Weizhong(BL40), and Sanyinjiao(SP6) are utilized to activate blood circulation and open up the veins. Additionally, supplementary points like Danzhong(CV17), Zhongwan(CV12), Qihai(CV6), Hegu(LI4), and Taichong(LR3) are employed to regulate qi and alleviate stagnation, facilitating the smooth flow of qi and blood. This comprehensive approach addresses both the symptoms and the root cause, simultaneously addressing deficiencies and replenishing the body. It aims to restore deficient yang, resolve blood stasis, promote the full and calm flow of qi and blood, nourish the five viscera and restore their proper function, ultimately leading to the self-healing of depression.关键词：depression;yang deficiency;cold-congealed blood stasis;warming yang and activating blood circulation;acupuncture
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发布时间：2024-08-02 - “最新研究揭示，"三法三穴"推拿手法能有效改善轻度慢性压迫性神经损伤大鼠的疼痛症状，其镇痛机制可能与NMDAR1/cGMP/蛋白激酶G信号通路有关。”摘要：ObjectiveTo explore the analgesic initiation mechanism of " three-manipulations and three-acupoints" of tuina on minor chronic constriction injury (minor CCI) model rats.MethodsAccording to the random number table method, 35 SD rats were randomly divided into five groups: normal group, sham group, model group, tuina group, and tuina + MK-801 group. The model group, tuina group, and tuina + MK-801 group were subjected to ligation of the right sciatic nerve trunk to establish a minor CCI rat model. The sham group was only exposed to the right sciatic nerve without ligation, and the normal group was not subjected to any operation. The normal group was not subjected to any intervention measures. On the seventh day after modeling, the model group and the sham group underwent 9 minutes of grasping restraint, while the tuina group underwent one intervention of three-manipulations (point method, dialing method, and kneading method) and three-acupoints (right " Yinmen" (BL37), " Chengshan" (BL57), and " Yanglingquan" (GB34)acupoints) with each manipulation and acupoint intervention for 1 minute for a total of 9 minutes. The tuina+ MK-801 group received intrathecal injection of MK-801 from the fifth to seventh days after modeling, with a dose of 6 μg (10 μL) per day, tuina intervention was performed 30 minutes after the last intrathecal injection, and the specific operation of tuina was the same as that of the tuina group. Before modeling, after modeling, and after intervention, each group of rats was subjected to cold sensitivity threshold (CST) and mechanical withdrawal threshold (MWT) testing. After intervention, immunohistochemistry was used to detect the positive expression of cyclic guanosine monophosphate (cGMP) in the spinal dorsal horn (SDH) at L4-6 segments; protein expressions of N-methyl-D-aspartate receptor 1 (NMDAR1), neurogenic nitric oxide synthase (nNOS), soluble guanylyl cyclase β (sGCβ), and protein kinase G1 (PKG1) in SDH at L4-6 segments were detected by Western blotting; mRNA expressions of NMDAR1, nNOS, sGCβ, cGMP, and PKG1 in SDH at L4-6 segments were detected by real-time PCR.ResultsCompared with the normal and sham groups, after modeling, CST increased and MWT decreased in the model group, tuina group and tuina+ MK-801 group (P<0.05); after intervention, the positive protein expression of cGMP was increased, the protein expressions of NMDAR1, nNOS, sGCβ, and PKG1 were increased, and mRNA expressions of NMDAR1, nNOS, sGCβ, cGMP, and PKG1 were increased in SDH at L4-6 segments in the model group (P<0.05). Compared with the model group, after intervention, CST decreased and MWT increased in the tuina group and tuina+ MK-801 group (P<0.05); the positive protein expression of cGMP was decreased, the protein expressions of NMDAR1, nNOS, sGCβ, and PKG1 were decreased, and mRNA expressions of NMDAR1, nNOS, sGCβ, cGMP, and PKG1 were decreased in SDH at L4-6 segments in the tuina group and tuina+ MK-801 group (P<0.05).ConclusionOne-time tuina intervention can effectively improve the symptoms of thermal and mechanical hyperalgesia induced by peripheral nerve injury, which may initiate analgesia through the NMDAR1/cGMP/protein kinase G signaling pathway, thereby exerting immediate analgesic effect.关键词：tuina;peripherally-induced neuropathic pain;N-methyl-D-aspartate receptor 1;spinal dorsal horn;analgesic;rats
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发布时间：2024-08-02
Acupuncture Moxibustion and Tuina
- “在中药外用制剂领域，研究人员利用气泡微针技术和温敏型材料，成功设计制备了温敏型贮库式微针，有效解决了微针载药量低的问题。该微针具有高载药量、良好机械强度和皮肤穿刺能力，体外和在体释药行为表现出色，为中药外用制剂提供了一种新的高效、微创的给药方式。”摘要：ObjectiveThis paper focuses on the manufacturing technique of bubble microneedles and temperature-sensitive materials in order to design and prepare a temperature-sensitive reservoir microneedle. The objective is to evaluate the feasibility of addressing the issue of low drug load in traditional Chinese medicine (TCM) external preparations using microneedles.MethodsThe study involved the utilization of sinomenine hydrochloride as the model drug. The drug, along with the temperature-sensitive material N-isopropylacrylamide, was filled into the cavity of the bubble microneedle made from chitosan. Through positioning and curing processes, a temperature-sensitive sinomenine hydrochloride reservoir microneedle was prepared. The microneedle consisted of a needle body, a positioning layer, a basal layer, and a drug reservoir. The drug load, size, length, mechanical properties, and puncture ability of the prepared reservoir microneedle were measured to characterize and evaluate its drug load and mechanical properties. In addition, the in vitro release characteristics of the microneedles were determined using Franz diffusion cells, while the in vivo release characteristics were evaluated using the percutaneous microdialysis technique.ResultsThe research result demonstrated that the prepared temperature-sensitive reservoir microneedle had a drug load of approximately 5.76 mg/cm2. The exposed needle tip had a conical shape with a height of around 650 μm, exhibiting good mechanical strength and skin puncture ability. The in vitro release tests showed that the microneedle could simulate the temperature of the skin and release the drug in a controlled and gradual manner, displaying characteristics of diffusion and dissolution of the skeleton. Furthermore, compared to conventional external preparations, the reservoir microneedles significantly enhanced transdermal permeation of the drug in the in vivo percutaneous studies.ConclusionThe study demonstrated that reservoir-type microneedles prepared using temperature-sensitive materials and bubble microneedle preparation techniques could significantly increase the drug load of microneedles, providing the advantage of microinvasion.关键词：reservoir microneedles;transdermal absorption;N-isopropylacrylamide;sinomenine hydrochloride
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发布时间：2024-08-02
Selected Highlights of Chinese Materia Medica
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Discussion on the health preservation of the elderly by reading the
Zhonghua Yizang Yangsheng Volume AI导读“最新研究揭示，《中华医藏·养生卷》类序对老年养生具有重要指导意义。中医养生学科需继承传统，创新发展，培养专业人才，为我国养老事业贡献力量。”摘要：By reading the preface of Zhonghua Yizang Yangsheng Volume, this paper discusses the health preservation of the elderly and emphasizes the importance of original image thinking in the health preservation of traditional Chinese medicine (TCM) from the aspects of the development status, development trend, personnel training, and discipline construction. The elderly care industry of China should abide by the excellent tradition of Chinese civilization, considering the nation as its foundation, never forget the origin, be compatible with foreign essence, better build TCM health preservation discipline, serve the elderly care industry of China, and make it possible for the elderly to " aging gracefully" .关键词：health preservation of traditional Chinese medicine;image thinking;aging gracefully;Zhonghua Yizang- 67
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发布时间：2024-08-02
Editor-in-Chief Essay
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