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Exploring the pathogenesis of Takayasu arteritis from a theory of "heat-toxin in blood vessels developing into lumps"

  • role： First author第一作者
  • Affiliation：

    Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China

    Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China

  • Introduction：王双瑛，女，在读硕士生
WANG Shuangying12,  
  • Affiliation：

    Beijing North Medical District, PLA General Hospital, Beijing 100094, China

MENG Yuhang3,  
  • Affiliation：

    Graduate School of China Academy of Chinese Medical Sciences, Beijing 100700, China

MENG Peipei4,  
  • Affiliation：

    Graduate School of China Academy of Chinese Medical Sciences, Beijing 100700, China

YANG Zijing4,  
  • role： Corresponding author通信作者
  • Affiliation：

    Graduate School of China Academy of Chinese Medical Sciences, Beijing 100700, China

  • Email：ywb823@126.com
  • Introduction：Prof. YANG Weibin, Ph. D., Chief Physician, Doctoral Supervisor. Graduate School of China Academy of Chinese Medical Sciences, No.16, Nanxiaojie, Dongzhimennei, Dongcheng District, Beijing 100700. E-mail: ywb823@126.com
YANG Weibin4*

реферат

Takayasu arteritis (TAK) is a chronic granulomatous vasculitis with an unknown etiology that often manifests over time. It has a dismal prognosis and is currently clinically refractory. The theory of poisonous evil has drawn more attention in recent years in the treatment of autoimmune disorders. Poisonous evil tends to accumulate and transform into heat, which causes a variety of symptoms to gradually emerge. Our team believes that the main cause of TAK is the prolonged stagnation of poisonous evil, the transformation of heat into fire, and the damage to the vessels and collaterals. Blood stasis is the basic pathogenesis. This disease is located in the blood vessels, which is also closely related to the spleen and kidney. TAK also belongs to a deficiency in origin and excess in superficislity. Kidney and spleen deficiencies, and a lack of essence and blood, cause only partially filled blood vessels and restricted blood flow. The collection of evil qi and the transformation of heat-toxin culminates in the accumulation of heat-toxin and congestion of blood vessels. The illness persists and the evil qi remains and penetrates the internal organs, causing a lack of vital qi, and the viscera loses its nourishment. Unblocking the blood vessels and boosting blood circulation is the cornerstone of clinical treatment. The focus of treatment is on removing heat-toxin during the active phase, while during the remission phase, the focus is on strengthening the spleen and kidney, nourishing the vessels, taking into consideration detoxification, and dredging collaterals. The goal of the cicatricial period is to dredge collaterals in order to enrich vital qi. Based on relevant theories of traditional Chinese medicine and pathological mechanisms research of western medicine, the significance of heat-toxin in the pathogenesis of TAK is explained. Our team believes that the heat-toxin in blood vessels developing into lumps is the vasculature are the cause of the disease’s morbidity. The heat-toxin can be cleared to remove blood stasis and eliminate lumps, which will improve clinical symptoms, slow the disease’s progression, and provide ideas for clinical treatment.

ключеви́че слова́

heat-toxin;blood vessels;lumps;Takayasu arteritis;pathogenesis

References

  1. [1].
    FIROUZI A, KHALILIPUR E, KHAJALI Z, et al. The Treatment Dilemma of Arteriopathy in Takayasu Arteritis－ A State-of-the-Art Approach[J/OL]. Curr Probl Cardiol，2023，48(1)：101359[2022－11－08]. .
  2. [2].
    GRAYSON PC, PONTE C, SUPPIAH R, et al. 2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis[J].Ann Rheum Dis，2022，81(12)：1654－1660.
  3. [3].
    WATTS RA, HATEMI G, BURNS JC, et al. Global epidemiology of vasculitis[J].Nat Rev Rheumatol，2022，18(1)：22－34.
  4. [4].
    中国医疗保健国际交流促进会血管疾病高血压分会专家共识写作组．锁骨下/颅外椎动脉狭窄的处理：中国专家共识[J]. 中国循环杂志，2019，34(6)：523－532.
  5. [5].
    蔡云，甘可．大动脉炎中医证治阐微[J]. 世界科学技术－中医药现代化，2022，24(1)：408－413.
  6. [6].
    杨丽娜，李明，董全伟，等．脉痹考辨[J]. 中华中医药杂志，2019，34(1)：75－77.
  7. [7].
    马芳，周彩云，韩淑花，等．房定亚清络散血法治疗自身免疫性血管炎经验[J]. 北京中医药，2017，36(5)：432－435.
  8. [8].
    张会永，张哲，杨关林．《黄帝内经》“血脉”理论发微[J]. 中国中医基础医学杂志，2011，17(6)：596－598.
  9. [9].
    周琪，夏士林，刘建均，等．“因毒生热”：毒热理论体系的构建与发展[J].中华中医药学刊，2019，37(7)：1702－1705.
  10. [10].
    尤怡．金匮要略心典[M].杨旭杰，点校．北京：人民军医出版社，2009：33.
  11. [11].
    邱丙庆．论毒邪[J]. 中医药学报，2013，41(4)：7－9.
  12. [12].
    张秉成．成方便读[M].杨威，校注．北京：中国中医药出版社，2002：100.
  13. [13].
    张介宾．类经[M].郭洪耀，吴少祯，校注．北京：中国中医药出版社，1997：121.
  14. [14].
    华佗．华氏中藏经[M].古求知，校注．北京：中国医药科技出版社，2011：15.
  15. [15].
    张介宾．景岳全书[M].夏之秋，校注．北京：中国中医药出版社，1994：277.
  16. [16].
    WEN D, FENG L, DU X, et al. Biomarkers in Takayasu arteritis[J].Int J Cardiol，2023，371：413－417.
  17. [17].
    INDER SJ, BOBRYSHEV YV, CHERIAN SM, et al. Accumulation of lymphocytes, dendritic cells, and granulocytes in the aortic wall affected by Takayasu's disease[J].Angiology，2000，51(7)：565－579.
  18. [18].
    SAADOUN D, VAUTIER M, CACOUB P. Medium－ and Large-Vessel Vasculitis[J].Circulation，2021，143(3)：267－282.
  19. [19].
    章楠．灵素节注类编　医门棒喝三集[M].方春阳，孙芝斋，点校．杭州：浙江科学技术出版社，1986：248.
  20. [20].
    崔炎，刘宝辉，孙莎莎．崔公让对多发性大动脉炎的治疗经验[J]. 辽宁中医杂志，2012，39(4)：628－629.
  21. [21].
    顾世澄．疡医大全[M].叶川，夏之秋，校注．北京：中国中医药出版社，1994：684.
  22. [22].
    李用粹．证治汇补[M].吴唯，校注．北京：中国中医药出版社，1999：156.
  23. [23].
    COMARMOND C, DESSAULT O, DEVAUX JY, et al. Myocardial perfusion imaging in Takayasu arteritis[J].J Rheumatol，2013，40(12)：2052－2060.
  24. [24].
    CHEN Z, LI J, YANG YJ, et al. The renal artery is involved in Chinese Takayasu's arteritis patients[J].Kidney Int，2018，93(1)：245－251.
  25. [25].
    冯兆张．冯氏锦囊秘录[M].田思胜，校注．北京：中国中医药出版社，1996：589.
  26. [26].
    田珂，庞宏永，朱岩．四妙勇安汤加减治疗下肢动脉硬化闭塞症患者的疗效和其部分机制[J]. 世界中医药，2019，14(2)：454－458.
  27. [27].
    孙建慧，杨倩，张纨，等．脾虚浊毒论[J]. 北京中医药大学学报，2021，44(9)：812－817.
  28. [28].
    鲍相璈．验方新编[M].北京：中国中医药出版社，1994：169.

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