Objective To study the influences of seasonal changes of winter and summer on human peripheral blood immune lymphocytes based on the theory of correspondence between nature and human.Methods The levels of immune substance were detected with different methods respectively at the Summer Beginning（SB）

Summer Solstice（SS）

Winter Beginning（WB） an Winter Solstice（WS） in 20 college volunteers.The outcomes were then divided into the SB group

SS group

WB group and WS group.The serum content of lymphocyte immunological markers（CD3+

CD4+

CD8+ and CD56+） were analysed by using flow cytometry.Results The content of CD3+

CD4+

and the ratio of CD4+ to CD8+（CD4+/CD8+） were higher significantly in the SB group and SS group than those in the WB group and WS group in varying degrees.The seasons of summer or winter had no significant influence on CD8+ in T cells and CD56+ in natural killer cells（NK）.Conclusion Winter or summer had some regulation actions on body’s immunity.The immunity tends to strong in summer and poor in winter

which accords with TCM theory of correspondence between nature and human

and defense function of lung and defense aspect.