Objective To observe the preventive effect of alcohol extract of Qincaigen（root of Apium graveolens L.

Uygur medicinal） on the acute hepatic lesion induced by D-galactosamine（D-GalN） in rats.Methods Wistar rats were randomly divided into the normal group

model group

bifendate group

groups of high-dose and low-dose alcohol extract of Qincaigen（high-dose group and low-dose group）.The medicinal groups were given intragastrically medicinal for 7 days and one hour after the last medicinal administration the rats in all groups

except the normal group

were injected intraperitoneally D-GalN for establishing the model of acute hepatic lesion.After 24 hours the samples of blood and liver tissue were collected and the activaties of AST and ALT

and SOD activity and MDA content were detected by using biochemical method and pathological changes of lever tissue were observed by microscope after HE staining and paraffin sectioning.Results The alcohol extract of Qincaigen decreased significantly the levels of serum AST and ALT and liver MDA（P<0.05 or P<0.01）

and increased the activity of liver SOD（P<0.01）.In the high-dose group

the pathological changes of liver cells were relieved with completed liver rope structure

dilated hepatic sinus and mild hyperemia.In the low-dose group

part of liver cells showed necrosis with obvious steatosis and some inflammatory cell infiltration

areosis-like change and cytoplasmic edema.Conclusion The alcohol extract of Qincaigen can inhibit the lipid peroxidation

relieve the pathological lesion of liver cells

and has a preventive effect on the acute hepatic lesion induced by D-GalN in rats.