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Explore the mechanism of endothelial cell injury in diabetic microangiopathy based on the theory of "turbid blood"

  • role： First author第一作者
  • Affiliation：

    Shandong University of Traditional Chinese Medicine, Jinan 250013, China

  • Introduction：怀宝赓，男，在读博士生
HUAI Baogeng1,  
  • Affiliation：

    Qilu Hospital of Shandong University, Jinan 250012, China

LI Changling2,  
  • Affiliation：

    Qilu Hospital of Shandong University, Jinan 250012, China

HUAI Baosha2,  
  • Affiliation：

    Qilu Hospital of Shandong University, Jinan 250012, China

CAO Yingjuan2,  
  • Affiliation：

    The First Affiliated Hospital of Shandong First Medical University, Jinan 250013, China

XIN Tao3,  
  • role： Corresponding author通信作者
  • Affiliation：

    Qilu Hospital of Shandong University, Jinan 250012, China

  • Email：liudeshan@sdu.edu.cn
  • Introduction：Prof. LIU Deshan, Ph.D., Chief Physician, Doctoral Supervisor. Qilu Hospital of Shandong University, No.107, Wenhua West Road, Lixia District, Jinan 250012. E-mail: liudeshan@sdu.edu.cn
LIU Deshan2*,  
  • Affiliation：

    Shandong University of Traditional Chinese Medicine, Jinan 250013, China

WANG Xinlu1

résumé

"Turbid blood" theory as a new theory of traditional Chinese medicine(TCM), refers to the pathological phenomenon that blood loses its pure state and becomes chaotic, turbid and dysfunctional under the action of various factors. As a pathological product, turbid blood can also be a secondary pathogenic factor of many diseases. Microangiopathy is one of the common complications of diabetes, along with kidney disease and retinopathy. Endothelial cells are a layer of special flat cells between plasma and the blood vessel wall. They have many functions, such as metabolic exchange between plasma and the tissue fluid, synthesis and secretion of bioactive substances, and maintenance of vascular tension. Endothelial cell injury and dysfunction induced by diabetes are the key pathological factors leading to microangiopathy, which is highly consistent with the characteristics of turbid blood. Turbid blood is the cause of endothelial cell damage, and the sustained injury of endothelial cells is the pathological basis of turbid blood followed by disease. In this article, we explain the origin of the theory of turbid blood, emphasize that turbid blood belongs to the theory of TCM, and introduce the close relationship between turbid blood and endothelial cell injury. This article is based on the belief that turbid blood and endothelial cell injury are the core pathogenesis leading to diabetic microangiopathy. Moreover, based on the theory of turbid blood and combined with the disease characteristics of diabetic microangiopathy, the pathogenic evolution characteristics of the disease are summarized as yin deficiency leading to dryness-heat, endogenous turbid blood, and collateral stasis obstruction, and the proposed treatment is based on nourishing yin and protecting vessels, clearing turbid blood, and dredging blood stasis to delay the process of diabetic microangiopathy, thereby improving the clinical symptoms of patients.

mots-clés

turbid blood;endothelial cells;diabetic microangiopathy

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