предыдущий|следующий

Comparison of traditional Chinese medicine patterns and brain glucose metabolism between dementia with Lewy bodies and Alzheimer’s disease

  • role： First author第一作者
  • Affiliation：

    Xuanwu Hospital Capital Medical University, Beijing 100053, China

  • Introduction：王晶，女，在读博士生
WANG Jing1,  
  • Affiliation：

    Xuanwu Hospital Capital Medical University, Beijing 100053, China

YU Yueyi1,  
  • Affiliation：

    Xuanwu Hospital Capital Medical University, Beijing 100053, China

YANG Hongwei1,  
  • Affiliation：

    Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China

WANG Yu2,  
  • Affiliation：

    Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China

SUN Wenjun3,  
  • role： Corresponding author通信作者
  • Affiliation：

    Xuanwu Hospital Capital Medical University, Beijing 100053, China

  • Email：qumiao@xwhosp.org
  • Introduction：Prof.QU Miao, Ph.D., Chief Physician, Doctoral Supervisor.Xuanwu Hospital Capital Medical University. No.45, Changchun Street, Xicheng District, Beijing 100053.E-mail: qumiao@xwhosp.org
QU Miao1*

реферат

ObjectiveBy analyzing the traditional Chinese medicine syndrome and cerebral glucose metabolism of dementia with lewy bodies(DLB) and Alzheimer's disease (AD), this study intends to find the features of effective differential diagnosis of DLB and AD.MethodsFrom January 2020 to December 2020, a total of 60 patients meeting the criteria were included, including 30 patients with DLB and 30 patients with AD.The general demographic data of the patients were collected. The total score of the Clinical Dementia Rating Scale (CDR) was used to assess the severity of dementia and the dementia syndrome factor weighting scale was used to determine the syndrome types of the patients. Positron emission computer tomography was performed after intravenous injection of the tracer 18F-fluorodeoxyglucose.ResultsYin deficiency and yang hyperactivity, qi deficiency of lung and kidney, liver-kidney deficiency were the most common syndromes in DLB patients.The syndromes of spleen deficiency and phlegm turbid, heat-toxity and blood stasis, spleen-kidney deficiency were the most common in AD patients. The changes of brain metabolism in DLB patients with suspected dementia were mainly reduced in the parietal lobe and temporal lobe. The metabolism of frontal, parietal and temporal lobes was decreased in DLB patients with mild and moderate dementia. In AD patients with non-severe dementia, the metabolism of the parietal lobe, temporal lobe and frontal lobe is decreased, while in some AD patients with moderate dementia, the metabolism of the occipital lobe is decreased.In patients with DLB, the changes in brain metabolism in patients with syndrome of yin deficiency and yang hyperactivity were mainly reduced metabolism in frontal lobe, parietal lobe, temporal lobe and occipital lobe; the changes in brain metabolism in patients with syndrome of qi deficiency of lung and kidney were mainly reduced metabolism in frontal lobe, parietal lobe and temporal lobe; the changes in brain metabolism in patients with liver-kidney deficiency syndrome were mainly reduced metabolism in parietal lobe and temporal lobe. However, patients with AD with different TCM syndromes mainly have low metabolism in frontal lobe, parietal lobe and temporal lobe.ConclusionThere are significant differences in TCM syndrome and cerebral glucose metabolism characteristics between DLB and AD patients, which is helpful for the differential diagnosis of DLB and AD. The brain metabolic characteristics of DLB patients with different syndromes are different, which is conducive to the precise treatment of DLB.

ключеви́че слова́

dementia with Lewy bodies;Alzheimer’s disease;TCM pattern;positron emission tomography and computed tomography

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