Objective To observe the anti-depression effect of Kaixinjieyu Decoction（KD） with the actions of benefiting the original qi and relieving stagnation in rat model of vascular depression.Methods All SD rats were randomly divided into 8 groups including the normal control group（group 1）

depression model group（group 2）

group of depression treated with KD（group 3）

group of depression treated with Western medicine（group 4）

hyperlipidemia control group（group 5）

vascular depression model group（group 6）

group of vascular depression treated with KD（group 7） and group of vascular depression treated with Western medicine（group 8）.The depression model was established by chronic unpredictable mild stress（CUMS） in group 2

the hyperlipidemia model was established by high fat feeding

and the model of vascular depression was established by CUMS on the base of high fat feeding.All groups were intervened with KD or Western medicine respectively.The weight and sucrose consumption were detected regularity in rats of all groups.The horizontal and vertical activities of rats were determined by open-field test.Results In group 2 and 6

the body weight

sucrose consumption

horizontal and vertical activities all decreased compared with those in group 1.In group 3 and 7（22 g/kg of KD administrated intragastrically for 22 days） the sucrose consumption

horizontal and vertical activities all increased.Conclusion Kaixinjieyu Decoction can relieve significantly the depression state in rats with depression or vascular depression.