Objective To evaluate the effects of chronic illness management intervention and TCM treatment based on pattern identification by stage on the quality of life in patients with diabetic kidney disease（ DKD）. Methods 120 DKD patients were randomly divided into the observation group and control group（ n = 60 in each group）. Comprehensive conventional treatment was offered in both groups. Intervention of chronic illness management and TCM treatment by stage was added to the control group for a course of 24 months and one follow-up every 6 months afterwards. SF-36 Quality of Life（ Qo L SF-36）was used to measure changes of physiological function

psychological condition and overall life quality.Results The physiological function

psychological condition and general life quality were all improved in the two groups at different stages during the 24-month period when compared with baseline data in each group（ P < 0. 05）; Compared with the control group

the observation group started to exhibit more improvement in physiological function and general life quality at the end of 12 month（ P < 0. 05） and maintained the superiority in psychological and social dimension between 18 and 24 months（ P < 0. 05）.Conclusion The combined intervention of chronic illness management and TCM treatment based on pattern identification at different stages may improve psychological and social functions of DKD patients on the basis of improving physiological functions

with an overall benefit of their life quality.