In vitro studies of the anti-inflammatory activity of micheliolide on myeloproliferative neoplasm cell lines

  • role: First author第一作者
  • Affiliation:

    First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China

    National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China

  • Introduction:
CHEN Meng12,  
  • Affiliation:

    Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medicial Sciences & Peking Union Medicial College, Tianjin 300020, China

LIU Jinqin3,  
  • Affiliation:

    First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China

    National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China

ZHANG Ying12,  
  • role: Corresponding author通信作者
  • Affiliation:

    First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China

    National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China

  • Email:shzhx0604@163.com
  • Introduction:Prof. SHI Zhexin, Ph.D., Chief Physician, Doctoral Supervisor. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No.88, Changling Road, Xiqing District, Tianjin 300381. E-mail: shzhx0604@163.com
SHI Zhexin12*,  
  • Affiliation:

    Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medicial Sciences & Peking Union Medicial College, Tianjin 300020, China

XIAO Zhijian3

реферат

Целью настоящего исследования было изучение воздействия микелиолида на экспрессию факторов клетки происхождения опухоли костного мозга серии UKE-1 и клеток острого мегакариоцитарного лейкоза SET-2 через путь сигнала и активации транскрипции 3 (СTAT3) и ядерного транскрипционного фактора-κВ (NF-κB) и механизм влияния.

ключеви́че слова́

含笑内酯;骨髓增殖性肿瘤;cytokine;信号传导和转录激活因子3;核转录因子-κB

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