Objective To observe the curative effect of electroacupuncture combining with selective estrogen receptor modulators（Tibolone） on menopausal affective disorders.Methods The menopausal patients with affective disorders（n=40） were randomly divided into two groups（each n=20） according to their visiting orders.The treatment group was treated with electroacupuncture（4 times a week） and Tibolone（2.5 mg/piece） one table every other day.The control group was treated with only Tibolone（2.5 mg/piece） one table every other day.The treatment cycle was 4 weeks.The degree of patients depression was reviewed by using Hamilton Depression Scale（HAMD） before and after the treatment.Results The observation showed that there was a significant difference in HAMD scores between two groups after the treatment（P<0.05）

and the total effective rate was significantly different between two groups（P<0.05）.Conclusion Electroacupuncture combining Tibolone has a better effect than only Tibolone on menopausal affective disorders.