Objective To study the effects of Xiaosheng San（ XSS

Xiaosheng Granules） on goblet cells of dry eyes in mice and evaluate its mechanism. Methods 180 male C57BL/6 mice were divided into six groups: normal control（ group A）

model（ group B）

saline（ group C）

XSS low-dose（ group D）

XSS medium-dose（ group E） and high-dose（ group F） groups. Dry eye model was established by injecting scopolamine subcutaneously at the base of rear legs in all groups except normal control group.Schirmer I test（ SIT）

tear break-up time（ BUT）

corneal fluorescent（ FL） staining

and the number of conjunctival goblet cells before and after modeling

and at four weeks after intervention were measured.Results BUT

SIT

and number of goblet cells in group B

C

D

E

and F were significantly decreased after scopolamine treatment（ P < 0. 05）

while no significant difference（ P > 0. 05） was found in group A. FL were significantly increased after model establishment（ P < 0. 05）. Medium-and high-dose XSS significantly improved SIT

BUT and the number of goblet cells in group E and F（ P < 0. 05）. No such changes were observed in group A

B and C（ P > 0. 05）. Conclusion Subcutaneous injecfion of scopolamine could effectively establish dry eye model in mice. Xiaosheng Granules could increase tear secretion

prolong tear break-up time

improve stability

inhibit apoptosis of goblet cells and reduce injury to eye surface.