Objective To observe the influences of the effective components of Baijili（Fructus Tribuli） on myocardial fibrosis and expressions of relative cytokines in spontaneously hypertension rats（SHR）

and discuss the possible mechanism of the effective components of Baijili in ameliorating ventricular remodeling and inhibiting the lesion of hypertensive target organs.Methods Male SHR（n=32

14 weeks old） were randomly divided into the model group

captopril group

Baijili group and combination group（each n=8）

and other Wistar rats（n=8

same aged） were included into the normal group.The captopril group was given captopril（30 mg/kg/d）

Baijili group was given the effective components of Baijili（15 mg/kg/d）

combination group was given the effective components of Baijili（15 mg/kg/d） and captopril（30 mg/kg/d）

and model group and normal group were given normal saline solution（2 mL/kg/d） all for 8 weeks.The pathological changes and fibrosis of myocardium were observed by applying HE and VG staining.The expressions of myocardial transforming growth factor β1（TGFβ1） and connective TGF（CTGF） were detected by using ELISA.Results The systolic pressure increased significantly in SHR（14 weeks old） compared with Wistar rats（14 weeks old

P<0.01）.After 8 weeks

the systolic pressure was significantly higher in the model group（22 weeks old） than that in the same group（14 weeks old

P<0.05）.The systolic pressure decreased significantly in the Baijili group than that in the model group（P<0.01）.The outcomes of VG staining showed that the model group（22 weeks old） had myocardial fibrosis and relieved in all medicinal groups similarly.The expressions of TGFβ1 and CTGF increased significantly in the model group compared with the normal group（P<0.05）.Compared with the model group

the expression of TGFβ1 was down-regulated in the captopril group（P<0.05）

and the levels of TGFβ1 and CTGF were significantly down-regulated in the Baijili group（P<0.05）.The levels of TGFβ1（P<0.01） and CTGF（P<0.05） were significantly down-regulated in the combination group.Conclusion The effective components of Baijili can decrease the systolic pressure of SHR

and has inhibitory effect on myocardial fibrosis verified from the angle of morphology.The expressions of TGFβ1 and CTGF increase significantly in SHR

which can be inhibited by the effective components of Baijili and accordingly

the ventricular remodeling induced by hypertension is ameliorated significantly.