Influences of Shi’s acupuncture therapy of awakening brain and opening orifices on plasma content of AngII,CGRP and ET in rat model of cerebral ischemia-reperfusion
ZHENG Yu1, ZHANG Lu-fen2, REN Xiao-xuan2, et al. Influences of Shi’s acupuncture therapy of awakening brain and opening orifices on plasma content of AngII,CGRP and ET in rat model of cerebral ischemia-reperfusion[J]. Journal of Beijing University of traditional Chinese Medicine, 2011, 34(2): 140-144.
ZHENG Yu1, ZHANG Lu-fen2, REN Xiao-xuan2, et al. Influences of Shi’s acupuncture therapy of awakening brain and opening orifices on plasma content of AngII,CGRP and ET in rat model of cerebral ischemia-reperfusion[J]. Journal of Beijing University of traditional Chinese Medicine, 2011, 34(2): 140-144.DOI:
Objective To observe the effects and significance of Shi’s acupuncture therapy of awakening brain and opening orifices on the plasma content of angiotensin Ⅱ(AngII)
calcitonia gene related peptide(CGRP) and endothelin(ET) in rat model of cerebral ischemia-reperfusion.Methods The rat model was established by using thread approach
and then treated with Shi’s acupuncture therapy of awakening brain and opening orifices and Xiangdan Injection at different intervention times.After successful modeling for 72 hours
the plasma content of AngII
CGRP and ET were detected by applying radioimmunoassay.Results Acupuncture reverted the disordered ratio between CGRP and AngII or ET in rat model of cerebral ischemia-reperfusion in varying degrees.Conclusion The early intervention of acupuncture plays an important role in the development of cerebral ischemia-reperfusion through regulating rennin-angiotensin system
ET and CGRP.Shi’s acupuncture therapy of awakening brain and opening orifices can correct the abnormal content of AngII
CGRP and ET based on holistic regulation
which has therapeutic effectiveness and necessity of treatment course.