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低酸素1α（Ad-shNC）およびタンパク質相互作用3（BNIP3）およびHIF-1α/Bcl-2シグ

  • role： First author第一作者
  • Affiliation：

    School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China

  • Introduction：刘田静，女，在读硕士生
LIU Tianjing1,  
  • Affiliation：

    School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China

CHEN Xiangyun1,  
  • Affiliation：

    School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China

TANG Xiaofang1,  
  • Affiliation：

    School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China

LU Yuxin1,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China

  • Email：lyfengcxy2010@163.com
  • Introduction：A/Prof. LI Yaofeng, Ph.D., Master′s Supervisor. Guizhou University of Traditional Chinese Medicine, No.4, Dongqing Road, Guiyang 550025. E-mail: lyfengcxy2010@163.com
LI Yaofeng1*

サマリー

この研究の目的は、血液および空気の滴による治療と、低酸素1α（Ad-shNC）およびタンパク質相互作用3（BNIP3）およびHIF-1α/Bcl-2シグナル伝達経路のキープロテイン1αを介したラットMIRI心筋細胞のプログラムされた細胞死を抑制するメカニズムを調査することである。研究の結果、血液および空気の滴の予防治療は、ラットのMIRIでCK-MB血清レベルを低下させ、心筋組織の外見を改善し、心筋細胞のアポトーシスを減少させ、Bcl-2タンパク質の発現を増加させ、Baxタンパク質、切断されたカスパーゼおよびHIF-1α、HO-1タンパク質の発現を減少させることが示された。

キーワード

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