最新刊期
卷 47 ， 期 8 ， 2024
- “在慢性胃炎“炎癌转化”研究领域，专家基于胃络理论，探讨了病机演变特点及防治策略，为临床治疗提供了新思路。”摘要：The " inflammation cancer transformation" in chronic gastritis is a complex process that involves multiple factors, stages, and mechanisms. As the disease progresses, morphological changes occur in the gastric mucosal gland orifices and capillary vessels, and pathologically, it is characterized by a reduction in the number of glands, structural disarray, or cellular atypia. In traditional Chinese medicine, the onset of chronic gastritis is believed to be related to external pathogenic factors invading the stomach or the internal generation of various pathogenic factors. The disease process is considered to progress from qi to blood, and from meridians to collaterals, which is in line with the theory of " prolonged disease invading collaterals". This article explores the pathogenesis, prevention, and treatment of the " inflammation cancer transformation" in chronic gastritis based on the theory of the stomach collaterals, summarizing the characteristics of the disease evolution as follows: the stomach collaterals are invaded by pathogenic factors, leading to disharmony of qi and collaterals; obstruction of the stomach collaterals, resulting in the internal production of turbid toxins; and deficiency of the stomach collaterals, leading to the loss of nourishment and masses. Clinically, the therapeutic methods include expelling pathogenic factors, regulating qi, and activating collaterals; resolving stasis and detoxifying to unblock collaterals; and replenishing deficiency and eliminating masses to nourish the collaterals, thereby ensuring the patency of the stomach collaterals and the nourishment of the stomach. Starting from the theory of the stomach collaterals and integrating modern scientific research, this article aims to provide theoretical reference and practical guidance for the differential diagnosis and dynamic comprehensive management of the " inflammation cancer transformation" in chronic gastritis.关键词：chronic gastritis;inflammation cancer transformation;stomach collaterals
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发布时间：2024-09-05 - “在癫痫治疗领域，专家基于“脑气络－病络”理论，提出理气通络法，为中医证治提供新思路。”摘要：Epilepsy is a disease of the central nervous system caused by excessive neuronal discharges in the brain, characterized by sudden, recurrent and self-limited onset. The brain′s qi collateral and the brain neural network are highly correlated and internally consistent in terms of structure and function. The theory of " brain′s qi collateral-abnormal collateral", which is centered on the structural disorder and dysfunction of brain′s qi collateral leading to the poor circulation of brain′s qi collateral, can comprehensively explain the related pathogenesis of epilepsy and the law of disease evolution, so it has important clinical value. Taking the pathogenic characteristics as an entry point and based on the theory of " brain′s qi collateral-abnormal collateral", this paper argues that phlegm and qi stagnation, wind in the brain′s qi collateral, and phlegm and blood stagnation damaging the brain′s collaterals, as well as the structural and functional characteristics of brain′s qi collateral that circulate bi-directionally are the key factors for epilepsy to present sudden, recurrent, and self-limited characteristics. According to the therapeutic principle of " Collaterals need to be unobstructed to function normally", it is proposed that the method of regulating the qi and collaterals should be used as the basic treatment principle throughout the treatment. In addition, the method of resolving phlegm and eliminating blood stasis is supplemented for different pathological changes, while combining the syndrome differentiation of zang-fu viscera and attaching importance to the accompanying symptoms of epileptic seizures, to regulate the brain′s qi collateral to achieve the effects of wind quenching and epileptic arrest. This is to provide reference for the treatment of epilepsy in traditional Chinese medicine.关键词：epilepsy;brain′s qi collateral;abnormal collateral;pathogenic characteristics;pathogenesis
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发布时间：2024-09-05 - “在中医治疗慢性肾脏病领域，吕仁和教授发展了癥瘕学说，形成了肾络癥瘕辨证方法，为临床诊疗提供新思路。”摘要：The pattern differentiation method is the most representative part of the inheritance of the experience of renowned practitioners of traditional Chinese medicine, reflecting their clinical thinking characteristics. Among them, Professor LYU Renhe proposed and developed the theory of abdominal masses in the long-term diagnosis and treatment of kidney diseases. Based on his clinical experience, he formed the method of differentiation of Shenluozhengjia (tangible or intangible abdominal masses of kidney collaterals). This differentiation method is characterized by its simple and easy clinical application. Tangible or intangible abdominal masses of kidney collaterals refer to chronic kidney disease, which is based on the basic cause of kidney deficiency. External or internal pathogenic factors cannot be eliminated, and prolonged illness invades the kidney collaterals, causing pathological products, such as qi stagnation, blood stasis, phlegm dampness, heat toxin, and turbid toxin to stagnate in the kidney collaterals, resulting in damage to the kidney body and loss of kidney function. The basic pathogenesis is a deficiency of kidney qi and the formation of tangible or intangible abdominal masses of the kidney collaterals. During pattern differentiation, the type is determined by the deficiency, which is fixed, and the pattern is determined by the excess, which is constantly changing with the condition and can be combined. Furthermore, he summarized the dietary principles as having more essence and less coarseness, more milk and less meat, a phased diet, and the selection of the symptomatic diet. To inherit and improve the theory and clinical practice of the pattern differentiation theory of tangible or intangible abdominal masses of kidney collaterals, this article reviews and summarizes the unique pattern differentiation method of the kidney collateral pattern from the aspects of definition, theoretical origin, etiology and pathogenesis, differentiation and treatment, and regulation, providing a basis for forming suitable diagnosis and treatment method for clinical promotion.关键词：tangible or intangible abdominal masses of kidney collaterals;pattern differentiation methods;chronic kidney disease;chronic, deficiency, and wane consumptive conditions;three main patterns and four secondary patterns;eight stagnation patterns
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发布时间：2024-09-05 - “在女性生殖健康领域，专家从胞宫玄府－络脉郁闭角度，提出开玄通络新疗法，为治疗盆腔炎性疾病后遗症提供新思路。”摘要：The sequelae of pelvic inflammatory disease (SPID) is a gynecological disease that seriously affects the reproductive health and quality of life of women of childbearing age, which is repeated and intractable. In traditional Chinese medicine (TCM), it belongs to the categories of women′s abdominal pain, zhengjia, infertility, etc. The uterus xuanfu-collaterals can maintain the orderly progress of female physiological function by adjusting the circulation of qi and liquids, and also play an important role in the pathological process of SPID. If the opening and closing of the uterus xuanfu-collaterals are orderly, and the qi and liquids are circulating smoothly, the pelvic microcirculation will maintain a balance of homeostasis. If the uterus xuanfu-collaterals are stagnated, the qi and liquids do not circulate smoothly, the pelvic microcirculation will be disordered, leading to the occurrence of SPID. Therefore, from the perspective of the pathogenesis of xuanfu-collaterals stasis, taking opening xuanfu and dredging collaterals as the treatment method, it can be used to smooth qi, relieve stagnation, supplement deficiency, and remove blockage in order to restore the microcirculation in the pelvic region, which can provide new ideas and methods for the treatment of SPID with TCM.关键词：sequelae of pelvic inflammatory disease;uterus;xuanfu-collaterals;pelvic microcirculation disorder;opening xuanfu and dredging collaterals
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发布时间：2024-09-05 - “在中医学领域，专家系统梳理了玄府、气液、胃络的历史源流及其关系，为慢性萎缩性胃炎治疗提供新思路。”摘要：Chronic atrophic gastritis is a common and frequent disease in clinical practice. The symptoms of this disease can be attributed to the categories of " gastric pain" and " plumpness" in traditional Chinese medicine, and its pathogenesis is closely related to the dysfunction of xuanfu, qi-fluids, and stomach collaterals. In this study, we systematically rationalize the historical origin of the xuanfu, qi-fluids, and stomach collaterals and the relationship between them. According to the structure, physiological function and pathological characteristics of " xuanfu-qi-fluids-stomach collaterals", combined with the evolution of the chronic atrophic gastritis disease process, xuanfu depression and closure is believed to be the direct cause of chronic atrophic gastritis occurrence. The disharmony between qi and fluids is the core of the progression of chronic atrophic gastritis. Collateral deficiency and toxin damage are the root causes of the progression of chronic atrophic gastritis. Based on the mechanism of " xuanfu depression and closure-the disharmony between qi and fluids-collateral deficiency and toxin damage", it is proposed to open the xuanfu, restore the pivotal mechanism, activate blood circulation and diuresis, propagate qi and fluids, and supplement deficiency to unblock collaterals. From the perspective of " xuanfu-qi-fluids-stomach collaterals", a more systematic and comprehensive understanding of the dynamic development process of chronic atrophic gastritis can be achieved, which will provide new ideas for the treatment of this disease in traditional Chinese medicine.关键词：Xuanfu;qi-fluids;stomach collaterals;chronic atrophic gastritis;pathogenesis
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发布时间：2024-09-05
Special Theme: TCM Prevention and Treatment of Meridian Diseases
- “在中医肾病治疗领域，专家基于六味地黄丸“三泻”药作用，提出肾藏泻互用理论，为临床诊治肾病提供新思路。”摘要：The theories of " absence of kidney excess syndrome" and " treating kidney disease only by the tonifying method without the purgative method" have been highly praised by medical practitioners throughout history. However, the syndrome of intermingled deficiency and excess of kidney in clinical practice is not uncommon, and there are many cases that treating kidney disease with the method of expelling kidney turbidity. However, its theoretical basis has not been systematically organized and studied. This article, based on the consideration of the " three purging" herbs of Liuwei Dihuang Pill, finds that " kidney" in traditional Chinese medicine not only stores essence, but also removes turbidity. From the theory of storage-expelling of five zang viscera, the physiological characteristic of kidney is integrated with storing and expelling functions. In addition to storing essence and qi to maintain normal life activities in the human body, it also exercises the function of excretion through the bladder and sanjiao. Under pathological conditions, both the function of storing essence and excretion of turbidity in kidney can be affected, which manifests as lack of essence and accumulation of turbidity. The pathological features of this disease are characterized by kidney qi deficiency as the root cause, accumulation of turbidity as the result, and intertwined with each other. Based on the physiology and pathology of visceral manifestation of kidney in traditional Chinese medicine, the theory of " retaining essence and removing turbidity" can be used in the clinical diagnosis and treatment of kidney disease. When treating kidney disease, the method of invigorating the kidney can also be combined with the method of expelling kidney turbidity, such as promoting diuresis, dissipating phlegm, promoting blood circulation, or removing toxin. Flexible selection of the above treatment methods can improve the therapeutic effect.关键词：kidney;visceral manifestation;storage-expelling characteristics of five zang viscera;retaining essence and removing turbidity;Liuwei Dihuang Pill
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发布时间：2024-09-05 - “报道：中医学视角下，张景岳“阳动而散”理论为抑郁症治疗提供新思路，强调通阳解郁、温补阳气、调畅气机。”摘要：Depression, as a common mental illness in the world, has troubled hundreds of millions of patients, affecting the normal life and work of patients, and in serious cases, suicidal tendencies may occur. Depression can be classified into the categories of stagnation syndrome, running piglet, lily disease, and other diseases in traditional Chinese medicine, the mechanism of the disease is mostly related to depression and stagnation, and the clinical symptoms such as low mood and oppression in chest often appear. Based on ZHANG Jingyue′s theory of " yang moving and dispersing", under the pathological state of " yang moving and dispersing", yang disperses and is deficient, leading to yang immobile, and then becomes depression, which ultimately leading to yang depression and the onset of the disease. Clinical treatment should be based on the basic therapeutic method of promoting yang and resolving depression, warming and tonifying yang qi, and regulating qi movement, so as to carry out the syndrome differentiation and treatment of depression.关键词：yang moving and dispersing;yang transforming qi;yang depression;promoting yang and resolving depression;depression
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发布时间：2024-09-05 - “在神经发育障碍性疾病领域，中医专家基于“象－气化”理论，深入探索抽动障碍的内风妄动病理，建立了五风辨治体系，为抽动障碍治疗提供新方案。”摘要：Tic disorder (TD) is a neurodevelopmental disorder. According to the core symptoms, it can be classified as " liver wind", " wind syndrome", and " concurrent". The clinical syndrome of TCM is based on wind, and the pathogenesis is based on the liver. However, the clinical symptoms of this disease are relatively complicated. Based on the " manifestation-qi transformation" theory, this study further explores the liver wind, lung wind, heart wind, spleen wind, and kidney wind from the pathological basis of intrinsic wind rash movement and proposes that the liver wind caused by hyperactivity of liver yang is the main cause of intrinsic wind rash movement in TD, and the lung wind caused by lung loss is the main cause. The liver is related to the heart, spleen, and kidney. Together, the five-wind affect the onset, development, and outcome of TD. Based on this understanding of the pathogenesis, it is necessary to identify the specific syndromes of the patients. The five-wind differentiation and treatment system uses the method of calming the liver and dispelling the lungs to treat the root of the internal wind rash movement. Xiaochaihu Decoction, Sangju Decoction, Cang′erzi Powder, and other prescriptions can be used with modification and subtract and use method of controlling heart fire, transporting spleen soil, and nourishing kidney water to treat derived images. Meanwhile, Xieqing Pill, Daochi Powder, Yigong Powder, Erchen Decoction, Liuwei Dihuang Pill, and other prescriptions can be used with modification.关键词：wind;manifestation;five-wind;five viscera;tic disorder
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发布时间：2024-09-05
Theoretical Studies
- “在传统医药领域，专家深入研究诃子的药用部位和药效，为临床应用提供新见解。”摘要：As a foreign medicine, Terminalia chebula is an important part of the Suhexiang Pill. However, the medicinal parts of Terminalia chebula in the Suhexiang Pill recorded in different prescription books are disparate. Combining historical and social factors, this article refers to and sorts ancient books and documents, classics of ethnic medicine, and Dunhuang manuscripts to determine whether the peel and pulp of Terminalia chebula in Suhexiang Pill mentioned in different prescription books should be the same part. Ethnic medicine is very familiar with the understanding and clinical application of Terminalia chebula. With the progress of the times and an in-depth understanding of Terminalia chebula by various ancient doctors and herbalists in clinical practice, its main efficacy is changing. Modern clinical pharmacology research not only confirms the pharmaceutical effects of Terminalia chebula recorded in ancient documents, but also finds new pharmaceutical actions. Meanwhile, it also explains the use of different parts of the Terminalia chebula from a pharmacological perspective. This article discusses herbal textual research, medicinal parts, and analysis of pharmaceutical effects, and similarities and differences in Terminalia chebula processing to carry out this in-depth study and provide clinical guidance for its use.关键词：Terminalia chebula;Suhexiang Pill;medicinal parts;pharmaceutical effects;processing of medicines
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发布时间：2024-09-05
Literature Studies
- “在高脂血症防治领域，研究团队利用UPLC-Q-Exactive Orbitrap MS技术，揭示了雪菊黄酮类成分的潜在活性成分及其作用机制，为高脂血症的防治提供了新的科学依据。”摘要：ObjectiveTo investigate the potential active ingredients and the mechanism of Coreopsis tinctoria Nutt. in the prevention and treatment of hyperlipidemia.MethodsUltra-high performance liquid chromatography-Quadrupole-Exactive Orbitrap mass spectrometry (UPLC-Q-Exactive Orbitrap MS) was used to qualitatively analyze the fractions and blood components of flavones in Coreopsis tinctoria Nutt. The intersection targets of flavones in Coreopsis tinctoria Nutt. and hyperlipidemia were screened, and the protein-protein interaction network was constructed and analyzed by the STRING 12.0 database. Finally, the gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used for enrichment analysis.ResultsA total of 25 compounds were detected from the flavones in Coreopsis tinctoria Nutt., and their structures were identified, including ten chalcones, nine flavanones, four flavonols, one aurone, and one biflavone. The analysis of blood components showed that marein, flavanomarein, okanin, isookanin and 5, 7, 3′, 5′-tetrahydroxyflavanone-7-O-β-D-glucopyranoside were the main components of the flavones in Coreopsis tinctoria Nutt. in blood. Network pharmacological GO and KEGG enrichment analysis showed that the flavones in Coreopsis tinctoria Nutt. may regulate phosphatidylinositol 3-kinase/protein kinase B, tumor necrosis factor, hypoxia-inducible factor-1 signaling pathway and other signaling pathways in the regulation and prevention of hyperlipidemia.ConclusionCoreopsis tinctoria Nutt. can prevent and treat hyperlipidemia, and the mechanism may be related to the five blood components of the flavones in Coreopsis tinctoria Nutt., including marein, flavanomarein, okanin, isookanin and 5, 7, 3′, 5′-tetrahydroxyflavanone-7-O-β-D-glucopyranoside.关键词：Coreopsis tinctoria Nutt.;hyperlipidemia;ultra-high performance liquid chromatography-Quadrupole-Exactive Orbitrap mass spectrometry;blood component;network pharmacology
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发布时间：2024-09-05 - “在医学研究领域，最新发现表明参苓白术散能通过Nrf2/HO-1/GPX4信号通路抑制铁死亡，改善高尿酸血症小鼠的睾丸生精功能。”摘要：ObjectiveWe aimed to investigate the effect of ferroptosis on Shenling Baizhu Powder, a compound prescription of Chinese herbal medicine, in improving testicular spermatogenic function in hyperuricemic mice with spermatogenic dysfunction.MethodsSixty BALB/c mice were randomly divided into normal group, model group, Shenling Baizhu Powder high-, medium-, and low- dose groups (20.14, 10.07, 5.04 g/kg, by gavage), and ferrostatin-1(Fer-1) group (0.8 mg/kg, by tail vein injection), with 10 mice each group. Except for the normal group, the other groups were intraperitoneally injected with potassium oxonate suspension [600 mg/(kg·d)] for 7 days to establish the hyperuricemic model, and then the corresponding intervention was given for consecutive 14 days. Content of serum uric acid (UA), testicular Fe2+, reduced glutathione (GSH), malondialdehyde (MDA) and superoxide dismutase (SOD) activity were detected by biochemical method. Epididymal and testicular indices were measured. The spermatogenic function of testes was evaluated by eosin-hematoxylin staining. Sperm quality was detected by an automatic animal sperm analyzer. Prussian blue staining was used to detect iron deposition in testicular tissue. Immunohistochemistry was used to detect the related protein expressions of acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) and glutathione peroxidase 4 (GPX4) in testicular tissue. Western blotting was used to detect the related protein expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1(HO-1)/GPX4 signaling pathway in testicular tissue.ResultsCompared with the normal group, the contents of serum UA, MDA, and Fe2+ in the testis tissue of the model group were increased, the GSH content and SOD activity were decreased, the epididymal and testicular index, testicular spermatogenic function, sperm density and activity rate were decreased, and the iron deposition and ACSL4 protein expression in the testis tissue were increased. The expressions of kelch-like ECH-associated protein-1 (Keap1) and Nrf2 were increased. The expressions of nuclear Nrf2, HO-1, GPX4, and recombinant solute carrier family 7 member 11 (SLC7A11) protein were decreased (P<0.01). Compared with the model group, the above indexes in the Shenling Baizhu Powder groups and the Fer-1 group were improved to varying degrees (P<0.05, P<0.01).ConclusionShenling Baizhu Powder can inhibit the ferroptosis of testicular cells through the Nrf2/HO-1/GPX4 signaling pathway, and improve the testicular spermatogenic function of mice with hyperuricemia spermatogenic dysfunction.关键词：Shenling Baizhu Powder;hyperuricemia;spermatogenesis dysfunction;nuclear factor erythroid 2-related factor 2/heme oxygenase-1/glutathione peroxidase 4 signaling pathway;ferroptosis;mice
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发布时间：2024-09-05
Experimental Studies
- “最新研究发现，膝骨关节炎患者关节液中MMP-13和TGF-β1含量与中医证候评分相关，为证候基础研究提供新视角。”摘要：ObjectiveWe aimed to compared matrix metalloproteinase-13 (MMP-13) and transforming growth factor-β1 (TGF-β1) in synovial fluid, the phosphorylation level of Smad3 in articular cartilage (P-Smad3), and their correlation with traditional Chinese medicine (TCM) patterns in patients with knee osteoarthritis (KOA) of liver-kidney deficiency pattern and pattern of intermingled phlegm and blood stasis.MethodsUsing a cross-sectional field investigation method, KOA patients hospitalized in the Orthopedics Department of Dongzhimen Hospital, Beijing University of Chinese Medicine from September 2019 to February 2023 were collected. A total of 112 KOA patients were included, among which 63 cases were diagnosed with liver-kidney deficiency pattern, and 49 cases were diagnosed with pattern of intermingled phlegm and blood stasis. The intensity of knee pain, function, and X-ray imaging result were quantified using the Visual Analogue Scale (VAS), Lysholm Knee Scoring Scale, and Kellgren-Lawrence (K-L) Grading Scale, respectively. The TCM pattern was identified and quantified using a TCM Pattern Scoring Scale. Immunohistochemistry was used to determine the phosphorylation characteristics of Smad3 in articular cartilage, and ELISA was used to measure the contents of MMP-13 and TGF-β1 in synovial fluid. The level characteristics and their correlation with the degree of syndrome were analyzed.Results(i) There was no statistically significant difference in VAS scores, Lysholm scores, and K-L grades between KOA patients with different TCM patterns. (ii) Compared with KOA patients with pattern of intermingled phlegm and blood stasis, patients with pattern of liver-kidney deficiency had higher levels of MMP-13 in synovial fluid and lower levels of TGF-β1 in synovial fluid (P < 0.05). (iii) In KOA patients with liver-kidney deficiency pattern, there was a positive correlation between the level of MMP-13 in synovial fluid and the score of TCM pattern (r = 0.292, P=0.020), while there was a negative correlation between the level of TGF-β1 in synovial fluid and the score of TCM pattern (r = -0.781, P < 0.001). In KOA patients with pattern of intermingled phlegm and blood stasis, there was also a positive correlation between the level of MMP-13 in synovial fluid and the score of TCM pattern (r=0.936, P<0.001). (iv) The mean optical density value of P-Smad3 in articular cartilage was lower in KOA patients with liver-kidney deficiency pattern than in pattern of intermingled phlegm and blood stasis (P < 0.05).ConclusionKOA patients with liver-kidney deficiency pattern or pattern of intermingled phlegm and blood stasis have different levels of TGF-β1 and MMP-13 in synovial fluid, as well as varying degrees of Smad3 phosphorylation in articular cartilage, which is consistent with the analysis of etiology and pathogenesis under different patterns. The levels of TGF-β1 and MMP-13 in synovial fluid of patients with liver-kidney deficiency pattern can reflect the severity of the pattern to a certain extent, and the mechanism may be related to the inhibition of the activation level of the TGF-β/Smad signaling pathway. This study enriches the research content of the material basis of TCM patterns.关键词：knee osteoarthritis;liver-kidney deficiency pattern;pattern of intermingled phlegm and blood stasis;transforming growth factor-β1;matrix metalloproteinase-13;phosphorylation of Smad3
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发布时间：2024-09-05 - “安徽中医药大学研究显示，丹蛭降糖胶囊联合达格列净能显著改善2型糖尿病周围血管病变患者血脂谱和炎性指标，中西医结合治疗更有效。”摘要：ObjectiveThis study aimed to explore the effect of the combined Danzhi Jiangtang Capsule with dapagliflozin on the blood lipid profile and related inflammatory markers in patients with type 2 diabetes mellitus with peripheral vascular disease.Methods72 patients with type 2 diabetes mellitus with peripheral vascular disease who met the inclusion criteria were admitted to the Department of Endocrinology, The First Affiliated Hospital of Anhui University of Chinese Medicine, from April 2021 to April 2023. The patients were assigned to the experimental group and the control group using the random number table method (36 cases in each group). The control group was treated with dapagliflozin in addition to standard treatment, while the experimental group received the Danzhi Jiangtang Capsule for 12 weeks. Clinical efficacy, glucose and lipid metabolism indicators, hypersensitive C-reactive protein (hs-CRP), body mass index (BMI) levels, and traditional Chinese medicine (TCM) syndrome scores were observed pre- and post-treatment.ResultsIn post-treatment, the clinical efficacy was higher in the experimental group than in the control group. Significant reductions in fasting blood glucose (FPG), 2 h postprandial glucose (2 hPG), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), hs-CRP, BMI, and increased high-density lipoprotein cholesterol (HDL-C) were observed. Scores for TCM syndrome and individual items also decreased (P<0.05). Comparisons within the groups for pre- and post-treatment showed reductions in FPG, 2 hPG, TG, TC, LDL-C, hs-CRP, and an increase in HDL-C, along with a decrease in total scores of TCM syndrome (P<0.05).ConclusionThe Danzhi Jiangtang Capsule combined with dapagliflozin in the treatment of type 2 diabetes mellitus with peripheral vascular disease can regulate the blood lipid profile, reduce inflammatory factors, and improve patient′s symptoms. Integrated traditional Chinese and Western medicine treatment are more conducive to controlling the disease, and TCM can be used in clinical practice as a combination treatment.关键词：diabetes peripheral vascular disease;Danzhi Jiangtang Capsule;blood lipid profile;hypersensitive C-reactive protein;traditional Chinese medicine syndrome
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发布时间：2024-09-05 - “在生殖医学领域，专家运用心肾交济理论，为卵巢低反应治疗提供新策略，推动中医药临床应用。”摘要：Poor ovarian response (POR) is a pathological condition in which the ovary responds poorly to gonadotropins, and is a major constraint on the unsatisfactory outcome of in vitro fertilization-embryo transfer (IVF-ET). Follicular growth, development, maturation, and expulsion are all affected by the yin-yang balance between heart and kidney, as well as the elevation exchange. If the heart and kidney essence and blood are insufficient, water and fire are out of harmony, and qi movement is not smooth, fewer high-quality follicles will be recruited and acquired during the ovarian stimulation cycle, resulting in a low transferable embryo rate and unacceptable pregnancy result. Sympathetic treatment of heart and kidney should be based on the following principles at different stages of the IVF-ET cycle: replenishing the heart, kidney, essence, and blood before entering the cycle, in order to nourish the essence and assist in the growth of the follicles; nourishing renal water, and clearing heart fire during the pituitary down-regulation period, in order to lessen the negative effects of the down-regulation medicinals; regulating the depression of the heart, liver, spleen, and kidney meridians during the follicle′s retrieval period, in order to encourage the smooth release of the ova; and warming heart and kidney fire to improve endometrial tolerance during the implantation period. The application of the theory of intercourse of heart and kidney to elucidate the pathogenesis of POR is critical to the development of clinical strategies for fertility enhancement, as well as providing new ideas for the clinical application of traditional Chinese medicine in the field of reproduction.关键词：intercourse of heart and kidney;poor ovarian response;in vitro fertilization-embryo transfer;pathogenesis;treatment
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发布时间：2024-09-05 - “在心房颤动治疗领域，专家基于中医学理论，提出心外膜脂肪组织异常蓄积与阴阳失衡有关，为提高临床疗效提供新思路。”摘要：Epicardial adipose tissue (EAT) is a fat reservoir close to the myocardium and visceral pericardium. It has special anatomical and physiological characteristics. The volume and deposition site of EAT are closely related to the occurrence and development of atrial fibrillation (AF). This article discusses the connotation of the traditional Chinese medicine theory, " yang transforming qi and yin shaping up the body", and holds that the essence of abnormal accumulation of EAT is " yang transforming qi deficiency and yin constituting form too much". Yin pathogen gradually accumulates, local yin and yang imbalance occurs, and abnormal secretion occurs. With the extension of time, the intrinsic yang heat is accompanied and becomes increasingly exuberant. Finally, yin is difficult to control yang, resulting in EAT infiltrating normal tissues, inducing and promoting the occurrence and progression of AF. Under the guidance of this theory, when distinguishing the amount of yin and yang between the body and EAT, considering the ability of " yang transforming qi" and " yin constituting form" in the whole and part, the method of supporting yang and eliminating yin should be reasonably selected. At the beginning of the disease, it is mainly to restore " yang transforming qi". By avoiding the accumulation of evil from the yin, it dissipates the body of the yin that has become. When the disease progresses, it is necessary to " eliminate pathogenic factor", supplemented by different treatment methods such as eliminating dampness, activating qi, and promoting blood circulation. Furthermore, the whole course of the disease should take care of the patient′s deficiency, pay attention to strengthening yang and tonifying the healthy qi, and eliminate yin and evil promptly to improve clinical efficacy.关键词：yang transforming qi;yin shaping up the body;atrial fibrillation;epicardial adipose tissue;tonifying yang and eliminating yin
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发布时间：2024-09-05
Clinical Studies
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Health preservation strategies of the elderly from the perspective of traditional Chinese medicine AI导读
“报道：中医学养生思想体系为应对老龄化社会提供健康管理新思路。”摘要：With the rapid development of society and the improvement of Western medicine, the average life expectancy of the Chinese population has steadily increased. Since the beginning of the 21th century, China has officially entered an aging society and is currently in a phase of rapid growth in the elderly population. The effective management and improvement of the health levels of the elderly have become urgent issues that society needs to address. Traditional Chinese medicine (TCM), rooted in Chinese traditional culture, has developed a rich system of health preservation through thousands of years of historical practice, which has important guiding significance in actively coping with the aging of the population. This article discusses the historical evolution of the theory of health preservation in TCM, the interpretation of aging mechanisms by TCM, and the strategies for elderly health preservation from the perspective of TCM. By exploring TCM health preservation concepts, a theoretical framework for the health care of the elderly is constructed, so as to provide a scientific basis for their health management.关键词：traditional Chinese medicine;health preservation of the elderly;health preservation strategies- 56
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发布时间：2024-09-05 -
Clinical study of Compound
Congrong Yizhi Capsule in treating mild to moderate Alzheimer′s disease AI导读“在阿尔茨海默病治疗领域，青岛大学附属医院及首都医科大学宣武医院的专家通过临床试验验证了复方苁蓉益智胶囊的疗效，为早期干预提供了新方案。”摘要：ObjectiveWe aimed to observe the clinical efficacy and safety of Compound Congrong Yizhi Capsule in subjects with mild to moderate Alzheimer′s disease (AD).MethodsA total of 65 subjects with mild to moderate AD who visited the Affiliated Hospital of Qingdao University and Xuanwu Hospital of Capital Medical University from February 2023 to February 2024 were selected and divided into the Compound Congrong Yizhi Capsule group (40 cases) and the Donepezil Hydrochloride group (25 cases) for a 6-month treatment. The primary outcome measures included the Alzheimer′s Disease Assessment Scale-cognitive subscale (ADAS-Cog) score and Auditory Verbal Learning Test (AVLT) score. Secondary outcome measures included the Mini-Mental State Examination (MMSE), Activities of Daily Living (ADL), Rey-Osterrieth Complex Figure Test (ROCFT), Trail Making Test (TMT), Verbal Fluency Test (VFT), Symbol Digit Modalities Test (SDMT), Digital Span Test (DST), Clock Drawing Test (CDT), and Boston Naming Test (BNT) scores, as well as clinical biochemical indicators including blood lipids, blood glucose, liver and kidney function.ResultsCompared with the Donepezil Hydrochloride group after treatment, subjects in the Compound Congrong Yizhi Capsule group showed an increase in ADAS-Cog and AVLT-total scores, and a decrease in MMSE, Rey-Osterrieth Complex Figure Copy Test, and CDT scores (P<0.05). Additionally, there was an increase in alanine aminotransferase (ALT), blood urea nitrogen(BUN), and total bilirubin (TBIL) levels, and a decrease in indirect bilirubin (IBIL) levels (P<0.05).ConclusionCompound Congrong Yizhi Capsule exerts a regulatory effect on cognitive function in subjects with AD, especially in the cognitive domains of episodic memory and visual-spatial processing ability. It also improves certain clinical indicators such as ALT, BUN, TBIL, and IBIL. This suggests that the early intervention with Compound Congrong Yizhi Capsule in AD can effectively improve symptoms, delay disease progression, and fully embody the concept of traditional Chinese medicine′s preventive approach to illness.关键词：Compound Congrong Yizhi Capsule;mild to moderate Alzheimer′s disease;cognitive function;clinical efficacy;preventive treatment of disease- 36
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发布时间：2024-09-05
Health Preservation and Active Aging
- “最新研究揭示，偏颇体质对健康相关生命质量有负面影响，睡眠质量在其中扮演中介角色，为改善生命质量提供新视角。”摘要：ObjectiveTo explore the effects of biased constitutions on health-related quality of life (HRQOL) and mechanisms of the role of sleep quality in the relationship between biased constitutions and HRQOL.MethodsData collected from the propulation of Beijing and Shijiazhuang, Hebei province for health check-up from March 2015 to December 2016. The biased constitutions were evaluated using the Constitution in Chinese Medicine Questionnaire (CCMQ) score; CCMQ consists of gentleness type (A type), qi-deficiency type (B type), yang-deficiency type (C type), yin-deficiency type (D type), phlegm-wetness type (E type), wet-heat type (F type), blood-stasis type (G type), qi-depression type (H type), and special diathesis type (I type), the eight constitutions except A type are classified as biased constitution (BC), Sleep quality (SQ) was evaluated using the Pittsburgh Sleep Quality Index (PSQI). HRQOL was evaluated using the 36-item Short Form Health Survey (SF-36). Pearson′s correlation analysis was used to explore the correlation among the eight BCs, SQ, and HRQOL, and the structural equation model was further constructed to explore the effects of the eight BCs on HRQOL and the mediating effect of SQ.ResultsA total of 2, 170 samples were included in the database. Finally, 1, 982 samples were included as study subjects after excluding 188 unqualified samples. The SF-36 and PSQI scores of the samples were 79.73 ± 12.89 and 4.29 ± 2.66, respectively, and the scores for the eight BCs were 27.46 ± 14.84, 25.12 ± 19.17, 23.55 ± 14.99, 21.57 ± 15.20, 23.67 ± 15.49, 21.68 ± 14.49, 22.00 ± 16.14, and 16.13 ± 14.19 for B, C, D, E, F, G, H, and I types, respectively. The result of Pearson′s correlation analysis showed that all biased constitution scores were negatively correlated with the SF-36 score (r = -0.562 to -0.327, P < 0.01), and were positively correlated with the PSQI score (r = 0.272 to 0.431, P < 0.01), and PSQI score was negatively correlated with the SF-36 score (r = -0.471, P < 0.01). The result of the structural equation model showed that all biased constitutions had a negative effect on HRQOL and that the mediating role of SQ in the relationship between eight BCs and HRQOL was all statistically significant. The total effects of the eight BCs on HRQOL were -0.776, -0.528, -0.603, -0.684, -0.596, -0.678, -0.751, and -0.452 for the B, C, D, E, F, G, H, and I types, respectively. Moreover, the absolute effects of the B and H types were significantly higher than in other BCs; the mediation effect of SQ was -0.242, -0.272, -0.291, -0.261, -0.265, -0.395, -0.203, and -0.287 for the B, C, D, E, F, G, H, and I types, respectively, the absolute value of the mediation effect between G type and HRQOL was significantly higher than that of other BCs.ConclusionThe eight BCs had negative effects on HRQOL, and SQ played a mediator role in the relationship between the eight BCs and HRQOL.关键词：TCM constitution;biased constitution;health-related quality of life;sleep quality;mediating effect
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发布时间：2024-09-05
TCM Constitution
- “最新研究发现，电针刺激特定穴位能激活肌卫星细胞，促进骨骼肌损伤修复，为肌肉损伤治疗提供新策略。”摘要：ObjectiveTo investigate the mechanism of inducing macrophage polarization induced by acupoint effect of electroacupuncture to promote the repair of acute skeletal muscle injury.Methods45 SD rats were randomly divided into blank group, model group, electroacupuncture group(EA group), sodium chrominate group (DSCG group) and electroacupuncture + sodium chrominate group (hereinafter referred to as EA + DSCG group), with 9 rats in each group. The rats in the EA group and the EA + DSCG group were subjected to EA intervention at the right " Chengshan" (BL57) and " Yanglingquan" (GB34), with a frequency of 2 Hz/100 Hz. The gait changes of rats were recorded by animal gait analyzer. The morphological changes of the right gastrocnemius were observed by HE staining. The changes of mast cell aggregation and degranulation in local skin muscles of " chengshan" point were observed by toluidine blue staining. The expressions of Pax7, MyoD and skin mast cells and 5-HT in the right gastrocnemius were detected by immunofluorescence method. The positive expressions of CD68 and CD206 in right gastrocnemius macrophage was observed by immunohistochemical staining.ResultsCompared with blank group, the wiggle time of the right hind leg in model group and DSCG group increased, stride length decreased, HE staining showed inflammatory cell infiltration, myocyte enlargement, degeneration and necrosis. The degranulation rate of local skin mast cells in " Chengshan" (BL57) area increased, and the expressions of mast cell tryptase, 5-HT, Pax7, MyoD, CD68 and CD206 increased (P<0.05). Compared with model group, the wiggle time of the right hind leg in EA group and EA + DSCG group decreased, stride length increased, HE staining showed that inflammatory cell infiltration was reduced, muscle cells were uniform in size and arranged neatly. Mast cell degranulation rate increased significantly in EA group, and the expressions of mast cell tryptase, 5-HT, Pax7, MyoD and CD206 increased (P<0.05), while CD68 expression decreased (P<0.05). Compared with EA + DSCG group, the degranulation rate of mast cells and the expressions of mast cell tryptase, 5-HT, Pax7, MyoD and CD206 increased (P<0.05), while CD68 expression decreased in EA group (P<0.05).ConclusionEA " Chengshan" (BL57) and " Yanglingquan" (GB34) can stimulate acupuncture points to locally induce mast cell degranulation, promote the polarization of macrophages, and then activate muscle satellite cells to play the regulatory process of repairing skeletal muscle injury.关键词：electroacupuncture;acupoint effect;macrophages;muscle satellite cells
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发布时间：2024-09-05 - “南昌市洪都中医院研究显示，长蛇灸联合加味独活寄生汤治疗腰椎间盘突出症肝肾亏虚证，显著提升临床疗效，有效减轻炎症反应，改善腰椎功能。”摘要：ObjectiveThis study aimed to investigate the clinical effect of long-snake moxibustion combined with modified Duhuo Jisheng Decoction in the treatment of the liver-kidney deficiency pattern of lumbar disc herniation.MethodsAll patients with liver-kidney deficiency pattern of lumbar disc herniation admitted to Nanchang Hongdu Hospital of Traditional Chinese Medicine from March 2021 to April 2023 were assigned the control group and the experimental group by random number table method, with 68 cases in each group. The control group was treated with conventional Western medicine, and the experimental group was treated with long-snake moxibustion combined with modified Duhuo Jisheng Decoction based on the control group for four consecutive weeks. Observe the clinical efficacy, the Japanese Orthopedic Association (JOA) score, and traditional Chinese medicine syndrome score of two groups of patients. Detect the serum levels of prostaglandin E2 (PGE2), transforming growth factor-β 1 (TGF-β1), interleukin-1β (IL-1β), matrix metalloproteinase-2 (MMP-2), and hypoxia-inducible factor-1α (HIF-1α) in two groups of patients.ResultsCompared with the control group (79.41%), the clinical efficaly of experimental group (94.12%) was increased (P<0.05). Compared with before treatment, TCM syndrome score of 2 groups was decreased, JOA score was increased, serum PGE2, TGF-β1, MMP-2, HIF-1α, and IL-1β were decreased after treatment (P<0.05). After treatment, compared with control group, TCM syndrome score of experimental group was decreased, JOA score was increased, serum PGE2, TGF-β1, MMP-2, HIF-1α, and IL-1β were decreased (P<0.05).ConclusionLong-snake moxibustion combined with modified Duhuo Jisheng Decoction can significantly reduce the inflammatory response of patients with liver-kidney deficiency pattern of lumbar disc herniation, inhibit the secretion of pain mediators, improve lumbar function, and thus improve clinical efficacy.关键词：long-snake moxibustion;modified Duhuo Jisheng Decoction;lumbar disc herniation;liver-kidney deficiency pattern
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发布时间：2024-09-05
Acupuncture Moxibustion and Tuina
- 关键词：syndrome/pattern of defensive qi deficiency;diagnostic specification
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发布时间：2024-09-05 - “在中医证候研究领域，专家构建了卫气虚证定性诊断标准，为规范化研究提供新思路。”摘要：The syndrome/pattern of defensive qi deficiency is a common basic syndrome of traditional Chinese medicine in clinical practice. However, there is a lack of standardized and operable diagnostic specifications in practical applications. Based on the previous literature, this study proposed the idea of starting from the elements of the syndrome, qualitative diagnostic criteria for the syndrome/pattern of defensive qi deficiency oriented to the entire region of the disease were constructed based on the two dimensions of " deficient defensive qi failing to consolidate the exterior" and " qi deficiency" and constructing a set of quantitative evaluation criteria as the supporting content for the diagnostic items. The core members of the research group attempted to formulate the draft standard, then reached a consensus through the Delphi method expert questionnaire consultation and the Nominal group technique, and finally evaluated the reliability and validity of the standard through clinical verification to provide ideas for the standardization and normalization of research on syndromes.关键词：defensive qi;syndrome/pattern of defensive qi deficiency;diagnostic specification;thought and method
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发布时间：2024-09-05
Standard & Guidelines
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