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Platelet-rich plasma injection combined with warm acupuncture and moxibustion for treating patients with knee osteoarthritis and cold dampness obstruction syndrome

  • role： First author第一作者
  • Affiliation：

    Anhui University of Chinese Medicine, Hefei 230012, China

  • Introduction：尚祥，男，在读博士生
SHANG Xiang1,  
  • Affiliation：

    Anhui University of Chinese Medicine, Hefei 230012, China

WANG Fei1,  
  • Affiliation：

    Anhui University of Chinese Medicine, Hefei 230012, China

YANG Qiqi1,  
  • Affiliation：

    The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, China

JIANG Tianxin2,  
  • Affiliation：

    The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, China

ZHANG Fen2,  
  • Affiliation：

    The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, China

WU Sanbing2,  
  • Affiliation：

    The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, China

YANG Yonghui2,  
  • role： Corresponding author通信作者
  • Affiliation：

    The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230061, China

  • Email：ahzjyykjk@163.com
  • Introduction：Prof. LI Fei, Master′s Degree, Doctoral Supervisor. The Second Affiliated Hospital of Anhui University of Chinese Medicine, No.300, Shouchun Road, Luyang District, Hefei 230061. E-mail: ahzjyykjk@163.com
LI Fei2*

추상적인

ObjectiveTo determine the clinical efficacy of platelet-rich plasma (PRP) injection combined with warm acupuncture and moxibustion for treating patients with knee osteoarthritis and cold dampness obstruction syndrome.MethodsOne hundred and twenty-eight patients with knee osteoarthritis and cold dampness obstruction syndrome who visited the Rehabilitation Department and Orthopedics Department of the Second Affiliated Hospital of Anhui University of Chinese Medicine from January 2023 to March 2024 and who met the inclusion and exclusion criteria were randomly divided into an experimental (n=64) and control group (n=64) using the random number table method. The experimental group was treated with PRP injection combined with warm acupuncture and moxibustion, whereas the control group was treated with normal saline injection combined with warm acupuncture and moxibustion treatment. PRP and normal saline injections were administered once every two weeks, a total of four times. Patients were treated with warm acupuncture and moxibustion once a day, six times a week, for four consecutive weeks. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Traditional Chinese Medicine (TCM) syndrome, visual analog scale (VAS), and Lysholm scores were determined before treatment, at week 4 and week 8 of treatment, and week 16 of follow-up. Serum interleukin-6 (IL-6), matrix metalloproteinase-3 (MMP-3), tumor necrosis factor-α (TNF-α), osteoprotegerin (OPG), bone gla protein(BGP), and cartilage oligomeric matrix protein (COMP) levels were compared between the two groups before and after 8 weeks of treatment. The clinical efficacy and safety indicators between the two groups were also compared.ResultsThere was no statistical difference in baseline data such as gender, age, disease duration, and body mass index between the two groups of patients. Compared with before treatment, both groups showed decreased WOMAC total and subscale, TCM syndrome total score and symptom scores, and VAS scores, and an increase in Lysholm scores at 4, 8, and 16 weeks after treatment. After treatment, serum IL-6, MMP-3, TNF-α, and COMP levels decreased, whereas serum OPG and BGP levels increased (P<0.05). Compared with the control group, patients in the experimental group showed decreased WOMAC total and subscale, TCM syndrome total score and symptom scores, and VAS scores, and an increase in Lysholm score at 4, 8, and 16 weeks after treatment. Compared with the control group, patients in the experimental group showed decreased serum IL-6, MMP-3, TNF-α, and COMP levels and an increase in serum OPG and BPG levels after treatment (P<0.05). The total effective rate of the experimental group was 91.94%, higher than that of the control group (81.97%; P<0.05).ConclusionPRP injection combined with warm acupuncture and moxibustion can improve various TCM symptoms, improve knee joint function and bone metabolism, and reduce inflammation in patients with knee osteoarthritis and cold dampness obstruction syndrome.

키워드

knee osteoarthritis;platelet-rich plasma;Western Ontario and McMaster Universities Osteoarthritis Index score;inflammatory factor;bone metabolism

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