Objective To investigate the changes of plasma levels of prostaglandin I

2

（PGI

2

） and thromboxaneA

2

（TXA

2

） in rat model with renal hypertension and the depressor mechanism of Shouwujiangya Capsules.Method The rat model of renal hypertension was established by using 2K1C method and the plasma levels of 6-Keto-PGF

1α

and TXB

2

were observed.Result After the（administration） of Shouwujiangya Capsules the blood pressures in group 1（with high dose of（Shouwujiangya） Capsules）

group 2（with low dose of Shouwujiangya Capsules） and group 3（with（captoril）） were lower significantly than that in the model group and the difference was significant（P

<

0.001

P

<

0.05

P

<

0.001）.The result showed that Shouwujiangya Capsules and captoril all had a good depressor effect.The plasma level of 6-Keto-PGF

1α

in he group 1 and group 2 was significantly（increased） respectively（P

<

0.01

P

<

0.05）

while the TXA

2

level was decreased significantly（P

<

0.01

P

<

0.05） compared with those in the model group.Conclusion The hypertension in rat model is correlated to the decrease of plasma level of 6-Keto-PGF

1α

and increase of TXB

2

level.Shouwujiangya Capsules can decrease effectively blood pressure and its depressor mechanism may be related to the（regulation） of plasma level of PGI

2

and TXA

2

level.