Objective To study the feasibility of colon-specific delivery of New Chang’ankang Formula in the treatment of ulcerative colitis （ UC） . The study was conducted through observing the influences

on rat model of acetic acid-induced UC

of gastrointestinal decomposition delivery of New Chang’ankang Formula

intragastrical delivery of the exact of Huangqi （ Radix Astragalus）

intraintestinal delivery of berberin hydrochloride and extract of Muxiang （ Radix Aucklandiae）

and intragastrical delivery of New Chang’ankang Formula singly. The study took New Chang’ankang Formula （ exacts of Huangqi and Muxiang

and berberin hydrochloride） as the carrier. Methods The rat model of acetic acid-induced UC was established and then the rats were divided into the normal control group

model control group

Sulfasalazine Tablets （ SASP） group

high-dose

mid-dose and low-dose groups of oral delivery

and high-dose

mid-dose and low-dose groups of colon-specific delivery. The medicinals were given to relevant groups 24 hours after the establishment of the model once a day for 6 days. The changes of fecal occult blood （ OB） were recorded every day. After the test ended

the colonic weight was weighed

the colonic length and width were measured

colonic weight index （ colonic weight/colonic length） was calculated and colonic mucosal damage index （ CMDI） and histological score （ HS） were reviewed. Results The effects of gastrointestinal decomposition delivery of New Chang’ankang Formula was as that of the same as its intragastrical delivery singly in the improvement of colonic length

weight and width

and was superior in the improvement of OB

colonic weight index

CMDI and HS. Conclusion The gastrointestinal decomposition delivery of New Chang’ankang Formula has a better protective effect on colonic mucosa in rats with acetic acid-induced UC.