Objective To observe the inhibitory effect of berberine on hypertrophic cardiomyopathy（HCM） in the model and influence of berberine on the content of exocellular matrix collagen.Methods Two-kidney one-clip（2K1C） method was used to establish rat model of HCM.After 4 weeks the rats were divided into 5 groups according to their systolic pressure levels

including the HCM model group

the groups with 5

10

20 mg/kg berberine respectively and the group with 45mg/kg captopril

while the control group was given sham-operation.The drugs were orally administered for 6 weeks in different groups.Then cardiac weight indexes

contents of collagen and angiotensin II（AngII） in left ventricular tissue were measured.Results The cardiac weights and cardiac weight indexes

contents of collagen and AngII in left ventricular tissue decreased in model rats after constant administration of berberine for 6 weeks.The effect of berberine was in a dose-dependent manner.Conclusion Berberine can improve the ventricular remodeling by inhibiting ventricular interstitial fibrosis

which maybe related to its regulation effect on AngII and some other nervous endocrine factors.