复方苦三芪胶囊对溃疡性结肠炎大鼠模型结肠黏膜细胞Bcl-2、Bax、Fas和FasL表达的影响

王常松; 邱颂平; 陈建

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复方苦三芪胶囊对溃疡性结肠炎大鼠模型结肠黏膜细胞Bcl-2、Bax、Fas和FasL表达的影响

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- 复方苦三芪胶囊对溃疡性结肠炎大鼠模型结肠黏膜细胞Bcl-2、Bax、Fas和FasL表达的影响
- Influences of Compound Kusanqi Capsules on expressions of Bcl-2,Bax,Fas and FasL of colonic mucosal cells in rat model of ulcerative colitis
- 北京中医药大学学报 2010年33卷第2期页码：110-112
- 作者机构：
  
  1. 福建中医学院中医系
  2. 福建中医学院药学系
- 作者简介：
- 基金信息：
  
  福建省青年人才基金资助项目（No.2006F301030079）()
- DOI：
  中图分类号： R285.5
- 纸质出版：2010-02-01
- 稿件说明：
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[1]王常松,邱颂平,陈建.复方苦三芪胶囊对溃疡性结肠炎大鼠模型结肠黏膜细胞Bcl-2、Bax、Fas和FasL表达的影响[J].北京中医药大学学报,2010,33(02):110-112.

WANG Chang-song1, QIU Song-ping2, CHEN Jian1. Influences of Compound Kusanqi Capsules on expressions of Bcl-2,Bax,Fas and FasL of colonic mucosal cells in rat model of ulcerative colitis[J]. Journal of Beijing University of traditional Chinese Medicine, 2010, 33(2): 110-112.
[1]王常松,邱颂平,陈建.复方苦三芪胶囊对溃疡性结肠炎大鼠模型结肠黏膜细胞Bcl-2、Bax、Fas和FasL表达的影响[J].北京中医药大学学报,2010,33(02):110-112. DOI：

WANG Chang-song1, QIU Song-ping2, CHEN Jian1. Influences of Compound Kusanqi Capsules on expressions of Bcl-2,Bax,Fas and FasL of colonic mucosal cells in rat model of ulcerative colitis[J]. Journal of Beijing University of traditional Chinese Medicine, 2010, 33(2): 110-112. DOI：

摘要

目的观测复方苦三芪胶囊对溃疡性结肠炎（UC）鼠模型结肠黏膜细胞凋亡的干预作用。方法采用二硝基氯苯、乙醇和乙酸综合刺激法复制溃疡性结肠炎鼠模型

以复方苦三芪胶囊高、中、低3个剂量分别进行干预

通过观察其对UC鼠模型结肠黏膜细胞Bcl-2、Bax、Fas和FasL调控蛋白的表达观察其疗效。结果通过15 d的干预治疗

复方苦三芪胶囊高、中、低剂量各组UC鼠模型结肠黏膜细胞Bcl-2、Bax、Fas和FasL蛋白的表达都有不同程度的改善

与模型阳性对照组相比差异具有统计学意义（P<0.01或<0.05）。结论复方苦三芪胶囊对UC鼠模型结肠黏膜细胞凋亡有调节作用。

Abstract

Objective To observe the interventional effect of Compound Kusanqi Capsules on the apoptosis of colonic mucosal cells in rat model of ulcerative colitis（UC）.Methods The rat model of UC was established by administrating dinitrochlorbenzene（DNCB）

alcohol and acetic acid.The model then was intervened by Compound Kusanqi Capsules in high dose

middle dose and low dose respectively.The curative effect was observed through detecting the expressions of modulin Bcl-2

Bax

Fas and FasL of colonic mucosal cells in the model.Results After the intervention for 15 days the expressions of Bcl-2

Bax

Fas and FasL of colonic mucosal cells were improved in varying degrees in the groups of high-dose

mid-dose and low-dose Compound Kusanqi Capsules

which had significant difference statistically compared with those in the model positive control group（P<0.01 or P<0.05）.Conclusion Compound Kusanqi Capsules has the regulation effect on the apoptosis of colonic mucosal cells in rat model of UC.

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