HUANG Ya-ting, PAN Ting, WEN Jing, et al. Quality representation and correlation analysis of the characteristic spectrum of Rougui based on drug system[J]. Journal of Beijing University of traditional Chinese Medicine, 2015, 38(5): 344-350.
HUANG Ya-ting, PAN Ting, WEN Jing, et al. Quality representation and correlation analysis of the characteristic spectrum of Rougui based on drug system[J]. Journal of Beijing University of traditional Chinese Medicine, 2015, 38(5): 344-350.DOI: 10.3969/j.issn.1006-2157.2015.05.012.
Objective To establish quality representation and correlation analysis method for analyzing the characteristic spectrum of Rougui( Cinnamomum cassia Presl.) based on drug system
evaluating the quality of Rougui decocting pieces comprehensively. Methods HPLC-PDA method was adopted to establish the characteristic spectrum of Rougui decocting pieces
and seven characteristic peaks were screened. The qualitative relevance was presented with the relative retention time characterization.Simultaneously
six main effective index components( protocatechuic acid
epicatechin
coumarin
cinnamic alcohol
cinnamic acid
and cinnamaldehyde) were measured
and characterization contents of the main phenols and the main phenylpropanoids were presented
whose quantitative relevance was represented with correlation analysis. Results Using batch 13 as reference standards
based on thequalitative representation model and correlation analysis
seven characteristic peaks of Rougui decocting pieces were detected to have two characteristic peaks of phenols and five characteristic peaks of phenylpropanoids; the seven characteristic peaks were found in 15 batches of Rougui decocting pieces chromatograms. Based on the quantitative representation model and correlation analysis
the overall amount of effective index components in batch 14 were higher than those in batch 13; the levels of components in batch 4
6
8
and 10 were highly related to batch 13. Comprehensive evaluation result showed that the quality of batch 14
13
4
6
8
and 10 were comparatively higher. Conclusion Quality representation was carried out on the basis of the qualitative characterization. This method could evaluate Rougui pieces’ quality comprehensively
provide a basis for the screening of resources
for controlling the quality of pharmaceutical raw materials
and for the related application
and also provide a new methodology for quality evaluation of Chinese materia medica