Análisis dinámico del daño mutuo entre cáncer de mama y trastorno mixto de ansiedad y depresión basado en "Estancamiento de la Tierra y Supresión de la Madera"

  • role: First author第一作者
  • Introduction:
WEI Yingyi,  
  • No information about the author is available
LI Feifei,  
  • No information about the author is available
SHAN Yufei,  
  • No information about the author is available
YAN Yongrui,  
  • No information about the author is available
SHI Youyang,  
  • Introduction:E-maillsshtcm@163. com
  • No information about the author is available
LIU Sheng

resumen

Resumen: Este artículo analiza, a partir de la teoría de "Estancamiento de la Tierra y Supresión de la Madera", la interacción dinámica mutua entre el cáncer de mama y el trastorno de ansiedad y depresión mixtos (MADD), integrando evidencia de mecanismos patológicos donde el daño físico y el trauma emocional son causas y consecuencias recíprocas. Proporciona un marco teórico para explicar la unidad intrínseca de la red de interacción microbiota-neuro-tumoral en el círculo vicioso de las comorbilidades malignas. La comorbilidad del cáncer de mama y MADD presenta características de daño mutuo dinámico, cuya patogenia central corresponde a la teoría de la medicina tradicional china "Estancamiento de la Tierra y Supresión de la Madera": la obstrucción del bazo provoca la acumulación de humedad y turbidez, el mal funcionamiento del centro medio afecta la regulación del Qi hepático; la supresión hepática se transforma en fuego que afecta al bazo. Ambos se perjudican y superponen mutuamente, conduciendo a la formación de nódulos de toxinas, flema y estasis sanguínea, con una enfermedad prolongada, daño recíproco del cuerpo y el espíritu, desgaste progresivo hasta la destrucción física y declive espiritual, agotamiento de Tierra y Madera, toxicidad que irradia por meridianos extraños, y separación del yin y yang. El desequilibrio de la microbiota intestinal induce anomalías en las redes metabólicas, inmunológicas y neuroendocrinas, provocando trastornos emocionales y agravando el microambiente tumoral. Este mecanismo confirma el contenido de "obstrucción del bazo y supresión hepática - daño recíproco de cuerpo y espíritu", y aclara cómo induce colapsos en cascada multisistémicos que llevan a una evolución patológica con múltiples síntomas malignos.

palabra clave

Estancamiento de la Tierra y Supresión de la Madera;Cáncer de mama;Trastorno mixto de ansiedad y depresión

References

  1. [1].
    TURNER KM,YEO SK,HOLM TM,et al. Heterogeneity within molecular subtypes of breast cancer[J]. Am J Physiol Cell Physiol, 2021, 321(2): C343-C354.
  2. [2].
    TAO FY,XU MN,ZOU Q,et al. Prevalence and severity of anxiety and depression in Chinese patients with breast cancer: a systematic review and meta-analysis[J]. Front Psychiatry, 2023, 14: 1080413.
  3. [3].
    BIPARVA AJ, RAOOFI S, RAFIEI S, et al. Global depression in breast cancer patients: systematic review and meta-analysis[J]. PLoS One, 2023, 18(7): e0287372.
  4. [4].
    SOUSA RD, ZAGLO DM, COSTA T, et al. Exploring depression in adults over a decade: a review of longitudinal studies[J]. BMC Psychiatry, 2025, 25(1): 378.
  5. [5].
    ROBERTS BL, KARATSOREO IN. Brain-body responses to chronic stress: a brief review[J]. Fac Rev, 2021, 10: 83.
  6. [6].
    胡升芳, 谷焕鹏, 陈红风, 等. 陆德铭教授扶正袪邪法治疗乳腺癌经验[J]. 中华中医药学刊, 2013, 31(12): 2732-2734.
  7. [7].
    刘静, 陆德铭. 陆德铭教授谈乳腺癌与情志[J]. 西部中医药, 2016, 29(7): 49-51.
  8. [8].
    池志恒. 中医对恶性肿瘤病因病机认识的历史演进[D]. 江苏: 南京中医药大学, 2018.
  9. [9].
    刘頔, 纪立金. 浅谈“土壅木郁”理论与临床运用[J].中华中医药杂志, 2021, 36(4): 1956-1958.
  10. [10].
    张仲景. 金匮要略[M]. 广州: 广东科技出版社, 2022.
  11. [11].
    朱震亨. 丹溪心法[M]. 沈阳: 辽宁科技出版社, 1997.
  12. [12].
    黄元御. 四圣心源[M]. 孙洽熙, 校注. 北京: 中国中医药出版社, 2009: 24.
  13. [13].
    YAN J, WANG L, GU Y, et al. Dietary patterns and gut microbiota changes in inflammatory bowel disease: current insights and future challenges[J]. Nutrients, 2022, 14(19): 4003.
  14. [14].
    WANG X, WU M, LAI XX, et al. Network pharmacology to uncover the biological basis of spleen qi deficiency syndrome and herbal treatment[J]. Oxid Med Cell Longev, 2020, 2020: 2974268.
  15. [15].
    DU ZW, LIU XX, XIE ZH, et al. The relationship be tween a high-fat diet, gut microbiome, and systemic chronic inflammation:insights from integrated multiomics analysis[J]. Am J Clin Nutr, 2025, 121(3): 643-653.
  16. [16].
    SLEVIN E, BAIOCCHI L, WU N, et al. Kupffer cells:inflammation pathways and cell-cell interactions in alcohol-associated liver disease[J]. Am J Pathol, 2020, 190(11): 2185-2193.
  17. [17].
    FLEISHMAN JS, KUMAR S. Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets[J]. Signal Transduct Target Ther, 2024, 9(1): 97.
  18. [18].
    XING C, HUANG X, WANG DX, et al. Roles of bile acids signaling in neuromodulation under physiological and pathological conditions[J]. Cell Biosci, 2023, 13(1): 106.
  19. [19].
    陶彦林, 沈漫, 黄菲. 中医肝郁证与抑郁症的“疏肝解郁”之道:青年人心理健康新视角[J]. 心理月刊, 2023, 18(24): 237-240.
  20. [20].
    MALYSZCZAK K, PAWLOWSKI T. Distress and functioning in mixed anxiety and depressive disorder[J]. Psychiatry Clin Neurosci, 2006, 60(2): 168-173.
  21. [21].
    QIN X, PAN HQ, HUANG SH, et al. GABAA(δ) receptor hypofunction in the amygdala-hippocampal circuit underlies stress-induced anxiety[J]. Sci Bull (Beijing), 2022, 67(1): 97-110.
  22. [22].
    MBIYDZENYUY NE, QULU LA. Stress, hypotha-lamicpituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression[J]. Metab Brain Dis, 2024, 39(8):1613-1636.
  23. [23].
    XIAO X, GAO Y, YAN LC, et al. M1 polarization of macrophages promotes stress-induced hair loss via interleukin-18 and interleukin-1beta[J]. J Cell Physiol, 2024, 239(4): e31181.
  24. [24].
    YANG JJ, WEI W, ZHANG SQ, et al. Chronic stress influences the macrophage M1-M2 polarization balance through beta-adrenergic signaling in hepatoma mice[J]. Int Immunopharmacol, 2024, 138: 112568.
  25. [25].
    陈实功. 外科正宗[M]. 北京: 人民卫生出版社, 2023.
  26. [26].
    李杲. 脾胃论[M]. 北京: 人民卫生出版社, 2023: 51.
  27. [27].
    南京中医学院. 诸病源候论校释[M]. 北京: 人民卫生出版社, 1980: 1140.
  28. [28].
    叶天士. 临证指南医案[M]. 苏礼, 校注. 北京: 人民卫生出版社, 2018: 997.
  29. [29].
    杜光庭. 玉函经[M]. 北京: 中国中医药出版社, 2016: 12.
  30. [30].
    CARTER JR, GOLDSTEIN DS. Sympathoneural and adrenomedullary responses to mental stress[J]. Compr Physiol, 2015, 5(1): 119-146.
  31. [31].
    MORATO A, MARTIGNANI E, MIRETTI S, et al. External and internal EGFR-activating signals drive mammary epithelial cells proliferation and viability[J]. Mol Cell Endocrinol, 2020, 520: 111081.
  32. [32].
    SHIVAPPA N, HÉBERT JR, RIETZSCHEL ER, et al. Associations between dietary inflammatory index and inflammatory markers in the Asklepios Study[J]. Br J Nutr, 2015, 113(4): 665-671.
  33. [33].
    SPÄTH-SCHWALBE E, BORN J, SCHREZENMEIER H, et al. Interleukin-6 stimulates the hypothala-muspituitary-adrenocortical axis in man[J]. J Clin Endocrinol Metab, 1994, 79(4): 1212-1214.
  34. [34].
    CHEN XJ, GIANFERANTE D, HANLIN L, et al. HPAaxis and inflammatory reactivity to acute stress is related with basal HPA-axis activity[J]. Psychoneuroendocrinology, 2017, 78: 168-176.
  35. [35].
    GIL DEL ALCAZAR CR, ALECˇKOVI'C M, POLYAK K. Immune escape during breast tumor progression[J]. Cancer Immunol Res, 2020, 8(4): 422-427.
  36. [36].
    CHEN J, CAO X, LI BL, et al. Warburg effect is a cancer immune evasion mechanism against macrophage immunosurveillance[J]. Front Immunol, 2021, 11: 621757.
  37. [37].
    XIE HH, WANG S, NIU DL, et al. A bibliometric analysis of the research landscape on vascular normalization in cancer[J]. Heliyon, 2024, 10(7): e29199.
  38. [38].
    KAUFHOLD S, BONAVIDA B. Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention[J]. J Exp Clin Cancer Res, 2014, 33(1): 62.
  39. [39].
    THIBAUT MM, GILLARD J, DOLLY A, et al. Bile acid dysregulation is intrinsically related to cachexia in tumorbearing mice[J]. Cancers (Basel), 2021, 13(24):6389.
  40. [40].
    PARK M, KIM D, KO S, et al. Breast cancer metastasis: mechanisms and therapeutic implications[J]. Int J Mol Sci, 2022, 23(12): 6806.
  41. [41].
    LIU LX, WANG HY, CHEN XY, et al. Gut microbiota and its metabolites in depression: from pathogenesis to treatment[J]. EBioMedicine, 2023, 90: 104527.
  42. [42].
    QIN J, MA ZH, CHEN XL, et al. Microglia activation in central nervous system disorders: a review of recent mechanistic investigations and development efforts[J]. Front Neurol, 2023, 14: 1103416.
  43. [43].
    MIAO Z, WANG Y, SUN ZS. The relationships between stress, mental disorders, and epigenetic regulation of BDNF[J]. Int J Mol Sci, 2020, 21(4): 1375.
  44. [44].
    DOUGLASS AM, RESCH JM, MADARA JC, et al. Neural basis for fasting activation of the hypothalamic pituitary-adrenal axis[J]. Nature, 2023, 620(7972):154-162.
  45. [45].
    DZIUKOWSKA E, WESOLOWSK M. Cortisol as a biomarker of mental disorder severity[J]. J Clin Med, 2021, 10(21): 5204.
  46. [46].
    范缜. 神灭论[M]// 齐豫生,夏于全. 中华文学名著百部. 第37部,古典散文篇. 乌鲁木齐: 新疆青少年出版社, 2000.
  47. [47].
    张介宾. 类经[M]. 北京: 人民卫生出版社, 1965: 655.
  48. [48].
    陈继儒. 养生肤语[M]. 上海: 上海古籍出版社, 1990: 7.
  49. [49].
    朱浩熙. 彭祖[M]. 北京: 作家出版社, 1995: 290.
  50. [50].
    MBIYDZENYUY NE, QULU LA. Stress, hypothalamicpituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression[J]. Metab Brain Dis, 2024, 39(8):1613-1636.
  51. [51].
    GU X, WEI S, LYU X. Circulating tumor cells: from new biological insights to clinical practice[J]. Signal Transduct Target Ther, 2024, 9(1): 226.
  52. [52].
    LIN DF, SHEN LS, LUO M, et al. Circulating tumor cells: biology and clinical significance[J]. Signal Transduct Target Ther, 2021, 6(1): 404.
  53. [53].
    BEUREL E, TOUPS M, NEMEROFF CB. The bidirectional relationship of depression and inflammation: double trouble[J]. Neuron, 2020, 107(2): 234-256.
  54. [54].
    MUNEER A. Kynurenine pathway of tryptophan metabolism in neuropsychiatric disorders: pathophysiologic and therapeutic considerations[J]. Clin Psychopharmacol Neurosci, 2020, 18(4): 507-526.
  55. [55].
    LIU Y, HU P, ZHENG ZH, et al. Photoresponsive vaccine-like CARM system with high-efficiency central immune regulation for inflammation-related depression[J]. Adv Mater, 2022, 34(11): e2108525.
  56. [56].
    CHAPLEAN CA, LARIMORRE JL, THEIBERT A, et al. Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: fundamental roles in neurodevelopmental disorders associated with mental retardation and autism[J]. J Neurodev Disord, 2009, 1(3): 185-196.
  57. [57].
    MÖLLER HJ, BANDEL B, VOLZ HP, et al. The relevance of 'mixed anxiety and depression' as a diagnostic category in clinical practice[J]. Eur Arch Psychiatry Clin Neurosci, 2016, 266(8): 725-736.
  58. [58].
    YAN JJ, CHEN YB, LUO MH, et al. Chronic stress in solid tumor development: from mechanisms to interventions[J]. J Biomed Sci, 2023, 30(1): 8.
  59. [59].
    ZHENG YF, WANG N, WANG SQ, et al. Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling[J]. J Exp Clin Cancer Res, 2023, 42(1): 129.
  60. [60].
    GRAHAM J. Breast cancer: the psychological impact of diagnosis, treatment, and remission[J]. Cureus, 2024, 16(10): e70814.
  61. [61].
    中国中西医结合学会肿瘤专业委员会, 北京乳腺病防治学会中西医结合专业委员会, 北京中西医慢病防治促进会乳腺癌整合防治全国专家委员会. 乳腺癌中西医结合诊疗共识[J]. 中国医学前沿杂志(电子版), 2021, 13(7): 44-64.
  62. [62].
    陈芍冰. 中药治疗乳腺癌患者焦虑、抑郁状态的meta分析及用药规律挖掘[D]. 广州: 南方医科大学, 2024.
  63. [63].
    朱震亨. 格致余论[M]. 北京: 人民卫生出版社, 2023: 91.

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