Objective To reveal the correlation between angiotensin II-l receptor（ AT1R） gene polymorphism and environmental factors and its implication for different TCM patterns in essential hypertension by analyzing the correlation between two genetic loci of AT1 R and environmental factors. Methods Four groups of EH patients with different TCM patterns and one healthy control group were selected（ n = 100 in each group）. Gene locus polymorphism of A1166 C and T573 C of AT1 R gene was detected by using multiple high temperature ligase detection reaction genotyping technique（ i MLDR） while the effects of correlation between the AT1 R gene polymorphism and environmental factors on different TCM patterns in essential hypertension were assessed by using Multifactor Dimensionality Reduction（ MDR）. Results The results indicated the optimal diagnostic model of excessive phlegm-dampness pattern and yin-yang deficiency pattern were the combination of low-density lipoprotein cholesterol（ LDL-C）

body mass index（ BMI）

salt intake and alcohol consumption with T573 C locus of AT1 R gene. The optimal diagnostic model of liver-fire hyperactivity pattern was the combination of LDL-C and BMI. The optimal diagnostic model of yin deficiency with yang hyperactivity pattern was mono-factor model of dietary habit. It showed that there was a close correlation among LDL-C

salt intake

alcohol consumption with AT1 R T573C gene locus in excessive phlegm-dampness pattern. Meanwhile

it also showed a close interaction of LDL-C

BMI

and dietary habit with AT1 R T573C gene locus in yin-yang deficiency group. Conclusion Correlation between internal and external factors of human may be used to signify different patterns of EH. The correlation between environment factors and T573 C locus of AT1 R gene may be important to the formation of excessive phlegm-dampness pattern and yin-yang deficiency pattern.